EKS-TEN-00585

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00585

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	342.8	1.6E-102	20	316	297

Status

Unreviewed

Ensembl Protein

ENSTNIP00000012387

UniProt Accession

H3BYN7;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK6

Gene Synonyms/Alias

MAPK6;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000009514	ENSTNIP00000001103	ENSTNIT00000001825
ENSTNIG00000009514	ENSTNIP00000012387	ENSTNIT00000012578

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

751

Protein Sequence
(FASTA)

MAEKFESLMN IHGFDLGSRY MDLKPLGYGG NGLVFSAVDT DCDKRVAVKK IILTDPQSVK 60

HALREIKIIR RLDHDNIVKV FETLGPNGRR LTEDVVSLTE VNSVYIVQEY METDLCQLLE 120

RGLLSEGHAR LFMYQLLRGL KYIHSANVLH RDLKPANLFV NTEDLVLKIG DFGLARIMDP 180

HYSHKGHLSE GLVTKWYRSP RLLLSPNNYT KAIDMWAAGC IFAEMLTGKT LFAGAHELEQ 240

MQLILESIPV LREEDCQELH SVIPVFIRND MSKPHTPLAK LLPDVSPQAL DFLEKILTFN 300

PMDRLTAEEA LAHPYMADYS FPLDEPVSLH PFHIEDEVDD ILLMDQSHSH TWDSSRCHES 360

QLSEADWHLH STHDPDEVQV DPRGLSDVTD EEEVQVDPRK YADGDREKFL DEPSFDYSLH 420

FPPDRSWQEN DHHENKYCDL QCSHTCNYKA VSPSYLDNLI WRDSEVNHYY EPKLIIDLSN 480

WKEQQSKEKA DRKKSKCEKN GLVKAQIALK EAGKTQGPAE KSQGFDFDSF IASTIKLSLQ 540

PEPCPEVALL NDVGFLNELN SSVSQLEAPR SGSMSKSVSQ EKEEKCLVNL AQLGGGALGL 600

GDGTWPAEPC PSLAFGLRVE ESGCLIDEAC WDIRGEEHLQ KESTYTSYLD QLFSRKEEGV 660

VETVASLEME ASVVREVDES FLSRNAEIVL NVQLDSLALP LPLPLPLPLP GFDGADDLPL 720

KSIQASLTPC AVKCSPQIAH KTYSSIFKHL N 751

Nucleotide Sequence
(FASTA)

ATGGCAGAGA AGTTTGAGTC CCTGATGAAC ATCCACGGTT TTGACCTGGG TTCTCGCTAC 60

ATGGACTTAA AGCCACTCGG TTACGGCGGG AATGGCCTGG TGTTCTCCGC AGTCGACACA 120

GACTGTGATA AGCGTGTGGC TGTGAAGAAA ATCATCTTGA CCGACCCGCA GAGTGTGAAG 180

CATGCCCTGC GGGAAATCAA GATCATCAGA CGCCTTGACC ACGACAACAT AGTGAAGGTG 240

TTTGAGACAT TAGGTCCTAA CGGTCGCAGG CTCACAGAGG ATGTCGTGTC CCTGACGGAG 300

GTCAACTCGG TGTACATTGT GCAAGAGTAC ATGGAGACAG ACCTTTGTCA GCTGCTGGAG 360

AGGGGCCTTC TCTCAGAGGG CCACGCCAGA CTCTTCATGT ACCAGCTCCT GAGGGGCCTT 420

AAGTATATCC ACTCCGCTAA CGTGCTGCAC CGGGACCTCA AGCCCGCTAA CTTGTTTGTC 480

AATACGGAGG ACCTGGTACT TAAGATTGGG GATTTTGGCC TGGCTCGCAT TATGGACCCG 540

CACTATTCTC ACAAGGGCCA TCTCTCAGAG GGTCTGGTCA CCAAGTGGTA TAGATCGCCT 600

CGTCTGCTGC TCTCTCCGAA TAACTACACC AAAGCCATCG ACATGTGGGC AGCTGGCTGC 660

ATCTTTGCCG AGATGCTCAC AGGGAAAACC CTCTTTGCTG GAGCCCACGA GCTGGAGCAG 720

ATGCAGCTGA TTCTGGAGTC CATACCTGTG CTGAGGGAAG AAGACTGCCA AGAGCTCCAC 780

AGCGTCATCC CCGTCTTCAT CCGTAACGAT ATGTCCAAGC CTCACACACC ACTAGCCAAG 840

CTGCTGCCTG ATGTCAGTCC CCAGGCCTTG GATTTCTTGG AGAAGATCCT GACGTTTAAC 900

CCCATGGATC GGCTGACTGC GGAAGAGGCC CTGGCCCACC CCTATATGGC TGACTACTCC 960

TTCCCCTTAG ATGAGCCGGT GTCTCTGCAC CCCTTCCACA TAGAGGATGA GGTCGACGAT 1020

ATCCTGCTCA TGGACCAGAG TCACAGCCAC ACCTGGGACA GTAGCAGATG TCACGAAAGC 1080

CAGCTGTCGG AGGCCGACTG GCACCTACAC AGCACCCACG ACCCAGATGA AGTTCAGGTG 1140

GACCCGAGAG GACTCTCTGA CGTGACAGAT GAAGAAGAGG TCCAGGTGGA CCCTCGTAAA 1200

TATGCCGATG GAGATCGGGA GAAGTTCCTG GATGAGCCGT CCTTTGACTA CTCCCTTCAT 1260

TTCCCTCCAG ACAGATCCTG GCAGGAGAAT GACCACCACG AGAATAAATA CTGTGACTTA 1320

CAGTGTAGCC ATACATGTAA CTACAAGGCC GTGTCACCCT CGTACCTAGA CAACCTCATC 1380

TGGAGGGACA GTGAAGTCAA CCACTACTAC GAGCCCAAGC TCATCATCGA CCTCTCCAAC 1440

TGGAAGGAGC AGCAGAGCAA GGAGAAAGCC GACCGCAAGA AGAGCAAGTG TGAGAAGAAC 1500

GGGCTGGTGA AGGCACAGAT TGCGTTAAAG GAAGCCGGAA AGACCCAGGG TCCTGCCGAG 1560

AAGAGCCAGG GCTTTGATTT TGACTCCTTT ATCGCCAGCA CCATCAAACT GAGCCTGCAG 1620

CCGGAGCCCT GTCCGGAGGT GGCGCTGCTC AACGACGTGG GCTTCCTCAA CGAGCTCAAC 1680

TCCTCCGTCT CCCAGCTGGA GGCTCCACGC TCGGGCTCCA TGTCCAAGTC TGTGAGCCAG 1740

GAGAAAGAGG AGAAGTGCCT GGTGAACCTC GCCCAGTTAG GAGGAGGGGC GCTGGGCCTC 1800

GGGGACGGCA CCTGGCCCGC CGAGCCTTGT CCAAGTTTGG CCTTCGGGTT GCGAGTCGAG 1860

GAGAGCGGCT GCTTGATAGA CGAAGCGTGC TGGGACATAC GCGGCGAGGA GCACCTGCAG 1920

AAGGAGAGCA CTTACACCAG CTACCTGGAC CAGCTGTTCA GCCGGAAGGA GGAGGGCGTG 1980

GTGGAGACGG TGGCCAGCCT GGAGATGGAG GCGTCGGTGG TGAGAGAGGT GGACGAGAGC 2040

TTCCTCAGCA GGAACGCGGA GATCGTGCTG AACGTGCAGC TGGATTCTCT GGCCCTGCCC 2100

CTGCCCCTGC CCCTGCCGCT GCCCCTGCCC GGCTTTGACG GCGCCGACGA CCTGCCTCTG 2160

AAATCCATCC AGGCCTCTCT GACTCCCTGC GCTGTCAAAT GCTCCCCACA AATTGCCCAC 2220

AAAACCTACA GCAGCATTTT CAAGCATCTT AACTAA 2256

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++lkplg G +g+v+savd+++++rva+kk+   +++ +s+k++lRE+k++++l+h+Ni

Q: 20    YMDLKPLGYGGNGLVFSAVDTDCDKRVAVKKII--LTDPQSVKHALREIKIIRRLDHDNI  77

         7899****************************9..9************************

S: 61    iklldvftpee........eleelkdvYlvtelmetdLkkviksqklsdehiklllyqil  112

         +k+++ + p+         +l+e+++vY+v+e+metdL++++++  ls+ h++l++yq+l

Q: 78    VKVFETLGPNGrrltedvvSLTEVNSVYIVQEYMETDLCQLLERGLLSEGHARLFMYQLL  137

         *********999999999999***************************************

S: 113   rglkylHsanviHrDlKPsNllvnedce.lkildFGlarsadkekekk..lteyvatrwY  169

         rglky+Hsanv+HrDlKP+Nl+vn++   lki dFGlar++d+++++k  l+e ++t+wY

Q: 138   RGLKYIHSANVLHRDLKPANLFVNTEDLvLKIGDFGLARIMDPHYSHKghLSEGLVTKWY  197

         ************************876449**************999999**********

S: 170   raPeillslkeytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflk  229

         r+P++lls ++ytka+D+W++GCI+aE+ltgk+lf+g++e++q+++ile ++  +ee+++

Q: 198   RSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVLREEDCQ  257

         ************************************************************

S: 230   kieseearnyikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         +++s  +  +i++ ++k+++++++l+p+ s++ald+lek+L+++p++R+++eeaL+hpY+

Q: 258   ELHSV-IPVFIRNDMSKPHTPLAKLLPDVSPQALDFLEKILTFNPMDRLTAEEALAHPYM  316

         ****5.*****************************************************7

Domain Sequence
(FASTA)

YMDLKPLGYG GNGLVFSAVD TDCDKRVAVK KIILTDPQSV KHALREIKII RRLDHDNIVK 60

VFETLGPNGR RLTEDVVSLT EVNSVYIVQE YMETDLCQLL ERGLLSEGHA RLFMYQLLRG 120

LKYIHSANVL HRDLKPANLF VNTEDLVLKI GDFGLARIMD PHYSHKGHLS EGLVTKWYRS 180

PRLLLSPNNY TKAIDMWAAG CIFAEMLTGK TLFAGAHELE QMQLILESIP VLREEDCQEL 240

HSVIPVFIRN DMSKPHTPLA KLLPDVSPQA LDFLEKILTF NPMDRLTAEE ALAHPYM 297

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR008350	; MAPK_ERK3/4.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01771

; ERK3ERK4MAPK.

Created Date

20-Feb-2013