EKS-TEN-00054
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TEN-00054
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Jak274.98.6E-828131078266
StatusUnreviewed
Ensembl ProteinENSTNIP00000012963
UniProt AccessionH3CXH8;
Protein NameTyrosine-protein kinase
Protein Synonyms/Alias
Gene NameJAK3
Gene Synonyms/Alias JAK3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTNIG00000010067ENSTNIP00000012963ENSTNIT00000013155
OrganismTetraodon nigroviridis
Functional Description
Protein Length1098
Protein Sequence
(FASTA)
LVIRDRGGSQ TSSSSAGGSL QVHLYFVPAT KKATTIHMTS GQISAENVCI QAGKKSGILP 60
VYIGLFGLAS ADLSFWYPPS HMFNTEENLH VCFRVRFFFG NWFDQGPRTA CRYSLTRDRT 120
SPVLDHSGIA YLFAQLRTDF TSSEAGLSPP LTTQDECLGL AVLDLWRLAK EQQSSVKDLC 180
KSVSYKSCLP KSHRVDIEKR NWVERFRIRN TLKHFLKKFG SCAVDDCNLK LMYLTALAGI 240
QPSLGSETFH VDPSSSCLNS RSAVSLVQVT GEIGIQTSEG CEGVVWQTFC DFKEITDISI 300
KRICREQVPN DSRMVTITRK DDACLEVAFQ SLKEALSLVS LVDGYFRLTT DSTHYFCQDT 360
APPSILEGIK NHCHGPITSE FAVNKLKKWG SEDGTFLLRQ SPKTYGEFFL TVCLQTPLGL 420
DYKDCLVIKN KHYSLPGVSK SFSSLKELTV YYQQNKLLLA DVPVRLSRCC PPRSQELTNL 480
IIMRNSSFVE AQLSPTLEGN KLIHIQFQMI KYEDLQWGES LGQGSFTRLF KGYKSNLSEG 540
GKRVSVFLKE LDVNHRNLWE SFFEAASLMS QFSHKHLILV YGVSVSGVKN IMVQEFVEYG 600
ALDLYLKRGR SVSVSWKLDV AKQLASVLTF LEQNNIVHGN ICAKNLLLAR EGDPSQSIPP 660
FIKLSDPGIS VLMLGKDVIV DRIPWVAPEV LASPENLTLE SDKWSFGATL WELFNNGNNP 720
LLGWDLDMKQ KFYESFQQLP PSQWTELADL INQCMDYQAD FRPSCRSIIR QLNSLITSDY 780
VILFATEPDT QNPAWRALTP SQQEQTVFEE RHLRYISLLG KGNFGSVELC CYDPLGDNTG 840
ELVAVKKLQP SKKSSMEDFK KEVKTLSVLH CEYIVKYKGV CYSMGRLSMG LVTEYLPYGS 900
LIGYLENNRH KVDTRRMLLF ASQICKGMEY LQSLRFVHRD LAARNILVAS ESLVKIADFG 960
LTKIIPCNKE YYRVTQPGES PIFWYAPESI NESRFSHESD VWSFGVVLYE LFSYCDINSN 1020
PKRLYMQQIG HNVQTPSISL HLANILKSNW RLPAPPDCPA KVYSLMKECW LYDFMERPCL 1080
LIPEETRLKS SCRMSETA 1098
Nucleotide Sequence
(FASTA)
CTGGTGATCA GGGACCGCGG AGGCAGCCAG ACATCCAGTT CCAGCGCCGG AGGAAGCCTA 60
CAAGTCCACC TCTACTTTGT CCCCGCGACA AAAAAAGCCA CAACAATTCA CATGACATCC 120
GGACAAATCT CGGCTGAGAA CGTCTGTATA CAAGCAGGGA AGAAAAGCGG AATCCTGCCT 180
GTCTACATCG GTCTTTTTGG CCTAGCGTCG GCCGACCTTT CCTTTTGGTA TCCTCCGTCA 240
CACATGTTCA ACACGGAAGA AAACTTGCAC GTCTGCTTCA GAGTCAGGTT TTTCTTTGGA 300
AACTGGTTTG ATCAAGGTCC CAGAACAGCC TGCCGCTACA GTCTGACCAG GGACAGGACA 360
AGTCCGGTGT TGGACCACAG CGGCATCGCC TACCTGTTTG CTCAGCTCAG GACCGATTTT 420
ACGTCTAGCG AGGCGGGATT GTCTCCGCCT CTGACCACCC AAGATGAATG CCTCGGCCTG 480
GCAGTGCTGG ATTTGTGGAG GCTGGCTAAA GAGCAACAAA GCAGCGTGAA AGATCTGTGC 540
AAGAGCGTCA GCTATAAGTC GTGCCTTCCG AAGTCACACC GTGTCGATAT CGAGAAAAGA 600
AACTGGGTGG AACGTTTCCG GATCCGAAAC ACCCTCAAGC ATTTCTTGAA GAAGTTTGGG 660
AGTTGCGCGG TGGACGACTG CAACCTGAAG CTCATGTACC TGACTGCGCT GGCTGGCATC 720
CAGCCTTCTC TGGGCAGCGA AACCTTCCAC GTGGATCCCT CTTCTTCCTG TCTGAACTCC 780
CGGTCGGCTG TTTCTCTGGT TCAGGTTACT GGGGAAATTG GGATTCAAAC CAGTGAAGGC 840
TGTGAAGGAG TTGTGTGGCA GACCTTTTGT GATTTCAAAG AAATCACAGA CATCAGTATC 900
AAAAGGATCT GCCGTGAGCA GGTTCCCAAC GACAGCCGAA TGGTGACAAT AACCCGCAAA 960
GATGACGCAT GCTTGGAAGT GGCGTTCCAG AGCCTCAAGG AAGCGCTGTC GCTCGTGTCA 1020
CTGGTCGACG GCTACTTCAG ACTGACCACA GACTCCACCC ACTACTTCTG CCAGGACACC 1080
GCTCCTCCGA GTATCCTGGA AGGCATCAAA AACCACTGTC ACGGTCCAAT CACATCAGAG 1140
TTTGCAGTCA ATAAGCTGAA AAAGTGGGGA TCTGAAGACG GCACCTTCCT CCTGCGGCAA 1200
AGCCCCAAGA CCTACGGCGA ATTCTTCCTC ACCGTTTGCC TGCAGACTCC TCTTGGGCTG 1260
GATTATAAGG ACTGTCTTGT CATTAAGAAT AAACACTACA GCCTTCCCGG CGTCTCCAAA 1320
TCCTTTTCCA GCCTGAAGGA GCTCACCGTT TATTACCAGC AGAACAAGCT GCTGCTGGCT 1380
GATGTTCCTG TGAGGCTGTC CCGCTGCTGT CCACCCCGAT CACAAGAACT CACAAATCTG 1440
ATCATCATGC GCAACAGCAG CTTTGTGGAG GCTCAGCTGT CCCCCACCCT GGAAGGAAAC 1500
AAACTGATTC ATATCCAGTT CCAGATGATC AAATATGAAG ACCTGCAGTG GGGGGAAAGC 1560
CTCGGTCAGG GGTCCTTCAC TCGCCTTTTC AAAGGCTACA AATCAAACCT GAGCGAGGGC 1620
GGCAAGCGCG TGTCCGTTTT TCTGAAGGAA CTCGACGTCA ATCACAGGAA CCTTTGGGAG 1680
TCATTCTTCG AAGCCGCCAG TCTGATGAGT CAGTTCTCAC ACAAGCACCT CATTCTCGTG 1740
TACGGCGTCA GCGTTAGCGG TGTGAAAAAC ATCATGGTCC AGGAGTTTGT GGAGTACGGG 1800
GCTCTTGACC TTTACTTGAA AAGGGGCAGA TCTGTGTCAG TGAGCTGGAA ACTGGACGTA 1860
GCCAAGCAGC TTGCGTCAGT GCTGACCTTC CTGGAGCAAA ATAACATCGT TCATGGAAAT 1920
ATCTGTGCCA AAAACCTGCT GCTGGCCAGA GAGGGGGACC CATCTCAGAG CATCCCTCCT 1980
TTCATCAAGC TGAGCGACCC TGGAATCAGC GTTCTGATGC TGGGGAAAGA TGTGATCGTG 2040
GACCGGATTC CTTGGGTGGC GCCTGAGGTG CTGGCCTCCC CTGAGAACCT GACTCTGGAG 2100
AGCGATAAGT GGAGCTTTGG TGCCACACTG TGGGAGCTCT TCAACAACGG GAACAATCCT 2160
CTGCTGGGCT GGGACCTGGA CATGAAGCAG AAGTTTTACG AGAGCTTCCA GCAGCTGCCT 2220
CCGTCTCAGT GGACCGAGCT GGCCGACCTG ATCAATCAGT GCATGGACTA CCAGGCGGAC 2280
TTCAGACCCT CCTGCCGCAG CATCATCCGA CAGCTCAACA GTCTGATCAC TTCAGACTAC 2340
GTGATTCTTT TTGCCACCGA GCCCGACACG CAGAACCCTG CCTGGAGGGC CCTCACACCC 2400
TCTCAGCAGG AACAGACCGT GTTTGAGGAG AGACACTTGC GTTACATCTC CCTACTGGGA 2460
AAAGGAAACT TTGGGAGCGT CGAACTTTGC TGTTACGACC CGCTGGGTGA CAACACGGGT 2520
GAGCTGGTTG CTGTGAAGAA GCTACAACCC AGCAAGAAGT CGTCCATGGA GGACTTCAAG 2580
AAGGAGGTCA AAACCTTGAG CGTTTTACAC TGCGAATACA TCGTGAAGTA CAAAGGGGTC 2640
TGCTACAGCA TGGGTCGTCT CAGTATGGGT TTGGTGACGG AGTACCTGCC CTATGGCAGC 2700
CTCATTGGCT ACTTGGAAAA TAATCGACAC AAGGTGGACA CAAGACGGAT GCTGCTGTTC 2760
GCCTCTCAGA TCTGTAAGGG GATGGAGTAC CTGCAGTCCC TGCGTTTTGT GCACAGAGAC 2820
CTGGCAGCCA GAAACATCCT GGTGGCCAGC GAGTCGCTGG TGAAAATAGC CGATTTTGGG 2880
CTGACCAAGA TTATTCCTTG TAACAAGGAA TACTACCGGG TCACGCAGCC CGGAGAGAGT 2940
CCCATCTTCT GGTACGCCCC AGAGTCCATC AATGAATCCA GATTCTCCCA CGAATCCGAC 3000
GTTTGGAGTT TTGGAGTGGT TCTTTACGAG CTCTTCTCCT ACTGTGACAT CAATTCCAAC 3060
CCTAAAAGAC TTTATATGCA GCAGATTGGA CATAACGTGC AGACTCCATC TATTTCATTA 3120
CACCTGGCAA ATATTCTAAA GAGTAACTGG AGGCTTCCGG CCCCTCCGGA CTGCCCTGCC 3180
AAGGTGTACA GCTTGATGAA GGAGTGCTGG CTGTATGATT TCATGGAGCG GCCATGTTTA 3240
CTCATTCCTG AGGAAACCAG ATTGAAGTCA TCATGCAGGA TGAGCGAGAC AGCA 3294
Domain Profile
S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLkesgedisrdfkreaeilsqlshe  60
         l++i+ Lgkg+f++v+++++d+ gd+t+e va+k L++s +  ++dfk+e+++ls l+ e
Q: 813   LRYISLLGKGNFGSVELCCYDPLGDNTGELVAVKKLQPSKKSSMEDFKKEVKTLSVLHCE  872
         578999******************************************************
S: 61    hivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYLe  118
          ivk+kgvc++ g+    lV+ey+++GsL  yL+++++++++ + l +a+q++k+meYL+
Q: 873   YIVKYKGVCYSMGRLsmGLVTEYLPYGSLIGYLENNRHKVDTRRMLLFASQICKGMEYLQ  932
         ***********99988899*****************************************
S: 119   dkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwla  177
         + ++vhrd+aarn+Lv++es       vk++d+gl+k ++ + eYy v ++++s+i+w+a
Q: 933   SLRFVHRDLAARNILVASESL------VKIADFGLTKIIPCNkEYYRVTQPGESPIFWYA  986
         *********************......*********************************
S: 178   peclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle........rklel  224
         pe+++e++ +s +sdvWsFgv+lyel++ c+ +++p    +++++++        ++ ++
Q: 987   PESINESR-FSHESDVWSFGVVLYELFSyCDINSNPkrlyMQQIGHNvqtpsislHLANI  1045
         ********.***************************997755555558899999******
S: 225   leekerlpkpk.cpaelaelmtnclsyepsqrp  256
         l+++ rlp+p+ cpa+++ lm++c+ y+  +rp
Q: 1046  LKSNWRLPAPPdCPAKVYSLMKECWLYDFMERP  1078
         ****************************99998
Domain Sequence
(FASTA)
LRYISLLGKG NFGSVELCCY DPLGDNTGEL VAVKKLQPSK KSSMEDFKKE VKTLSVLHCE 60
YIVKYKGVCY SMGRLSMGLV TEYLPYGSLI GYLENNRHKV DTRRMLLFAS QICKGMEYLQ 120
SLRFVHRDLA ARNILVASES LVKIADFGLT KIIPCNKEYY RVTQPGESPI FWYAPESINE 180
SRFSHESDVW SFGVVLYELF SYCDINSNPK RLYMQQIGHN VQTPSISLHL ANILKSNWRL 240
PAPPDCPAKV YSLMKECWLY DFMERP 266
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Danio rerio"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>
EKS-DAR-00044
EKS-GAM-00014
EKS-GAA-00050
EKS-ORN-00050
EKS-ORL-00047
EKS-TAR-00050
EKS-XIM-00048
Gene Ontology
GO:0005856; C:cytoskeleton
GO:0016020; C:membrane
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0007243; P:intracellular protein kinase cascade
KEGG
InterPros
IPR019749; Band_41_domain.
IPR000299; FERM_domain.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016251; Tyr_kinase_non-rcpt_Jak/Tyk2.
Pfam
PF07714; Pkinase_Tyr; 2.
PF00017; SH2; 1.
SMARTs
SM00295; B41; 1.
SM00252; SH2; 1.
SM00219; TyrKc; 2.
Prosites
PS50057; FERM_3; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
Prints
PR01823; JANUSKINASE.
PR00109; TYRKINASE.
Created Date20-Feb-2013