EKS-TEN-00552
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TEN-00552
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Syk430.52.0E-129335582248
StatusUnreviewed
Ensembl ProteinENSTNIP00000013062
UniProt AccessionH3CXS7;
Protein Name
Protein Synonyms/Alias
Gene NameZAP70
Gene Synonyms/Alias ZAP70;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTNIG00000010164ENSTNIP00000013062ENSTNIT00000013254
OrganismTetraodon nigroviridis
Functional Description
Protein Length601
Protein Sequence
(FASTA)
MSTDPAAELP FFYGSISRAE AEQHLKLAGM DDGLFLLRQC IRSLGGYVLS VVCSLEFHHY 60
SIEKQLNGTF CIAGGKPHCG PAELCEFYSK DPDGLVCLLR KPCLRPADMP VRPGTFENLK 120
EKMVRDYVKQ TWNLEGEAME QAIVSQASQL EKLIAITAHE QMPWYHGNIP RQEGERRLYC 180
GAQPDGKFLV RERDEPGSFA LSVMYGKTVY HYQILQAKSG KYSMPGGTNF DTIWQLVEYL 240
KMKPDGLVTV LGEVCINGRA AEKPPNVPQP VSFTRPQRQN GYTPPPGGHL AEARAAAPKT 300
SVSMAADQDP GTDSNPYHNP NEIRKFSIQR SQLLIDEVEL GSGNFGCVKK GVLRTDSGQV 360
DVAIKVLKSD NESLVKDEMM REAEIMYQLS NRYIVRMLGL CNAENLMLVM EMAPAGPLNK 420
FLSSKRDTVT VENIVQLMHQ VSMGMKYLEE KNFVHRDLAA RNVLLVNQRF AKISDFGLSK 480
ALGADDSYYK ARTAGKWPLK WYAPECINFR KFSSKSDVWS FGVTMWEAFS YGGKPYKKMK 540
GPEVNQFIEA GNRMERPEPC PEKMYALMKE CWTYKHEDRP DFKKVEESMK SYYTSISNKS 600
Q 601
Nucleotide Sequence
(FASTA)
ATGTCCACGG ACCCGGCGGC CGAGCTGCCC TTCTTCTACG GCAGCATCAG CCGGGCGGAG 60
GCGGAGCAGC ACCTGAAGCT GGCCGGGATG GACGACGGCC TCTTCCTGCT GCGCCAGTGC 120
ATCCGCAGCC TGGGGGGCTA CGTTCTGTCG GTGGTGTGCA GCCTGGAGTT TCACCATTAC 180
TCCATCGAGA AGCAGCTGAA CGGGACTTTC TGCATAGCCG GGGGGAAGCC TCACTGCGGG 240
CCGGCCGAGC TGTGCGAGTT CTACAGCAAA GACCCGGACG GGCTGGTGTG CCTCCTGAGG 300
AAACCCTGCC TGCGGCCCGC GGACATGCCC GTACGGCCCG GCACCTTCGA GAACCTGAAG 360
GAGAAGATGG TGAGGGACTA CGTGAAGCAG ACCTGGAACC TGGAGGGGGA GGCCATGGAG 420
CAGGCCATCG TCAGTCAGGC GTCCCAGCTG GAGAAACTGA TCGCCATCAC CGCTCACGAG 480
CAGATGCCTT GGTACCACGG TAACATCCCC CGCCAGGAGG GCGAGAGGCG GCTTTACTGT 540
GGAGCCCAAC CGGACGGGAA GTTCCTGGTG AGAGAGAGGG ATGAGCCGGG CTCCTTCGCT 600
CTCTCCGTCA TGTACGGGAA AACGGTGTAC CACTATCAAA TCCTCCAGGC CAAATCGGGC 660
AAATATTCCA TGCCAGGGGG GACAAACTTT GACACCATCT GGCAGCTGGT TGAGTACCTG 720
AAAATGAAAC CGGACGGCCT GGTGACGGTT CTCGGAGAGG TGTGCATTAA TGGCAGAGCG 780
GCTGAAAAGC CCCCCAATGT TCCACAGCCG GTGAGTTTTA CACGGCCGCA GCGACAAAAT 840
GGCTACACGC CGCCCCCTGG CGGCCACCTG GCCGAAGCGC GGGCCGCGGC CCCAAAGACG 900
TCTGTGTCGA TGGCTGCAGA TCAGGACCCC GGGACAGACT CCAACCCCTA CCACAACCCA 960
AATGAAATAC GGAAGTTCAG CATCCAGAGG AGCCAGCTCC TCATCGATGA GGTGGAGCTG 1020
GGCTCCGGGA ACTTCGGCTG CGTCAAGAAA GGCGTCCTCA GGACTGACTC AGGCCAGGTT 1080
GACGTTGCCA TCAAAGTGCT GAAGAGCGAT AACGAGAGTC TGGTGAAGGA CGAGATGATG 1140
CGGGAGGCAG AGATCATGTA CCAGCTCAGC AACCGCTACA TCGTCCGCAT GCTGGGCCTG 1200
TGCAACGCCG AGAACCTGAT GCTCGTCATG GAAATGGCCC CTGCTGGACC CCTCAACAAG 1260
TTCCTCTCTT CAAAGAGAGA CACGGTGACG GTGGAGAACA TCGTCCAGCT GATGCACCAG 1320
GTCTCCATGG GGATGAAGTA TCTGGAGGAG AAGAACTTTG TGCACAGAGA CTTGGCGGCG 1380
CGCAACGTCC TGCTGGTCAA CCAGCGTTTC GCCAAGATCA GTGACTTTGG GCTCTCCAAG 1440
GCCCTGGGAG CAGACGACAG CTATTACAAG GCCCGTACTG CAGGCAAATG GCCACTGAAG 1500
TGGTACGCTC CAGAGTGCAT CAACTTCCGC AAGTTCTCCA GTAAAAGCGA CGTGTGGAGT 1560
TTCGGCGTCA CCATGTGGGA GGCCTTCTCC TACGGAGGCA AACCCTACAA GAAAATGAAA 1620
GGACCGGAGG TGAACCAGTT TATCGAGGCT GGGAACCGCA TGGAGCGTCC AGAGCCGTGT 1680
CCAGAGAAGA TGTACGCACT GATGAAGGAG TGTTGGACAT ACAAGCACGA GGATCGTCCC 1740
GACTTCAAGA AGGTGGAGGA GTCCATGAAG TCCTACTACA CTTCCATATC TAACAAGAGC 1800
CAGTGA 1806
Domain Profile
S: 2     vedkelGsGnfGsvkkGyyrmkkkrlevaikvlkeadekadkdellreasvmqqldnkyi  61
         + + elGsGnfG+vkkG++r    +++vaikvlk  +e   kde++rea++m ql n+yi
Q: 335   IDEVELGSGNFGCVKKGVLRTDSGQVDVAIKVLKSDNESLVKDEMMREAEIMYQLSNRYI  394
         7789********************************************************
S: 62    vrliGiakaealmlvmelaelGpllkylldkreeikaknvlelvhqvamGmkyleeknfv  121
         vr++G+++ae lmlvme+a+ Gpl+k+l  kr+ ++++n+++l+hqv+mGmkyleeknfv
Q: 395   VRMLGLCNAENLMLVMEMAPAGPLNKFLSSKRDTVTVENIVQLMHQVSMGMKYLEEKNFV  454
         ************************************************************
S: 122   hrdlaarnvllvarhyakisdfGlskalradesyykarsaGkwpvkwyapecinlrkfss  181
         hrdlaarnvllv++ +akisdfGlskal+ad+syykar+aGkwp+kwyapecin+rkfss
Q: 455   HRDLAARNVLLVNQRFAKISDFGLSKALGADDSYYKARTAGKWPLKWYAPECINFRKFSS  514
         ************************************************************
S: 182   ksdvwsfGvtlweafsyGqkpykelkgsevlalvekGerlecpaecpaelyalmsscwky  241
         ksdvwsfGvt+weafsyG kpyk++kg+ev +++e G+r+e p+ cp+++yalm++cw+y
Q: 515   KSDVWSFGVTMWEAFSYGGKPYKKMKGPEVNQFIEAGNRMERPEPCPEKMYALMKECWTY  574
         ************************************************************
S: 242   kvedrpdf  249
         k edrpdf
Q: 575   KHEDRPDF  582
         *******9
Domain Sequence
(FASTA)
IDEVELGSGN FGCVKKGVLR TDSGQVDVAI KVLKSDNESL VKDEMMREAE IMYQLSNRYI 60
VRMLGLCNAE NLMLVMEMAP AGPLNKFLSS KRDTVTVENI VQLMHQVSMG MKYLEEKNFV 120
HRDLAARNVL LVNQRFAKIS DFGLSKALGA DDSYYKARTA GKWPLKWYAP ECINFRKFSS 180
KSDVWSFGVT MWEAFSYGGK PYKKMKGPEV NQFIEAGNRM ERPEPCPEKM YALMKECWTY 240
KHEDRPDF 248
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00407
EKS-BOT-00437
EKS-CAP-00470
EKS-CIS-00192
EKS-DAR-00833
EKS-DIO-00086
EKS-DRM-00206
EKS-EQC-00428
EKS-ERE-00039
EKS-FEC-00418
EKS-GAG-00368
EKS-GAA-00534
EKS-GOG-00429
EKS-ICT-00420
EKS-LAC-00453
EKS-MAM-00436
EKS-MEG-00362
EKS-MIM-00075
EKS-MOD-00427
EKS-MUM-00469
EKS-MUP-00431
EKS-NOL-00398
EKS-OCP-00104
EKS-ORN-00558
EKS-ORC-00410
EKS-ORL-00508
EKS-OTG-00441
EKS-PAT-00413
EKS-POA-00428
EKS-PRC-00042
EKS-RAN-00450
EKS-SAH-00406
EKS-SUS-00387
EKS-TAG-00504
EKS-TAR-00548
EKS-XET-00547
EKS-XIM-00548
Gene Ontology
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0001946; P:lymphangiogenesis
GO:0090050; P:positive regulation of cell migration involved in sprouting angiogenesis
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR023420; Kinase_SYK/ZAP-70_inter-SH2.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 2.
SMARTs
SM00252; SH2; 2.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 2.
Prints
PR00401; SH2DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013