EKS-TEN-00119

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00119

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/PIKK	339.7	2.2E-101	339	663	325

Status

Unreviewed

Ensembl Protein

ENSTNIP00000013816

UniProt Accession

H3CZY0;

Protein Name

Protein Synonyms/Alias

Gene Name

MTOR

Gene Synonyms/Alias

MTOR;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000010886	ENSTNIP00000013816	ENSTNIT00000014011

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

735

Protein Sequence
(FASTA)

MNFEAVLHYK HQNQGRDEKK KLRHGSGASA NSEASNSDSE ADSTDHSPSP GQKKVNEDLS 60

KTLLLYTVPA VQGFFRSISL SRGNNLQDTL RVLTLWFDYG HWPEVNEALV EGIKTIQIDT 120

WLQVIPQLIA RIDTPRALVG RLIHQLLTDI GRYHPQALIY PLTVASKSTT TARHNAANKI 180

LKNMCEHCNT LVQQAIMVSE ELIRVAILWH EMWHEGLEEA SRLYFGERNV KGMFAVLEPL 240

HAMMERGPQT LKETSFNQAY GRDLMEAQDW CRKYMRSGNV KDLTQAWDLY YHVFRRISKQ 300

LPQLTSLELQ YVSPKLLMCR DLELAVPGTY DPNQPIIRIQ SIAPSLQVIT SKQRPRKLTI 360

MGSNGHEFMF LLKGHEDLRQ DERVMQLFGL VNTLLANDPA SLRKNLSIQR YAVIPLSTNS 420

GLIGWVPHCD TLHALIRDYR EKKKILLNIE HRIMLRMAPD YDHLTLMEKV EVFEHAVNNT 480

AGDDLAKLLW LKSPSSEVWF DRRTNYTRSL AVMSMVGYIL GLGDRERRII IILGYKTGCQ 540

VWYCNTIMII HLHKSIRNIH GRLNGRSNLT NLRLVTGLDG NYRITCHTVM EVLREHRDSV 600

MAVLEAFVYD PLLNWRLMDT NTKGNKRSRT RNDSYTAGQS VEALEGIDMG ETTHKKPGNT 660

VPESIHSFIG DGLVQPEALN KKAIQIINRV RDKLTGRDFS HDDTLDVPIQ VELLIKQATS 720

HENLCQCYIG WCPFW 735

Nucleotide Sequence
(FASTA)

ATGAATTTCG AGGCTGTGCT CCACTACAAG CACCAGAACC AAGGACGGGA TGAGAAGAAG 60

AAACTGCGTC ACGGTAGCGG TGCCAGCGCG AACAGCGAAG CCAGCAACAG CGACAGCGAG 120

GCTGACAGCA CCGATCACAG TCCCTCACCG GGTCAGAAAA AGGTCAATGA GGACCTCTCC 180

AAGACGCTAC TGCTGTACAC AGTTCCTGCT GTTCAAGGCT TCTTCCGCTC CATTTCCCTT 240

TCCAGAGGCA ACAACTTGCA GGACACGCTC AGGGTTTTGA CCTTGTGGTT CGACTATGGC 300

CACTGGCCTG AGGTGAACGA AGCCCTGGTG GAGGGCATCA AGACTATTCA GATAGACACA 360

TGGCTGCAGG TGATCCCTCA GCTTATAGCT CGAATAGACA CCCCACGAGC TCTAGTGGGT 420

CGGCTCATCC ACCAGCTGCT GACAGACATT GGTCGATATC ATCCACAGGC CTTAATCTAC 480

CCGCTAACCG TGGCTTCCAA GTCCACCACC ACCGCCCGCC ATAATGCTGC TAATAAGATC 540

CTGAAGAACA TGTGCGAGCA CTGCAACACT CTGGTCCAGC AGGCCATCAT GGTGAGCGAG 600

GAGCTTATCC GAGTGGCCAT CTTGTGGCAT GAGATGTGGC ACGAAGGACT CGAGGAGGCA 660

TCACGTCTTT ACTTTGGCGA ACGCAACGTC AAAGGCATGT TCGCTGTGCT CGAACCCCTG 720

CATGCCATGA TGGAGAGGGG ACCACAGACC CTGAAAGAGA CCTCTTTTAA CCAGGCTTAT 780

GGCCGGGATT TGATGGAGGC GCAGGACTGG TGCAGGAAGT ACATGCGCTC CGGAAATGTC 840

AAAGACCTGA CGCAGGCCTG GGACCTCTAC TATCACGTAT TCAGACGCAT CTCAAAACAG 900

CTCCCTCAGT TGACCTCCTT GGAGCTACAG TACGTGTCTC CGAAGCTGCT GATGTGCCGA 960

GACCTGGAGC TGGCAGTGCC GGGCACTTAC GACCCCAATC AGCCCATCAT CCGCATTCAG 1020

TCCATTGCCC CTTCACTGCA GGTCATCACC TCCAAGCAGC GGCCACGCAA GCTCACCATT 1080

ATGGGCAGTA ACGGCCATGA GTTCATGTTC CTGCTGAAGG GCCACGAGGA CCTGAGGCAG 1140

GACGAGAGAG TCATGCAGCT GTTCGGCCTG GTTAACACGC TGCTCGCCAA TGACCCCGCA 1200

TCCTTGCGCA AGAACCTCAG CATCCAGCGC TACGCTGTGA TCCCTCTGTC CACCAACTCG 1260

GGCCTGATTG GATGGGTGCC CCACTGCGAC ACCCTGCATG CCCTCATCAG AGACTACAGA 1320

GAAAAGAAGA AGATTCTGCT CAACATCGAG CATCGCATCA TGCTGAGGAT GGCCCCAGAC 1380

TACGACCACC TGACCCTGAT GGAGAAGGTG GAGGTGTTTG AGCACGCCGT CAACAACACT 1440

GCCGGAGATG ACCTCGCCAA GCTGCTGTGG CTGAAGAGCC CCAGCTCGGA GGTGTGGTTT 1500

GACAGAAGGA CCAATTACAC CCGCTCCCTG GCCGTCATGT CCATGGTGGG CTACATCCTG 1560

GGACTTGGAG ACAGAGAAAG GCGTATTATA ATAATATTGG GATATAAAAC AGGCTGTCAG 1620

GTATGGTATT GTAACACAAT AATGATAATT CATCTACACA AAAGCATAAG GAACATACAT 1680

GGGAGGCTAA ATGGCAGAAG TAACTTAACA AACTTGCGAC TGGTGACAGG CTTGGATGGA 1740

AACTACCGCA TCACCTGCCA CACTGTGATG GAGGTGCTGA GGGAGCACCG GGACAGCGTC 1800

ATGGCCGTGC TGGAGGCCTT CGTCTACGAT CCGCTGCTCA ACTGGAGGCT GATGGACACA 1860

AACACCAAAG GCAACAAGCG CTCCCGCACC AGAAACGACT CGTACACCGC CGGACAATCA 1920

GTGGAGGCCC TTGAAGGAAT CGACATGGGA GAGACCACGC ACAAGAAACC GGGGAACACG 1980

GTCCCCGAGT CCATCCACTC TTTCATTGGA GACGGTTTAG TCCAACCTGA GGCACTCAAC 2040

AAGAAAGCCA TTCAGATTAT CAACAGGGTG AGAGACAAGC TTACAGGGCG AGACTTTTCC 2100

CACGACGACA CGCTGGATGT GCCCATCCAA GTGGAGCTCC TCATCAAACA GGCCACATCG 2160

CACGAAAACC TGTGCCAGTG CTACATCGGA TGGTGCCCCT TCTGGTGA 2208

Domain Profile

S: 1     iagfderveilaskqkpkklllrGsdgkeypyLvkgkeDlrqdervlqlfslvNtlLakd  60

         i+++++++++++skq+p+kl+++Gs+g+e+++L+kg+eDlrqderv+qlf+lvNtlLa+d

Q: 339   IQSIAPSLQVITSKQRPRKLTIMGSNGHEFMFLLKGHEDLRQDERVMQLFGLVNTLLAND  398

         899*********************************************************

S: 61    ketsrrkLkirtykVvplstrsgliewventvsLkellkklvekkavlldqpisyrykdl  120

         +++ r++L+i++y+V+plst+sgli+wv+++++L++l+++++ekk++ll+        ++

Q: 399   PASLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLN-------IEH  451

         *************************************************9.......9**

S: 121   stvqarkpklkhlkls..levfkevlenlvpkdllkklllekfpspeewfelrkaytrsl  178

         +++ +++p+++hl+l+  +evf+++++n ++ d l+kll+ k+ps+e+wf++r++ytrsl

Q: 452   RIMLRMAPDYDHLTLMekVEVFEHAVNN-TAGDDLAKLLWLKSPSSEVWFDRRTNYTRSL  510

         ****************************.999****************************

S: 179   AvislvgyiLgLgdrhlenllidqetgevvhidfgvafekaktqlkvpekvPFRLT..rn  236

         Av+s+vgyiLgLgdr    ++i      + + + +  +       k  + +  RL    n

Q: 511   AVMSMVGYILGLGDRERRIIIILGYKTGCQVWYCNTIMIIHLH--KSIRNIHGRLNgrSN  568

         ******************9998776666777777765544433..567777788853379

S: 237   ivnalgvtgveGvfrasceavlrvlreskeklltiLevflydplvdwkkkkktsketeee  296

         ++n+  vtg++G++r++c++v++vlre++++++++Le+f+ydpl++w+ +++++k+++++

Q: 569   LTNLRLVTGLDGNYRITCHTVMEVLREHRDSVMAVLEAFVYDPLLNWRLMDTNTKGNKRS  628

         ************************************************************

S: 297   laekakaealkikkllskvekaenavatrdlllle  331

         +++++++ a +++++l++++ +e+ +++ +++++e

Q: 629   RTRNDSYTAGQSVEALEGIDMGETTHKKPGNTVPE  663

         ***************************99888876

Domain Sequence
(FASTA)

IQSIAPSLQV ITSKQRPRKL TIMGSNGHEF MFLLKGHEDL RQDERVMQLF GLVNTLLAND 60

PASLRKNLSI QRYAVIPLST NSGLIGWVPH CDTLHALIRD YREKKKILLN IEHRIMLRMA 120

PDYDHLTLME KVEVFEHAVN NTAGDDLAKL LWLKSPSSEV WFDRRTNYTR SLAVMSMVGY 180

ILGLGDRERR IIIILGYKTG CQVWYCNTIM IIHLHKSIRN IHGRLNGRSN LTNLRLVTGL 240

DGNYRITCHT VMEVLREHRD SVMAVLEAFV YDPLLNWRLM DTNTKGNKRS RTRNDSYTAG 300

QSVEALEGID MGETTHKKPG NTVPE 325

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0008144	; F:drug binding
GO:0016301	; F:kinase activity
GO:0016773	; F:phosphotransferase activity, alcohol group as acceptor

KEGG

InterPros

IPR003152	; FATC.
IPR011009	; Kinase-like_dom.
IPR000403	; PI3/4_kinase_cat_dom.
IPR018936	; PI3/4_kinase_CS.
IPR003151	; PIK-rel_kinase_FAT.
IPR014009	; PIK_FAT.
IPR009076	; Rapamycin-bd_dom.
IPR026683	; TOR/Smg1.

Pfam

PF02259	; FAT; 1.
PF02260	; FATC; 1.
PF00454	; PI3_PI4_kinase; 1.
PF08771	; Rapamycin_bind; 1.

SMARTs

SM00146

; PI3Kc; 1.

Prosites

PS51189	; FAT; 1.
PS51190	; FATC; 1.
PS00915	; PI3_4_KINASE_1; 1.
PS50290	; PI3_4_KINASE_3; 1.

Prints

Created Date

20-Feb-2013