EPS-TEN-00033

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-TEN-00033

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	218.2	1.8E-64	96	346	251

Status

Unreviewed

Ensembl Protein

ENSTNIP00000013983

UniProt Accession

H3D0E7;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1K

Gene Synonyms/Alias

PPM1K;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000011047	ENSTNIP00000013983	ENSTNIT00000014178

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

374

Protein Sequence
(FASTA)

VMSAACLVRL GRCSVTLQKV LGPFQQHNNL QLTGFRRPLY TPSEKRQSNT RFDPDSSGRP 60

TTWDSFGIWD NRIDEPILLP SSIRYGKPIP KVSLSKVGCA SLIGQRKENE DRFQVSQMTD 120

NILYFAVFDG HGGPEAADFC EKYMEKFIKD LVTDECDLEL ILTKAFLEVD KALEKHLNYS 180

PNAPRINPGT TSTVALLRDG IELVVASVGD SRAMLCRKGK ALKLTVDHTP ERKDEKERIK 240

KTGGFITWNS LGQPNVNGRL AMTRSIGDFD LKKMGVVAEP ETKRITLHHV HDSFLALTTD 300

GINFIMNSQE ICNVINQCHD PKEAAQRISD QALHYGSEDN STIIVVPFGA WGKHENFDSN 360

FSFSRGFVSS GRWA 374

Nucleotide Sequence
(FASTA)

GTGATGTCAG CGGCATGTCT TGTGCGCCTC GGAAGGTGCA GCGTTACCTT GCAGAAAGTA 60

CTAGGGCCAT TTCAGCAGCA CAACAACCTG CAGCTCACAG GCTTCCGGAG ACCACTTTAC 120

ACCCCCTCTG AAAAACGACA GAGCAACACG CGTTTTGATC CGGACAGCAG CGGCCGCCCC 180

ACTACTTGGG ATTCGTTCGG CATCTGGGAC AATCGCATTG ACGAGCCAAT CCTACTGCCT 240

TCCAGCATTC GCTACGGCAA GCCCATTCCA AAGGTCAGCC TTTCAAAAGT AGGCTGTGCT 300

TCCCTCATTG GTCAACGCAA GGAGAATGAG GACCGCTTTC AGGTCTCACA GATGACTGAC 360

AACATCCTGT ACTTTGCTGT TTTCGATGGT CATGGTGGGC CAGAAGCCGC CGACTTCTGT 420

GAAAAATACA TGGAAAAATT CATCAAGGAC CTAGTCACTG ATGAGTGTGA CCTAGAATTA 480

ATTCTAACCA AGGCCTTCCT TGAAGTTGAC AAAGCTCTTG AAAAGCACTT GAACTACTCA 540

CCAAATGCGC CGCGGATAAA CCCAGGAACC ACCTCCACCG TGGCGCTCCT GAGGGACGGC 600

ATCGAGCTGG TGGTGGCCAG CGTGGGGGAC AGCCGCGCCA TGCTGTGTCG GAAGGGCAAG 660

GCTCTTAAAC TGACGGTGGA CCACACTCCT GAGAGGAAGG ACGAGAAGGA GAGAATCAAG 720

AAAACTGGCG GTTTTATCAC CTGGAATAGT TTGGGGCAGC CAAACGTCAA CGGCAGGTTA 780

GCCATGACGC GCAGTATCGG AGACTTTGAC CTGAAGAAAA TGGGCGTCGT CGCTGAACCC 840

GAGACAAAGA GAATAACCTT GCACCACGTC CACGACTCCT TCTTGGCACT GACCACCGAT 900

GGCATTAACT TCATTATGAA CAGCCAGGAG ATCTGCAACG TCATTAACCA GTGCCACGAC 960

CCCAAAGAAG CAGCTCAGAG AATATCGGAC CAGGCTCTTC ACTACGGCTC AGAGGACAAC 1020

AGCACAATAA TCGTGGTGCC GTTCGGCGCC TGGGGAAAGC ACGAGAATTT TGATTCCAAT 1080

TTCTCCTTCA GCAGAGGGTT CGTGTCCAGC GGACGTTGGG CCTAG 1125

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         +vg++s+ g+r+e ed++++s++       +d++ +f+v+DGhgg e+a+fc + +++++

Q: 96    KVGCASLIGQRKENEDRFQVSQM-------TDNILYFAVFDGHGGPEAADFCEKYMEKFI  148

         689***************87333.......33489*************************

S: 62    aeelesseseerkvkkalakaFlstdeel.kvleeksldidk....sGstavvalikds.  115

         +  +     +e +++ +l+kaFl++d++l k l++    +++     G+t +val++d

Q: 149   KDLVT----DECDLELILTKAFLEVDKALeKHLNYS---PNAprinPGTTSTVALLRDGi  201

         ***88....9*******************4344444...33355689************9

S: 116   klyvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkd.ga.RvlGvLa  173

         +l+va vGdSra+Lcr+gka++l++dH+p+r+dE+eRi++ gg ++ ++ g+  v+G La

Q: 202   ELVVASVGDSRAMLCRKGKALKLTVDHTPERKDEKERIKKTGGFITWNSlGQpNVNGRLA  261

         ******************************************99997779999*******

S: 174   vsRalGdlylkpy.vtpePevtshrltsede.fliLasDGlwdvvsneeavslvrdvlek  231

         ++R++Gd++lk++ v++ePe+  ++l++ ++ fl L +DG+  +++++e++++++++++

Q: 262   MTRSIGDFDLKKMgVVAEPETKRITLHHVHDsFLALTTDGINFIMNSQEICNVINQCHD-  320

         ***********888************998888***************************.

S: 232   keaeqeaakkLvklalargskdnvsaivv  260

            ++eaa+++ ++al++gs+dn ++ivv

Q: 321   ---PKEAAQRISDQALHYGSEDNSTIIVV  346

         ...*********************99997

Domain Sequence
(FASTA)

KVGCASLIGQ RKENEDRFQV SQMTDNILYF AVFDGHGGPE AADFCEKYME KFIKDLVTDE 60

CDLELILTKA FLEVDKALEK HLNYSPNAPR INPGTTSTVA LLRDGIELVV ASVGDSRAML 120

CRKGKALKLT VDHTPERKDE KERIKKTGGF ITWNSLGQPN VNGRLAMTRS IGDFDLKKMG 180

VVAEPETKRI TLHHVHDSFL ALTTDGINFI MNSQEICNVI NQCHDPKEAA QRISDQALHY 240

GSEDNSTIIV V 251

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0007420	; P:brain development
GO:0048565	; P:digestive tract development
GO:0007507	; P:heart development
GO:0001889	; P:liver development
GO:0043066	; P:negative regulation of apoptotic process
GO:0031016	; P:pancreas development
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013