EKS-TEN-00193

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00193

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/RSK	356.4	1.2E-106	89	349	261

Status

Unreviewed

Ensembl Protein

ENSTNIP00000014588

UniProt Accession

H3D250;

Protein Name

Protein Synonyms/Alias

Gene Name

RPS6KB1 (1 of 2)

Gene Synonyms/Alias

RPS6KB1 (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000011636	ENSTNIP00000014588	ENSTNIT00000014787

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

518

Protein Sequence
(FASTA)

IRRRRQKKLY KQLPIFFDAI APAMAGIFDI DLDQPEENIS DDELDDGGQL NEYMEQCSSF 60

DFYMEDCEKF EISENSVNKG TEQIRPECFE LLKVLGKGGY GKVFQVRKVS GVTSGKIFAM 120

KVLKKAMIVR NAKDTAHTKA ERNILEEVKH PFIVDLIYAF QTGGKLYLIL EYLSGGELFM 180

QLEREGIFME DTACFYLAEI SMALGHLHQK GIIYRDLKPE NIMLNNDGHV KLTDFGLCKE 240

SIHDGTVTHT FCGTIEYMAP EILMRGHNRA VDWWSLGALM YDMLTGAPPF TGENRKKTID 300

KILKCKLSLP PYLTQEARDL LKKLLRRNAS LRLGAGPGDA AEVQAHPFFR HVNWDDLLAH 360

KVEPPFKPFL QSADDASQFD SKFTSQTPVD SPDDSALSES ANQVFLGFTY VAPSVLENVK 420

EKFSFEPKVR SPRKFPGSPR TPVSPVKFAR GDCWPRGPTL SACPSHLMTR IAAEQPVAEA 480

AAGEPMDTTP SEASAPLPYK KHTYPVNAKR PEHLRMNL 518

Nucleotide Sequence
(FASTA)

ATTCGCAGAA GACGACAAAA AAAACTGTAC AAACAATTAC CGATTTTTTT TGACGCCATT 60

GCGCCAGCCA TGGCTGGGAT TTTCGACATC GATTTGGATC AACCGGAGGA GAACATCTCG 120

GACGACGAAC TTGATGACGG GGGCCAACTT AATGAATACA TGGAACAATG TAGCAGTTTT 180

GACTTTTACA TGGAGGATTG TGAGAAGTTT GAAATTTCAG AGAACAGCGT GAATAAAGGA 240

ACAGAGCAAA TCAGGCCCGA ATGCTTTGAG CTGCTGAAGG TCTTGGGCAA AGGCGGCTAT 300

GGGAAGGTGT TTCAGGTGAG GAAGGTATCA GGCGTCACGT CTGGGAAGAT ATTTGCCATG 360

AAAGTTTTAA AAAAGGCCAT GATTGTGCGC AATGCCAAGG ACACAGCGCA CACCAAAGCA 420

GAGAGGAACA TTCTGGAGGA GGTGAAGCAC CCTTTCATAG TGGACCTCAT CTACGCCTTT 480

CAGACGGGCG GAAAGTTGTA TCTTATCTTG GAGTATTTGA GTGGCGGAGA GCTGTTCATG 540

CAGCTGGAAA GAGAAGGCAT CTTCATGGAG GACACAGCGT GTTTCTATCT AGCGGAGATC 600

TCCATGGCGC TGGGTCACCT GCACCAGAAA GGCATCATCT ACAGAGACCT GAAGCCCGAG 660

AACATCATGC TCAACAACGA CGGACACGTG AAGTTAACGG ACTTTGGTCT TTGTAAAGAG 720

TCCATCCACG ATGGGACGGT CACGCACACC TTCTGCGGCA CCATTGAATA CATGGCTCCA 780

GAGATCCTGA TGCGCGGCCA CAACAGAGCG GTGGACTGGT GGAGTTTGGG AGCGCTCATG 840

TACGACATGC TGACCGGAGC ACCTCCGTTC ACTGGTGAAA ACCGGAAGAA GACCATCGAC 900

AAAATCCTGA AATGCAAACT CAGCCTCCCT CCGTACCTCA CGCAGGAAGC CAGGGACCTT 960

CTGAAAAAGC TTCTAAGGAG AAATGCCTCC CTGCGACTTG GGGCGGGTCC GGGAGATGCA 1020

GCCGAAGTGC AGGCCCACCC GTTCTTCCGG CACGTGAACT GGGATGACCT CCTCGCTCAC 1080

AAAGTCGAGC CTCCGTTCAA ACCCTTCCTG CAATCGGCAG ACGACGCCAG CCAGTTCGAC 1140

TCCAAGTTCA CCAGCCAGAC TCCGGTGGAC AGCCCCGACG ACTCCGCGCT CAGCGAAAGC 1200

GCCAACCAAG TCTTCCTGGG TTTCACCTAC GTCGCTCCGT CTGTGCTGGA AAACGTCAAG 1260

GAGAAGTTCT CCTTTGAGCC AAAAGTTCGC TCCCCGCGGA AGTTCCCGGG AAGCCCAAGA 1320

ACACCTGTGA GTCCGGTGAA ATTTGCCCGC GGGGACTGCT GGCCCCGGGG GCCCACGCTG 1380

AGCGCCTGCC CGTCCCACCT GATGACCCGC ATCGCCGCGG AACAGCCCGT GGCGGAGGCG 1440

GCGGCCGGCG AACCGATGGA CACCACCCCC TCCGAGGCCT CGGCCCCTCT TCCCTACAAG 1500

AAGCACACCT ACCCCGTGAA CGCCAAGCGG CCAGAACACC TGAGAATGAA TTTATGA 1557

Domain Profile

S: 1     fellkvlgkGaygkvflvrkvekkdtgklyavKvlkkaelvk..kkkertkeereiLeev  58

         fellkvlgkG+ygkvf+vrkv++ ++gk++a+Kvlkka +v+  k++++tk+er+iLeev

Q: 89    FELLKVLGKGGYGKVFQVRKVSGVTSGKIFAMKVLKKAMIVRnaKDTAHTKAERNILEEV  148

         89***********************************9999999****************

S: 59    ehpfivklheafqdekklylvlellkGgeLlerlkkkklfseeeasfilaelvlaleylH  118

         +hpfiv+l +afq+  klyl+le+l+GgeL+++l+++++f+e++a+f+lae+++al +lH

Q: 149   KHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLH  208

         ************************************************************

S: 119   skgvvyrDLkpeNilldeeghvkltDfglakekiaeneekaysfcgTleyvaPevlkrkg  178

         +kg++yrDLkpeNi+l+++ghvkltDfgl+ke+i ++++ +++fcgT+ey+aPe+l+r g

Q: 209   QKGIIYRDLKPENIMLNNDGHVKLTDFGLCKESI-HDGTVTHTFCGTIEYMAPEILMR-G  266

         *********************************9.9999999**************85.9

S: 179   ydeavDlwslGvllyemLtGktPftgeerketlarilkgkfslklpaweelseeakdlvk  238

         +++avD+wslG+l+y+mLtG++Pftge+rk+t+++ilk+k  l+lp +  l++ea+dl+k

Q: 267   HNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCK--LSLPPY--LTQEARDLLK  322

         ****************************************..99****..**********

S: 239   klLkkdpakRlga...taeeikehkfl  262

         klL+++ + Rlga   +a+e+++h+f+

Q: 323   KLLRRNASLRLGAgpgDAAEVQAHPFF  349

         *************9***********97

Domain Sequence
(FASTA)

FELLKVLGKG GYGKVFQVRK VSGVTSGKIF AMKVLKKAMI VRNAKDTAHT KAERNILEEV 60

KHPFIVDLIY AFQTGGKLYL ILEYLSGGEL FMQLEREGIF MEDTACFYLA EISMALGHLH 120

QKGIIYRDLK PENIMLNNDG HVKLTDFGLC KESIHDGTVT HTFCGTIEYM APEILMRGHN 180

RAVDWWSLGA LMYDMLTGAP PFTGENRKKT IDKILKCKLS LPPYLTQEAR DLLKKLLRRN 240

ASLRLGAGPG DAAEVQAHPF F 261

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007165	; P:signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016238	; Ribosomal_S6_kinase.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013