EKS-TEN-00089

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00089

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	361.1	4.3E-108	671	963	293

Status

Unreviewed

Ensembl Protein

ENSTNIP00000014668

UniProt Accession

H3D2D0;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK12

Gene Synonyms/Alias

CDK12;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000011717	ENSTNIP00000014668	ENSTNIT00000014868

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

1238

Protein Sequence
(FASTA)

MPGSDRHHGT KRKPDSRTSG LPQASSYTSM GDKTTRDGEA LLKSSMSSSS SKRKRHKIKH 60

NRDSLVVSGP AYFTLADPAP PSANVVKPLV EYDDISSDSD SFLDPLSSRP LERVVLDRLD 120

HSPDYERESI VREVSTVDIK GHRHSRKKSK DPNKFRDSGN GEGGSKKKIS KDREKGGSAK 180

TKNRTASAGL SFKYQAHLES STTSSTSSSR SKESSRSGKS HKDRQQRREA RGEGSHSSSQ 240

KIRTERSHRK SSKSRKSAPK SKSSRGSPRR KATSSVLSPS PRRVAGSESP QGSGRRLPQQ 300

SPSPYREASY RGRQRSESPY GSRHRSSSYE RDSSPYSRRR SISPYGNRRS SSTSPVSRRS 360

GRSRSRSPFP YSSSHRSSSR SRNKRHTSSG LGAGSSHSSR PASHSPPSLL PLNSSLGAEL 420

SRRKKERLAA EAAARASGST SPPSLAHKLV SSSVRSAKPE APQLDRDSAV VSEPLPPPPA 480

PQPQDPPGAE DHAAAPVRPP SSPSASFSPP QPSPPVAPSP ATKVPPPPPP PQAETVTQIP 540

VSSVTSQSKS PTPVTTYSPL RQTPLHKTST LPPLPLPPAL LGNVLDSPKK STPPQKISRK 600

EKDVRGRPSL IDLPLPPTLT GLDSSPPQSP IRQMPSLPQP ALKKRPKICC PRYGERKHTQ 660

SDWGKRCVDK FDIIGIIGEG TYGQVYKAKD KDTGELVALK KVRLDNEKEG FPITAIREIK 720

ILRQLKHRSV VNMKEIVTDK QDALDFKKDK EGAFYLVFEY MDHDLMGLLE SGLVQFSHEH 780

VRSFMRQMEG LDYCHKNNFL HRDIKCSNIL LNNRGQIKLA DFGLARLYNS EESRPYTNKV 840

ITLWYRPPEL LLGEERYSPA IDVWSCGCIL GELFTKRPIF QANQELLQLE LISRLCGSPC 900

PAVWPDVIKL PLFNTMKPKK QYRRRLREEF AFLPTAALDL LDRMLTLDPT RRCTSEQALI 960

SDFLSDIDPS KMPPPDLPHH QDCHELWSKK RRRARQSGVP EDASVPKVPR KEATGTSSGE 1020

NSRPQTSPAA APPPPPPGKP PTTTNLECLG PAAEQLNPAE LAVLLNLLQG QTDLSLPQVA 1080

QLLNLSNPET LSQSLSALSE ASDHQGTSDD HGPTTTRPPE PPPEPQEPSP SGDSSLNQED 1140

QANLLALILS HIIKPQKEAL ARSSSASTTD RKDGAPSKRN RPVENQIPPH SQQRPPSPLG 1200

PPPALAAQQA GSEPQSSRDI SPAVAAALLQ LISQQDAE 1238

Nucleotide Sequence
(FASTA)

ATGCCTGGGT CGGACCGACA CCATGGGACC AAGAGGAAGC CGGATTCCAG GACGAGCGGT 60

TTGCCACAGG CCTCCAGTTA TACGTCCATG GGAGACAAGA CGACCAGAGA CGGTGAGGCT 120

CTGCTAAAGT CTTCGATGTC CTCTTCTTCC TCAAAACGAA AAAGACATAA AATTAAACAT 180

AATCGGGACT CATTGGTAGT TTCGGGACCT GCATATTTTA CCCTTGCCGA CCCGGCGCCA 240

CCTAGTGCCA ACGTAGTGAA GCCTCTAGTA GAATACGACG ATATCAGCTC AGATTCGGAC 300

TCGTTCTTGG ACCCACTTTC CTCCAGGCCT TTGGAGAGAG TGGTTCTTGA TCGACTGGAT 360

CATTCACCCG ACTATGAGAG GGAAAGTATT GTCAGAGAAG TGAGCACAGT AGACATCAAA 420

GGGCACAGGC ACTCCCGAAA AAAGTCCAAG GACCCCAATA AATTCAGAGA CTCTGGAAAT 480

GGGGAAGGTG GGTCAAAGAA GAAGATCAGT AAAGATCGCG AGAAAGGAGG TTCTGCAAAG 540

ACCAAGAATC GGACTGCTTC AGCTGGCCTG TCTTTCAAAT ACCAGGCCCA CCTGGAAAGT 600

AGCACAACTT CCTCCACATC ATCATCTCGC AGCAAGGAAA GTAGTCGTTC AGGGAAGTCG 660

CATAAAGACC GACAGCAACG ACGAGAAGCC AGAGGAGAGG GCAGCCACAG CTCCTCTCAG 720

AAAATCCGAA CCGAAAGGAG CCATCGCAAG TCTTCAAAGA GCCGGAAGTC CGCTCCCAAA 780

AGCAAATCTT CAAGAGGAAG CCCTCGCAGG AAGGCCACCA GCTCTGTACT TTCACCTAGC 840

CCCAGACGAG TAGCCGGAAG TGAAAGTCCA CAGGGCAGTG GACGAAGACT GCCCCAGCAA 900

AGCCCCAGTC CCTACAGAGA AGCGTCGTAT CGGGGCAGAC AGAGATCTGA GAGCCCCTAC 960

GGCAGCAGAC ATCGATCCTC CAGCTATGAG CGAGACAGCA GCCCGTATTC AAGGAGGCGC 1020

TCCATCAGCC CCTATGGTAA CCGCAGGTCC TCCAGCACCA GTCCAGTGTC TCGACGTTCT 1080

GGTCGCTCCA GGAGTCGCTC CCCTTTCCCT TACTCCTCTT CCCACCGCTC CTCTTCTCGG 1140

TCCCGTAACA AGAGGCACAC TTCCTCTGGT CTCGGAGCGG GCAGCTCCCA CAGCAGCCGC 1200

CCAGCTAGCC ACTCTCCTCC CTCTCTGCTA CCCCTGAATT CCAGCCTTGG TGCAGAGCTG 1260

AGCCGACGGA AGAAGGAACG CCTCGCTGCT GAGGCGGCAG CTCGTGCCAG CGGGAGCACA 1320

TCCCCGCCTT CCTTGGCTCA CAAGCTTGTA AGCTCCTCCG TACGGTCAGC TAAGCCTGAG 1380

GCTCCACAGC TAGACAGAGA CTCTGCAGTA GTATCCGAAC CCCTGCCACC TCCACCTGCA 1440

CCACAACCAC AGGATCCTCC CGGTGCCGAA GATCACGCCG CTGCTCCTGT ACGCCCTCCA 1500

TCTTCGCCTT CCGCATCCTT TTCTCCACCT CAGCCCTCTC CTCCCGTGGC ACCAAGCCCG 1560

GCCACCAAAG TTCCACCACC TCCGCCGCCC CCTCAGGCAG AAACGGTTAC TCAGATCCCA 1620

GTTTCTTCAG TTACATCCCA GTCAAAATCA CCAACTCCAG TTACGACTTA CAGTCCACTC 1680

CGGCAAACAC CTCTCCACAA GACATCAACT TTACCACCAC TACCTTTACC CCCTGCACTG 1740

CTGGGAAATG TTCTTGACAG TCCAAAGAAG TCCACCCCAC CTCAGAAGAT ATCAAGGAAG 1800

GAGAAAGATG TCCGCGGCCG GCCATCACTA ATAGACCTTC CTTTACCACC CACTCTGACC 1860

GGACTCGACT CTTCACCGCC ACAGTCTCCT ATTCGCCAAA TGCCATCATT ACCCCAGCCA 1920

GCCCTTAAGA AAAGACCAAA GATTTGTTGC CCACGATATG GCGAGCGCAA ACACACACAG 1980

AGTGACTGGG GCAAACGTTG TGTAGATAAA TTTGATATAA TTGGCATCAT AGGAGAGGGC 2040

ACCTATGGCC AAGTCTACAA AGCCAAGGAC AAAGACACGG GAGAACTGGT TGCTTTGAAG 2100

AAAGTACGTT TAGACAATGA AAAGGAAGGT TTTCCTATCA CAGCCATTAG GGAGATCAAG 2160

ATCCTTCGGC AGCTCAAACA CCGTAGTGTG GTCAACATGA AAGAGATTGT CACCGACAAG 2220

CAAGATGCTC TTGATTTTAA AAAGGACAAA GAAGGTGCCT TTTATCTGGT GTTTGAATAT 2280

ATGGACCATG ACCTGATGGG TCTGCTGGAG TCAGGTCTGG TTCAGTTCTC CCACGAGCAC 2340

GTCCGCAGCT TTATGCGGCA GATGGAGGGT CTGGACTACT GCCACAAGAA CAACTTCCTT 2400

CACAGAGACA TCAAATGTTC CAACATACTG CTCAACAACC GAGGTCAGAT CAAACTGGCT 2460

GACTTTGGCT TGGCTCGGCT CTACAATTCA GAGGAAAGTC GGCCATACAC TAACAAAGTA 2520

ATTACTCTAT GGTACCGCCC CCCTGAACTT CTGCTGGGAG AGGAGAGATA TTCTCCAGCG 2580

ATCGATGTCT GGAGCTGCGG ATGTATTTTG GGAGAACTCT TCACCAAACG GCCGATATTT 2640

CAGGCTAACC AGGAGCTCCT GCAGTTGGAG CTCATCAGCC GTCTGTGTGG AAGTCCCTGT 2700

CCTGCTGTGT GGCCTGACGT CATAAAACTT CCTCTTTTCA ACACCATGAA GCCCAAAAAA 2760

CAGTACCGGC GGCGACTGCG GGAAGAATTT GCCTTTTTGC CTACTGCCGC CCTGGACCTG 2820

CTTGACCGAA TGCTGACTCT TGACCCTACA CGGCGCTGCA CCTCGGAGCA AGCTCTCATC 2880

AGTGACTTCC TATCTGACAT TGATCCCAGC AAGATGCCGC CGCCAGATCT TCCTCACCAT 2940

CAGGACTGCC ATGAGCTGTG GAGTAAGAAG AGACGACGTG CGCGCCAGAG TGGGGTGCCT 3000

GAAGACGCGT CTGTGCCTAA AGTGCCCCGT AAGGAGGCGA CAGGGACCAG TAGTGGTGAG 3060

AACAGCCGCC CCCAAACGAG TCCAGCTGCA GCGCCGCCGC CGCCGCCACC AGGAAAACCA 3120

CCTACCACAA CTAATTTGGA GTGCCTGGGA CCGGCAGCCG AACAGTTGAA CCCTGCAGAG 3180

TTGGCCGTGC TGCTAAATCT GCTCCAGGGC CAGACTGATC TCAGTTTGCC CCAGGTGGCC 3240

CAACTCCTAA ACCTCTCCAA TCCAGAGACT CTCAGCCAGT CATTGTCTGC TCTCAGTGAG 3300

GCCTCTGACC ACCAGGGGAC TTCAGACGAT CACGGCCCGA CCACCACTAG GCCCCCGGAG 3360

CCACCTCCTG AACCACAGGA GCCTTCACCT TCTGGTGATT CATCTCTTAA CCAGGAAGAC 3420

CAGGCCAACC TCCTGGCTCT TATTTTGAGC CATATCATCA AACCTCAAAA GGAGGCACTA 3480

GCACGCAGTT CATCTGCCTC TACTACTGAT CGCAAGGATG GTGCCCCATC TAAAAGGAAC 3540

CGGCCTGTGG AGAACCAGAT TCCTCCACAC AGTCAGCAGC GTCCACCCTC CCCACTGGGA 3600

CCACCTCCAG CCCTTGCTGC ACAGCAGGCC GGGTCTGAAC CCCAGTCCAG CCGGGACATT 3660

AGCCCAGCCG TGGCGGCTGC CTTGCTCCAA CTCATTTCTC AGCAGGACGC CGAA 3714

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         ++ +  igeGtyg+vykakdk+tge+vAlKk+rl++ekeg+pita+rEi++l++lkh+ +

Q: 671   FDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLKHRSV  730

         667889******************************************************

S: 61    vkLlevva..........kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqll  110

         v+++e+v+           ++  +yLvfe++++dL+ ll++    ++s+e+v+s+++q+

Q: 731   VNMKEIVTdkqdaldfkkDKEGAFYLVFEYMDHDLMGLLESGLV-QFSHEHVRSFMRQM-  788

         ****************9555599******************999.************95.

S: 111   eglaylHsnkilHRDlKpqNlLiskegklklaDfGlarafssplk.tytkevvTlwYraP  169

         egl+y+H+n++lHRD+K++N+L++++g++klaDfGlar ++s+++  yt++v+TlwYr+P

Q: 789   EGLDYCHKNNFLHRDIKCSNILLNNRGQIKLADFGLARLYNSEESrPYTNKVITLWYRPP  848

         9***************************************7766527*************

S: 170   elLlgakeYstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevs  229

         elLlg+++Ys a+D+Ws+gcil el+t++p+fq+++e  qle i++l+g+p  +vwp+v

Q: 849   ELLLGEERYSPAIDVWSCGCILGELFTKRPIFQANQELLQLELISRLCGSPCPAVWPDVI  908

         ************************************************************

S: 230   klpeykksfpkkkkk.klkekvkklkekaldllekllaldpkkRisakealqhky  283

         klp +++  pkk+++ +l+e++  l ++aldll+++l+ldp++R+++++al +++

Q: 909   KLPLFNTMKPKKQYRrRLREEFAFLPTAALDLLDRMLTLDPTRRCTSEQALISDF  963

         ******7777777777******999999**********************98877

Domain Sequence
(FASTA)

FDIIGIIGEG TYGQVYKAKD KDTGELVALK KVRLDNEKEG FPITAIREIK ILRQLKHRSV 60

VNMKEIVTDK QDALDFKKDK EGAFYLVFEY MDHDLMGLLE SGLVQFSHEH VRSFMRQMEG 120

LDYCHKNNFL HRDIKCSNIL LNNRGQIKLA DFGLARLYNS EESRPYTNKV ITLWYRPPEL 180

LLGEERYSPA IDVWSCGCIL GELFTKRPIF QANQELLQLE LISRLCGSPC PAVWPDVIKL 240

PLFNTMKPKK QYRRRLREEF AFLPTAALDL LDRMLTLDPT RRCTSEQALI SDF 293

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013