EKS-TEN-00557
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TEN-00557
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/DMPK435.48.7E-13178341264
StatusUnreviewed
Ensembl ProteinENSTNIP00000003483
UniProt AccessionH3D439;
Protein Name
Protein Synonyms/Alias
Gene NameROCK2 (2 of 2)
Gene Synonyms/Alias ROCK2 (2 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTNIG00000012308ENSTNIP00000015277ENSTNIT00000015481
ENSTNIG00000012308ENSTNIP00000003483ENSTNIT00000003293
OrganismTetraodon nigroviridis
Functional Description
Protein Length1375
Protein Sequence
(FASTA)
IMPGAESRQE SRLSKLEALI RNPQSALNLE TLLDSISALA RDLNYPALRK NKNIDAFLNR 60
YEKAASQLQE LQVKLSDFDK VKLIGRGAYG EVQLVRHKTS QKVYAMKQLN KFEMIKRSDS 120
AFFWEERHIM AFSNSPWVVQ LCCAFQDDRH LYMVMEFMPG GDVVTLTMNY DIPEKWARFY 180
TAEVVLALDA IHSMGFIHRD VKPDNMLLDQ HGHLKLADFG TCMKMDSTGM VHCDTAVGTP 240
DYISPEVLQS QGGDGFYGRE CDWWSVGVFI YELLVAGETP FYAESLVGTY GKIMNHMNSL 300
VFPEDVEMSS DARDLICAFL TDRKVRLGRN GVEDIKRHAF FQNNQWTFDN IRETVAPVVP 360
ELSSDIDTTN FEDIEDDKGK AETFPPPKAF VGNQLPFVGF TYFKEDQLLE VNNKYSAEAS 420
KPVLYNGQLQ KKLHQLEEQL DCEMQAKDEL EQKYRNATNR LEKLVKELDK EMSSRQKVEA 480
SLRQLERDRA LLQHQSAENL RKVEIETERK RGLENEQVNN LRDQLEDLRK KNQDSQMSNE 540
KNIQLQKQLD ETNAVLQAEQ EAAARMKKSQ TEVQKHAQSL EASLGEMKER CSQLEKERME 600
LEKRLMALQA QLDEERRDRN LRTETIADLQ GRIERLNEEV KEVKSSRSEV LLEKKTLQEK 660
FSDLQKEKNN QEIDLMFKLR TLQQSMELEE LEHKATKARL ADKNKIDQSI EEANSEALRE 720
MESALQEERS FKMQVEAKLL QLKKEHSMLD CDYKQAKQKL EELQAQKEKL SEEAKNLKLR 780
LEQESHKRSL SQSELKMQNQ QVSVLHSSEK QLKQELNLLL DMKQTLDKQN QELRREKQEV 840
GGQLKELKDQ LEAEQYFTTL YKTQIRELKG DCDQKSKQCK EMQRRLAEYK EERESLTAQL 900
EASLTKADTE QLARSIAEEQ YSDLEKEKIM KELEIKDMMA RHKQELGDKE ATISSLEESN 960
RTLTVDVANL AGEKEELNNQ LKEMQQKLQK AREAERQMNS LKVSFERLLQ NERTLKIQAV 1020
NKLAEVMNRR VRGGHRGNDT EVHRREKENR KLQLELRAEK EKLNSTIIKY QREMTDMQAL 1080
LAEENQVRLE LQMALDSKES DIEQLRCQLS TLSVHSLDST SISSSNDLDT SEGYPDSRLE 1140
GWISLPTKNT KRFGWDKKYI VVSSKKILFY NSELDREQGN PFMTLDIDKL FHVRPVTHTD 1200
VYRADPKEIP RIFQILYANE GEIKRDQEVV MEQTPFGERA MYISHKGHEF IPTLYHFPSS 1260
CEVCTRPLWH VFKPPPAECR RCHAKCHKDH LKKEEVIVPC KVNYDMSTAK ELLLLTTSQE 1320
EQQRWVNHLL KRIPRKHPTL SSPHMSPHRG AIKIQSARQQ QTSGKTSLVS LGDPN 1375
Nucleotide Sequence
(FASTA)
ATCATGCCTG GAGCGGAGAG CAGACAGGAA AGCCGGTTGT CGAAGCTGGA GGCTCTAATC 60
AGGAACCCCC AGTCGGCTCT AAACTTGGAA ACCCTACTGG ACTCCATCAG TGCACTGGCT 120
CGTGATCTGA ACTATCCAGC CCTGCGGAAA AACAAAAACA TAGATGCCTT TCTTAATCGA 180
TATGAGAAAG CAGCCAGTCA GCTGCAGGAG CTGCAGGTGA AGCTCTCCGA CTTTGACAAA 240
GTGAAGCTGA TCGGCCGAGG GGCCTACGGA GAGGTGCAGC TGGTCCGTCA CAAGACCTCT 300
CAGAAGGTCT ACGCCATGAA GCAACTCAAC AAGTTTGAGA TGATCAAGCG GTCCGACTCG 360
GCCTTCTTTT GGGAGGAGCG GCACATCATG GCTTTCTCCA ACAGTCCCTG GGTGGTGCAG 420
CTGTGCTGCG CGTTCCAAGA TGACCGCCAC CTCTACATGG TGATGGAGTT CATGCCCGGC 480
GGCGACGTGG TCACTCTCAC CATGAACTAC GACATCCCTG AGAAGTGGGC TCGCTTCTAC 540
ACGGCCGAGG TGGTGCTGGC GCTGGACGCC ATCCACTCCA TGGGCTTCAT CCACCGCGAC 600
GTCAAACCGG ACAACATGCT GCTCGACCAG CACGGCCACC TCAAGCTGGC AGACTTTGGC 660
ACCTGCATGA AGATGGACTC GACAGGCATG GTGCACTGTG ACACAGCTGT AGGTACACCT 720
GATTACATCT CCCCCGAGGT GCTCCAGTCT CAGGGTGGGG ATGGTTTCTA CGGCCGGGAA 780
TGTGACTGGT GGTCCGTGGG AGTCTTTATC TATGAGTTAC TGGTTGCAGG TGAAACACCC 840
TTTTACGCCG AGTCTCTCGT CGGAACCTAC GGGAAGATAA TGAACCACAT GAACTCGCTA 900
GTCTTCCCAG AAGATGTGGA AATGTCTTCG GATGCCAGAG ACCTCATCTG TGCCTTTCTA 960
ACCGACAGGA AAGTTCGTCT GGGACGCAAT GGAGTGGAGG ACATTAAGCG CCACGCTTTT 1020
TTCCAGAATA ACCAGTGGAC CTTTGACAAC ATCAGAGAGA CTGTGGCTCC AGTCGTGCCA 1080
GAGCTGAGCA GCGACATCGA CACCACCAAC TTTGAAGACA TAGAGGATGA TAAAGGCAAG 1140
GCCGAGACCT TCCCTCCACC CAAGGCATTT GTGGGCAACC AGCTTCCATT TGTTGGCTTC 1200
ACTTACTTTA AGGAGGACCA GTTACTGGAG GTAAATAACA AATACTCCGC AGAAGCTTCG 1260
AAGCCCGTCC TTTACAATGG ACAGCTTCAG AAAAAGCTCC ATCAGCTGGA GGAACAACTC 1320
GACTGTGAGA TGCAGGCTAA AGATGAGCTG GAACAGAAGT ACAGAAATGC CACCAACCGT 1380
TTGGAAAAGC TCGTCAAAGA GCTGGACAAA GAGATGAGCA GCAGGCAGAA AGTGGAGGCC 1440
TCGCTCCGTC AGCTGGAGAG AGATCGGGCA CTGTTGCAGC ACCAGAGTGC CGAGAACCTG 1500
CGCAAAGTGG AGATCGAGAC CGAGAGGAAA CGGGGTCTGG AGAACGAACA AGTGAACAAC 1560
CTGAGGGATC AGCTGGAGGA TCTTCGGAAA AAGAACCAGG ACTCCCAAAT GTCAAATGAG 1620
AAAAATATCC AACTGCAGAA ACAACTCGAC GAAACCAACG CCGTGCTGCA GGCGGAGCAG 1680
GAGGCAGCAG CCAGGATGAA GAAGAGTCAG ACGGAGGTGC AGAAACATGC TCAGAGCCTG 1740
GAGGCCAGCC TCGGGGAGAT GAAGGAGAGG TGTAGCCAGC TGGAAAAGGA AAGGATGGAG 1800
CTGGAGAAGC GACTGATGGC ACTGCAGGCC CAGCTGGATG AGGAGAGGAG AGATCGAAAC 1860
CTCCGGACAG AAACCATCGC TGACCTGCAG GGGCGTATTG AGAGGCTGAA TGAGGAGGTG 1920
AAAGAAGTGA AGTCCTCCCG CTCTGAAGTC CTGTTGGAAA AGAAGACTCT TCAGGAGAAG 1980
TTCAGTGACC TGCAAAAGGA GAAGAACAAC CAGGAGATTG ACTTGATGTT CAAGCTGAGG 2040
ACTCTGCAGC AGAGTATGGA GCTGGAGGAG CTGGAGCACA AGGCCACCAA AGCCAGGCTG 2100
GCCGATAAAA ATAAGATCGA CCAGTCCATT GAGGAGGCGA ACTCTGAGGC CCTGAGAGAG 2160
ATGGAATCGG CTCTGCAGGA AGAGCGCAGC TTTAAGATGC AGGTGGAGGC GAAGCTGCTG 2220
CAGCTGAAGA AGGAGCACTC CATGCTGGAC TGTGACTACA AGCAGGCCAA GCAGAAGCTG 2280
GAGGAGCTGC AGGCACAGAA GGAGAAACTC TCTGAAGAGG CAAAGAATCT AAAACTGCGG 2340
CTGGAGCAGG AGAGCCACAA GAGGAGTTTG AGCCAGAGCG AGCTGAAGAT GCAGAACCAG 2400
CAGGTGTCGG TGCTTCATTC CTCAGAGAAA CAGCTCAAGC AGGAGCTCAA TCTCCTGCTG 2460
GACATGAAGC AGACCCTGGA CAAGCAGAAC CAGGAGCTAC GCAGGGAGAA GCAGGAGGTG 2520
GGTGGCCAGC TGAAGGAACT GAAAGACCAG CTGGAGGCAG AGCAGTATTT CACGACCCTT 2580
TACAAGACGC AGATCCGTGA GCTGAAGGGC GACTGCGACC AGAAGAGCAA ACAGTGCAAA 2640
GAGATGCAGC GGCGGCTGGC AGAGTACAAG GAGGAGAGGG AGTCACTCAC AGCCCAGCTG 2700
GAAGCCAGTT TGACTAAGGC AGACACTGAG CAGCTGGCTC GCTCCATCGC TGAGGAGCAG 2760
TACTCTGACC TGGAGAAGGA GAAGATCATG AAGGAGCTGG AGATCAAGGA CATGATGGCC 2820
AGGCACAAGC AGGAACTGGG CGACAAGGAG GCCACCATCA GCTCGCTGGA GGAGTCCAAC 2880
CGTACCCTGA CGGTGGACGT AGCCAACCTG GCTGGAGAGA AGGAGGAGCT CAACAACCAG 2940
CTGAAAGAAA TGCAGCAGAA GCTGCAGAAA GCCAGAGAGG CAGAGAGGCA GATGAACTCC 3000
CTCAAAGTGT CTTTTGAAAG GCTGCTGCAG AACGAACGCA CACTGAAAAT TCAGGCGGTG 3060
AACAAGTTGG CCGAGGTGAT GAACAGGAGA GTGAGGGGGG GCCACCGAGG CAACGACACA 3120
GAGGTGCACA GGAGGGAGAA GGAGAACAGG AAGCTGCAAC TGGAGCTGCG GGCGGAGAAG 3180
GAGAAACTCA ACAGCACCAT CATCAAGTAT CAGAGGGAAA TGACGGACAT GCAGGCGCTG 3240
TTGGCGGAGG AGAACCAGGT ACGACTGGAG CTTCAGATGG CGCTAGACAG CAAAGAGAGC 3300
GACATTGAGC AGCTGCGGTG CCAGCTCTCC ACCCTCAGCG TTCACTCTCT GGACTCCACC 3360
AGCATCAGCA GCAGCAACGA TCTGGACACA AGCGAGGGAT ACCCAGACTC CAGGCTGGAG 3420
GGCTGGATCT CACTTCCCAC CAAGAACACA AAGCGGTTTG GCTGGGACAA AAAATATATA 3480
GTTGTCAGCA GTAAGAAGAT CCTCTTCTAC AACAGCGAGC TGGACCGAGA GCAGGGCAAT 3540
CCTTTTATGA CTCTTGACAT TGATAAACTG TTTCATGTCC GACCAGTCAC TCACACCGAC 3600
GTGTACCGAG CCGATCCCAA AGAAATTCCA AGGATATTCC AGATCCTGTA CGCTAACGAA 3660
GGCGAGATTA AACGCGATCA GGAGGTCGTG ATGGAGCAGA CGCCGTTTGG TGAACGAGCC 3720
ATGTACATCA GCCACAAGGG TCACGAGTTC ATCCCCACCC TCTACCACTT CCCGTCCAGC 3780
TGCGAGGTCT GTACCCGCCC CCTGTGGCAC GTCTTCAAGC CCCCGCCTGC CGAGTGCCGC 3840
CGCTGCCACG CCAAGTGCCA CAAGGACCAT CTGAAGAAGG AGGAAGTTAT TGTTCCTTGC 3900
AAGGTGAACT ACGACATGTC CACCGCCAAA GAGCTGCTCC TGCTGACCAC CTCCCAGGAA 3960
GAGCAGCAGC GCTGGGTGAA TCACCTCCTC AAGCGCATCC CGAGGAAGCA CCCGACGTTG 4020
AGTTCTCCTC ATATGTCGCC GCACCGCGGA GCCATCAAGA TCCAGTCGGC TAGACAGCAG 4080
CAGACGTCCG GCAAAACGAG CCTGGTTTCC CTGGGTGATC CCAAC 4125
Domain Profile
S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60
         f+ +k+iGrGa+gev++vr+k+++kvyamk l+k+e++kr++saff+eer+++++++s+w
Q: 78    FDKVKLIGRGAYGEVQLVRHKTSQKVYAMKQLNKFEMIKRSDSAFFWEERHIMAFSNSPW  137
         7789********************************************************
S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120
         +vql +afqd+++ly+vme+++GGd++tl  +y+  +pe++arfy+ae+vlald++h++g
Q: 138   VVQLCCAFQDDRHLYMVMEFMPGGDVVTLTMNYD--IPEKWARFYTAEVVLALDAIHSMG  195
         **********************************..************************
S: 121   yvhrdikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkaleegk  180
         ++hrd+kpdn+lld++Gh+kladfG+c+k++++g+v++++avGtpdyispevl++++ g+
Q: 196   FIHRDVKPDNMLLDQHGHLKLADFGTCMKMDSTGMVHCDTAVGTPDYISPEVLQSQG-GD  254
         ********************************************************9.**
S: 181   geygkecdwwslGvilyellv.getpfyaeslvetyskilnhkeslkfpedekvseeakd  239
         g yg+ecdwws+Gv++yellv getpfyaeslv ty+ki+nh +sl fped+++s++a+d
Q: 255   GFYGRECDWWSVGVFIYELLVaGETPFYAESLVGTYGKIMNHMNSLVFPEDVEMSSDARD  314
         ******************98649*************************************
S: 240   likklltsreerlgregiedlkkhpff  266
         li+++lt+r+ rlgr+g+ed+k+h+ff
Q: 315   LICAFLTDRKVRLGRNGVEDIKRHAFF  341
         **************************9
Domain Sequence
(FASTA)
FDKVKLIGRG AYGEVQLVRH KTSQKVYAMK QLNKFEMIKR SDSAFFWEER HIMAFSNSPW 60
VVQLCCAFQD DRHLYMVMEF MPGGDVVTLT MNYDIPEKWA RFYTAEVVLA LDAIHSMGFI 120
HRDVKPDNML LDQHGHLKLA DFGTCMKMDS TGMVHCDTAV GTPDYISPEV LQSQGGDGFY 180
GRECDWWSVG VFIYELLVAG ETPFYAESLV GTYGKIMNHM NSLVFPEDVE MSSDARDLIC 240
AFLTDRKVRL GRNGVEDIKR HAFF 264
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Oreochromis niloticus"; ?>Oryzias latipes"; ?>Takifugu rubripes"; ?>
EKS-ORN-00563
EKS-ORL-00512
EKS-TAR-00553
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0046872; F:metal ion binding
GO:0005543; F:phospholipid binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0000910; P:cytokinesis
GO:0035556; P:intracellular signal transduction
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR001849; Pleckstrin_homology.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR020684; Rho-assoc_coiled-coil_kin.
IPR015008; Rho-bd.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
PF08912; Rho_Binding; 1.
SMARTs
SM00109; C1; 1.
SM00233; PH; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS50081; ZF_DAG_PE_2; 1.
Prints
Created Date20-Feb-2013