EKS-TEN-00301

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00301

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	381.6	1.7E-114	53	305	253

Status

Unreviewed

Ensembl Protein

ENSTNIP00000015361

UniProt Accession

H3D4C3;

Protein Name

Protein Synonyms/Alias

Gene Name

MARK3 (1 of 2)

Gene Synonyms/Alias

MARK3 (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000012393	ENSTNIP00000015361	ENSTNIT00000015566

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

743

Protein Sequence
(FASTA)

MSTKTPLPTV NEKVTESHTT HSNGRQEISA RSARTGVRSR SSEEPQQPHV GNYRLLKTIG 60

KGNFAKVKLA RHILHGPRAV AIKIIDKTQL NPNSLQKLFR EVRIMKILNH PNIVKLFEVI 120

ETERTLYLVM EYASGGEVFD YLVAHGRMKE KEARAKFRQI VSAVQYCHQK HIVHRDLKAE 180

NLLLDADMNI KIADFGFSNE FTLGNKLDTF CGSPPYAAPE LFQGKKYDGP EVDVWSLGVI 240

LYTLVSGSLP FDGQNLKELR ERVLRGKYRI PFYMSTDCEN LLKRFLVLNP SKRGTLEQIM 300

KDRWINTGFE EDELKPYTEP ELDITDQKRI DVMVGMGYNL EEIQDSLAKM KYDEITATYL 360

LLGRKASELE PSESASSSNL SLTKPRPNSE LNGQSPTHIK VQRSVSSSHK QRRYSEQAGQ 420

NVPPGMAHPK RSQTSTTDSS PKEDGGVQLR KPSTPGSRGA PPSSPLLGNA NNPNKADIPE 480

RRKGVASGPS NNTASAGMTR RNTYVCSDRN NADRLSVIPN GKENSVAVSP SAQRNPVASI 540

HSIANATTPD RLRFPRGTAS RSTFHGGHLR DRRTATYNPP ASPTLSHDAT PLSQTRSRGT 600

SNLFSKLTSK LTRRVSTEFE RNGRLEGSSR HVPGDQKGET KDGKPRSLRF TWSMRTTSSM 660

EPCDIMREIR KVLDANNCDY EQQESFLLLC VHGDGHAENL VQWEMEVCKL PRLSLNGVRF 720

KRISGSSIAF KNIASKVANE LKL 743

Nucleotide Sequence
(FASTA)

ATGTCAACAA AAACTCCTTT ACCAACGGTC AACGAGAAGG TGACGGAAAG TCACACAACG 60

CACAGCAATG GCCGCCAGGA GATCAGCGCA CGTTCGGCCC GGACCGGCGT CCGATCCCGA 120

AGCTCCGAGG AGCCGCAGCA GCCCCACGTG GGCAACTACC GACTGCTCAA AACCATCGGG 180

AAGGGCAACT TTGCCAAGGT CAAGCTGGCT CGGCACATCC TACACGGGCC GAGAGCAGTG 240

GCAATAAAAA TAATAGACAA GACCCAGCTG AACCCAAACA GCCTTCAGAA GCTTTTCAGA 300

GAAGTTAGAA TAATGAAGAT CTTGAATCAT CCCAATATTG TCAAACTCTT TGAGGTGATC 360

GAGACGGAGA GGACGCTCTA CCTGGTGATG GAGTACGCCA GCGGAGGAGA AGTCTTCGAC 420

TACCTGGTCG CGCATGGAAG AATGAAAGAA AAAGAGGCCA GGGCTAAATT TAGACAGATC 480

GTGTCAGCGG TGCAGTATTG TCACCAGAAG CACATCGTTC ACCGAGACCT GAAGGCTGAA 540

AACCTCCTGC TGGATGCAGA CATGAACATT AAGATAGCAG ATTTTGGCTT CAGTAATGAG 600

TTCACGCTGG GCAACAAGCT GGACACCTTC TGCGGTTCTC CGCCGTACGC CGCACCGGAG 660

CTGTTTCAGG GAAAGAAGTA CGACGGGCCG GAGGTGGACG TCTGGAGCCT GGGGGTCATC 720

CTGTACACGC TGGTCAGCGG CTCGCTCCCC TTCGATGGGC AGAACCTCAA GGAGCTGCGC 780

GAGCGTGTGC TCAGAGGGAA GTACCGAATC CCCTTCTACA TGTCCACAGA CTGCGAGAAC 840

CTGCTCAAAC GCTTCCTGGT GCTCAACCCG TCCAAGCGGG GCACTCTCGA GCAAATTATG 900

AAGGATCGAT GGATCAACAC AGGATTCGAA GAGGACGAGC TGAAGCCTTA CACCGAGCCT 960

GAGCTGGACA TCACAGACCA GAAGAGAATA GATGTGATGG TGGGGATGGG CTACAACCTG 1020

GAGGAGATCC AGGACTCTCT GGCCAAGATG AAGTATGACG AGATCACAGC CACCTACCTG 1080

CTGCTGGGCA GGAAGGCGTC CGAGCTGGAG CCCAGCGAGT CGGCCTCCAG CAGCAACTTG 1140

TCTCTGACCA AACCTCGACC CAACAGCGAG CTCAACGGCC AGTCGCCCAC CCACATCAAA 1200

GTCCAGAGGA GCGTCTCCTC CAGTCACAAA CAGAGACGCT ACAGCGAGCA AGCGGGTCAG 1260

AACGTCCCTC CAGGAATGGC TCACCCGAAG AGGAGCCAGA CCTCCACCAC CGACAGCAGC 1320

CCGAAGGAAG ACGGCGGAGT CCAGCTCCGT AAGCCCAGCA CCCCGGGTAG CCGCGGAGCG 1380

CCGCCCTCCA GCCCTCTGCT GGGCAACGCC AACAACCCCA ACAAGGCCGA TATCCCGGAG 1440

CGCAGGAAGG GCGTGGCCAG CGGCCCGAGC AATAACACGG CCTCCGCAGG AATGACCAGG 1500

AGGAACACGT ACGTGTGCAG CGACAGGAAC AACGCAGACC GACTCTCCGT CATCCCCAAC 1560

GGGAAGGAGA ACAGCGTCGC CGTGTCTCCC AGCGCGCAGC GGAACCCGGT GGCGTCCATC 1620

CACAGCATCG CCAACGCCAC CACGCCGGAC CGCCTGCGCT TCCCGCGGGG CACCGCCAGC 1680

CGCAGCACCT TCCACGGCGG GCACCTGAGA GACCGGCGCA CCGCCACCTA CAACCCGCCG 1740

GCCTCCCCCA CGCTCTCCCA CGATGCCACC CCCCTGTCCC AGACCCGCAG CCGTGGAACC 1800

AGCAACCTTT TCTCCAAACT CACCTCCAAA CTCACCCGCA GAGTCTCAAC CGAGTTTGAG 1860

AGAAACGGGA GACTTGAGGG CTCAAGTCGC CATGTACCTG GGGATCAAAA AGGGGAAACT 1920

AAAGACGGTA AACCCCGCTC CCTCAGATTC ACTTGGAGTA TGAGGACCAC CAGCTCCATG 1980

GAGCCCTGCG ACATCATGCG GGAGATCCGC AAGGTGCTCG ACGCCAACAA CTGCGACTAC 2040

GAACAACAAG AGAGTTTCCT GCTTCTTTGC GTCCACGGGG ACGGCCACGC CGAGAACCTG 2100

GTCCAGTGGG AGATGGAGGT CTGCAAGCTT CCCCGTCTCT CCCTCAACGG CGTCAGGTTC 2160

AAGCGGATAT CCGGATCATC CATCGCTTTC AAGAACATTG CTTCCAAAGT TGCCAACGAG 2220

CTAAAGCTAT GA 2232

Domain Profile

S: 1     ykllktlGegsfgkVklakhk.etkekvavKiikkkklseeslekikrEieilkklkhpn  59

         y+llkt+G+g+f+kVkla+h  +  ++va+Kii+k++l+ +sl+k++rE++i+k+l+hpn

Q: 53    YRLLKTIGKGNFAKVKLARHIlHGPRAVAIKIIDKTQLNPNSLQKLFREVRIMKILNHPN  112

         99*******************556689*********************************

S: 60    iikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgi  119

         i+kl+eviet+++lylv+eyasgge+fdy++++gr+kekear+ f+q+vsav+Y+h+k+i

Q: 113   IVKLFEVIETERTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKHI  172

         ************************************************************

S: 120   vHrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkv  179

         vHrDlK+eNllld+++nikiaDFG++n+f+ g++l+tfcGsppYaaPel++gkkY+gp+v

Q: 173   VHRDLKAENLLLDADMNIKIADFGFSNEFTLGNKLDTFCGSPPYAAPELFQGKKYDGPEV  232

         ************************************************************

S: 180   DvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpek  239

         DvWslGv+Ly+lv+g+lPfd++nlkel+e++l+gk++ip+++s+++e+Ll+++Lv +p+k

Q: 233   DVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPSK  292

         ************************************************************

S: 240   Ratieeilkhewl  252

         R t+e+i+k++w+

Q: 293   RGTLEQIMKDRWI  305

         ************7

Domain Sequence
(FASTA)

YRLLKTIGKG NFAKVKLARH ILHGPRAVAI KIIDKTQLNP NSLQKLFREV RIMKILNHPN 60

IVKLFEVIET ERTLYLVMEY ASGGEVFDYL VAHGRMKEKE ARAKFRQIVS AVQYCHQKHI 120

VHRDLKAENL LLDADMNIKI ADFGFSNEFT LGNKLDTFCG SPPYAAPELF QGKKYDGPEV 180

DVWSLGVILY TLVSGSLPFD GQNLKELRER VLRGKYRIPF YMSTDCENLL KRFLVLNPSK 240

RGTLEQIMKD RWI 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR001772	; Kinase-assoc_KA1.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF02149	; KA1; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220	; S_TKc; 1.
SM00165	; UBA; 1.

Prosites

PS50032	; KA1; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013