EKS-TEN-00186

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00186

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	525.9	1.9E-158	432	699	268

Status

Unreviewed

Ensembl Protein

ENSTNIP00000002998

UniProt Accession

H3C429;

Protein Name

Fibroblast growth factor receptor

Protein Synonyms/Alias

Gene Name

FGFR3

Gene Synonyms/Alias

FGFR3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000012404	ENSTNIP00000015373	ENSTNIT00000015578
ENSTNIG00000012404	ENSTNIP00000000356	ENSTNIT00000003896
ENSTNIG00000012404	ENSTNIP00000002998	ENSTNIT00000001111

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

764

Protein Sequence
(FASTA)

SDSVSSETAY LEDYVLGVGD TLEMTCDLED HPEPVSWFKD GAVLASSNRT RVGPRLLRII 60

NVSYEDSGVY SCRLARSNLL LSNYTIRVTD SLSSGDDEDY DEDPENAVSP TEAPYWTRPE 120

RMDKKLLAIP AANTVKFRCP ASGNPTPTIH WLKNGKEFKG EQRMGGIKLR HQQWSLVMES 180

AVPSDRGNYT CVVQNKYGSI SHTYQLDVLE RSPHRPILQA GLPANQTVVV GSNVEFHCKV 240

YSDAQPHIQW LKHIEVNGSR HGPDGAPYVH ILKTADINTT DKELEVLFLP NVSFEDAGEY 300

TCLAGNSIGY TYHSAWLTVL PGTEVSPGKD DFFADILIYV TGCVLFILAL VIVVLCRMRM 360

TAQKTLPTPP VQKLSKFPLK RQVSLDSNSS MNSNTPLVRI ARLSSSDGPM LANVSELELP 420

PDPKWEFPRT RLTLGKPLGE GCFGQVVMAD AVGIDKEKPN KPLTVAVKML KDDATDKDLS 480

DLVSEMEMMK MIGKHKNIIN LLGACTQDGP LYVLVEYASK GNLREYMDYS FDTCKIPDEQ 540

LTFKDLVSCA YQVARGMEYL ASQKCIHRDL AARNVLVTDD NVMKIADFGL ARDVHNIDYY 600

KKTTNGRLPV KWMAPEALFD RVYTHQSDVW SYGVLMWEIF TLGGSPYPGI PVEELFKLLK 660

EGHRMDKPTN CTHELYMIMR ECWHAVPSQR PTFRQLVEDH DRVLSMTSTD EYLDLAVPFE 720

QYSPTCQDSN STCSSGDDSV FAHDSLPDEP CLPKQPPSNG VIRT 764

Nucleotide Sequence
(FASTA)

TCAGACTCGG TGTCCAGTGA GACGGCCTAC CTGGAGGACT ATGTCCTGGG CGTGGGGGAC 60

ACCCTGGAAA TGACCTGCGA CCTGGAGGAC CACCCGGAGC CCGTCAGCTG GTTCAAAGAT 120

GGCGCCGTTT TGGCGTCCAG CAACCGCACG CGGGTGGGCC CGAGGCTCCT GCGCATCATC 180

AACGTGTCCT ACGAGGACTC GGGCGTCTAC TCGTGTCGGC TCGCTCGCAG CAACCTGCTG 240

CTGAGTAACT ACACCATCAG GGTGACAGAT TCTCTGTCAT CTGGTGATGA TGAAGATTAC 300

GATGAAGACC CGGAAAACGC AGTCTCGCCA ACAGAGGCGC CGTATTGGAC CCGGCCCGAG 360

CGGATGGACA AGAAGCTCCT GGCCATCCCG GCGGCCAACA CCGTCAAGTT CCGCTGCCCG 420

GCATCGGGCA ACCCGACGCC GACCATCCAC TGGCTGAAGA ACGGCAAAGA GTTCAAAGGG 480

GAGCAGCGGA TGGGCGGGAT CAAGTTGCGA CACCAGCAGT GGAGCCTGGT GATGGAGAGC 540

GCCGTGCCGT CGGACCGCGG CAACTACACC TGCGTGGTGC AGAACAAGTA CGGCTCCATC 600

TCCCACACCT ACCAGCTGGA CGTCCTGGAG CGGTCCCCCC ACAGGCCCAT CCTCCAGGCG 660

GGGCTGCCGG CCAATCAGAC GGTTGTGGTG GGCAGCAACG TGGAGTTCCA CTGCAAGGTT 720

TACAGCGATG CCCAGCCGCA CATCCAGTGG CTGAAGCACA TCGAGGTGAA CGGCAGCCGC 780

CACGGGCCTG ACGGCGCCCC CTATGTCCAC ATCCTGAAGA CAGCTGACAT TAACACTACA 840

GATAAGGAGC TTGAGGTTCT CTTCTTGCCC AATGTGTCTT TTGAGGATGC GGGCGAGTAC 900

ACTTGCCTGG CGGGGAACTC TATCGGCTAT ACTTACCACT CTGCCTGGCT GACGGTGCTT 960

CCAGGGACAG AGGTGAGCCC GGGGAAGGAC GACTTCTTTG CCGATATCCT CATTTATGTG 1020

ACGGGCTGCG TGCTCTTCAT CCTCGCCTTG GTCATCGTGG TGCTTTGCCG CATGAGGATG 1080

ACCGCGCAGA AGACGCTGCC GACGCCGCCC GTGCAGAAGC TGTCCAAGTT TCCCCTCAAG 1140

AGACAGGTGT CCTTGGATTC CAACTCTTCC ATGAACTCCA ACACGCCGCT GGTGAGGATC 1200

GCCCGCCTGT CGTCCAGCGA CGGGCCGATG CTTGCTAACG TCTCTGAGCT GGAGCTGCCG 1260

CCAGACCCCA AGTGGGAGTT TCCTCGTACA CGGCTCACTC TTGGCAAACC TCTGGGCGAG 1320

GGCTGTTTCG GTCAGGTGGT CATGGCCGAC GCCGTCGGTA TCGACAAGGA GAAGCCCAAT 1380

AAGCCACTGA CCGTCGCCGT GAAAATGCTC AAAGACGACG CCACAGACAA AGACCTGTCG 1440

GACCTGGTGT CAGAGATGGA GATGATGAAG ATGATTGGAA AGCACAAAAA CATCATCAAC 1500

CTGCTGGGAG CGTGCACGCA GGACGGTCCT CTGTACGTCC TGGTGGAATA CGCCTCCAAA 1560

GGTAACCTGA GGGAGTACAT GGACTACTCC TTCGACACCT GCAAGATCCC CGATGAGCAG 1620

CTAACGTTCA AAGACCTGGT GTCGTGCGCC TACCAGGTCG CTCGGGGGAT GGAGTACCTG 1680

GCCTCGCAAA AGTGCATCCA CAGAGACCTG GCAGCCAGAA ACGTTCTGGT GACGGACGAC 1740

AACGTGATGA AAATCGCCGA CTTCGGCCTC GCAAGAGACG TGCACAACAT AGACTACTAC 1800

AAGAAGACCA CCAACGGTCG TCTGCCCGTG AAATGGATGG CTCCGGAGGC TCTGTTCGAC 1860

CGGGTCTACA CGCACCAGAG CGACGTGTGG TCCTACGGGG TCTTGATGTG GGAGATCTTC 1920

ACGCTGGGGG GGTCTCCATA CCCAGGCATC CCAGTGGAGG AGCTCTTCAA GCTGCTGAAG 1980

GAGGGACATC GAATGGACAA ACCCACCAAC TGCACCCACG AGCTGTACAT GATCATGAGG 2040

GAATGCTGGC ACGCCGTGCC GTCGCAGAGG CCGACCTTCC GACAGCTGGT GGAGGATCAC 2100

GACCGGGTGT TATCGATGAC CTCCACAGAT GAGTACCTGG ACCTGGCCGT GCCCTTTGAG 2160

CAGTACTCCC CTACCTGTCA GGACTCCAAC AGCACCTGCT CCTCCGGAGA CGACTCGGTC 2220

TTCGCCCACG ACTCGCTGCC GGATGAGCCC TGTCTTCCCA AGCAGCCCCC CAGTAACGGG 2280

GTGATACGGA CGTAA 2295

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         l+lgk+lGeG+fGqvv+a+a+g+dk+k++k  tvavkmlk+datdkdl+dlvseme++k+

Q: 432   LTLGKPLGEGCFGQVVMADAVGIDKEKPNKPLTVAVKMLKDDATDKDLSDLVSEMEMMKM  491

         79**********************************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120

         iGkhkniinllGactq+Gplyv+veya+kGnlre++        ++s d++k+++eqlt+

Q: 492   IGKHKNIINLLGACTQDGPLYVLVEYASKGNLREYM--------DYSFDTCKIPDEQLTF  543

         **********************************95........89**************

S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180

         kdlvs+ayqvarGmeylas+kcihrdlaarnvlvt+dnv+kiadfGlardvh+idyykkt

Q: 544   KDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTDDNVMKIADFGLARDVHNIDYYKKT  603

         ************************************************************

S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240

         tnGrlpvkwmapealfdrvyt+qsdvws+Gvl+wei+tlGgspypgi+veelfkllkeGh

Q: 604   TNGRLPVKWMAPEALFDRVYTHQSDVWSYGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH  663

         ************************************************************

S: 241   rmekpakctkelyvlmrecwhakaserptfkqlved  276

         rm+kp++ct+ely++mrecwha++s+rptf+qlved

Q: 664   RMDKPTNCTHELYMIMRECWHAVPSQRPTFRQLVED  699

         **********************************97

Domain Sequence
(FASTA)

LTLGKPLGEG CFGQVVMADA VGIDKEKPNK PLTVAVKMLK DDATDKDLSD LVSEMEMMKM 60

IGKHKNIINL LGACTQDGPL YVLVEYASKG NLREYMDYSF DTCKIPDEQL TFKDLVSCAY 120

QVARGMEYLA SQKCIHRDLA ARNVLVTDDN VMKIADFGLA RDVHNIDYYK KTTNGRLPVK 180

WMAPEALFDR VYTHQSDVWS YGVLMWEIFT LGGSPYPGIP VEELFKLLKE GHRMDKPTNC 240

THELYMIMRE CWHAVPSQRP TFRQLVED 268

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0008284	; P:positive regulation of cell proliferation

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 3.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 3.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013