EKS-TEN-00271

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00271

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/NKF2	452.7	8.4E-136	143	494	352

Status

Unreviewed

Ensembl Protein

ENSTNIP00000015393

UniProt Accession

H3D4F5;

Protein Name

Protein Synonyms/Alias

Gene Name

PINK1

Gene Synonyms/Alias

PINK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000012423	ENSTNIP00000015393	ENSTNIT00000015598

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

562

Protein Sequence
(FASTA)

MSLKHAVSRG LEWGRSVFQL GLIKSGGRVV AKFRADRFRV GPQARGLQPR AFLPARYRYY 60

RTSLRGLAAQ LQSAAFRRGF GGGAARNRAV FLAFGLGVGL IEQQLEDDRR SDAACQEIQA 120

VFKKKRLQAP LRPFTSGYRL EDYVIGNQIG KGSNAAVYEA AASLAPLAPL KDEACVVELK 180

EDGEQPVRPL TCCSLRNFPL AIKMMWNFGA GSSSEAILRS MSQELVPVGR AALNRRDQVV 240

LDGHFGVSPK GLAAHPNIVR VCRVFTAEVP LLPGALEEYP DMLPARLNPA GLGNNRTLFL 300

VMKNYPYTLQ RFLAESAPSR RQRALMLLQL LEGVDHLCRH GVAHRDLKSD NVLLELDAAG 360

DPRVVISDFG CCLSQRDRSL QLPFSSVCVS RGGNVSLMAP EVINALPGTN MVIDYSKADA 420

WAVGAIAYEI FGRPNPFYRG VGLESRRYQE KQLPPLPSWV PGDVQSLIRL LLRRNPEKRP 480

SARVAANMLH LSLWGRRALA DHDGAAMGEL VDWLLCQSAL VLLKGPRGNT VEAELQTIFL 540

AQLELEELRA AVGFLLYGRE RR 562

Nucleotide Sequence
(FASTA)

ATGTCTCTCA AACACGCCGT GAGCCGGGGT CTGGAGTGGG GCCGCTCCGT CTTTCAGCTC 60

GGTCTCATCA AGTCTGGTGG TCGAGTCGTA GCAAAGTTTC GAGCTGATCG TTTCCGCGTA 120

GGCCCGCAGG CCCGCGGCCT TCAGCCTCGG GCTTTCCTGC CGGCTCGGTA CCGCTACTAC 180

CGCACTTCTC TGAGGGGCCT GGCAGCTCAG CTGCAGTCCG CCGCCTTCAG GAGAGGGTTC 240

GGCGGTGGGG CAGCGCGGAA CAGGGCCGTG TTTCTGGCCT TCGGTCTCGG CGTGGGGCTC 300

ATCGAACAGC AGCTTGAAGA CGACAGAAGG AGCGATGCGG CCTGCCAGGA GATCCAGGCT 360

GTTTTTAAGA AGAAACGTCT GCAGGCGCCG CTCAGGCCGT TCACCTCTGG ATACAGACTG 420

GAGGACTATG TCATCGGGAA CCAGATTGGG AAGGGCTCCA ACGCTGCCGT GTATGAGGCC 480

GCGGCCTCGC TGGCCCCCCT GGCCCCCCTG AAGGACGAGG CCTGCGTGGT TGAGCTGAAG 540

GAAGATGGGG AGCAACCTGT TCGACCTCTG ACCTGCTGCT CGCTAAGGAA CTTCCCTCTG 600

GCCATCAAGA TGATGTGGAA CTTTGGGGCA GGGTCGTCCA GCGAGGCCAT ATTAAGGTCC 660

ATGTCCCAGG AGCTGGTCCC AGTGGGTCGT GCAGCCTTGA ACCGGCGGGA CCAAGTTGTT 720

CTGGATGGGC ACTTTGGAGT CTCCCCAAAA GGGCTGGCGG CGCACCCAAA CATCGTCAGA 780

GTGTGTCGGG TGTTCACGGC CGAAGTCCCG TTGCTCCCAG GAGCCCTGGA GGAGTATCCA 840

GACATGCTCC CAGCCAGGCT CAACCCTGCT GGTCTGGGCA ACAACCGCAC CCTCTTCCTG 900

GTCATGAAGA ATTACCCCTA CACGCTGCAG CGGTTCCTGG CAGAGTCGGC GCCGAGCCGC 960

CGGCAGCGGG CGCTGATGCT GCTGCAGCTC CTGGAGGGCG TGGACCATCT GTGCCGACAC 1020

GGCGTCGCCC ACAGGGATCT CAAGTCTGAC AACGTGCTGC TGGAGCTGGA TGCCGCTGGG 1080

GACCCTCGTG TGGTGATCAG CGACTTTGGC TGCTGCCTGT CTCAGCGCGA CCGCAGCCTG 1140

CAGCTGCCCT TCAGCAGCGT GTGCGTCAGC AGGGGAGGAA ACGTGTCGCT CATGGCCCCG 1200

GAGGTGATCA ACGCCCTTCC TGGAACCAAC ATGGTGATTG ACTACAGCAA AGCGGACGCC 1260

TGGGCCGTGG GCGCCATCGC CTATGAGATA TTTGGACGGC CCAATCCTTT CTACAGAGGG 1320

GTGGGCCTGG AGAGCCGGAG GTACCAGGAG AAGCAGCTTC CTCCTCTGCC CTCCTGGGTT 1380

CCTGGAGACG TGCAGTCCCT GATCCGTTTG CTCCTCAGGA GGAACCCTGA GAAGCGCCCC 1440

AGTGCACGTG TAGCAGCCAA CATGCTACAC CTCAGCCTGT GGGGACGGAG GGCCCTGGCC 1500

GATCACGACG GCGCCGCTAT GGGGGAGCTA GTTGACTGGC TGCTGTGCCA GTCAGCCCTG 1560

GTCCTCCTGA AGGGGCCGCG GGGGAACACG GTGGAGGCGG AGCTTCAGAC CATCTTTCTG 1620

GCCCAGCTGG AGCTGGAGGA GCTGCGTGCT GCCGTGGGCT TCCTGCTGTA TGGAAGGGAG 1680

CGTCGC 1686

Domain Profile

S: 1     yligealgkgcnaavyeatlatldqelekakhlgllgkevtvvlaeidqesavaakkfpl  60

         y ig+ +gkg naavyea  + ++    k +   +  ke +   + + +    + ++fpl

Q: 143   YVIGNQIGKGSNAAVYEAAASLAPLAPLKDEACVVELKEDG--EQPVRPLTCCSLRNFPL  200

         89***************988777766555555555555444..456778889999*****

S: 61    aiklmfnieadssseallksmsqelvpasrva........ldgeygavpkllakhPnivr  112

         aik+m+n+ a+sssea+l+smsqelvp+ r+a        ldg++g  pk la hPnivr

Q: 201   AIKMMWNFGAGSSSEAILRSMSQELVPVGRAAlnrrdqvvLDGHFGVSPKGLAAHPNIVR  260

         ******************************996677777778888888************

S: 113   vlrafidsvkllPdalldyPdalparlypeglgegktlylvmkrydqtlreylesqdrst  172

         v r+f+ +v+llP+al++yPd+lparl+p glg+++tl+lvmk+y+ tl+ +l +  +s

Q: 261   VCRVFTAEVPLLPGALEEYPDMLPARLNPAGLGNNRTLFLVMKNYPYTLQRFLAESAPSR  320

         ************************************************************

S: 173   rlaalllaqlleavdhlvkhgvahrdlksdnilveldddeiPvlviadfGCcladkvdgl  232

         r++al+l+qlle+vdhl +hgvahrdlksdn+l+eld  + P +vi+dfGCcl+++  +l

Q: 321   RQRALMLLQLLEGVDHLCRHGVAHRDLKSDNVLLELDAAGDPRVVISDFGCCLSQRDRSL  380

         ************************************************************

S: 233   rlpyessevdkGGnaalmaPeistavpGpsavinyekadtWavGalayeifglsnPfyge  292

         +lp++s  v++GGn +lmaPe+ +a pG + vi+y+kad+WavGa+ayeifg+ nPfy

Q: 381   QLPFSSVCVSRGGNVSLMAPEVINALPGTNMVIDYSKADAWAVGAIAYEIFGRPNPFY--  438

         **********************************************************..

S: 293   gkaslesasyqeaqlPalpesvppelrqlvydllkreaskrvsadiaanvlqlslf  348

             les+ yqe+qlP+lp+ vp +++ l++ ll+r+++kr+sa++aan+l+lsl+

Q: 439   RGVGLESRRYQEKQLPPLPSWVPGDVQSLIRLLLRRNPEKRPSARVAANMLHLSLW  494

         7789***************************************************9

Domain Sequence
(FASTA)

YVIGNQIGKG SNAAVYEAAA SLAPLAPLKD EACVVELKED GEQPVRPLTC CSLRNFPLAI 60

KMMWNFGAGS SSEAILRSMS QELVPVGRAA LNRRDQVVLD GHFGVSPKGL AAHPNIVRVC 120

RVFTAEVPLL PGALEEYPDM LPARLNPAGL GNNRTLFLVM KNYPYTLQRF LAESAPSRRQ 180

RALMLLQLLE GVDHLCRHGV AHRDLKSDNV LLELDAAGDP RVVISDFGCC LSQRDRSLQL 240

PFSSVCVSRG GNVSLMAPEV INALPGTNMV IDYSKADAWA VGAIAYEIFG RPNPFYRGVG 300

LESRRYQEKQ LPPLPSWVPG DVQSLIRLLL RRNPEKRPSA RVAANMLHLS LW 352

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tupaia belangeri"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005829	; C:cytosol
GO:0005739	; C:mitochondrion
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0071542	; P:dopaminergic neuron differentiation
GO:0051402	; P:neuron apoptotic process
GO:0060872	; P:semicircular canal development

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013