EKS-TEN-00481

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00481

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	318.4	3.8E-95	148	383	236

Status

Unreviewed

Ensembl Protein

ENSTNIP00000015557

UniProt Accession

H3D4W8;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K12 (1 of 2)

Gene Synonyms/Alias

MAP3K12 (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000012586	ENSTNIP00000015557	ENSTNIT00000015763

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

883

Protein Sequence
(FASTA)

SLSGFSTPIS EPLYRRLDGD TPACTPETDL TPTQCVLRNV LSIDTGGQAV PGGSSPTPSD 60

GPSAHFDNSV LKLHELRRGS RGRHSPEAGA VRSQAENIRL QSGSGGFLEG LFGCLKPVWT 120

MIGKAYSTEH KHSNEESWEV PFEEISDLQW VGSGAQGAVF LGKFHGEEVA VKKVRDIKET 180

EIKHLRKLKH PNIITFKGVC TQAPCYCILM EYCAQGQLYE VLRAGRKITP SLLVDWSMGI 240

AGGMNYLHLH KIIHRDLKSP NMLITHDDLV KISDFGTSKE LSDKSTKMSF AGTVAWMAPE 300

VIRNEPVSEK VDIWSFGVVL WEMLTGEIPY KDVDSSAIIW GVGNNSLQLP VPESCPDGFK 360

ILLRQCWNCK PRNRPSFRQI LLHLDIASAD VLSTPQETYF KSQAEWREEV KRHFEKIKSE 420

GTCLHRLDEE LINRRREELR HALDIREHYE RKLERANNLY MELSAVMLQL ELKEKELQRR 480

EQSLDKKYPG LFKHHSSRQS SSTNTMDKLI KKRNVPQKLP SGKRPDLLKS EVIIPKMDSS 540

VMQITIPACP NRSSTSPSRS RRVKTRHRKA GKGSSGDLAG LKATQSSPNR DSSAQTNGPT 600

TNPSQQLLEP GLRGLGHEQP QRQLSSSSPD LLSASAGLGG SEAGAAGLDD LTETPPRSDT 660

PSEDAASFPF SSSPDSPAGE ARPPDGEDKE EGAGAVRLPR GCSGGIGSQH LTPSAILYRA 720

AITRKQRRGV SSEEEEGEVD SEVELPRRRR PTSITKCQSV STFSSENLSV SDGEEGHTTD 780

HSHSGTPDVV STNTDDRLDD RSDDLLSQGS EIPADNTDPA QASDGLSERD GAPGQAKAQL 840

DAGQNPSENR ALCDDSDCDS AELDQSGSGE PSRPPSAGAW APP 883

Nucleotide Sequence
(FASTA)

TCCCTGTCAG GCTTCAGCAC CCCCATCTCT GAACCCCTCT ATCGACGGCT CGATGGAGAC 60

ACCCCTGCCT GCACCCCCGA AACGGACCTG ACCCCCACCC AGTGCGTCCT TCGTAACGTG 120

CTCTCCATCG ACACGGGCGG ACAGGCGGTG CCGGGGGGCA GCAGCCCCAC TCCCAGCGAC 180

GGACCCTCCG CCCACTTTGA CAACAGCGTG CTAAAGCTGC ATGAACTGCG GCGGGGGAGC 240

CGAGGCCGGC ACAGCCCGGA GGCCGGCGCC GTCCGGAGCC AGGCCGAGAA CATTCGGCTG 300

CAGTCGGGAA GCGGAGGTTT TTTGGAGGGA CTGTTTGGCT GCCTGAAACC AGTTTGGACC 360

ATGATCGGAA AGGCCTACTC CACCGAACAC AAACACAGTA ACGAAGAGTC CTGGGAGGTT 420

CCTTTTGAGG AAATCTCCGA CTTGCAGTGG GTGGGCAGCG GAGCGCAGGG GGCCGTCTTC 480

CTGGGCAAGT TCCACGGGGA GGAGGTGGCC GTGAAGAAAG TGCGAGACAT CAAGGAGACT 540

GAGATCAAAC ACCTCCGCAA GCTCAAGCAC CCCAACATCA TCACTTTCAA GGGCGTGTGC 600

ACGCAGGCTC CCTGTTACTG CATCCTCATG GAATACTGCG CTCAAGGCCA GCTGTACGAG 660

GTGCTGAGGG CGGGCCGTAA GATCACCCCC TCCCTCCTGG TTGACTGGTC CATGGGCATA 720

GCGGGTGGCA TGAACTACCT CCACCTTCAC AAAATCATCC ATCGCGACCT CAAGTCACCT 780

AATATGCTGA TCACCCACGA CGACTTGGTG AAGATCTCCG ACTTCGGGAC GTCGAAGGAG 840

CTCAGCGACA AGAGTACCAA GATGTCGTTT GCGGGGACCG TGGCCTGGAT GGCCCCCGAG 900

GTCATTCGTA ATGAGCCTGT CTCAGAAAAG GTGGACATCT GGTCCTTCGG AGTGGTGCTG 960

TGGGAGATGC TGACGGGAGA GATCCCCTAC AAAGACGTGG ACTCCTCTGC CATCATCTGG 1020

GGGGTGGGGA ACAACAGCCT CCAGCTGCCG GTCCCCGAGA GCTGCCCCGA CGGCTTCAAG 1080

ATCCTGCTCA GGCAGTGCTG GAACTGTAAG CCTAGGAACA GGCCCTCCTT CCGCCAGATC 1140

CTCCTTCATC TGGATATTGC GTCTGCGGAC GTGCTGTCCA CCCCCCAGGA GACCTACTTC 1200

AAGTCTCAGG CTGAATGGCG AGAAGAGGTG AAACGGCACT TTGAGAAGAT CAAATCGGAG 1260

GGTACTTGTC TCCACCGGCT TGACGAAGAA CTGATCAACA GGCGCAGAGA GGAGCTCAGG 1320

CATGCTTTAG ATATCCGCGA GCACTACGAG AGGAAGCTGG AGAGAGCTAA CAACCTGTAC 1380

ATGGAGCTGA GTGCTGTCAT GCTGCAGCTG GAGCTGAAGG AGAAAGAGTT GCAGAGGAGG 1440

GAGCAGTCCC TGGATAAAAA GTACCCGGGT CTGTTCAAGC ATCACAGCTC CAGGCAGAGC 1500

AGCTCCACCA ACACCATGGA CAAGCTCATC AAGAAGAGAA ACGTTCCCCA GAAGCTCCCT 1560

TCAGGAAAGA GGCCAGACCT CCTCAAATCT GAGGTAATCA TTCCCAAAAT GGATTCTTCC 1620

GTGATGCAAA TCACCATTCC GGCGTGCCCC AACAGAAGCT CCACCTCCCC CAGCCGCTCC 1680

CGGAGGGTGA AAACCCGCCA CCGCAAAGCG GGGAAGGGCA GCAGCGGGGA CCTGGCCGGA 1740

CTCAAGGCCA CCCAGTCCTC CCCTAACAGG GACTCCAGCG CGCAGACCAA CGGCCCCACG 1800

ACCAACCCCT CCCAGCAGCT GCTGGAGCCG GGCCTGCGGG GCCTCGGCCA CGAGCAGCCG 1860

CAGCGGCAGC TGTCCTCCTC CAGCCCCGAC CTCCTCAGCG CCTCTGCGGG CTTAGGGGGG 1920

TCGGAGGCCG GGGCGGCCGG CCTGGACGAC CTCACCGAGA CGCCGCCGCG CAGCGACACG 1980

CCCAGCGAGG ACGCCGCCTC CTTCCCCTTC TCCAGCAGCC CGGACTCCCC TGCGGGAGAG 2040

GCGCGGCCGC CAGACGGCGA GGACAAGGAG GAGGGGGCCG GGGCGGTCCG GCTGCCACGG 2100

GGTTGTTCGG GGGGTATCGG GAGCCAGCAC CTCACCCCCT CAGCCATCCT GTACAGGGCC 2160

GCCATCACGC GGAAGCAGAG ACGCGGAGTG TCATCGGAAG AGGAGGAGGG TGAAGTGGAC 2220

AGCGAGGTGG AGTTGCCGCG GCGACGACGT CCGACCAGCA TCACCAAGTG CCAGTCGGTC 2280

TCCACCTTCA GCTCGGAGAA CCTGTCGGTG TCGGACGGCG AGGAGGGCCA CACCACCGAC 2340

CATTCGCACA GCGGCACGCC CGACGTGGTC AGCACCAACA CCGACGACAG ACTGGACGAC 2400

CGCAGCGACG ACCTCCTGTC TCAGGGTTCC GAGATCCCGG CGGACAACAC CGACCCGGCG 2460

CAGGCTTCCG ACGGCCTGTC GGAGAGAGAC GGAGCGCCGG GCCAGGCTAA AGCTCAGCTG 2520

GACGCCGGGC AGAATCCCAG CGAGAATCGC GCCCTGTGTG ACGACTCCGA CTGCGACAGC 2580

GCCGAGCTGG ACCAGTCCGG CAGCGGAGAA CCCAGCCGTC CTCCGAGCGC AGGGGCCTGG 2640

GCCCCGCCG 2649

Domain Profile

S: 4     eeligsgafgkvykakwrkkevavKklreeaeekekleklereakllsklshpniiellG  63

          +++gsga+g+v+ +k++++evavKk+r+ +e+         e+k+l+kl+hpnii+++G

Q: 148   LQWVGSGAQGAVFLGKFHGEEVAVKKVRDIKET---------EIKHLRKLKHPNIITFKG  198

         689**************************9999.........******************

S: 64    vcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseapkkii  123

         vc++ p+++++mey+++g+L++vl++   r+i+++ lv+w++ iA Gm+YLh +   kii

Q: 199   VCTQAPCYCILMEYCAQGQLYEVLRA--GRKITPSLLVDWSMGIAGGMNYLHLH---KII  253

         **************************..99************************...9**

S: 124   hrdLksknvLlseekktlkicdFGtarelsk.stkmsaagtlawmaPEvlkeekvseksD  182

         hrdLks+n+L+ ++++ +ki+dFGt++els+ stkms+agt+awmaPEv+++e+vsek+D

Q: 254   HRDLKSPNMLI-THDDLVKISDFGTSKELSDkSTKMSFAGTVAWMAPEVIRNEPVSEKVD  312

         ***********.99999*************99****************************

S: 183   vwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLmkecwnedpe  242

         +wS+gvvLWe+lt+e+Pykd+++ ai+++v++++l+lp+p+scp+ +k L+++cwn +p+

Q: 313   IWSFGVVLWEMLTGEIPYKDVDSSAIIWGVGNNSLQLPVPESCPDGFKILLRQCWNCKPR  372

         ************************************************************

S: 243   kRpsfseivks  253

         +Rpsf++i+ +

Q: 373   NRPSFRQILLH  383

         ********876

Domain Sequence
(FASTA)

LQWVGSGAQG AVFLGKFHGE EVAVKKVRDI KETEIKHLRK LKHPNIITFK GVCTQAPCYC 60

ILMEYCAQGQ LYEVLRAGRK ITPSLLVDWS MGIAGGMNYL HLHKIIHRDL KSPNMLITHD 120

DLVKISDFGT SKELSDKSTK MSFAGTVAWM APEVIRNEPV SEKVDIWSFG VVLWEMLTGE 180

IPYKDVDSSA IIWGVGNNSL QLPVPESCPD GFKILLRQCW NCKPRNRPSF RQILLH 236

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Caenorhabditis elegans"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Petromyzon marinus"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004709	; F:MAP kinase kinase kinase activity
GO:0000186	; P:activation of MAPKK activity
GO:0000165	; P:MAPK cascade
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR017419	; MAP3K12_MAP3K13.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013