EKS-TEN-00094

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00094

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	337.5	6.4E-101	26	335	310

Status

Unreviewed

Ensembl Protein

ENSTNIP00000015691

UniProt Accession

H3D5A2;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK8

Gene Synonyms/Alias

CDK8;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000012716	ENSTNIP00000015691	ENSTNIT00000015898

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

463

Protein Sequence
(FASTA)

MDYDFKVKLT GERERVEDLF EYEGCKVGRG TYGHVYKAKR KDGKDDKDYA LKQIEGTGIS 60

MSACREIALL RELKHPNVIS LQKVFLSHAD RKVWLLFDYA EHDLWHIIKF HRASKANKKP 120

LQLPRGMVKS LLYQILDGIH YLHANWVLHR DLKPANILVM GEGPERGRVK IADMGFARLF 180

NSPLKPLADL DPVVVTFWYR APELLLGARH YTKAIDIWAI GCIFAELLTS EPIFHCRQED 240

IKTSNPYHHD QLDRIFNVMG FPADKDWEDI KKMPEHSTLM KDFRRNTYTN CSLIKYMEKH 300

KVKPDSKAFH LLQKLLTMDP IRRITSEQAM QDPYFLEEPL PTSDVFAGCQ IPYPKREFLT 360

EEEPEDKADK KNQQQQGNNH TNGAGHTGNP DNSHAQGPPL KKVRVVPPTT TSGGLIMTSD 420

YQRSNPHAAY QNPGPSTSLP QSSMGYSSTS QQPPQYSHQT HRY 463

Nucleotide Sequence
(FASTA)

ATGGACTATG ATTTTAAAGT GAAACTCACC GGCGAAAGAG AGCGTGTCGA GGACTTGTTT 60

GAGTACGAAG GATGCAAAGT GGGCAGAGGT ACCTACGGTC ATGTTTACAA GGCGAAGAGA 120

AAAGATGGGA AGGATGACAA GGACTACGCC CTCAAGCAGA TTGAAGGCAC TGGCATCTCC 180

ATGTCAGCCT GCAGAGAGAT CGCACTGCTC CGGGAGCTGA AGCACCCCAA CGTCATCTCG 240

CTGCAGAAGG TTTTTCTGTC ACATGCAGAT CGTAAAGTCT GGCTGCTCTT CGACTACGCT 300

GAACATGATC TCTGGCACAT TATAAAGTTC CACCGAGCAT CCAAGGCCAA CAAGAAGCCA 360

CTTCAGCTGC CTAGGGGAAT GGTCAAATCC TTGCTCTACC AAATCCTGGA TGGCATCCAT 420

TACCTACACG CTAACTGGGT CCTCCACAGA GACCTTAAAC CAGCTAACAT TTTAGTAATG 480

GGGGAAGGTC CTGAGAGGGG TAGAGTAAAG ATTGCTGACA TGGGATTTGC CCGTCTCTTC 540

AATTCACCGC TTAAGCCTTT AGCAGATCTT GACCCGGTGG TGGTCACTTT CTGGTACAGA 600

GCACCTGAGC TTTTGCTCGG GGCTCGGCAT TACACCAAAG CCATCGACAT CTGGGCGATT 660

GGCTGCATCT TTGCAGAGCT GTTGACGTCT GAGCCCATAT TCCACTGTCG CCAAGAAGAT 720

ATCAAGACCA GTAACCCTTA CCACCACGAC CAACTGGACC GCATCTTCAA CGTCATGGGC 780

TTCCCTGCAG ATAAAGACTG GGAGGACATC AAAAAGATGC CAGAGCACTC CACACTAATG 840

AAGGACTTTC GGAGGAATAC ATACACAAAC TGCAGCCTTA TAAAATATAT GGAAAAGCAT 900

AAGGTTAAAC CAGACAGCAA AGCATTCCAT TTGTTGCAAA AGCTGTTGAC CATGGATCCC 960

ATCCGTAGAA TCACATCCGA GCAGGCCATG CAGGATCCCT ACTTCCTGGA GGAGCCGTTG 1020

CCCACCTCTG ATGTGTTTGC AGGCTGTCAG ATTCCTTACC CAAAGAGGGA GTTCTTAACG 1080

GAAGAAGAGC CCGAGGACAA GGCTGACAAA AAAAACCAGC AGCAGCAGGG AAACAACCAC 1140

ACAAACGGGG CAGGCCACAC TGGCAACCCC GACAACAGCC ATGCCCAGGG GCCCCCCCTG 1200

AAGAAAGTAC GAGTCGTCCC GCCCACCACT ACCTCAGGTG GCCTCATCAT GACCTCAGAC 1260

TACCAGCGCT CCAATCCACA TGCTGCCTAC CAGAACCCTG GACCAAGCAC ATCACTGCCC 1320

CAAAGCAGCA TGGGATACTC CTCTACCTCC CAACAGCCGC CCCAGTACTC CCACCAGACC 1380

CACCGCTACT GA 1392

Domain Profile

S: 6     kigeGtygkvykakdke..tgevvAlKkirlekekegvpitalrEisllkelkhknivkL  63

         k+g+Gtyg+vykak+k+  +++ +AlK+i    e +g++++a+rEi+ll+elkh+n+++L

Q: 26    KVGRGTYGHVYKAKRKDgkDDKDYALKQI----EGTGISMSACREIALLRELKHPNVISL  81

         79************986447778******....999************************

S: 64    levva.kdkkklyLvfefleqdLkkllkkkkkk.......klsleevkslllqlleglay  115

         ++v+  ++++k++L+f+++e+dL++++k ++++       +l++ +vksll+q+l+g++y

Q: 82    QKVFLsHADRKVWLLFDYAEHDLWHIIKFHRASkankkplQLPRGMVKSLLYQILDGIHY  141

         ****94555*********************9999999*9*********************

S: 116   lHsnkilHRDlKpqNlLiske....gklklaDfGlarafssplk...tytkevvTlwYra  168

         lH+n++lHRDlKp+N+L++ e    g++k+aD+G+ar f+splk   +++++vvT+wYra

Q: 142   LHANWVLHRDLKPANILVMGEgperGRVKIADMGFARLFNSPLKplaDLDPVVVTFWYRA  201

         *******************9988889*************99999665699**********

S: 169   PelLlgakeYstavDiWsvgcilaelltrkplfqgkse.........idqlerifkllgt  219

         PelLlga++Y++a+DiW++gci+aellt++p+f++++e         +dql+rif+++g

Q: 202   PELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEdiktsnpyhHDQLDRIFNVMGF  261

         ************************************************************

S: 220   psekvwpevsklpeyk...ksfpkkkkk..klkekvkklk....ekaldllekllaldpk  270

         p +k+w++++k+pe++   k+f++++++  +l ++++k k    +ka++ll+kll++dp

Q: 262   PADKDWEDIKKMPEHStlmKDFRRNTYTncSLIKYMEKHKvkpdSKAFHLLQKLLTMDPI  321

         ***************96644777777764455666644333354679*************

S: 271   kRisakealqhkyf  284

         +Ri++++a+q++yf

Q: 322   RRITSEQAMQDPYF  335

         *************9

Domain Sequence
(FASTA)

KVGRGTYGHV YKAKRKDGKD DKDYALKQIE GTGISMSACR EIALLRELKH PNVISLQKVF 60

LSHADRKVWL LFDYAEHDLW HIIKFHRASK ANKKPLQLPR GMVKSLLYQI LDGIHYLHAN 120

WVLHRDLKPA NILVMGEGPE RGRVKIADMG FARLFNSPLK PLADLDPVVV TFWYRAPELL 180

LGARHYTKAI DIWAIGCIFA ELLTSEPIFH CRQEDIKTSN PYHHDQLDRI FNVMGFPADK 240

DWEDIKKMPE HSTLMKDFRR NTYTNCSLIK YMEKHKVKPD SKAFHLLQKL LTMDPIRRIT 300

SEQAMQDPYF 310

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013