EKS-TEN-00374

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00374

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/DDR	477.0	2.2E-143	565	853	289

Status

Unreviewed

Ensembl Protein

ENSTNIP00000016156

UniProt Accession

H3D6L6;

Protein Name

Protein Synonyms/Alias

Gene Name

DDR2 (1 of 2)

Gene Synonyms/Alias

DDR2 (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000013173	ENSTNIP00000016156	ENSTNIT00000016367

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

855

Protein Sequence
(FASTA)

MKHLWRLYLL PLVLLHLFAA VRPQVNTGVC RYPLGMSGGQ IQDEDISASS QWSESTAARY 60

GRLDFEEGDG AWCPETTVEP DSLKEFLQID LRSLHFITLV GTQGRHAGGI GNEFAQMYKI 120

KYSRDGSRWI SWRNRQGEQV IEGNRNTYDI VLKDLEPPII ARFVRFMPVT DHSMNVCMRV 180

ELYGCEWLDG LVSYNAPAGE QMNLPSFLVY VNDSVYDGAV THSMTEGLGQ LTDGVFGLDD 240

FTNSCVYKAW PGYDYVGWSN ESFPSGYVEI MFEFDRIRNF TTMKVHCNNM FSNHVKVFRQ 300

VLCHFRSESD WEPSPLLFSP AADEKNPSAR FVTVSLANHM ASAIKCQFYF ADTWMLFSEI 360

TFQSDTAMYN TTLAPPKTGL PPNTPPGEDP THKVDDSNTR ILIGCLVAII FILVAIIVIM 420

LWRQVWQKML EKASRRMLDD ELITSLSIQS ETFVYNHNQS SGASEQESSS TYERIFPLGP 480

DYQEPSRFIC KLPEFAPSLE EPGSTAASKS TTSTVAQDGV PHYAEADVVN LQGVTGSNTY 540

AIPAVTMDLL SGKDVAVEEF PRKMLTFKEK LGEGQFGEVH LCEAEGMHKF MDKEFLFDVP 600

EDQPVLVAVK MLRSDANKNA RSDFLKEIKI MSRLKDPNII RLLAVCICSD PLCMITEYME 660

NGDLNQFLSR HEPEGQLALI SNASTVSFSN LCYMAAQIAS GMKYLSSLNF VHRDLATRNC 720

LVGKNFTIKI ADFGMSRNLY SGDYYRIQGR AVLPIRWMSW ESILLGKFTT ASDVWAFGVT 780

LWEILNFCKE QPYSQLTDEQ VIENTGEFFR DQKRQIYLPQ PGLCPDSLYK VMLSCWRRNA 840

KERPSFQEIH TTLLE 855

Nucleotide Sequence
(FASTA)

ATGAAGCACC TGTGGCGTCT TTACCTCCTC CCGCTCGTCC TCCTCCACCT GTTTGCAGCG 60

GTGCGGCCGC AGGTCAACAC AGGTGTGTGT CGCTATCCTC TGGGCATGTC AGGAGGGCAG 120

ATTCAGGATG AGGACATCTC TGCTTCCAGT CAGTGGTCCG AATCCACGGC TGCTCGATAC 180

GGCAGGCTGG ACTTTGAGGA GGGCGACGGC GCCTGGTGCC CGGAGACAAC AGTGGAGCCA 240

GACAGCCTGA AGGAATTCCT CCAGATCGAC CTGCGTTCCC TGCATTTCAT CACCCTGGTG 300

GGCACGCAGG GCCGACACGC CGGCGGGATC GGGAACGAGT TCGCCCAGAT GTACAAGATC 360

AAGTACAGTC GTGATGGAAG CCGCTGGATC TCGTGGAGGA ACAGGCAGGG CGAGCAGGTG 420

ATCGAAGGGA ACAGGAACAC CTACGACATT GTGCTGAAGG ACCTGGAGCC GCCCATCATC 480

GCTCGCTTCG TCCGTTTCAT GCCCGTCACG GATCACTCCA TGAATGTGTG CATGAGAGTG 540

GAGCTGTACG GCTGCGAATG GCTCGATGGT CTGGTGTCTT ACAACGCCCC AGCAGGAGAA 600

CAGATGAACT TGCCTTCTTT TCTTGTTTAT GTCAACGACT CAGTCTATGA CGGCGCTGTC 660

ACCCATAGCA TGACCGAGGG TTTGGGTCAG CTGACCGATG GAGTCTTTGG TCTGGATGAC 720

TTCACAAACA GCTGCGTTTA CAAGGCCTGG CCAGGCTATG ACTATGTGGG CTGGAGCAAC 780

GAGAGCTTCC CCAGCGGTTA TGTGGAAATC ATGTTTGAGT TTGACCGCAT ACGAAACTTC 840

ACCACCATGA AAGTTCACTG CAACAACATG TTCTCCAACC ACGTCAAGGT CTTCCGCCAG 900

GTCTTGTGCC ACTTCCGCTC TGAATCAGAC TGGGAGCCTT CACCGCTGCT CTTCAGTCCG 960

GCTGCGGACG AGAAGAACCC CAGCGCCCGC TTTGTCACCG TCAGCTTAGC CAACCATATG 1020

GCCAGCGCCA TCAAATGCCA GTTCTACTTT GCTGACACGT GGATGCTGTT CAGTGAGATC 1080

ACCTTTCAGT CAGATACAGC CATGTACAAC ACCACACTGG CTCCACCCAA GACAGGTCTC 1140

CCACCCAACA CACCGCCAGG GGAGGACCCC ACCCACAAAG TAGATGACAG TAACACCCGC 1200

ATTCTGATTG GTTGTCTGGT GGCCATTATT TTCATCCTGG TTGCCATTAT TGTCATCATG 1260

CTGTGGCGAC AGGTGTGGCA GAAGATGCTG GAGAAGGCCT CTCGCAGGAT GCTGGACGAT 1320

GAGCTAATCA CTAGTTTGTC AATACAGAGC GAGACCTTCG TCTACAACCA CAACCAGTCG 1380

AGTGGTGCCA GCGAGCAGGA GTCCAGCTCC ACCTACGAGC GCATCTTCCC CCTGGGCCCT 1440

GACTACCAGG AGCCGTCTCG CTTCATCTGC AAGCTGCCAG AATTTGCTCC GAGCTTAGAA 1500

GAGCCTGGTA GCACCGCTGC CTCCAAATCC ACCACCTCCA CCGTGGCCCA AGACGGCGTC 1560

CCTCACTACG CAGAGGCTGA CGTCGTCAAC CTGCAGGGCG TGACTGGGAG CAACACCTAC 1620

GCCATCCCCG CAGTGACCAT GGACCTGCTG TCAGGGAAGG ACGTTGCCGT GGAGGAGTTT 1680

CCACGCAAGA TGCTGACGTT TAAAGAAAAG CTGGGAGAAG GCCAGTTCGG AGAGGTCCAC 1740

CTGTGCGAAG CAGAGGGAAT GCACAAGTTC ATGGACAAAG AGTTTCTCTT TGACGTCCCT 1800

GAAGACCAAC CGGTCTTAGT GGCTGTGAAG ATGCTCCGTT CGGATGCCAA CAAAAATGCC 1860

AGGAGTGATT TCCTGAAAGA GATAAAGATC ATGTCGCGTT TGAAGGACCC CAACATCATC 1920

CGGCTGCTAG CTGTGTGCAT CTGCAGCGAT CCTCTGTGTA TGATCACGGA ATACATGGAG 1980

AACGGCGACC TCAACCAGTT CCTGTCCCGC CACGAGCCGG AGGGACAGCT AGCTCTGATA 2040

AGCAACGCAT CTACTGTGAG CTTTAGCAAT CTGTGCTACA TGGCGGCTCA GATAGCCTCG 2100

GGGATGAAGT ACCTCTCCTC CTTAAACTTT GTCCATCGAG ACTTGGCCAC TCGGAATTGT 2160

CTGGTGGGCA AAAACTTCAC TATAAAAATC GCTGACTTTG GCATGAGCAG AAATCTGTAC 2220

AGCGGCGACT ACTATCGGAT CCAGGGCAGG GCCGTATTGC CCATACGCTG GATGTCGTGG 2280

GAGAGCATCT TGCTGGGCAA GTTCACCACT GCCAGTGACG TGTGGGCTTT TGGGGTGACC 2340

CTGTGGGAGA TACTGAACTT CTGCAAGGAG CAACCCTACT CCCAGCTCAC GGACGAGCAG 2400

GTGATAGAAA ACACCGGCGA GTTCTTCAGG GACCAGAAAC GACAGATCTA CCTGCCCCAG 2460

CCTGGGCTGT GTCCAGACTC CCTCTACAAG GTCATGCTGA GCTGCTGGAG GAGGAACGCT 2520

AAGGAACGGC CCTCCTTCCA GGAAATACAC ACCACCCTTT TGGAATAA 2568

Domain Profile

S: 1     LlikeklGeGkfgevklCevegledlkekd.....skgsallvavkslredanknarkdf  55

         L++keklGeG+fgev+lCe eg++++++k+      + +++lvavk+lr+danknar df

Q: 565   LTFKEKLGEGQFGEVHLCEAEGMHKFMDKEflfdvPEDQPVLVAVKMLRSDANKNARSDF  624

         789**************************999999899**********************

S: 56    lkeikilsrlkdPnivrllgvcvrdeplclileyvenGdlnqflseheaed..selakek  113

         lkeiki+srlkdPni+rll+vc+  +plc+i+ey+enGdlnqfls+he+e   + +++++

Q: 625   LKEIKIMSRLKDPNIIRLLAVCICSDPLCMITEYMENGDLNQFLSRHEPEGqlALISNAS  684

         ************************************************876225578899

S: 114   tlsyellvsiatqiasglkyLeslnfvhrdlatrnclvgeeftvkiadfglsrslyagdy  173

         t+s+++l ++a+qiasg+kyL+slnfvhrdlatrnclvg++ft+kiadfg+sr+ly+gdy

Q: 685   TVSFSNLCYMAAQIASGMKYLSSLNFVHRDLATRNCLVGKNFTIKIADFGMSRNLYSGDY  744

         ************************************************************

S: 174   yrvqGravlPiRwmawesillgkfttasDvWafgvtlweiltlcreqPyeeltdeqvien  233

         yr+qGravlPiRwm+wesillgkfttasDvWafgvtlweil +c+eqPy++ltdeqvien

Q: 745   YRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWEILNFCKEQPYSQLTDEQVIEN  804

         ************************************************************

S: 234   agelfrdqkrkvvlsrPavcpselyelllrCwrrdeseRPsfeelhkll  282

         +ge+frdqkr+++l++P +cp++ly+++l+Cwrr+ +eRPsf+e+h  l

Q: 805   TGEFFRDQKRQIYLPQPGLCPDSLYKVMLSCWRRNAKERPSFQEIHTTL  853

         **********************************************875

Domain Sequence
(FASTA)

LTFKEKLGEG QFGEVHLCEA EGMHKFMDKE FLFDVPEDQP VLVAVKMLRS DANKNARSDF 60

LKEIKIMSRL KDPNIIRLLA VCICSDPLCM ITEYMENGDL NQFLSRHEPE GQLALISNAS 120

TVSFSNLCYM AAQIASGMKY LSSLNFVHRD LATRNCLVGK NFTIKIADFG MSRNLYSGDY 180

YRIQGRAVLP IRWMSWESIL LGKFTTASDV WAFGVTLWEI LNFCKEQPYS QLTDEQVIEN 240

TGEFFRDQKR QIYLPQPGLC PDSLYKVMLS CWRRNAKERP SFQEIHTTL 289

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tupaia belangeri"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0007155	; P:cell adhesion
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR000421	; Coagulation_fac_5/8-C_type_dom.
IPR008979	; Galactose-bd-like.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF00754	; F5_F8_type_C; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00231	; FA58C; 1.
SM00219	; TyrKc; 1.

Prosites

PS01285	; FA58C_1; 1.
PS01286	; FA58C_2; 1.
PS50022	; FA58C_3; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013