EKS-TEN-00366

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00366

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	367.5	5.1E-110	186	484	299

Status

Unreviewed

Ensembl Protein

ENSTNIP00000016273

UniProt Accession

H3D6Y2;

Protein Name

Protein Synonyms/Alias

Gene Name

BMPR2

Gene Synonyms/Alias

BMPR2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000013283	ENSTNIP00000016273	ENSTNIT00000016485

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

1014

Protein Sequence
(FASTA)

AAAQGEEREC AFTDQQQQWE VERMAGGEGQ ISPENTTVRC GKGSYCFGLW EKSPPGEVRL 60

VKQGCWTHVS DRQSCRDDRC VVTNLPPQIQ NGTYHFCCCG SDMCNVNFTE DFAQPSPTTA 120

QPIYNGTLGY EETVIITVAT VSVLAVLAVA AFFGDRMMHG NGKKGLHNLN MMEAAGSESS 180

LDLDNLKLLE LIGRGRYGTV YCGSLDERPV AVKVFTAANR QNFLNECSIY RLPLLEHDNI 240

ARFVAADERT GSEGRTEYLL VMDYYPHGSL NRYLSVQTND WVSSCRLAHS VTRGLAYLHT 300

ELFKGDLYKP AVSHRDLNSR NVLVKADGTC VIIDFGLSMK LTGNRPARHG EEENAAISEV 360

GTIRYMAPEV LEGAVNLRDC ESALKQVDMY ALGLLYWETF MRCTDLFPGE SAPEYQMAFQ 420

AEAGNHPTFE DMQVLVSREK QRPKFPEAWK ENSLAVRSLK ETMEDCWDQD AEARLTAQCA 480

EERLAELLLI WDRSKSVSPT LNPMSTTLHN ERNCDCFFAR NRMTPKSGTY TDHPSTYIEE 540

HDSVAKNTQG DNTSSVSSRT GTGTGERNRN SINQERQQAS ARLPSPEGSS TSMGLRGSPS 600

ASTTTTTIIS ESEGPVGVAT VPACLHLTQE DLETTKLDPK EVDKNLKESS DENLMEHSQK 660

QFCSPDPLSP GSSSLLYPLI KMATEASGVS DSAAPMPAAI FPLPKQQNLP KRPSSLQLRA 720

KPTKKESSSS SLRFKFGRSG KSNLRQVEGS KMNIGSGAGA NAAGDAHGST STNNTSAVRE 780

THVNGNVNGA VNGHPSAGLP SMAAGGLASF GGSGPSQSGP ASSRTDDGHL SLGTITASPD 840

EHEPLLSRER EQLDRRDAPS GVVPLRSARR ESTASAGESS GSGSAPADAQ GEALVVRRGE 900

ALLRQPRARR PERPNSLDLS FTTQDLASLG VQPDAALECA GEKIKKRVKT PYSLKKWRPT 960

TWVISTDARG PEVNNNGSAH GHGHSRPKST SAVYLCGGGL ASEASTKMVG AYCC 1014

Nucleotide Sequence
(FASTA)

GCAGCAGCAC AGGGCGAGGA AAGGGAATGT GCCTTCACAG ACCAGCAGCA GCAGTGGGAG 60

GTGGAGCGAA TGGCCGGAGG TGAAGGTCAG ATCTCACCAG AGAACACCAC CGTCAGATGT 120

GGCAAGGGCA GCTACTGCTT TGGACTGTGG GAGAAAAGCC CCCCGGGCGA GGTGCGACTC 180

GTCAAACAAG GTTGCTGGAC TCACGTGAGC GACCGCCAGA GTTGTCGGGA TGACCGCTGC 240

GTGGTGACCA ACCTCCCTCC GCAGATCCAA AACGGGACGT ACCATTTCTG CTGCTGCGGC 300

AGCGACATGT GCAACGTCAA CTTCACAGAG GACTTCGCCC AGCCCAGCCC CACCACGGCT 360

CAGCCCATCT ACAACGGCAC ACTTGGTTAC GAAGAGACGG TAATTATCAC CGTAGCAACA 420

GTCTCCGTGC TGGCCGTGCT TGCTGTAGCA GCCTTCTTTG GTGACCGCAT GATGCATGGC 480

AATGGAAAGA AAGGCCTTCA CAACCTGAAC ATGATGGAGG CTGCTGGATC TGAGAGCTCT 540

CTGGATCTGG ACAATCTGAA GCTGCTGGAG CTGATTGGCC GTGGGCGATA CGGCACCGTC 600

TACTGTGGCT CTCTGGACGA GCGGCCGGTA GCCGTGAAAG TCTTCACTGC AGCCAACCGG 660

CAGAATTTCC TCAACGAGTG TTCCATCTAC CGGCTGCCGC TGCTCGAGCA CGACAACATC 720

GCCCGCTTTG TTGCTGCTGA CGAGAGGACG GGCTCGGAGG GGCGCACCGA GTACCTGCTG 780

GTGATGGACT ACTACCCACA CGGCTCACTC AATCGTTACC TGAGCGTCCA GACAAACGAC 840

TGGGTCAGCA GCTGCCGGCT AGCTCACTCC GTCACCCGCG GCCTGGCGTA CCTGCACACG 900

GAGCTCTTTA AAGGAGATTT GTACAAGCCC GCTGTTTCCC ACCGGGATCT GAACAGTCGA 960

AATGTTCTGG TCAAAGCCGA CGGCACGTGC GTCATCATCG ATTTTGGCCT GTCCATGAAG 1020

CTGACGGGAA ATAGGCCTGC ACGCCACGGA GAGGAAGAGA ACGCTGCTAT AAGTGAGGTG 1080

GGAACCATCC GCTACATGGC TCCAGAGGTG CTGGAGGGGG CAGTTAACCT GAGGGACTGT 1140

GAGTCTGCCC TGAAGCAGGT GGATATGTAC GCTCTGGGCC TGCTCTACTG GGAGACCTTC 1200

ATGAGGTGCA CTGACCTTTT CCCAGGTGAG TCTGCGCCAG AGTACCAGAT GGCCTTCCAG 1260

GCGGAGGCAG GAAACCACCC CACATTTGAG GATATGCAGG TCCTGGTATC CAGGGAGAAG 1320

CAGCGGCCCA AATTCCCTGA GGCCTGGAAG GAGAACAGTT TGGCGGTTCG CTCTCTAAAA 1380

GAGACGATGG AGGACTGTTG GGACCAGGAC GCAGAGGCCC GCCTCACGGC TCAGTGTGCT 1440

GAGGAGCGTC TGGCAGAGCT GCTCCTCATC TGGGACCGCT CCAAGTCCGT CAGCCCCACG 1500

CTTAACCCCA TGTCCACCAC CCTGCACAAC GAGCGAAATT GCGACTGTTT CTTTGCCAGA 1560

AACCGGATGA CACCAAAGAG CGGCACCTAC ACGGACCATC CGTCCACCTA CATCGAGGAG 1620

CATGACAGCG TGGCCAAGAA CACGCAGGGG GACAACACTA GCTCCGTGAG CAGTCGAACC 1680

GGGACTGGCA CTGGGGAAAG AAACAGGAAC TCCATCAACC AGGAGCGACA GCAGGCCAGT 1740

GCCCGCCTGC CCAGCCCAGA GGGCAGCAGC ACTAGCATGG GCCTGAGGGG GAGCCCGTCC 1800

GCCTCCACCA CCACCACCAC TATCATTTCT GAGTCCGAGG GGCCAGTGGG GGTCGCCACA 1860

GTCCCGGCCT GCCTCCACCT TACCCAGGAA GACCTGGAAA CCACCAAGCT CGACCCAAAA 1920

GAAGTAGACA AGAACTTGAA GGAGAGTTCG GATGAGAACC TGATGGAGCA CTCGCAGAAG 1980

CAGTTCTGCT CCCCTGATCC ACTCAGCCCT GGCAGCTCCA GCCTCCTTTA CCCTCTCATC 2040

AAGATGGCCA CCGAGGCCTC GGGGGTGTCG GACTCTGCCG CTCCCATGCC CGCTGCCATC 2100

TTCCCCCTGC CCAAGCAGCA GAACCTGCCC AAAAGGCCGT CCAGTCTGCA GCTGCGCGCC 2160

AAGCCAACCA AGAAGGAGTC GTCATCCTCT TCTCTCAGGT TCAAATTTGG ACGTTCGGGG 2220

AAGTCCAACC TGCGGCAGGT GGAGGGATCA AAGATGAACA TTGGCTCGGG AGCAGGCGCA 2280

AACGCAGCTG GAGATGCTCA CGGGAGCACA AGCACAAACA ACACATCTGC GGTGCGTGAG 2340

ACCCATGTCA ACGGTAACGT TAACGGCGCT GTTAATGGGC ACCCTAGCGC TGGCCTCCCA 2400

TCTATGGCCG CAGGCGGATT GGCAAGTTTC GGAGGATCCG GCCCATCGCA GAGCGGCCCC 2460

GCGTCCTCGA GGACGGACGA TGGCCACCTG AGCCTCGGCA CCATCACCGC CAGCCCCGAC 2520

GAGCACGAGC CGCTTCTGAG CCGCGAGCGG GAGCAGCTGG ATCGCAGGGA CGCCCCCTCG 2580

GGCGTGGTTC CTCTGCGCTC AGCCCGGAGG GAAAGCACAG CGTCTGCAGG AGAAAGCTCG 2640

GGCTCGGGAT CAGCCCCCGC CGACGCCCAG GGGGAGGCTT TGGTGGTGAG GAGAGGGGAG 2700

GCCCTCCTCC GGCAGCCGAG AGCACGCCGC CCCGAGAGGC CCAACTCTCT GGACCTGTCG 2760

TTCACCACAC AGGACCTGGC TTCACTAGGA GTACAGCCGG ATGCAGCCCT GGAATGTGCC 2820

GGAGAAAAGA TCAAGAAGCG AGTAAAAACT CCTTACTCCC TGAAGAAGTG GCGGCCCACG 2880

ACGTGGGTCA TCTCCACGGA CGCCAGGGGG CCGGAGGTCA ACAACAATGG CTCGGCCCAC 2940

GGTCACGGGC ACAGCCGGCC CAAGTCCACG TCGGCTGTGT ACCTCTGTGG AGGAGGCTTG 3000

GCCAGCGAGG CAAGCACCAA AATGGTTGGG GCCTACTGCT GT 3042

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         lkllelig+Gryg+V+ ++l+++ vAvK+f++++++++ +E  iy+++ll+h+ni +f+a

Q: 186   LKLLELIGRGRYGTVYCGSLDERPVAVKVFTAANRQNFLNECSIYRLPLLEHDNIARFVA  245

         6899********************************************************

S: 61    adk.keedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgt  119

         ad+ + ++ +te+llv++y+++gsL  yL+ +t d+ +++rla+s+++Gla+LH+e+++

Q: 246   ADErTGSEGRTEYLLVMDYYPHGSLNRYLSVQTNDWVSSCRLAHSVTRGLAYLHTELFKG  305

         ***9999*************************************************8755

S: 120   kgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekee....ldlaansqvGtkR  175

          + +Kpa++HRDl+s+N+lvk d+tc+i D+GL++kl+ ++ +    +++aa+s+vGt R

Q: 306   -DLYKPAVSHRDLNSRNVLVKADGTCVIIDFGLSMKLTGNRPArhgeEENAAISEVGTIR  364

         .57**********************************999887777788899********

S: 176   YmaPEvleealnlkdfe.afkraDvYslgLvlWEvasRcee..vdeeveeyklpfeevvg  232

         YmaPEvle+a+nl+d+e a+k++D+Y+lgL++WE ++Rc++  ++e+++ey+++f+++ g

Q: 365   YMAPEVLEGAVNLRDCEsALKQVDMYALGLLYWETFMRCTDlfPGESAPEYQMAFQAEAG  424

         *****************99***********************9*****************

S: 233   sdPsleemkevvvekklrPkipeawkkke.alkelsklleecWdadpeaRltalrvkkrl  291

         ++P++e+m+ +v ++k+rPk+peawk+++ a+++l++++e+cWd+d+eaRlta++ ++rl

Q: 425   NHPTFEDMQVLVSREKQRPKFPEAWKENSlAVRSLKETMEDCWDQDAEARLTAQCAEERL  484

         ***************************9999*************************9986

Domain Sequence
(FASTA)

LKLLELIGRG RYGTVYCGSL DERPVAVKVF TAANRQNFLN ECSIYRLPLL EHDNIARFVA 60

ADERTGSEGR TEYLLVMDYY PHGSLNRYLS VQTNDWVSSC RLAHSVTRGL AYLHTELFKG 120

DLYKPAVSHR DLNSRNVLVK ADGTCVIIDF GLSMKLTGNR PARHGEEENA AISEVGTIRY 180

MAPEVLEGAV NLRDCESALK QVDMYALGLL YWETFMRCTD LFPGESAPEY QMAFQAEAGN 240

HPTFEDMQVL VSREKQRPKF PEAWKENSLA VRSLKETMED CWDQDAEARL TAQCAEERL 299

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0030509	; P:BMP signaling pathway
GO:0001947	; P:heart looping
GO:0048570	; P:notochord morphogenesis

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR015770	; BMPRII.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013