EKS-TEN-00183

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00183

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	551.7	2.6E-166	474	750	277

Status

Unreviewed

Ensembl Protein

ENSTNIP00000016409

UniProt Accession

H3D7B8;

Protein Name

Fibroblast growth factor receptor

Protein Synonyms/Alias

Gene Name

FGFR2

Gene Synonyms/Alias

FGFR2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000013415	ENSTNIP00000016409	ENSTNIT00000016622

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

766

Protein Sequence
(FASTA)

MALWAWLLAA VLLSLLTASV ARPPLTAAKE AEVTQEPEDT SNKNQISKPT VCSVHPGEVL 60

KLSCPLPATG TITWTKDGSS LGANNRTLIE QEVLQIRDAT PRDSGLYTCT SVGKDTVCFI 120

VNVTDATSSG DDEDDTERSE DSGAEAEQPS APYWISPEKM EKKLHAVPAA NTVKFRCAAG 180

GNPEPKLRWL KNNRPFRQED RMGGYKVRSQ HWTLIMESVV PSDKGNYTCL VENEYGSINH 240

TYFLDVVERS PHRPILQAGL PANTTVHVGE DARFVCKVYS DAQPHIQWLK HISQNGSSVG 300

PDGNAYVRVL KTAGVNTTDK EIEVLYLHNV TFEDAGEYTC LAGNSIGLSH QTAWLTVLPA 360

REESQDPLSP HYVEIAIYCA GVFLIACMVG IVVVCRMRNT TKKPDFGGQP AVHKLSKQIP 420

LRRQVTVSAD SSASMNSNTP LVRIMTRRSI AHDEPIPEYD LPEDPRWEFA RDRLTLGKPL 480

GEGCFGQVVM AEALGIDKDK PKEAVTVAVK MLKDDATEKE LSDLVSEMEM MKMIGKHKNI 540

INLLGACTQD GPLYVIVEYA SKGNLREYLR ARRPPGMEYS YDIARVSDEQ LTFKDLVSCT 600

YQVARGMEYL ASQKCIHRDL AARNVLVTES NIMKIADFGL ARDVHNIDYY KKTTNGRLPV 660

KWMAPEALFD RVYTHQSDVW SFGVLMWEIF TLGGSPYPGI PVEELFKLLK EGHRMDKPGN 720

CTNELYMMMK DCWHAISSQR PTFKQLVEDL DRILALSSNE VSLPQP 766

Nucleotide Sequence
(FASTA)

ATGGCCTTGT GGGCCTGGCT GCTGGCCGCC GTCTTGCTGT CCCTACTGAC CGCCAGTGTG 60

GCAAGGCCGC CGCTGACTGC CGCCAAGGAG GCGGAGGTCA CTCAGGAACC CGAAGACACA 120

TCGAACAAAA ACCAAATTTC TAAGCCCACG GTGTGCTCAG TGCACCCAGG CGAGGTGCTG 180

AAGCTGAGCT GCCCTCTGCC AGCAACGGGG ACCATCACCT GGACCAAAGA TGGCAGCTCT 240

CTGGGCGCCA ACAACCGCAC GCTGATAGAG CAGGAGGTGC TGCAGATTCG TGATGCCACG 300

CCAAGGGATT CAGGCCTGTA TACCTGCACC AGCGTGGGCA AAGATACGGT CTGCTTCATA 360

GTAAATGTCA CAGATGCCAC CTCGTCGGGG GACGATGAGG ACGATACAGA GCGTTCCGAG 420

GACTCTGGGG CCGAAGCAGA GCAGCCGAGT GCTCCGTACT GGATCTCACC AGAAAAGATG 480

GAAAAGAAAC TGCACGCCGT GCCAGCTGCT AATACGGTCA AGTTCCGCTG TGCTGCAGGA 540

GGCAACCCCG AGCCCAAGCT GCGCTGGCTC AAAAACAACA GGCCTTTCCG TCAAGAGGAC 600

CGCATGGGAG GCTATAAGGT CCGTAGCCAA CATTGGACCT TGATCATGGA GAGCGTGGTG 660

CCGTCGGACA AAGGCAACTA CACTTGCCTG GTGGAGAATG AGTACGGATC CATCAACCAC 720

ACATACTTCT TGGACGTCGT AGAACGCTCC CCTCACCGAC CGATTCTCCA GGCCGGCCTT 780

CCGGCGAACA CCACCGTGCA CGTAGGCGAA GACGCTCGCT TTGTCTGCAA AGTCTACAGC 840

GATGCCCAGC CACACATCCA GTGGCTGAAA CACATCTCTC AAAATGGCAG TAGCGTTGGA 900

CCCGATGGGA ACGCTTATGT TCGGGTGTTA AAGACCGCAG GTGTTAATAC CACAGATAAG 960

GAGATAGAAG TTCTCTACTT GCACAATGTT ACTTTTGAAG ATGCTGGGGA GTATACGTGC 1020

TTGGCGGGTA ATTCTATTGG GCTCTCCCAT CAAACTGCTT GGTTGACGGT GCTTCCAGCT 1080

CGTGAGGAAT CCCAGGATCC CCTTTCGCCT CACTACGTGG AGATCGCCAT ATACTGTGCG 1140

GGAGTCTTCC TCATCGCCTG CATGGTGGGC ATTGTGGTAG TGTGCCGGAT GAGGAACACA 1200

ACAAAGAAAC CTGATTTCGG GGGCCAGCCG GCTGTCCACA AACTGAGCAA GCAGATCCCT 1260

CTGCGGCGCC AGGTAACAGT GTCAGCGGAC TCGAGCGCCT CAATGAACTC CAACACACCT 1320

CTCGTCCGAA TTATGACGCG GCGAAGCATC GCGCACGACG AGCCGATCCC TGAATATGAC 1380

CTTCCGGAGG ACCCGCGGTG GGAGTTTGCC CGAGACAGAC TTACGCTGGG TAAGCCCCTG 1440

GGTGAAGGTT GCTTTGGTCA GGTTGTAATG GCAGAGGCTC TGGGCATCGA TAAAGACAAA 1500

CCCAAGGAAG CTGTGACTGT CGCCGTCAAA ATGCTGAAAG ATGACGCCAC GGAAAAAGAG 1560

CTGTCTGACT TGGTGTCAGA GATGGAAATG ATGAAGATGA TTGGCAAACA TAAGAACATC 1620

ATAAATCTTC TTGGGGCCTG TACACAAGAT GGTCCCCTTT ATGTGATTGT GGAATACGCC 1680

TCCAAAGGCA ACCTTAGGGA GTACCTCCGA GCCCGGAGGC CGCCTGGCAT GGAGTACTCT 1740

TATGATATCG CCAGAGTTTC AGATGAACAA CTTACCTTCA AAGATTTAGT GTCCTGCACC 1800

TACCAAGTGG CGAGGGGCAT GGAGTACCTG GCATCCCAGA AGTGTATACA CAGAGACCTT 1860

GCAGCCAGGA ACGTCCTGGT CACAGAGAGC AACATCATGA AGATCGCAGA CTTTGGCCTG 1920

GCCAGAGATG TCCACAACAT CGACTACTAT AAAAAGACAA CAAATGGTCG TCTCCCGGTG 1980

AAATGGATGG CTCCAGAGGC GCTGTTTGAC CGGGTCTACA CACACCAGAG TGATGTCTGG 2040

TCATTTGGGG TACTGATGTG GGAGATCTTC ACCTTAGGGG GCTCCCCGTA CCCCGGCATT 2100

CCTGTTGAAG AGCTCTTCAA GTTGCTTAAA GAGGGACATC GCATGGACAA GCCTGGCAAC 2160

TGCACCAACG AGCTGTACAT GATGATGAAA GACTGCTGGC ATGCCATCTC ATCTCAGAGA 2220

CCCACCTTCA AGCAGCTAGT AGAAGATCTG GATCGCATCC TCGCCCTCAG CAGCAATGAG 2280

GTGAGCCTAC CTCAGCCT 2298

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         l+lgk+lGeG+fGqvv+aea+g+dkdk+k++vtvavkmlk+dat+k+l+dlvseme++k+

Q: 474   LTLGKPLGEGCFGQVVMAEALGIDKDKPKEAVTVAVKMLKDDATEKELSDLVSEMEMMKM  533

         79**********************************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120

         iGkhkniinllGactq+Gplyviveya+kGnlre+lrarrp+g+e+s+d +++s+eqlt+

Q: 534   IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDIARVSDEQLTF  593

         ************************************************************

S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180

         kdlvs++yqvarGmeylas+kcihrdlaarnvlvte n++kiadfGlardvh+idyykkt

Q: 594   KDLVSCTYQVARGMEYLASQKCIHRDLAARNVLVTESNIMKIADFGLARDVHNIDYYKKT  653

         ************************************************************

S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240

         tnGrlpvkwmapealfdrvyt+qsdvwsfGvl+wei+tlGgspypgi+veelfkllkeGh

Q: 654   TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH  713

         ************************************************************

S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         rm+kp +ct+ely++m++cwha +s+rptfkqlvedl

Q: 714   RMDKPGNCTNELYMMMKDCWHAISSQRPTFKQLVEDL  750

         ***********************************97

Domain Sequence
(FASTA)

LTLGKPLGEG CFGQVVMAEA LGIDKDKPKE AVTVAVKMLK DDATEKELSD LVSEMEMMKM 60

IGKHKNIINL LGACTQDGPL YVIVEYASKG NLREYLRARR PPGMEYSYDI ARVSDEQLTF 120

KDLVSCTYQV ARGMEYLASQ KCIHRDLAAR NVLVTESNIM KIADFGLARD VHNIDYYKKT 180

TNGRLPVKWM APEALFDRVY THQSDVWSFG VLMWEIFTLG GSPYPGIPVE ELFKLLKEGH 240

RMDKPGNCTN ELYMMMKDCW HAISSQRPTF KQLVEDL 277

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0008284	; P:positive regulation of cell proliferation

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 3.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 3.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013