EKS-TEN-00388
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TEN-00388
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR457.99.9E-138690947258
StatusUnreviewed
Ensembl ProteinENSTNIP00000016548
UniProt AccessionH3C2C0;
Protein Name
Protein Synonyms/Alias
Gene NameEGFR (2 of 4)
Gene Synonyms/Alias EGFR (2 of 4);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTNIG00000013552ENSTNIP00000016548ENSTNIT00000016761
ENSTNIG00000013552ENSTNIP00000002388ENSTNIT00000003210
OrganismTetraodon nigroviridis
Functional Description
Protein Length1018
Protein Sequence
(FASTA)
KKICQGTSNR LNLLGNYENH YETMLRMFSN CSVVLENLEV TYAQKHHSLA FLQSIEEVVG 60
YVLIGMNDVA VVPLGNLRLI RGQSLYDGQF SLLVLSNYKR NPASPSGFSG LRQLQLSNHS 120
EIIRGAVKIT HNFLLCNIET IQWGDIVDSS SEPSIVLEKN ESRASGESCD PSCDNGSCWA 180
AGPDHCQKIT KLQCAEQCSR RCRGPKPSDC CNRHCAAGCT GPQADQCLAC RDFNDEGTCK 240
DTCRSHMFHN SKIHRGVPNP DAKYAFGPIC VKACPHNYVV TEGWCVRTCR AGMFEVEENG 300
VQQCRECNGP CPKVCDGLGV GAFNNSVAVN ASNIEFFRNC TKINGNVNFI ETSFTGDLFH 360
NIPPMDPAKL EYFRTVKEIT GFLLIQSWPE NLTSLSAFEN LHIIRGRATH NMRTSLVVTR 420
TEHLRWLGLR SLKEVSAGRV MVKNNPQLCF LQPLQWTHLF RSTGQTADIR NNKPVDVCKQ 480
QRQTCDPECS DQGCWGPGPE MCVSCLRVSR GGRCVPLCNV LDGDPREAEL NGSCVSCHSE 540
CQPQTGIPTC HGPGPGQCSQ CAHVQDGPSC VAHCPQGMLG EGDTEIWMYP DRAGRCQLCH 600
QNCTQGCSGP GLSGCTSSAG QSTLAVCVVG GLLIVVIVAL VTFVLLRRRR ITRRRTLRRQ 660
LQEKELVEPL TPSGEAPNQA MLRIMKETEF KKIRVLGSGA FGTVYKGLWI PEGENVRVSV 720
AIKVLREATS SKANKEILDE AYVMASIDHP HVCRLLGICL TSSIQLVTQL MPFGCLLDYV 780
RFHQDQIGAP WLLNWCVQIA KGMSYLEGRH LVHRDLAARN VLVKSPSHVT ITDFGLAKLL 840
TANEKAYRAD GGKVPIKWMA LESILQSTYT HQSDVWSFGV TVWELMTFGS KPYDGIPASE 900
ISSVLERGER LPHPPICTTD LYMIMVQCWM IDPSSRPTFR KLTAEFSTMA RDPSRFLVVQ 960
ANLPSPTNRR FYSRMLSSED MEGVIDADEY LQPYKEFGNH GDNSCSHTVA AHSSSITS 1018
Nucleotide Sequence
(FASTA)
AAAAAAATCT GCCAGGGGAC GAGCAACCGG CTGAACCTGT TGGGAAACTA TGAAAACCAT 60
TATGAGACGA TGCTGCGGAT GTTCTCCAAC TGCTCGGTGG TCCTGGAGAA CCTGGAGGTG 120
ACCTACGCCC AGAAACACCA CAGCCTCGCT TTCCTGCAGT CAATCGAAGA GGTGGTTGGC 180
TACGTCCTCA TCGGCATGAA CGACGTTGCC GTGGTGCCGC TGGGCAACCT GAGGCTGATC 240
CGAGGCCAGA GCCTGTACGA CGGCCAGTTC TCCCTGCTGG TTCTCTCCAA CTACAAACGC 300
AACCCGGCGT CGCCGTCAGG CTTCAGCGGA CTCCGGCAGC TGCAGCTGAG CAACCATTCA 360
GAAATCATCA GGGGAGCGGT GAAGATTACC CACAATTTTT TGCTGTGCAA CATTGAGACC 420
ATCCAGTGGG GGGACATCGT GGACAGCTCC AGTGAACCCA GTATCGTCTT GGAGAAGAAT 480
GAATCCCGTG CATCAGGCGA GAGCTGTGAT CCCTCCTGTG ATAACGGCTC GTGTTGGGCG 540
GCAGGACCAG ACCACTGCCA GAAAATCACC AAGCTGCAGT GTGCTGAGCA GTGCAGCCGG 600
AGGTGTCGCG GTCCCAAGCC CAGCGACTGT TGTAACCGTC ACTGTGCTGC GGGGTGTACC 660
GGACCCCAGG CCGACCAGTG TCTGGCCTGC AGGGACTTCA ACGACGAGGG AACCTGTAAG 720
GACACGTGTC GTTCTCACAT GTTCCACAAC TCCAAAATCC ACCGGGGGGT CCCCAACCCT 780
GACGCCAAGT ACGCCTTCGG TCCAATCTGC GTCAAGGCCT GCCCCCATAA CTACGTGGTG 840
ACGGAAGGCT GGTGTGTCCG TACCTGCCGC GCCGGGATGT TTGAGGTGGA GGAAAACGGC 900
GTTCAGCAGT GTCGAGAGTG TAACGGCCCG TGTCCTAAAG TCTGCGACGG CCTCGGGGTT 960
GGTGCTTTTA ACAACAGCGT GGCTGTAAAT GCCTCCAACA TTGAGTTCTT CAGGAACTGC 1020
ACCAAGATCA ACGGGAACGT GAACTTCATC GAGACCTCCT TCACTGGGGA TCTCTTTCAC 1080
AATATCCCAC CAATGGACCC GGCCAAGCTG GAGTACTTCA GGACGGTCAA GGAAATCACA 1140
GGCTTCCTGC TGATCCAGTC CTGGCCTGAG AATCTAACCT CGCTGTCTGC GTTTGAAAAC 1200
CTGCACATCA TCCGAGGAAG AGCCACACAT AACATGCGGA CCAGTCTGGT TGTTACCCGG 1260
ACCGAACATC TCCGCTGGCT TGGTCTCCGC TCCCTGAAAG AAGTGAGTGC AGGCAGGGTG 1320
ATGGTGAAGA ACAACCCTCA GCTCTGCTTC CTGCAGCCCC TCCAGTGGAC ACACCTCTTC 1380
AGGTCCACTG GGCAGACCGC CGACATCCGC AACAACAAGC CGGTGGACGT GTGCAAGCAG 1440
CAACGGCAGA CCTGTGACCC GGAGTGCTCG GACCAGGGCT GCTGGGGTCC GGGTCCGGAG 1500
ATGTGCGTGT CCTGTCTCCG CGTCAGCCGC GGGGGTCGCT GTGTGCCGCT CTGCAACGTG 1560
CTGGACGGTG ACCCCAGAGA AGCTGAACTG AACGGCAGCT GTGTTTCGTG CCACTCGGAG 1620
TGTCAGCCGC AAACAGGCAT CCCGACCTGC CACGGACCGG GTCCGGGCCA GTGTTCCCAG 1680
TGTGCTCATG TTCAGGATGG TCCCAGCTGT GTGGCACACT GCCCTCAAGG CATGCTGGGA 1740
GAGGGAGACA CGGAGATCTG GATGTACCCG GACAGGGCGG GCCGGTGCCA GCTCTGCCAC 1800
CAGAACTGCA CCCAGGGGTG TTCTGGTCCT GGACTATCAG GATGCACTAG TTCTGCCGGC 1860
CAGTCCACGC TGGCCGTCTG CGTGGTTGGT GGCCTTTTAA TCGTTGTCAT CGTGGCGCTG 1920
GTCACCTTTG TGCTGCTGCG GAGGCGGCGG ATCACCAGGA GGAGGACTTT ACGCCGCCAG 1980
CTGCAGGAGA AAGAGTTGGT AGAACCTCTG ACTCCAAGCG GGGAAGCTCC CAACCAGGCG 2040
ATGCTCCGGA TCATGAAGGA AACAGAGTTT AAGAAGATCC GAGTTCTGGG CTCCGGAGCC 2100
TTTGGGACCG TCTACAAGGG TCTCTGGATC CCTGAAGGAG AGAACGTGAG GGTCTCGGTG 2160
GCCATTAAGG TTCTCCGTGA AGCTACGTCA TCTAAAGCCA ATAAGGAAAT ACTGGATGAA 2220
GCGTACGTCA TGGCCAGCAT CGATCATCCT CACGTGTGTC GTCTACTGGG AATCTGTTTG 2280
ACCTCATCCA TCCAGCTGGT AACCCAGTTG ATGCCCTTCG GTTGCCTGCT GGATTACGTC 2340
CGCTTCCACC AGGATCAGAT CGGAGCCCCC TGGCTCTTGA ACTGGTGTGT CCAGATCGCA 2400
AAGGGAATGA GCTACCTGGA AGGGCGACAC CTGGTGCATC GAGACCTGGC AGCAAGAAAC 2460
GTTCTCGTCA AAAGCCCCAG TCATGTGACC ATCACAGACT TTGGACTGGC CAAGCTGCTG 2520
ACAGCCAATG AGAAAGCCTA CCGCGCTGAT GGAGGGAAGG TTCCTATTAA GTGGATGGCC 2580
CTGGAGTCCA TCCTGCAGTC CACCTACACA CACCAGAGTG ACGTCTGGAG CTTCGGCGTG 2640
ACCGTGTGGG AGCTGATGAC GTTTGGATCC AAGCCGTACG ACGGCATCCC GGCCAGCGAG 2700
ATCTCCTCGG TTCTGGAGCG AGGAGAGCGG CTGCCACACC CGCCCATCTG CACCACCGAC 2760
CTCTACATGA TCATGGTCCA ATGTTGGATG ATTGATCCCT CCAGTCGTCC AACGTTCAGA 2820
AAGCTGACGG CCGAGTTCTC CACGATGGCT CGAGATCCGT CCAGGTTCCT GGTCGTACAG 2880
GCCAACCTGC CCAGTCCCAC CAACCGCAGG TTTTACTCTC GTATGTTGAG CTCGGAGGAC 2940
ATGGAGGGTG TGATCGACGC AGACGAATAC CTTCAGCCTT ACAAAGAGTT TGGTAACCAT 3000
GGCGACAACT CCTGCAGCCA CACGGTAGCC GCACACAGCT CCAGTATAAC TTCA 3054
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         +kk++vlGsGafGtvykG+wipegenv++ vaikvl+e+t++kanke+ldea+v+as+dh
Q: 690   FKKIRVLGSGAFGTVYKGLWIPEGENVRVSVAIKVLREATSSKANKEILDEAYVMASIDH  749
         599*********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         ++++rllg+cl+s++qlvtql+p+Gclldyvr h+d++G+  llnwcvqiakGmsyle +
Q: 750   PHVCRLLGICLTSSIQLVTQLMPFGCLLDYVRFHQDQIGAPWLLNWCVQIAKGMSYLEGR  809
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
         +lvhrdlaarnvlvksp+hv itdfGlakll+a+ek ++a+ggkvpikw+alesil+ +y
Q: 810   HLVHRDLAARNVLVKSPSHVTITDFGLAKLLTANEKAYRADGGKVPIKWMALESILQSTY  869
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvws+Gvtvwel+tfG+kpydgipa+ei+++le+Gerl+ ppict d+ym++v+cw
Q: 870   THQSDVWSFGVTVWELMTFGSKPYDGIPASEISSVLERGERLPHPPICTTDLYMIMVQCW  929
         ************************************************************
S: 241   midaesrpkfkelaeefs  258
         mid++srp+f++l++efs
Q: 930   MIDPSSRPTFRKLTAEFS  947
         ****************96
Domain Sequence
(FASTA)
FKKIRVLGSG AFGTVYKGLW IPEGENVRVS VAIKVLREAT SSKANKEILD EAYVMASIDH 60
PHVCRLLGIC LTSSIQLVTQ LMPFGCLLDY VRFHQDQIGA PWLLNWCVQI AKGMSYLEGR 120
HLVHRDLAAR NVLVKSPSHV TITDFGLAKL LTANEKAYRA DGGKVPIKWM ALESILQSTY 180
THQSDVWSFG VTVWELMTFG SKPYDGIPAS EISSVLERGE RLPHPPICTT DLYMIMVQCW 240
MIDPSSRPTF RKLTAEFS 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Callithrix jacchus"; ?>Gasterosteus aculeatus"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Takifugu rubripes"; ?>
EKS-CAJ-00304
EKS-GAA-00371
EKS-ORN-00388
EKS-ORL-00359
EKS-TAR-00392
Gene Ontology
GO:0016020; C:membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 4.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013