EKS-TEN-00491

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00491

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	359.1	1.9E-107	596	850	255

Status

Unreviewed

Ensembl Protein

ENSTNIP00000016627

UniProt Accession

H3D7Y6;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K15

Gene Synonyms/Alias

MAP3K15;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000013628	ENSTNIP00000016627	ENSTNIT00000016841

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

1283

Protein Sequence
(FASTA)

RSLRVVYVLN DGLKSVMASS PESGALQCLQ RACDAESALL TTVTFGRLDF GETSVLDSFY 60

DADIAVVDMS DVFRQPSLFY HLGVRESFDM ANNVILYHDT DPDTAQSLKD MVVQKNTASS 120

GNYYFIPYIV TPNHEYTCCE SDAQRRASEY MQPNWDNLLA PLCVPLTDRF TSLLKDIHVT 180

SCASFKDTLL NDIRKAREKY QGEELAKELS RIKLRIDNTE VLTQDIVMNL LFSYRDIQDY 240

DAMVKLVQTL EMLPTCDLAT QPMIQFHFAF ALNRRNSPGD REQALRVMLQ VLQSCEHPAP 300

DMFCLCGRIY KDIFLDSDCK DTRNRDNAIH WYRKGFELQP TLYSGINLTV LLIVAGQQFE 360

NSMELRKIGV RLNSLLGRKG SLEKMNNYWD VGQFFTVSML ANDVPKATQA AEKLFKLKPP 420

LWYLRSVVQN LQLIQRFKKQ IVDHSPQRER LNFWMDIIVE ATQGTTNRLR FPVLILEPTK 480

VYQPSYVSIN NEDEEKNVSI WHVSPAETKG IHEWNFTAMS IKGISISKFD ERCCFLYVHD 540

NSDDFQIYFS TEEQCGRFCS TVKEMISDGT GNSVELEGEG DGDTLEYEYD TNETGDRVVL 600

GRGTYGVVYA GRDLSNQVRI AIKEIPERDS RYSQPLHEEI ALHKYLKHRN IVQYLGSVSE 660

NGYIKIFMEQ VPGGSLSALL RSKWGPLKEA TIIFYTRQIL EGLRYLHDNQ IVHRDIKGDN 720

VLVNTYSGVL KISDFGTSKR LAGVNPCTET FTGTLQYMAP EIIDKGPRGY GAPADIWSLG 780

CTIIEMATGK PPFHELGEPQ AAMFKVGMFK IHPEIPESLS LEAKSFILRC FEPDPLKRAI 840

ATDLLRDTFV RHHTKGKKSK IAFKPPGQHT YNSVISLPVH LQCEAIGSSS SEHGSVSPDC 900

DSKQDIFFQK KKNSGSENLL KPPNSNYLSV PDEGSVSEDR IAPPSPEDRD SGLFMLKKDS 960

ERRAILFKVL NEDQAKVISN LRENYIQQGS EALQLSLEHI KQIICILRDF IHSPERRVMA 1020

ATISKLKLDL DFDSTSINQI QLVLFGFQDS VNKVLRNHHI KPHWMFAMDN IIRRAVQAAI 1080

TILIPELQTH FGPSSECEGA EKEDEVDEEE AEFVPVLVPH ADDSGAAGDH GNASSVLHGA 1140

HSQDHQRSHH QLSTQLGRLK QETSRLLEEL LQKEKEYQQV LKTTLQQRTN DLELVKVRHR 1200

PPDVSPPSIF HIPADHEPDK QLTDWLEEQG ADADTIDKFV LEDYKLSDVL DDISKEDLRC 1260

LCLRGGVLCR IWRAIQRHRE RQR 1283

Nucleotide Sequence
(FASTA)

CGCTCCCTGC GGGTGGTGTA TGTCCTGAAC GACGGGCTCA AGTCGGTGAT GGCCAGCAGC 60

CCCGAGTCCG GAGCGCTGCA GTGCCTGCAG CGAGCCTGCG ACGCGGAGAG CGCGCTGCTG 120

ACCACGGTCA CCTTCGGGCG CCTGGACTTC GGGGAGACGT CGGTGCTGGA CAGTTTCTAC 180

GATGCAGACA TCGCCGTTGT GGACATGAGC GACGTGTTCC GGCAGCCGTC TCTGTTCTAC 240

CACCTGGGGG TGAGGGAGAG CTTCGACATG GCCAACAATG TCATCCTGTA CCACGACACT 300

GACCCCGACA CTGCCCAGTC CCTGAAGGAC ATGGTGGTGC AGAAGAACAC AGCCTCCAGT 360

GGCAACTACT ACTTCATCCC CTACATCGTG ACCCCGAACC ACGAGTACAC GTGCTGCGAG 420

AGCGACGCCC AGCGCCGGGC CAGCGAGTAC ATGCAGCCAA ACTGGGACAA CCTGCTGGCG 480

CCGCTCTGCG TCCCCCTGAC GGATCGTTTT ACCAGCCTGC TGAAGGACAT CCACGTCACG 540

TCCTGCGCCT CCTTTAAGGA CACGTTGCTA AATGACATCA GAAAGGCCAG AGAGAAATAC 600

CAGGGAGAGG AGCTAGCTAA GGAGCTTTCC CGAATCAAGC TACGCATCGA CAACACGGAG 660

GTCCTGACCC AGGACATCGT CATGAACCTG CTGTTCTCCT ACAGAGACAT ACAGGACTAC 720

GACGCCATGG TCAAGCTGGT CCAGACTCTG GAGATGCTCC CCACTTGTGA TCTGGCCACT 780

CAGCCCATGA TCCAGTTCCA CTTCGCCTTC GCCCTCAACA GGAGGAACAG TCCCGGAGAC 840

AGGGAGCAGG CGCTGCGGGT GATGCTGCAG GTGCTGCAGT CCTGCGAGCA TCCAGCGCCA 900

GACATGTTCT GCCTCTGCGG GCGCATTTAC AAAGACATCT TCCTGGACTC AGACTGCAAG 960

GACACCAGGA ACAGGGACAA CGCCATCCAC TGGTACAGAA AGGGTTTCGA GCTCCAACCG 1020

ACCCTCTACT CTGGCATCAA CCTCACTGTC CTCCTCATAG TGGCAGGTCA ACAGTTTGAG 1080

AACTCCATGG AACTGAGGAA AATTGGTGTG AGGCTCAACA GCCTTCTGGG CCGTAAAGGT 1140

TCCCTGGAGA AAATGAACAA CTACTGGGAT GTGGGCCAGT TCTTCACTGT TAGCATGCTT 1200

GCTAACGACG TGCCCAAAGC TACTCAAGCT GCCGAGAAGC TCTTCAAACT CAAGCCCCCT 1260

CTGTGGTATC TGCGCTCCGT AGTGCAGAAC CTGCAGCTGA TTCAGCGGTT TAAAAAACAG 1320

ATAGTGGACC ATTCCCCCCA GCGGGAGCGG CTCAACTTCT GGATGGACAT CATCGTCGAG 1380

GCCACGCAGG GCACCACCAA CCGCCTGCGC TTTCCAGTGC TGATCCTGGA GCCGACCAAG 1440

GTCTACCAGC CGTCCTACGT GTCCATCAAC AACGAGGACG AGGAGAAGAA CGTCTCCATC 1500

TGGCACGTTT CTCCAGCTGA GACAAAAGGG ATCCATGAGT GGAACTTCAC CGCCATGTCC 1560

ATCAAAGGCA TCAGTATCAG CAAGTTTGAC GAGCGCTGCT GCTTCCTCTA CGTCCACGAC 1620

AACTCGGACG ACTTCCAGAT CTACTTCTCC ACGGAGGAGC AGTGCGGCCG GTTCTGCTCC 1680

ACGGTGAAGG AGATGATCTC CGATGGGACA GGGAACTCTG TGGAGCTGGA GGGCGAAGGA 1740

GACGGAGATA CGCTGGAGTA CGAGTACGAC ACCAATGAGA CAGGTGATCG GGTGGTGTTA 1800

GGGCGGGGCA CCTATGGCGT GGTGTACGCG GGGAGAGACC TGAGCAACCA GGTCCGGATC 1860

GCCATCAAAG AGATCCCCGA GAGAGACAGC AGGTACTCGC AGCCGCTCCA CGAAGAAATC 1920

GCCCTCCACA AGTACCTGAA GCACAGGAAC ATTGTCCAGT ATCTGGGCTC GGTTTCGGAG 1980

AACGGATACA TCAAGATCTT CATGGAACAA GTGCCAGGAG GAAGTCTTTC TGCGCTGCTG 2040

CGCTCCAAGT GGGGCCCGCT GAAGGAGGCC ACCATCATCT TCTACACCAG GCAGATCCTG 2100

GAGGGACTCC GGTACCTGCA CGACAACCAG ATCGTCCATC GAGACATCAA GGGCGACAAC 2160

GTGTTGGTGA ATACCTACAG CGGAGTGCTC AAGATCTCTG ATTTTGGTAC CTCGAAGCGT 2220

TTGGCCGGAG TCAACCCCTG CACCGAGACC TTCACTGGGA CCTTGCAGTA CATGGCTCCA 2280

GAAATCATCG ATAAAGGCCC CCGAGGTTAC GGGGCCCCGG CGGACATTTG GTCCCTTGGG 2340

TGCACCATCA TAGAAATGGC CACCGGGAAA CCTCCCTTCC ACGAGTTGGG AGAACCACAG 2400

GCAGCCATGT TCAAGGTGGG CATGTTTAAG ATCCACCCGG AGATCCCCGA GTCCCTGTCC 2460

CTGGAGGCCA AGTCCTTCAT TTTGCGCTGC TTCGAGCCGG ACCCTCTGAA AAGAGCCATC 2520

GCCACCGACC TCCTCAGGGA CACCTTTGTC AGACACCACA CCAAAGGCAA GAAGAGCAAG 2580

ATCGCCTTCA AGCCTCCAGG TCAGCACACG TACAACAGCG TCATTTCCTT GCCGGTGCAC 2640

CTGCAGTGCG AAGCCATCGG GAGCAGCAGC AGCGAGCACG GCTCCGTCAG CCCCGACTGC 2700

GACTCCAAAC AGGACATTTT TTTCCAGAAG AAGAAAAACT CGGGCTCAGA AAACCTGCTC 2760

AAACCCCCCA ACTCCAACTA CCTGAGTGTT CCAGACGAGG GTTCGGTTTC AGAGGACCGC 2820

ATCGCCCCCC CTTCCCCTGA GGACAGGGAC AGCGGGCTGT TCATGCTGAA GAAGGACAGC 2880

GAGAGACGAG CCATCCTGTT CAAGGTCCTC AACGAAGACC AGGCAAAGGT CATCTCCAAC 2940

CTGAGGGAGA ACTACATCCA GCAGGGCAGC GAGGCTCTTC AGCTCTCACT GGAGCACATC 3000

AAGCAGATCA TCTGCATCCT GCGGGACTTC ATCCATTCCC CGGAGAGGCG CGTCATGGCA 3060

GCCACCATCT CCAAGCTGAA GCTGGACCTG GACTTTGACT CCACCTCCAT CAACCAGATT 3120

CAGCTCGTGC TTTTCGGCTT CCAGGACTCG GTGAACAAAG TCCTGAGGAA CCATCACATC 3180

AAACCTCACT GGATGTTTGC GATGGATAAC ATCATCAGAC GAGCCGTTCA GGCCGCCATC 3240

ACCATCCTCA TCCCAGAACT GCAGACCCAC TTTGGTCCGT CATCCGAGTG TGAAGGAGCG 3300

GAGAAGGAAG ACGAGGTGGA TGAAGAGGAG GCGGAGTTTG TTCCCGTTTT AGTCCCTCAT 3360

GCTGATGATT CGGGGGCGGC GGGCGACCAC GGCAACGCCT CCAGCGTGCT GCACGGTGCC 3420

CACTCTCAGG ACCATCAGCG CTCACACCAT CAACTGAGCA CACAGCTGGG GAGGCTGAAA 3480

CAGGAGACCA GCCGGTTGTT GGAGGAGCTG CTGCAGAAGG AGAAGGAGTA CCAACAGGTG 3540

CTGAAGACCA CGCTGCAGCA GAGAACAAAT GACCTGGAGC TGGTCAAAGT CCGGCACAGG 3600

CCTCCAGACG TATCTCCTCC CTCCATATTC CACATCCCTG CGGACCACGA GCCAGACAAG 3660

CAGCTCACCG ACTGGCTGGA AGAGCAGGGT GCAGACGCTG ACACCATCGA CAAGTTTGTG 3720

CTGGAGGATT ACAAGCTGTC TGACGTTCTG GACGACATCA GCAAAGAGGA CCTCCGCTGC 3780

CTGTGTCTAC GGGGCGGAGT CCTGTGTCGT ATCTGGCGGG CCATCCAACG GCACCGGGAG 3840

AGGCAGAGG 3849

Domain Profile

S: 3     krevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkHen  62

         +r v+g+G++g vya++d++++ ++a+Ke+   pe++s+  ++++l+eEi+l+k lkH+n

Q: 596   DRVVLGRGTYGVVYAGRDLSNQVRIAIKEI---PERDSR--YSQPLHEEIALHKYLKHRN  650

         5789**************************...888775..9******************

S: 63    ivkyyGveveeeelkiflEyvegGslsslle.kygkleesvikkytkqileglayLHekk  121

         iv+y+G+ +e++++kif+E+v+gGsls+ll+ k+g+l+e +i +yt+qilegl+yLH+++

Q: 651   IVQYLGSVSENGYIKIFMEQVPGGSLSALLRsKWGPLKEATIIFYTRQILEGLRYLHDNQ  710

         *******************************9****************************

S: 122   ivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvikkke  180

         ivHRDiKg+N+l+++ sgv+k+sDFG+skrla +n++   +e++tGtl+ymaPE+i+k+

Q: 711   IVHRDIKGDNVLVNTySGVLKISDFGTSKRLAGVNPC---TETFTGTLQYMAPEIIDKGP  767

         *************************************...8*******************

S: 181   kgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkdfl  240

         +gyg+ aDiWslgc++iem+tgk+Pf+el+e++a+mfkvg+ k++Peipe+ls e+k+f+

Q: 768   RGYGAPADIWSLGCTIIEMATGKPPFHELGEPQAAMFKVGMFKIHPEIPESLSLEAKSFI  827

         ************************************************************

S: 241   ekcleldpkkrpsaeeLLkhefl  263

          +c+e dp kr+ a++LL+++f+

Q: 828   LRCFEPDPLKRAIATDLLRDTFV  850

         ********************996

Domain Sequence
(FASTA)

DRVVLGRGTY GVVYAGRDLS NQVRIAIKEI PERDSRYSQP LHEEIALHKY LKHRNIVQYL 60

GSVSENGYIK IFMEQVPGGS LSALLRSKWG PLKEATIIFY TRQILEGLRY LHDNQIVHRD 120

IKGDNVLVNT YSGVLKISDF GTSKRLAGVN PCTETFTGTL QYMAPEIIDK GPRGYGAPAD 180

IWSLGCTIIE MATGKPPFHE LGEPQAAMFK VGMFKIHPEI PESLSLEAKS FILRCFEPDP 240

LKRAIATDLL RDTFV 255

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR025136	; DUF4071.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR013761	; SAM/pointed.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF13281	; DUF4071; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013