EKS-TEN-00365

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00365

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	369.1	1.7E-110	195	487	293

Status

Unreviewed

Ensembl Protein

ENSTNIP00000016823

UniProt Accession

H3D8I2;

Protein Name

Protein Synonyms/Alias

Gene Name

TGFBR2 (2 of 2)

Gene Synonyms/Alias

TGFBR2 (2 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000013820	ENSTNIP00000016823	ENSTNIT00000017037

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

517

Protein Sequence
(FASTA)

LKMSKLCKFC DVRATSCTGI GSCTVGCEIT STCADKEEVC VSIWRKAGSN VTFDTVCHNP 60

AYKLYGLVLD DYNNSKCEMK EIKGMGSKFF ICSCSTDECN EHIFFNPSPL ATNSEVVTVV 120

LVSLVPLLVM AVVVIASFYC YRIYRQRKAS TRYKKGPLLD FSDHRAIMID DEGSDSSSTH 180

ANNLNHNTEL LPIDLDVQVG KGRFAEVYKA KLKQGSSVSE EQGFETVAIK IFPYTEYASW 240

KIEKEIFSDA DLKHDNVLHF LTAEERKMQR QYWLITAYHP AGNLQEYLIQ HVINWHELWM 300

LGSTLACGVA HLHSDHTGCG RYKVPVAHRD IKSSNILVKN DLTCCLCDFG LALRLDNSLS 360

VDELANSGQV GTARYMAPEV LESRINLENI ESFKQADVYS MALVLWEITS RCNAIGEVKE 420

YEPPFGNVRE NPCVESMKDS VLRDRGRPEL PNSWINHSGI QMVCAAIEEC WDHDPEARLT 480

AQCVAERFYD MEYLDKLSAR SDSEEKIPEQ ISAAVDE 517

Nucleotide Sequence
(FASTA)

TTGAAGATGT CGAAGCTGTG CAAGTTCTGC GACGTGCGTG CCACCAGCTG CACGGGCATC 60

GGGAGCTGCA CGGTTGGGTG TGAGATCACA TCCACGTGCG CGGACAAGGA GGAGGTGTGC 120

GTCAGTATCT GGAGAAAGGC GGGTTCCAAC GTTACCTTCG ACACAGTCTG CCACAACCCT 180

GCTTACAAGC TGTACGGGCT GGTTCTGGAT GATTACAACA ACAGCAAGTG TGAAATGAAA 240

GAAATCAAAG GAATGGGCTC CAAGTTCTTT ATCTGTTCCT GCTCAACGGA CGAGTGCAAT 300

GAGCACATAT TCTTTAACCC AAGTCCCTTA GCCACAAACT CTGAGGTGGT TACAGTCGTC 360

TTAGTGAGTC TGGTGCCTCT CCTGGTCATG GCCGTTGTCG TCATTGCCTC TTTCTACTGC 420

TACCGAATCT ACCGCCAGCG GAAAGCCAGC ACACGGTACA AGAAAGGTCC TCTCCTGGAC 480

TTTAGCGATC ACCGAGCCAT CATGATAGAC GATGAAGGTT CCGACAGTAG CTCCACGCAC 540

GCGAACAACC TCAACCACAA CACGGAGCTG CTGCCTATTG ACCTGGATGT TCAGGTTGGG 600

AAAGGACGCT TTGCGGAGGT TTACAAAGCC AAGCTCAAGC AGGGCTCCTC GGTCAGCGAG 660

GAGCAGGGCT TTGAGACGGT GGCCATCAAG ATTTTCCCGT ACACGGAGTA TGCTTCCTGG 720

AAGATTGAGA AGGAAATCTT CTCCGATGCT GATCTGAAAC ATGACAATGT GCTCCACTTC 780

CTGACAGCGG AAGAAAGAAA GATGCAAAGA CAGTACTGGC TGATCACAGC CTACCACCCC 840

GCCGGGAACC TGCAGGAGTA CCTGATTCAG CATGTGATTA ACTGGCATGA GCTGTGGATG 900

CTGGGGAGTA CCCTGGCCTG TGGAGTGGCG CACCTTCACA GTGACCACAC CGGCTGCGGG 960

CGCTACAAAG TGCCAGTCGC ACACAGGGAC ATCAAGAGCT CCAACATCTT GGTGAAAAAT 1020

GACCTGACCT GCTGCCTGTG TGATTTCGGA CTTGCCCTGC GCCTGGACAA CAGTCTGTCA 1080

GTCGATGAGC TGGCCAACAG CGGACAGGTG GGAACAGCCA GGTACATGGC CCCCGAAGTG 1140

TTGGAGTCCA GAATCAACCT GGAAAACATC GAGTCCTTCA AGCAGGCTGA CGTGTATTCC 1200

ATGGCTCTCG TACTGTGGGA GATCACCTCC AGGTGTAATG CAATTGGAGA GGTCAAAGAA 1260

TATGAACCAC CCTTTGGGAA TGTGAGGGAA AATCCGTGTG TGGAGAGCAT GAAGGACAGT 1320

GTCCTCAGAG ACAGAGGAAG ACCTGAGCTC CCCAACAGCT GGATCAACCA CTCGGGCATC 1380

CAGATGGTGT GCGCCGCAAT CGAGGAGTGT TGGGACCATG ACCCGGAGGC CCGTCTGACA 1440

GCACAGTGCG TTGCTGAACG CTTCTATGAC ATGGAGTACC TGGACAAGCT GTCAGCCCGC 1500

TCCGACTCGG AGGAGAAGAT CCCTGAACAG ATCTCTGCGG CGGTGGACGA G 1551

Domain Profile

S: 3     lleligkGrygeVwkaklrg..........eevAvKifstedeaswkrEkeiyqtvllrh  52

         l  ++gkGr++eV+kakl++          e+vA+Kif++++ aswk Ekei++   l+h

Q: 195   LDVQVGKGRFAEVYKAKLKQgssvseeqgfETVAIKIFPYTEYASWKIEKEIFSDADLKH  254

         66789**************99***************************************

S: 53    enilqfiaadkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahL  112

         +n+l+f++a++++  ++ +++l+t+yh+ g+L++yL +++++++el  l ++la+G+ahL

Q: 255   DNVLHFLTAEERK--MQRQYWLITAYHPAGNLQEYLIQHVINWHELWMLGSTLACGVAHL  312

         **********987..569******************************************

S: 113   HeeivgtkgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvG  172

         H++  + +g++K  +aHRD+ks Nilvk+dltcc++D+GLal+l+++ ++ +la++ qvG

Q: 313   HSDH-TGCGRYKVPVAHRDIKSSNILVKNDLTCCLCDFGLALRLDNSLSVDELANSGQVG  371

         ***5.55699**************************************************

S: 173   tkRYmaPEvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvg  232

         t RYmaPEvle+++nl+++e+fk+aDvYs++LvlWE++sRc++  +ev+ey++pf   v+

Q: 372   TARYMAPEVLESRINLENIESFKQADVYSMALVLWEITSRCNA-IGEVKEYEPPF-GNVR  429

         *******************************************.999********.789*

S: 233   sdPsleemkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkr  290

         ++P++e+mk+ v++++ rP++p++w +++ +++++  +eecWd+dpeaRlta++v++r

Q: 430   ENPCVESMKDSVLRDRGRPELPNSWINHSGIQMVCAAIEECWDHDPEARLTAQCVAER  487

         *******************************************************987

Domain Sequence
(FASTA)

LDVQVGKGRF AEVYKAKLKQ GSSVSEEQGF ETVAIKIFPY TEYASWKIEK EIFSDADLKH 60

DNVLHFLTAE ERKMQRQYWL ITAYHPAGNL QEYLIQHVIN WHELWMLGST LACGVAHLHS 120

DHTGCGRYKV PVAHRDIKSS NILVKNDLTC CLCDFGLALR LDNSLSVDEL ANSGQVGTAR 180

YMAPEVLESR INLENIESFK QADVYSMALV LWEITSRCNA IGEVKEYEPP FGNVRENPCV 240

ESMKDSVLRD RGRPELPNSW INHSGIQMVC AAIEECWDHD PEARLTAQCV AER 293

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0043235	; C:receptor complex
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005026	; F:transforming growth factor beta receptor activity, type II
GO:0023014	; P:signal transduction by phosphorylation
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR017194	; Transform_growth_fac-b_typ-2.
IPR015013	; Transforming_GF_b_rcpt_2_ecto.

Pfam

PF08917	; ecTbetaR2; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013