EKS-TEN-00302

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00302

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	380.8	3.0E-114	30	282	253

Status

Unreviewed

Ensembl Protein

ENSTNIP00000016830

UniProt Accession

H3C304;

Protein Name

Protein Synonyms/Alias

Gene Name

MARK2

Gene Synonyms/Alias

MARK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000013826	ENSTNIP00000016830	ENSTNIT00000017044
ENSTNIG00000013826	ENSTNIP00000002622	ENSTNIT00000001348

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

628

Protein Sequence
(FASTA)

SKSSGRSSMS RCRNSVSTTT SDDQPHIGNY RLLKTIGKGN FAKVKLARHV LTGKEVAVKI 60

IDKTQLNSSS LQKLFREVRI MKLLNHPNIV KLFEVIETEK TLYLVMEYAS GGEVFDYLVA 120

HGRMKEKEAR AKFRQIVSAV QYCHQKCIVH RDLKAENLLL DADMNIKIAD FGFSNEFTLG 180

NKLDTFCGSP PYAAPELFQG KKYDGPEVDV WSLGVILYTL VSGSLPFDGQ NLKELRERVL 240

RGKYRIPFYM STDCENLLKK FLILNPSKRG SLEQQIMRDR WMNVGYEEEE LKPYIEPQPD 300

YKDPKKTDIM LQMGFSLEEI QDSLVNQKYN DVMAAYLLLD YRNSEVHNSK HLEEGCIKPR 360

PGSEVSNINA PSPPHKVQRS VSSNQNPKNR RATEQVILTA RSFRQGSSYS KRGGQTDNRS 420

AAEDSGRKGS SGSSTTKVPA SPVVSADRKK SATPSTNSIL STGTGRSRNS PLSERATLAQ 480

GIQNGKDSLN TPGSRASTAS AAAVLSSSSS ASSSRPRHHK SLSSSNHPCP SDLHAPRPSA 540

PPQRAPGASP SAHNINSSAA SERPNFSRGV GIRSTFHAGQ QRGARDQQGS SYTSGPASPS 600

LSHGNTQARR THGATGIFSK FTSKFVRR 628

Nucleotide Sequence
(FASTA)

TCCAAGTCAT CCGGCCGCTC CAGCATGTCG CGGTGTCGGA ACTCGGTGTC CACGACCACG 60

TCGGACGACC AGCCGCACAT CGGTAACTAC CGGCTGCTGA AAACCATCGG CAAAGGCAAC 120

TTCGCCAAAG TCAAGCTGGC GCGACACGTC CTCACCGGGA AAGAGGTGGC CGTAAAGATC 180

ATCGATAAGA CGCAGCTCAA CTCCTCCAGT TTGCAGAAGC TCTTCCGGGA GGTGAGGATC 240

ATGAAGTTGT TGAATCACCC CAACATAGTA AAGCTCTTTG AGGTAATAGA GACAGAGAAG 300

ACTTTGTACC TGGTAATGGA GTACGCCAGT GGAGGAGAGG TTTTTGATTA CTTGGTGGCC 360

CACGGCAGGA TGAAGGAAAA AGAAGCCCGT GCCAAATTCA GACAGATCGT GTCAGCGGTG 420

CAGTATTGCC ATCAGAAGTG TATAGTACAC AGAGACCTCA AGGCCGAGAA CCTGCTGCTG 480

GACGCAGACA TGAACATCAA AATAGCCGAC TTCGGCTTCA GCAACGAGTT CACTCTGGGG 540

AACAAGCTGG ACACGTTCTG CGGCTCCCCG CCCTACGCCG CCCCCGAGCT CTTCCAGGGC 600

AAGAAGTACG ACGGGCCCGA GGTGGACGTC TGGAGCCTGG GCGTCATCCT CTACACGCTG 660

GTCAGCGGCT CCTTGCCCTT CGATGGACAG AACCTCAAGG AGCTGAGAGA GCGCGTGCTG 720

CGTGGCAAAT ACAGGATTCC TTTCTACATG TCCACCGACT GCGAGAACCT GCTCAAAAAG 780

TTCCTCATCC TGAACCCCTC CAAAAGAGGC AGCCTGGAGC AGCAGATAAT GAGGGACCGG 840

TGGATGAACG TGGGCTACGA GGAGGAGGAG CTGAAACCAT ACATCGAACC CCAGCCGGAT 900

TATAAAGACC CCAAAAAGAC TGATATCATG CTACAAATGG GATTCTCCCT GGAGGAGATC 960

CAGGACTCGC TGGTGAACCA GAAGTATAAC GACGTCATGG CGGCGTATCT GCTCCTCGAC 1020

TACAGGAACT CTGAGGTACA CAACTCAAAA CACTTGGAGG AAGGTTGCAT CAAGCCTAGA 1080

CCAGGAAGCG AAGTAAGCAA CATAAACGCC CCTTCTCCGC CTCACAAGGT ACAGCGCAGC 1140

GTGTCGTCCA ATCAGAACCC GAAGAACCGC AGAGCCACCG AACAGGTTAT TTTGACGGCC 1200

CGATCCTTTC GCCAAGGCTC GTCCTACTCC AAGAGGGGCG GTCAGACGGA CAACAGGAGT 1260

GCAGCAGAGG ATTCTGGGAG GAAAGGCTCG TCGGGCAGCT CGACCACCAA GGTGCCAGCC 1320

AGCCCCGTGG TCTCCGCTGA CCGGAAGAAG AGCGCCACGC CTTCCACCAA TAGCATCCTG 1380

TCCACCGGTA CCGGCCGTAG TCGAAACTCC CCTCTGAGCG AGAGAGCCAC GCTGGCTCAG 1440

GGCATCCAGA ACGGCAAGGA CAGCCTAAAC ACTCCGGGTT CCCGCGCCTC CACCGCCTCA 1500

GCCGCAGCCG TCCTCTCCTC CTCCTCCTCC GCTTCCTCTT CACGTCCCCG CCATCACAAG 1560

TCCCTGTCCT CCTCCAACCA TCCATGCCCC TCTGACCTGC ACGCACCACG GCCCAGTGCT 1620

CCACCTCAGC GGGCGCCCGG CGCCTCCCCA TCCGCCCACA ACATCAACAG CAGCGCGGCG 1680

TCGGAGCGTC CCAACTTCTC CCGAGGGGTG GGCATCCGCA GCACATTCCA CGCAGGCCAG 1740

CAGCGGGGCG CCCGGGACCA GCAGGGCTCC TCCTACACCA GCGGGCCGGC CTCCCCCTCG 1800

CTGTCGCACG GCAACACCCA GGCCCGGAGG ACCCACGGCG CCACGGGCAT CTTCAGCAAG 1860

TTCACCTCCA AGTTTGTACG CAGGTGA 1887

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y+llkt+G+g+f+kVkla+h +t+++vavKii+k++l+++sl+k++rE++i+k l+hpni

Q: 30    YRLLKTIGKGNFAKVKLARHVLTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKLLNHPNI  89

         99**********************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         +kl+eviet+k+lylv+eyasgge+fdy++++gr+kekear+ f+q+vsav+Y+h+k iv

Q: 90    VKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKCIV  149

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvD  180

         HrDlK+eNllld+++nikiaDFG++n+f+ g++l+tfcGsppYaaPel++gkkY+gp+vD

Q: 150   HRDLKAENLLLDADMNIKIADFGFSNEFTLGNKLDTFCGSPPYAAPELFQGKKYDGPEVD  209

         ************************************************************

S: 181   vWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekR  240

         vWslGv+Ly+lv+g+lPfd++nlkel+e++l+gk++ip+++s+++e+Ll+k+L  +p+kR

Q: 210   VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKR  269

         ************************************************************

S: 241   atie.eilkhewl  252

          ++e +i++++w+

Q: 270   GSLEqQIMRDRWM  282

         **9637******7

Domain Sequence
(FASTA)

YRLLKTIGKG NFAKVKLARH VLTGKEVAVK IIDKTQLNSS SLQKLFREVR IMKLLNHPNI 60

VKLFEVIETE KTLYLVMEYA SGGEVFDYLV AHGRMKEKEA RAKFRQIVSA VQYCHQKCIV 120

HRDLKAENLL LDADMNIKIA DFGFSNEFTL GNKLDTFCGS PPYAAPELFQ GKKYDGPEVD 180

VWSLGVILYT LVSGSLPFDG QNLKELRERV LRGKYRIPFY MSTDCENLLK KFLILNPSKR 240

GSLEQQIMRD RWM 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Canis familiaris"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Erinaceus europaeus"; ?>Gasterosteus aculeatus"; ?>Monodelphis domestica"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220	; S_TKc; 1.
SM00165	; UBA; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013