EKS-TEN-00510
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TEN-00510
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR540.32.5E-162595950356
StatusUnreviewed
Ensembl ProteinENSTNIP00000017238
UniProt AccessionH3D9P7;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NamePDGFRB (1 of 2)
Gene Synonyms/Alias PDGFRB (1 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTNIG00000014225ENSTNIP00000017238ENSTNIT00000017455
OrganismTetraodon nigroviridis
Functional Description
Protein Length1046
Protein Sequence
(FASTA)
IQHATMKAAV LHLTVTLTAL LYSCTPANCL RMVPDDRRHI LAEGSSLSIT CSGSGETTWD 60
FKSEDAPFFQ MEAKSGGLNY KIVQSNRTTS VLTLWHVNWK YTGVYQCKDV LTKEMEEVAI 120
FVPGEFSNPE VWFIRSDHGM VPMNREESTV PCLVTNPNIR VTLHDKDTGL SIEGVYVPGE 180
GFKAYLEYRT YVCRGELNGE VKESQPYNVY SVHVPEDIDA YVNASKTVLK QGEPLTVNCT 240
VQGVELVNFS WVIPNRDSVG AQPQTDIISA TTMRSCLVFP HATVAHSGTY VCRAVEGIQN 300
QATNASINIS VLEKGFVAVK STQKQNITAK HQENVELRVE MEAYPPPQIL WKKDGATVKA 360
DRTIVIRQEH EIRYVTILTL VRVRSEQKGL YTVLITNEDD RKEVAFALEV QIPAQVKDLT 420
DHHLPGNKHL VTCVAEGVPT PVIQWRSCDR MLKCSNQSAL WQLLTADPEL LSIQTNVTEP 480
RGTKQVRSQV TFFKPQHVTV RCEASNQDGL IDRRDIKLVS STLFSQVALL AALLTLVPII 540
IMSIIILIAV WRKKPRYEIR WKVIESVSQD GHEYIYVDPI HLPYDLAWEM SRDNLVLGRT 600
LGSGAFGRVV EATAYGLMHS QSSIKVAVKM LKSTARESET QALMSELKIM SHLGPHLNIV 660
NLLAACTKHG PLYLVTEYCR YGDLVDYLHR NKHTFLQYYL DKNQDGGSLI SGGSTPLSQR 720
KGYVSFGSES DGGYMDMSKD EPAVYVPMQE QTDAIKYADI QPSPYDSPYQ QDIYQEQGGG 780
RVDLVISDSP ALTYDDLLGF SYQVAKGMEF LASKNCVHRD LAARNVLICE GKLVKICDFG 840
LARDIMHDSN YISKGSTFLP LKWMAPESIF HNLYTTLSDV WSYGILLWEI FTLGGTPYPD 900
LPMNELFYSA LKRGYRMAKP AHASDEVYEI MKRCWDETFE KRPDFSFLVH CVGNMLTDGY 960
KKKYREVNET FLKSNHPAVA RTKPRLSSPF PIANPAFGSP SQVGLSNFPD PYSQNTNVTY 1020
EADAQEVMTS FNEYIIPIPD PKPEEG 1046
Nucleotide Sequence
(FASTA)
ATTCAGCACG CCACTATGAA AGCAGCTGTG CTTCATCTGA CGGTCACGCT TACAGCTCTT 60
CTATACTCCT GCACCCCTGC CAACTGTCTG AGGATGGTCC CTGATGACAG GCGGCACATC 120
CTGGCCGAGG GCTCGTCCCT CTCCATCACC TGCTCCGGCT CGGGAGAGAC CACCTGGGAC 180
TTCAAGAGCG AAGACGCGCC CTTCTTCCAA ATGGAAGCCA AGAGCGGTGG CCTGAACTAC 240
AAAATCGTGC AGAGCAACCG CACCACCAGT GTTCTGACGT TATGGCACGT GAACTGGAAG 300
TACACGGGGG TGTATCAGTG CAAAGACGTT CTCACTAAAG AAATGGAAGA AGTGGCTATT 360
TTTGTCCCAG GTGAGTTTTC AAACCCAGAG GTGTGGTTCA TCAGGAGCGA CCACGGCATG 420
GTCCCAATGA ACAGAGAGGA AAGCACGGTT CCCTGCCTGG TCACCAATCC CAACATCAGG 480
GTCACCCTTC ACGACAAGGA CACCGGTTTG TCCATCGAGG GGGTTTATGT CCCTGGTGAG 540
GGCTTCAAGG CCTATCTGGA GTACAGGACC TATGTGTGTC GAGGAGAGCT GAACGGGGAG 600
GTGAAAGAGT CCCAGCCCTA CAACGTCTAC AGCGTTCATG TCCCGGAGGA CATCGACGCC 660
TACGTGAATG CCTCGAAGAC CGTCCTAAAG CAAGGCGAAC CGCTCACAGT CAACTGCACG 720
GTGCAGGGAG TGGAGCTGGT GAACTTCTCC TGGGTTATCC CCAACAGAGA CAGCGTTGGG 780
GCTCAGCCTC AAACAGACAT CATCTCGGCC ACAACCATGC GCTCCTGCCT GGTCTTTCCT 840
CATGCTACGG TGGCCCACAG TGGAACCTAC GTCTGTCGTG CTGTTGAGGG TATCCAGAAC 900
CAGGCGACCA ATGCCAGCAT TAACATCAGT GTTCTGGAGA AAGGGTTTGT GGCTGTGAAA 960
TCTACTCAGA AACAAAACAT CACCGCTAAA CACCAGGAAA ACGTGGAGCT GAGAGTGGAA 1020
ATGGAAGCCT ATCCTCCCCC TCAGATCCTC TGGAAGAAAG ATGGGGCCAC AGTCAAGGCA 1080
GACAGAACCA TCGTAATCAG ACAAGAGCAT GAAATCAGGT ACGTTACCAT TCTGACCTTA 1140
GTGAGGGTGA GGTCGGAGCA GAAGGGCCTC TACACTGTCC TCATCACAAA TGAAGACGAT 1200
AGAAAGGAAG TGGCCTTTGC CCTGGAAGTC CAAATCCCCG CTCAGGTTAA GGACCTGACG 1260
GACCACCACC TCCCCGGCAA TAAACACCTG GTGACGTGTG TAGCTGAGGG GGTCCCGACC 1320
CCCGTCATAC AGTGGCGCAG CTGCGACAGG ATGCTCAAGT GCAGCAACCA GTCAGCCTTG 1380
TGGCAGCTGC TGACAGCCGA TCCAGAGCTG CTGAGCATCC AGACCAACGT CACCGAGCCG 1440
CGGGGAACCA AGCAGGTACG GAGCCAGGTC ACCTTCTTCA AACCTCAGCA CGTCACGGTC 1500
CGCTGCGAGG CCAGCAACCA AGATGGACTC ATCGACAGGA GGGACATCAA ACTGGTGTCC 1560
AGCACTCTGT TCTCCCAGGT GGCCTTGTTG GCGGCTCTTC TGACATTAGT GCCCATTATT 1620
ATCATGTCTA TCATCATCCT CATCGCCGTG TGGAGGAAGA AGCCTCGCTA CGAGATCAGA 1680
TGGAAGGTGA TCGAGTCGGT GAGCCAGGAC GGCCACGAGT ACATCTACGT GGACCCCATC 1740
CACCTGCCCT ATGACCTGGC CTGGGAAATG TCGCGAGACA ACCTGGTTCT GGGTCGCACT 1800
CTTGGATCAG GAGCCTTCGG CAGGGTGGTC GAGGCCACTG CGTATGGACT CATGCATTCC 1860
CAGTCCAGCA TAAAAGTGGC GGTGAAAATG CTGAAATCTA CAGCCCGGGA GAGCGAGACC 1920
CAGGCTCTGA TGTCAGAACT GAAGATCATG AGCCACCTGG GGCCTCACCT CAACATTGTC 1980
AACTTACTGG CAGCTTGCAC CAAACATGGA CCTTTGTATC TGGTCACCGA GTATTGTCGC 2040
TATGGTGACC TGGTGGACTA CCTGCACAGA AACAAGCACA CCTTTCTGCA GTATTACCTG 2100
GACAAGAACC AGGATGGCGG CAGTCTTATC TCAGGAGGAA GCACTCCACT CAGCCAGAGA 2160
AAAGGCTATG TGTCTTTTGG AAGTGAGAGT GACGGGGGAT ACATGGACAT GAGCAAAGAC 2220
GAGCCCGCAG TTTACGTTCC CATGCAGGAG CAGACGGACG CCATCAAGTA TGCAGACATA 2280
CAGCCGTCTC CGTACGACTC GCCCTACCAG CAGGACATCT ACCAAGAGCA AGGTGGGGGC 2340
CGAGTGGACC TGGTCATCAG CGACTCTCCT GCTCTGACCT ACGACGACCT TCTGGGCTTC 2400
AGCTACCAGG TGGCCAAAGG GATGGAGTTC CTCGCCTCCA AAAACTGCGT CCACCGTGAC 2460
CTCGCCGCCA GAAATGTGTT GATCTGTGAG GGCAAACTTG TGAAGATCTG TGACTTTGGC 2520
CTGGCCAGAG ACATCATGCA CGACTCCAAC TACATCTCAA AAGGCAGCAC CTTCCTGCCG 2580
TTAAAATGGA TGGCACCAGA GAGCATTTTC CATAACCTGT ACACCACCCT GAGTGATGTG 2640
TGGTCATACG GGATCCTTCT CTGGGAGATT TTCACACTGG GAGGAACGCC GTACCCTGAT 2700
CTTCCCATGA ACGAGCTGTT CTACAGCGCG CTGAAGAGAG GCTATAGGAT GGCCAAACCG 2760
GCTCACGCCT CCGACGAAGT CTATGAGATC ATGAAGAGGT GCTGGGACGA GACATTCGAG 2820
AAGAGGCCCG ACTTTTCCTT TTTGGTCCAC TGTGTGGGGA ACATGCTGAC AGACGGCTAT 2880
AAAAAGAAAT ACAGAGAAGT AAATGAAACC TTCCTGAAGA GCAACCACCC AGCGGTGGCA 2940
CGCACCAAAC CTCGACTCTC CTCGCCTTTT CCGATTGCCA ACCCGGCGTT TGGCTCCCCG 3000
TCCCAGGTCG GACTGTCCAA CTTCCCGGAT CCCTACAGCC AAAACACAAA TGTCACATAT 3060
GAGGCAGACG CTCAGGAGGT CATGACTTCC TTCAACGAGT ACATCATTCC CATCCCAGAC 3120
CCCAAACCGG AGGAAGGT 3138
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l+lG++lGsGafG+vveatayGl +s++++kvavkmlkstar se +almselki+shlG
Q: 595   LVLGRTLGSGAFGRVVEATAYGLMHSQSSIKVAVKMLKSTARESETQALMSELKIMSHLG  654
         78**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h+nivnll actk Gp+y++teyc+yGdl++yl+r++++fl+ +l+k+++  + ++  +
Q: 655   PHLNIVNLLAACTKHGPLYLVTEYCRYGDLVDYLHRNKHTFLQYYLDKNQDGGSLISGGS  714
         ************************************************887766665555
S: 121   lladkslrsksslssesseeyvdlkkd................vsdvssskadklasekk  164
          +  ++ + ++s+ ses++ y+d++kd                ++d+++s +d+++++++
Q: 715   TP-LSQRKGYVSFGSESDGGYMDMSKDepavyvpmqeqtdaikYADIQPSPYDSPYQQDI  773
         44.455688999***********************************************8
S: 165   ksalerevkaaleeedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGk  224
          + +   + + ++ + s +l+++dll fsyqvakGmeflaskncvhrdlaarnvl++eGk
Q: 774   YQEQGGGRVDLVISD-SPALTYDDLLGFSYQVAKGMEFLASKNCVHRDLAARNVLICEGK  832
         877777766666655.9*******************************************
S: 225   vvkicdfGlardimkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifs  284
         +vkicdfGlardim+dsny++kG+++lp+kwmapesif++lyt+ sdvwsyGillweif+
Q: 833   LVKICDFGLARDIMHDSNYISKGSTFLPLKWMAPESIFHNLYTTLSDVWSYGILLWEIFT  892
         ************************************************************
S: 285   lGstpypgllvdskfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlve  342
         lG+tpyp+l++++ fy ++k+Gyrma+pa+a++e+yeim++cw++ +ekrp f+ lv+
Q: 893   LGGTPYPDLPMNELFYSALKRGYRMAKPAHASDEVYEIMKRCWDETFEKRPDFSFLVH  950
         *****************************************************99886
Domain Sequence
(FASTA)
LVLGRTLGSG AFGRVVEATA YGLMHSQSSI KVAVKMLKST ARESETQALM SELKIMSHLG 60
PHLNIVNLLA ACTKHGPLYL VTEYCRYGDL VDYLHRNKHT FLQYYLDKNQ DGGSLISGGS 120
TPLSQRKGYV SFGSESDGGY MDMSKDEPAV YVPMQEQTDA IKYADIQPSP YDSPYQQDIY 180
QEQGGGRVDL VISDSPALTY DDLLGFSYQV AKGMEFLASK NCVHRDLAAR NVLICEGKLV 240
KICDFGLARD IMHDSNYISK GSTFLPLKWM APESIFHNLY TTLSDVWSYG ILLWEIFTLG 300
GTPYPDLPMN ELFYSALKRG YRMAKPAHAS DEVYEIMKRC WDETFEKRPD FSFLVH 356
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00377
EKS-ANC-00390
EKS-BOT-00403
EKS-CAJ-00406
EKS-CAF-00403
EKS-CAP-00431
EKS-DAR-00792
EKS-EQC-00395
EKS-FEC-00387
EKS-GAG-00340
EKS-GAA-00491
EKS-GOG-00395
EKS-HOS-00408
EKS-ICT-00382
EKS-LAC-00418
EKS-LOA-00411
EKS-MAM-00401
EKS-MEG-00334
EKS-MUM-00434
EKS-MUP-00396
EKS-MYL-00398
EKS-NOL-00367
EKS-OCP-00083
EKS-ORN-00513
EKS-ORC-00377
EKS-ORL-00471
EKS-OTG-00404
EKS-PES-00358
EKS-POA-00393
EKS-RAN-00417
EKS-SAH-00371
EKS-SUS-00358
EKS-TAG-00472
EKS-TAR-00509
EKS-XIM-00505
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005021; F:vascular endothelial growth factor-activated receptor activity
GO:0001525; P:angiogenesis
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
GO:0038084; P:vascular endothelial growth factor signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR009134; Tyr_kinase_VEGFR_rcpt_N.
Pfam
PF07679; I-set; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 3.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR01832; VEGFRECEPTOR.
Created Date20-Feb-2013