EKS-TEN-00512
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TEN-00512
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR516.73.7E-155581911331
StatusUnreviewed
Ensembl ProteinENSTNIP00000017240
UniProt AccessionH3D9P8;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NameCSF1R (1 of 2)
Gene Synonyms/Alias CSF1R (1 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTNIG00000014226ENSTNIP00000017239ENSTNIT00000017456
ENSTNIG00000014226ENSTNIP00000017240ENSTNIT00000017457
OrganismTetraodon nigroviridis
Functional Description
Protein Length972
Protein Sequence
(FASTA)
MQSYLPLLMG IVASASSVEW RHPVIWFNSE VVQSSELVIK PGAPLELRCE GDGPVNWQTR 60
LPKHKRYMSR SPGNVRTIRI EHPTAEFTGT YRCFYSAWPQ HRHLSSSVHV YVKDPNHVFW 120
TSSASVSVVR KEGEDYLLPC LLTDPDATNL GLRMDNGTTV PQEMNFTVYR HRGILIRNLQ 180
PSFNADYVCT AKVKGVEKTS KAFSINVIQK LRFPPYVFLE MDEYVRIVGE ELKIRCMTHN 240
PNFNYNVTWN YTTKSVNIIL MECKNSGENR LDIQSILTIS AVVLADTGNI SCIGTNEAGV 300
NSSNTYLLVV EKPYIRLLPQ LMANRGLSVE VNEGEDLKLN VIVEAYPQIT EHRWHTPTSP 360
STSMQEHIYH ASLQLKRMNA QEQGQYTFYA RSNLVNASIT FHVKMYQKPI AVVRWENITT 420
LTCTSFGYPA PRIIWYQCFG IRPTCNGNNT GLQMAVPLQA PTVEVQREEY GAVEVESVLT 480
VGLSNRRMTV ECVAFNLVGV GSDTFTMEVS EKLFTSTLTG AAGVLAIFLL LLVFLLYKYK 540
QKPRYEIRWK IIEAREGNNY TFIDPTQLPY NEKWEFPRDK LKLGKVLGAG AFGKVVEATA 600
FGLGEDKDNT MRVAVKMLKV NAHSDEREAL MSELKILSHL GHHQNIVNLL GACTYGGPVL 660
VITEYCSLGD LLNFLRQKAE TFVNLVMNIP EIMENSSDYK NICNQKWYLE SDSGISSTSS 720
STYLEMRPSQ QTNMEISVQN SLSEDNGDWP LDIDDLLRFS LQVAQGLDFL ASRNCIHRDV 780
AARNVLLTDS RVAKICDFGL ARDIMNDSNY VVKGNARLPV KWMAPESIFD CVYTVQSDVW 840
SYGILLWEIF SLGKSPYPSM AVDSRFYKMV KRGYQMSQPD FAPPEIYMIM KMCWDLEPTE 900
RPTFNKISQM IERILGDQDE QEKLIYRNVQ PEQVPGGEGC DEPKCYDRPC DQSCDHEEEE 960
ELLMKTNNYQ FC 972
Nucleotide Sequence
(FASTA)
ATGCAGTCCT ACCTCCCACT GCTGATGGGG ATTGTGGCCT CCGCTTCTTC AGTGGAATGG 60
AGACACCCAG TGATCTGGTT CAACTCTGAG GTGGTGCAGA GTTCTGAGCT TGTGATCAAA 120
CCCGGAGCCC CTCTAGAGCT ACGGTGCGAA GGCGACGGGC CTGTAAACTG GCAAACCAGA 180
CTCCCCAAAC ACAAACGCTA CATGTCCAGG AGCCCCGGCA ACGTCCGCAC CATCAGGATC 240
GAGCATCCCA CCGCGGAGTT CACCGGAACC TACAGGTGTT TTTACAGCGC CTGGCCGCAG 300
CACCGTCACC TCAGCTCCTC GGTTCACGTC TATGTCAAAG ATCCAAACCA TGTGTTCTGG 360
ACCAGCAGTG CATCTGTGAG TGTGGTGAGG AAGGAGGGTG AGGATTACCT GCTGCCCTGC 420
CTGCTGACCG ACCCAGACGC TACCAATCTG GGCCTGCGCA TGGACAACGG CACCACAGTG 480
CCTCAAGAAA TGAACTTCAC AGTTTACCGA CACCGTGGAA TTCTCATCCG CAACCTCCAG 540
CCCAGCTTCA ACGCTGACTA CGTCTGCACA GCCAAGGTCA AAGGGGTCGA GAAGACGTCC 600
AAGGCCTTTT CCATCAACGT CATACAGAAG CTCCGTTTCC CTCCATATGT CTTCTTGGAG 660
ATGGATGAAT ATGTGCGTAT CGTCGGGGAA GAGCTCAAGA TCCGGTGCAT GACGCACAAC 720
CCCAACTTCA ACTACAACGT CACCTGGAAC TACACCACCA AGTCGGTCAA TATCATCCTC 780
ATGGAGTGTA AAAATAGCGG AGAGAACCGT CTGGACATCC AGAGCATACT GACCATCTCA 840
GCTGTAGTCC TCGCAGACAC TGGAAACATT TCCTGTATCG GCACGAATGA AGCAGGGGTG 900
AACAGTTCCA ACACTTACCT GCTGGTTGTG GAAAAGCCCT ACATTCGACT GTTGCCCCAG 960
CTGATGGCCA ACCGAGGTTT GTCGGTGGAA GTGAATGAGG GAGAAGATCT GAAGCTCAAC 1020
GTGATCGTTG AAGCGTACCC CCAGATCACA GAACACAGAT GGCACACGCC AACCTCTCCC 1080
AGCACATCCA TGCAAGAGCA CATATACCAC GCTAGTCTGC AGCTGAAGAG GATGAATGCT 1140
CAGGAGCAGG GACAGTACAC CTTCTATGCC CGGAGCAACT TGGTCAATGC CTCCATTACC 1200
TTCCATGTCA AAATGTATCA GAAACCTATC GCTGTGGTCA GATGGGAAAA CATAACCACA 1260
CTCACCTGCA CCTCCTTTGG ATATCCTGCT CCCAGGATCA TCTGGTATCA GTGCTTTGGG 1320
ATACGCCCGA CGTGTAATGG GAACAACACG GGACTGCAGA TGGCCGTTCC TCTCCAGGCT 1380
CCCACGGTGG AGGTGCAGAG GGAGGAGTAT GGAGCTGTGG AGGTGGAGAG CGTCCTCACT 1440
GTGGGGCTGT CCAACCGGAG GATGACAGTG GAGTGTGTGG CCTTTAACCT CGTTGGGGTC 1500
GGCAGCGACA CCTTTACTAT GGAGGTCTCT GAGAAGCTCT TCACATCCAC CCTGACTGGA 1560
GCAGCAGGCG TCCTGGCCAT CTTTCTATTG CTACTGGTTT TCCTGCTTTA TAAATACAAA 1620
CAAAAACCCA GATACGAGAT CCGCTGGAAA ATTATTGAAG CAAGAGAGGG AAACAACTAC 1680
ACGTTCATTG ACCCTACTCA GCTGCCCTAC AATGAGAAGT GGGAGTTTCC CAGAGACAAG 1740
CTCAAGCTAG GGAAGGTTCT TGGGGCAGGA GCGTTTGGAA AGGTGGTGGA GGCCACTGCC 1800
TTCGGTTTAG GAGAAGACAA GGACAACACA ATGCGTGTGG CTGTGAAAAT GCTAAAAGTC 1860
AACGCTCACT CAGATGAGAG GGAGGCTCTG ATGTCTGAGC TGAAGATCTT GAGTCACCTG 1920
GGCCACCATC AGAACATTGT CAACCTATTA GGAGCCTGCA CCTACGGAGG ACCAGTGCTT 1980
GTGATCACAG AGTACTGCAG CCTGGGGGAT CTTCTAAACT TTCTTCGCCA GAAGGCAGAG 2040
ACGTTTGTCA ACTTGGTTAT GAATATTCCT GAGATCATGG AGAACTCCAG TGACTACAAA 2100
AACATCTGCA ACCAGAAGTG GTACTTGGAG AGTGACAGCG GGATCTCCAG CACGTCTTCC 2160
AGCACATATC TGGAGATGAG ACCAAGCCAG CAGACCAATA TGGAAATTTC AGTACAGAAT 2220
TCTCTGAGTG AGGACAACGG TGATTGGCCA CTGGACATCG ACGACTTGCT GCGGTTTTCC 2280
CTTCAGGTGG CCCAGGGCCT TGACTTCTTG GCCAGCAGGA ATTGCATTCA CAGAGACGTA 2340
GCTGCTCGAA ATGTGCTGCT GACTGACAGC AGAGTGGCCA AAATCTGTGA CTTTGGCTTG 2400
GCGCGCGACA TCATGAACGA CTCCAACTAC GTGGTGAAGG GCAATGCACG TCTTCCAGTG 2460
AAGTGGATGG CCCCTGAGAG TATTTTTGAC TGCGTCTACA CCGTCCAGAG CGACGTCTGG 2520
TCCTACGGCA TCCTCCTGTG GGAGATCTTT TCTTTAGGCA AGAGCCCCTA CCCCAGCATG 2580
GCTGTGGACT CCAGGTTTTA CAAGATGGTC AAGCGCGGTT ACCAGATGTC CCAACCAGAT 2640
TTTGCCCCTC CTGAAATCTA CATGATCATG AAGATGTGCT GGGATCTGGA GCCCACGGAG 2700
CGTCCCACCT TTAACAAGAT CAGTCAGATG ATAGAAAGAA TACTCGGGGA CCAGGATGAG 2760
CAGGAAAAGC TGATCTACCG GAACGTGCAG CCGGAGCAGG TCCCAGGAGG CGAAGGATGT 2820
GATGAGCCCA AGTGTTACGA CCGCCCCTGT GATCAGTCCT GCGACCACGA GGAAGAGGAG 2880
GAACTTCTGA TGAAGACCAA CAATTACCAG TTTTGCTGA 2919
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsk.sdavlkvavkmlkstarssekealmselkilshl  59
         l+lGkvlG+GafGkvveata+Gl++ +d +++vavkmlk +a+s+e+ealmselkilshl
Q: 581   LKLGKVLGAGAFGKVVEATAFGLGEdKDNTMRVAVKMLKVNAHSDEREALMSELKILSHL  640
         78*********************972689*******************************
S: 60    GehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldsk  119
         G+h+nivnllGact gGp++viteyc  Gdlln+lr+k+e+f++  +++ +  e++ d+k
Q: 641   GHHQNIVNLLGACTYGGPVLVITEYCSLGDLLNFLRQKAETFVNLVMNIPEIMENSSDYK  700
         ************************************************************
S: 120   al.ladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaale.  177
         ++  ++ +l+s+s +ss ss++y++++++     +++++           e +v+++l+ 
Q: 701   NIcNQKWYLESDSGISSTSSSTYLEMRPS-----QQTNM-----------EISVQNSLSe  744
         **778889********************2.....22222...........2222333440
S: 178   eedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardi  237
         ++ + +l+++dll fs qva+G++flas+nc+hrd+aarnvllt+ +v+kicdfGlardi
Q: 745   DNGDWPLDIDDLLRFSLQVAQGLDFLASRNCIHRDVAARNVLLTDSRVAKICDFGLARDI  804
         445679******************************************************
S: 238   mkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvds  297
         m+dsnyvvkGnarlpvkwmapesifd++ytv+sdvwsyGillweifslG +pyp + vds
Q: 805   MNDSNYVVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGKSPYPSMAVDS  864
         ************************************************************
S: 298   kfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         +fyk++k+Gy+m+qp++a+ eiy im+ cw+ ep++rp+f+++++++
Q: 865   RFYKMVKRGYQMSQPDFAPPEIYMIMKMCWDLEPTERPTFNKISQMI  911
         *******************************************9986
Domain Sequence
(FASTA)
LKLGKVLGAG AFGKVVEATA FGLGEDKDNT MRVAVKMLKV NAHSDEREAL MSELKILSHL 60
GHHQNIVNLL GACTYGGPVL VITEYCSLGD LLNFLRQKAE TFVNLVMNIP EIMENSSDYK 120
NICNQKWYLE SDSGISSTSS STYLEMRPSQ QTNMEISVQN SLSEDNGDWP LDIDDLLRFS 180
LQVAQGLDFL ASRNCIHRDV AARNVLLTDS RVAKICDFGL ARDIMNDSNY VVKGNARLPV 240
KWMAPESIFD CVYTVQSDVW SYGILLWEIF SLGKSPYPSM AVDSRFYKMV KRGYQMSQPD 300
FAPPEIYMIM KMCWDLEPTE RPTFNKISQM I 331
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00376
EKS-ANC-00391
EKS-BOT-00405
EKS-CAF-00405
EKS-CAP-00434
EKS-DAR-00788
EKS-EQC-00397
EKS-FEC-00389
EKS-GAG-00342
EKS-GAA-00492
EKS-GOG-00397
EKS-HOS-00411
EKS-ICT-00384
EKS-LAC-00420
EKS-LOA-00414
EKS-MAM-00404
EKS-MEG-00336
EKS-MOD-00393
EKS-MUM-00437
EKS-MUP-00398
EKS-MYL-00400
EKS-ORN-00515
EKS-ORC-00380
EKS-ORL-00473
EKS-OTG-00407
EKS-PAT-00383
EKS-PES-00359
EKS-PTV-00115
EKS-RAN-00419
EKS-SAH-00375
EKS-SUS-00355
EKS-TAG-00474
EKS-TAR-00511
EKS-TUT-00118
EKS-XET-00514
EKS-XIM-00507
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005021; F:vascular endothelial growth factor-activated receptor activity
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
GO:0038084; P:vascular endothelial growth factor signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
IPR009134; Tyr_kinase_VEGFR_rcpt_N.
Pfam
PF07679; I-set; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 4.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
PR01832; VEGFRECEPTOR.
Created Date20-Feb-2013