EKS-TEN-00390

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00390

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/EGFR	401.9	1.3E-120	689	945	257

Status

Unreviewed

Ensembl Protein

ENSTNIP00000017624

UniProt Accession

H3DAT2;

Protein Name

Protein Synonyms/Alias

Gene Name

ERBB3 (2 of 2)

Gene Synonyms/Alias

ERBB3 (2 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000014596	ENSTNIP00000017624	ENSTNIT00000017845

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

1294

Protein Sequence
(FASTA)

AVCTGTQNFL SMTGNSEIHY NLTKTLYTGC EIVMGNLEIT MMEHGMDFSF LKSIREVTGY 60

ILLAVNTFSR LPLDNLRVIR GNELYENQYA LVVMINYPTK GGQGLQELGL THLTEILQGG 120

VKITQNRDLS FAPKVNWLDI VKDGTANITI FDNGPEKPCH KACGDVPCWG PGSDMCQILT 180

KTVCAPQCNF RCFGRSPGEC CHSECAGGCT GPLDTDCFAC RKFNDSGSCV PQCPMALIYN 240

KYTFRLEPNP NAKFQFGSIC VAQCPPNFLV DGTSCVRSCP ADKMEVEKNG VKRCEPCGGL 300

CPKACHGTGS PNGETVDALN IDSFINCTKI QGSLHFLLTG INGDNYNNVP PLDPEKLKIF 360

NTVREITDML VIQSWPTNMS DLSVFSNLQT IQGRKLYKLV FRGYSLMVVK TPSLTSLGLR 420

SLRKINDGGV YITGNKNLCY HDTVNWTLLL GSSSRQQRRH KNIDIKDNRP RSDCVRENFV 480

CDPLCSSDGC WGPGPSQCLS CKKYSRGGIC VADCMFLAGD RREFATASGE CMPCHPECKA 540

QTGRETCTGP GAAECLECAN LQDGPHCVSS CPEGVMGGEE IIFKYPDKQG RCEPCHGNCT 600

KGLSCYGPGI RDCVEAYGQT VTGIVVGVIV LLFVSFSVFV LTLLYRRGLA IRRKRAMRRY 660

MERGESFEPL EPGEKGAKVH ARILKPSELR TAKLLGNGVF GSVYKGIWIP EGETVKLPVA 720

IKVIHDRPGQ KTFSKPTEHM MTLGSLDHVN IVRILGICPG DSLQLVSQLS SQGSLLEHVR 780

NCKNKLNPQR LLNWCVQIAK GMYYLEENKV VHRNLAARNV LLKNNYTAQV SDYGVADLLY 840

RDDKKYFFNE AKTPIKWMAL ESILFRKYTH QSDVWSYGVT VWEMMSYGAE PYNTMRPQDI 900

SDLLEKGERL SQPQICTIDV YMVMVKCWMV DENVRPTFKE LANEFTRMAR DPPRYLVIKE 960

DCSQQDTAPD LDDLDFNEGV DAEMVNEVKE DEEDGLVPAP YYVPQSLGRL SKMDSYRVVL 1020

SSSNVAGYLP MTPGVDSTLT RICVFDPLQA PWPSRSRLNS GRAVSEGSEG CGPVVDGDVS 1080

EDFSMSGSPK RRRNRHDSAY TSQRDSMSGG LSETPTPDME EEDQNGYVLP GDSPKRDALF 1140

PTSQGVPGRM GKSHSSSLLD DPDDEEYEYM NKQTMSSYNS DSEPQGSDDV KYEYMDIRSV 1200

GKDDSPPAHA PPPPPADRQP AEAARPEEAA VYQNIQREGE GPAGQSPAQR SGFGAYVSVR 1260

AGVGLGDPAA VDRSFDNLEY WHSRMFPNPK AVQT 1294

Nucleotide Sequence
(FASTA)

GCCGTTTGCA CCGGCACCCA GAACTTCCTG AGCATGACCG GAAACTCGGA GATCCATTAC 60

AACCTCACCA AAACGTTGTA CACCGGCTGC GAGATCGTGA TGGGCAACCT TGAGATCACC 120

ATGATGGAGC ACGGCATGGA CTTCTCCTTC CTGAAGTCAA TCAGGGAGGT GACGGGCTAC 180

ATCCTGCTGG CCGTCAACAC GTTCAGCCGC CTGCCCCTGG ACAACCTGCG CGTCATCAGA 240

GGCAACGAGC TGTACGAGAA CCAGTATGCC CTGGTCGTAA TGATCAACTA CCCGACAAAG 300

GGGGGGCAGG GCCTTCAGGA GCTGGGCCTG ACTCACCTTA CAGAGATTCT GCAGGGAGGA 360

GTGAAGATCA CCCAGAACAG GGACCTGAGC TTCGCCCCCA AGGTGAACTG GTTGGACATC 420

GTGAAGGACG GAACGGCCAA CATCACCATC TTTGACAACG GGCCTGAGAA GCCTTGTCAC 480

AAAGCGTGTG GCGACGTTCC GTGCTGGGGT CCGGGGAGCG ACATGTGCCA GATCTTGACC 540

AAGACCGTGT GCGCTCCTCA GTGTAACTTC CGATGCTTCG GTCGGAGCCC GGGCGAGTGC 600

TGCCACAGCG AATGCGCCGG AGGCTGCACG GGACCCCTGG ACACGGACTG CTTTGCTTGC 660

AGGAAGTTCA ACGACTCGGG CTCCTGCGTG CCCCAGTGCC CCATGGCCCT CATTTACAAC 720

AAGTACACCT TCAGGCTGGA GCCCAACCCC AACGCCAAGT TCCAGTTTGG TTCCATCTGT 780

GTGGCTCAGT GCCCCCCTAA CTTCTTGGTG GATGGCACCT CGTGCGTCCG CAGCTGTCCC 840

GCCGATAAAA TGGAGGTGGA GAAGAACGGC GTGAAAAGAT GTGAACCCTG TGGAGGCCTC 900

TGTCCGAAAG CTTGTCACGG GACAGGAAGT CCAAACGGAG AGACCGTAGA CGCTCTCAAC 960

ATCGACAGTT TCATAAACTG CACCAAGATT CAGGGCAGTC TGCACTTCCT CCTGACCGGC 1020

ATCAATGGCG ACAACTACAA TAACGTGCCA CCGCTCGACC CAGAGAAGCT GAAGATCTTC 1080

AACACCGTGA GGGAGATTAC AGACATGCTG GTTATCCAGT CGTGGCCGAC AAACATGTCT 1140

GACCTGTCAG TCTTCTCCAA CCTCCAAACC ATTCAGGGCA GAAAGCTTTA CAAGCTGGTG 1200

TTCAGGGGCT ACTCGCTGAT GGTGGTGAAG ACCCCCTCCC TGACCTCGCT GGGGCTGCGC 1260

TCCCTTCGGA AAATAAACGA TGGCGGCGTC TACATAACGG GAAACAAGAA TCTGTGCTAC 1320

CACGACACTG TCAACTGGAC GCTTCTGTTA GGCAGCAGCT CCCGCCAGCA GCGCCGCCAC 1380

AAAAACATCG ACATTAAGGA CAACAGGCCC AGAAGCGATT GCGTCAGGGA AAACTTTGTG 1440

TGCGACCCCC TCTGCTCCTC CGATGGCTGC TGGGGTCCGG GGCCAAGCCA GTGCCTGTCC 1500

TGTAAGAAGT ACAGCCGGGG GGGCATCTGT GTGGCCGACT GCATGTTCCT AGCTGGGGAC 1560

AGACGGGAGT TTGCAACGGC GTCAGGAGAG TGTATGCCAT GCCACCCGGA GTGTAAGGCT 1620

CAGACGGGGA GGGAGACCTG CACAGGCCCG GGAGCTGCGG AGTGTTTGGA ATGCGCCAAC 1680

CTGCAAGACG GCCCGCACTG CGTCTCCTCC TGTCCTGAGG GCGTGATGGG AGGCGAGGAG 1740

ATCATTTTCA AATACCCGGA CAAGCAAGGC CGCTGTGAAC CGTGCCACGG GAACTGTACC 1800

AAAGGGCTCA GCTGCTACGG CCCAGGGATC CGAGACTGCG TTGAAGCCTA TGGACAAACG 1860

GTCACGGGCA TCGTGGTGGG AGTCATTGTC CTTCTCTTCG TTTCCTTCTC CGTGTTTGTG 1920

CTGACCCTGC TGTACCGCCG AGGTCTGGCC ATTCGGCGCA AGCGGGCTAT GAGGAGATAC 1980

ATGGAACGGG GAGAGAGCTT TGAGCCTCTG GAGCCTGGAG AGAAGGGGGC CAAGGTCCAC 2040

GCTCGAATCC TGAAGCCCTC TGAGCTCCGG ACGGCGAAGC TGCTGGGTAA CGGGGTGTTT 2100

GGATCCGTCT ATAAGGGCAT TTGGATTCCT GAGGGGGAAA CGGTCAAGCT TCCGGTGGCC 2160

ATCAAGGTGA TTCATGACCG CCCTGGACAA AAGACCTTCA GCAAGCCCAC CGAGCACATG 2220

ATGACGCTGG GGAGCTTGGA CCACGTGAAC ATCGTCCGCA TCCTGGGCAT CTGTCCTGGG 2280

GACAGCCTGC AGCTGGTCAG CCAGCTCAGC AGCCAGGGCT CCCTGCTGGA GCACGTCAGG 2340

AACTGCAAGA ACAAGCTGAA CCCACAGAGA CTGCTCAACT GGTGTGTCCA AATCGCAAAG 2400

GGCATGTATT ATCTGGAGGA GAACAAGGTG GTGCACCGAA ACCTGGCAGC CAGAAACGTG 2460

CTCCTGAAGA ATAATTACAC GGCCCAGGTG TCCGACTACG GCGTCGCAGA CCTGCTTTAC 2520

CGTGACGATA AGAAGTACTT TTTCAACGAG GCAAAGACTC CCATTAAATG GATGGCACTA 2580

GAGAGCATCT TGTTTCGTAA ATACACGCAT CAGAGTGACG TTTGGAGCTA CGGTGTGACG 2640

GTGTGGGAGA TGATGTCCTA CGGAGCAGAG CCTTACAACA CGATGCGCCC GCAGGACATT 2700

TCTGATCTCC TGGAGAAAGG CGAGCGGCTG TCGCAGCCTC AAATCTGCAC CATCGACGTC 2760

TACATGGTCA TGGTGAAGTG CTGGATGGTC GACGAGAACG TCCGTCCAAC ATTCAAGGAG 2820

CTGGCGAATG AATTTACCAG AATGGCCAGA GATCCGCCTC GATATCTGGT GATCAAAGAG 2880

GACTGCAGCC AGCAGGACAC AGCCCCAGAC CTGGACGACC TGGATTTCAA TGAAGGTGTG 2940

GACGCAGAGA TGGTGAACGA GGTGAAAGAG GATGAGGAAG ACGGCCTGGT TCCAGCCCCC 3000

TACTACGTGC CTCAGAGCCT CGGTCGTCTG TCAAAGATGG ACTCTTACAG AGTGGTTCTC 3060

TCGTCATCGA ATGTGGCGGG ATACCTGCCG ATGACCCCAG GAGTTGACAG CACCCTAACA 3120

CGCATCTGTG TTTTTGACCC CCTGCAGGCC CCATGGCCTT CTCGCTCTCG GCTAAACTCG 3180

GGGCGCGCCG TGTCAGAGGG TTCGGAGGGT TGCGGCCCGG TGGTGGACGG GGACGTGAGC 3240

GAGGACTTTT CCATGTCAGG AAGCCCGAAA AGGCGCCGCA ATCGCCATGA CAGCGCTTAC 3300

ACGTCCCAAA GGGACAGCAT GTCTGGAGGA CTGTCGGAGA CGCCGACCCC AGACATGGAG 3360

GAAGAGGACC AGAACGGATA TGTCCTTCCT GGAGACAGCC CAAAGAGAGA CGCCCTATTT 3420

CCCACATCTC AAGGCGTCCC CGGCAGGATG GGGAAGTCTC ACTCGTCCAG TCTGTTGGAC 3480

GACCCCGACG ATGAAGAATA CGAATACATG AACAAACAGA CGATGAGCAG TTACAACTCC 3540

GATTCAGAGC CGCAGGGCTC CGATGATGTC AAGTATGAGT ACATGGACAT CAGAAGCGTC 3600

GGTAAAGATG ACAGTCCTCC TGCACATGCT CCTCCTCCTC CTCCGGCGGA CAGACAGCCG 3660

GCTGAAGCAG CACGACCAGA AGAAGCGGCG GTCTATCAGA ACATCCAAAG GGAAGGGGAG 3720

GGGCCAGCGG GGCAAAGCCC AGCACAGCGG TCCGGCTTTG GGGCCTACGT CAGCGTGCGG 3780

GCCGGGGTCG GGTTGGGAGA CCCGGCAGCT GTTGACAGAT CCTTTGACAA CCTGGAATAC 3840

TGGCACAGCA GGATGTTCCC CAATCCGAAG GCTGTGCAAA CCTGA 3885

Domain Profile

S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60

         l+  k lG G+fG+vykGiwipege+vk+pvaikv++++ g+k++++ ++++++l+sldh

Q: 689   LRTAKLLGNGVFGSVYKGIWIPEGETVKLPVAIKVIHDRPGQKTFSKPTEHMMTLGSLDH  748

         5889********************************************************

S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120

          n+vr+lg+c  ++lqlv+ql   G+ll++vr+ k+kl +q llnwcvqiakGm+ylee+

Q: 749   VNIVRILGICPGDSLQLVSQLSSQGSLLEHVRNCKNKLNPQRLLNWCVQIAKGMYYLEEN  808

         ************************************************************

S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180

         ++vhr+laarnvl+k+    +++d+G+a+ll  d+k++  +++k+pikw+alesil+rky

Q: 809   KVVHRNLAARNVLLKNNYTAQVSDYGVADLLYRDDKKYFFNEAKTPIKWMALESILFRKY  868

         ************************************************************

S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240

         thqsdvwsyGvtvwe++++Ga+py++++ ++i+dllekGerl+qp+ictidvymv+vkcw

Q: 869   THQSDVWSYGVTVWEMMSYGAEPYNTMRPQDISDLLEKGERLSQPQICTIDVYMVMVKCW  928

         ************************************************************

S: 241   midaesrpkfkelaeef  257

         m+d+++rp+fkela+ef

Q: 929   MVDENVRPTFKELANEF  945

         ****************9

Domain Sequence
(FASTA)

LRTAKLLGNG VFGSVYKGIW IPEGETVKLP VAIKVIHDRP GQKTFSKPTE HMMTLGSLDH 60

VNIVRILGIC PGDSLQLVSQ LSSQGSLLEH VRNCKNKLNP QRLLNWCVQI AKGMYYLEEN 120

KVVHRNLAAR NVLLKNNYTA QVSDYGVADL LYRDDKKYFF NEAKTPIKWM ALESILFRKY 180

THQSDVWSYG VTVWEMMSYG AEPYNTMRPQ DISDLLEKGE RLSQPQICTI DVYMVMVKCW 240

MVDENVRPTF KELANEF 257

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR000494	; EGF_rcpt_L.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00261	; FU; 4.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013