EKS-TEN-00385

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00385

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/EGFR	480.7	1.1E-144	685	942	258

Status

Unreviewed

Ensembl Protein

ENSTNIP00000017881

UniProt Accession

H3DBI9;

Protein Name

Protein Synonyms/Alias

Gene Name

EGFR (1 of 4)

Gene Synonyms/Alias

EGFR (1 of 4);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000014840	ENSTNIP00000017881	ENSTNIT00000018105

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

1170

Protein Sequence
(FASTA)

CQGITNRLNR LSSTDDHYAN MLKTYSNCTV VLENLEITHM EEHRDLSFLR SIEEVGGYVL 60

IALNTVSRIH LDNLRIIRGH SLYDNKFALK VISNYNKSTG LGTSELLLNS LTGLEILKGG 120

VKISSKMLCN VDTIQWNDIV NTETKPAMEL PEKSNNPQCQ KCHSSCFNGS CWAPGSQNCQ 180

QLTKLNCAQQ CSRRCNGPAP SNCCNEHCAA GCTGPRATDC LACRDFQDDG VCKDSCPGLI 240

RYDPNLHQLV PNPHGKYNFG AKCVKTCPHN YVVTDHGACV RTCSGNTYEI EEGGIRKCAK 300

CDGLCPKVCN GLGTGELANT ISINATNIES FRNCTKINGN INIIRTSFDG DSYTKTPKMH 360

PSQLDVFKTV REISGYLLIQ QWPENLHSLS PFENLEIIRG RTKRSGSRSL VVAGLSITSL 420

GLRSLKEISD GDVIITMNKN LCYTSESHWK KLFRSEGQSA TIKENADVAT CAQRNNICDR 480

KCTAEGCWGP GPDMCFTCSD YSRGGSCVDS CNILEGESRE TVVNKTCVKC HPECERMNGT 540

TTCSAPGSGN CTRCANFQDG LFCVSRCPRG VPGEDDMLVW KYADNNKVCQ LCHRNCTQGC 600

TGPGLAGCQD KSTSGFSLIA AGVVGGLLAV LLAGLSVFVL LRRRHIKRKR TMRRLLQERE 660

LVEPLTPSGE APNQALLRIL KEPEFKKIKV LGSGAFGTVY KGLWVPEGED VKIPVAIKVL 720

REATSPKANK DILDEAYVMA SVEHPHVCRL LGICLTSTVQ LITQLMPFGC LLDYVKENKD 780

NVGSQYLLNW CVQIAKGMNY LEERHLVHRD LAARNVLVKT PQHVKITDFG LAKLLNADEK 840

EYHADGGKEV PIKWMALESI LNRTYTHQSD VWSYGVTVWE LMTFGTKPYD GIPASEIAGI 900

LEKGERLPQP PICTIDVYMI MVKCWMINAV NRPRFRELIA EFTKMARDPS RYLVIQGDDR 960

MHLPSPTDKK LFRTLISGEG LDAVDADEYL VPQRGFFSSP STSHTPLHHS TVSRFTQLCN 1020

VFTSDNGLPS RDGSFVFRYT PDPTDKLLDE AFKPSSGISH YMNQNGASDM MNPNYKYPGP 1080

PRSILPTISS DDTESEYLNC FKNGTIQPEY LNEVPSSSNF PFTPNTQKYA PQNSIDNPDY 1140

QQDFTPTFKT HTNGHIPAAE NTEYTSVRTD 1170

Nucleotide Sequence
(FASTA)

TGTCAAGGCA TCACCAATCG TTTGAACCGG TTGAGCTCCA CAGACGACCA CTATGCGAAC 60

ATGCTGAAGA CCTACAGCAA CTGCACTGTG GTGCTGGAGA ACCTGGAGAT CACCCATATG 120

GAGGAACATC GGGACCTGTC CTTCCTCAGG TCTATTGAAG AGGTGGGCGG ATATGTGCTG 180

ATTGCCTTGA ACACAGTGTC CAGGATTCAC CTGGATAACC TCCGCATCAT CCGTGGTCAC 240

TCGCTTTATG ACAACAAGTT TGCCCTAAAA GTGATCAGCA ACTATAACAA GAGTACCGGC 300

CTGGGGACCA GTGAGCTGCT TCTGAACAGC CTTACCGGTT TAGAGATTCT AAAGGGAGGT 360

GTAAAAATTT CAAGCAAAAT GCTCTGCAAT GTCGATACGA TACAATGGAA TGATATTGTC 420

AACACTGAGA CCAAACCTGC CATGGAGCTT CCAGAGAAAA GCAACAATCC CCAGTGTCAG 480

AAATGTCACT CAAGTTGCTT CAATGGCTCT TGCTGGGCAC CTGGTTCTCA AAACTGTCAG 540

CAACTAACAA AGCTGAACTG TGCACAGCAG TGTTCCAGAA GATGCAATGG CCCTGCACCC 600

AGCAATTGCT GCAATGAGCA CTGTGCTGCC GGCTGCACCG GGCCACGGGC CACGGATTGT 660

CTGGCATGTC GGGACTTCCA GGACGATGGG GTGTGCAAGG ACTCGTGCCC GGGTCTTATA 720

CGCTACGACC CCAACCTTCA CCAGCTCGTA CCCAATCCTC ATGGAAAGTA CAACTTCGGG 780

GCCAAGTGTG TCAAAACCTG TCCACATAAT TATGTTGTGA CCGATCATGG GGCGTGTGTG 840

CGTACATGCA GCGGCAACAC ATATGAGATC GAGGAGGGAG GGATCAGGAA GTGCGCCAAG 900

TGTGACGGAC TGTGCCCAAA AGTATGTAAT GGGCTTGGGA CAGGAGAGCT GGCCAATACT 960

ATTTCCATCA ATGCCACAAA CATCGAATCC TTTAGGAATT GCACAAAAAT TAATGGTAAC 1020

ATTAATATCA TCCGCACCTC ATTTGATGGT GATAGCTATA CCAAAACGCC AAAGATGCAC 1080

CCTTCCCAGC TAGATGTGTT CAAGACTGTT AGAGAAATTT CAGGATATTT GTTGATTCAA 1140

CAATGGCCGG AGAACTTGCA CTCACTTAGT CCTTTTGAGA ACCTGGAGAT CATCCGTGGC 1200

CGAACAAAGC GCAGTGGTAG CCGTAGTTTG GTGGTGGCTG GTCTCAGTAT CACATCACTG 1260

GGCCTTCGCT CCCTGAAAGA AATCAGTGAT GGAGATGTGA TCATCACGAT GAACAAGAAC 1320

CTGTGCTACA CCAGTGAAAG CCACTGGAAA AAGCTCTTCA GGTCCGAGGG TCAAAGTGCC 1380

ACCATAAAGG AAAATGCGGA CGTTGCCACA TGTGCCCAAC GCAACAACAT TTGTGACCGG 1440

AAGTGTACTG CAGAAGGCTG CTGGGGCCCC GGCCCGGACA TGTGCTTCAC TTGCAGTGAC 1500

TACAGCCGTG GTGGGAGTTG TGTTGACTCC TGCAACATCC TGGAGGGTGA ATCACGGGAG 1560

ACTGTCGTGA ATAAAACCTG TGTGAAGTGT CACCCTGAGT GTGAACGCAT GAATGGGACT 1620

ACAACCTGCA GTGCCCCCGG TAGTGGAAAC TGCACAAGGT GTGCCAACTT CCAGGATGGA 1680

CTGTTCTGTG TGTCTCGGTG TCCCCGAGGC GTGCCAGGGG AAGATGACAT GCTGGTGTGG 1740

AAATATGCAG ACAACAATAA AGTGTGCCAA CTGTGCCACC GAAACTGCAC TCAAGGGTGC 1800

ACTGGTCCTG GTCTTGCAGG TTGCCAAGAT AAAAGCACGT CTGGTTTTTC CTTGATTGCG 1860

GCTGGTGTCG TTGGCGGGTT GCTGGCTGTT CTTCTAGCGG GCCTGTCTGT TTTTGTGTTG 1920

CTACGCCGAC GCCACATCAA GAGGAAGAGA ACCATGCGTA GACTCCTCCA AGAGAGAGAG 1980

TTGGTTGAGC CGTTGACACC AAGCGGCGAG GCACCAAACC AGGCTCTGTT GCGTATCCTG 2040

AAAGAGCCCG AATTTAAAAA AATCAAAGTC CTGGGATCAG GGGCTTTCGG CACAGTTTAC 2100

AAGGGGCTGT GGGTTCCAGA GGGAGAGGAT GTGAAGATCC CAGTGGCCAT CAAGGTTTTA 2160

CGAGAGGCAA CATCACCAAA AGCAAACAAA GACATTTTGG ATGAGGCTTA TGTGATGGCC 2220

AGTGTGGAAC ACCCGCATGT GTGCCGCCTG CTGGGCATCT GCCTGACCTC GACGGTGCAG 2280

CTCATCACCC AGCTGATGCC CTTCGGCTGC CTGCTGGACT ACGTCAAAGA GAACAAGGAC 2340

AATGTCGGCT CCCAGTACTT GCTCAACTGG TGTGTGCAGA TAGCGAAGGG TATGAACTAC 2400

CTGGAGGAGC GTCACCTGGT GCACCGTGAT TTGGCAGCGA GAAACGTCCT TGTGAAGACT 2460

CCGCAGCATG TCAAGATCAC AGATTTTGGT CTGGCCAAGC TCCTCAATGC CGATGAGAAA 2520

GAGTACCACG CAGATGGTGG GAAGGAGGTA CCAATAAAAT GGATGGCTTT GGAATCCATC 2580

CTGAACAGAA CGTACACACA CCAGAGTGAT GTTTGGAGTT ATGGTGTGAC GGTGTGGGAG 2640

CTGATGACAT TTGGGACCAA ACCATATGAT GGGATTCCAG CCAGTGAGAT AGCTGGGATC 2700

CTGGAGAAAG GCGAGAGGCT GCCTCAACCA CCGATCTGTA CCATAGACGT CTATATGATA 2760

ATGGTGAAAT GTTGGATGAT CAATGCAGTC AACAGGCCTC GTTTCCGGGA ACTAATAGCT 2820

GAGTTTACAA AGATGGCTCG AGATCCTTCA CGCTATCTTG TCATACAGGG TGATGACCGC 2880

ATGCACCTGC CAAGTCCGAC AGACAAAAAG CTGTTCCGTA CTCTGATCAG CGGGGAAGGA 2940

CTTGACGCGG TAGATGCAGA CGAGTATTTG GTGCCCCAGC GTGGATTCTT CAGCAGCCCA 3000

AGCACTTCTC ACACGCCTCT GCACCACTCT ACAGTAAGTC GTTTTACACA GCTGTGTAAC 3060

GTTTTCACAT CTGATAACGG ATTACCAAGC AGAGATGGCA GCTTTGTTTT TCGGTATACT 3120

CCCGACCCCA CAGACAAACT TTTAGACGAG GCCTTCAAGC CATCTTCAGG TATCTCCCAC 3180

TACATGAATC AAAATGGAGC CTCAGACATG ATGAATCCCA ACTACAAGTA CCCTGGTCCC 3240

CCTCGTAGCA TCCTTCCCAC CATCTCCTCC GATGACACAG AGTCTGAATA CCTGAACTGC 3300

TTTAAAAATG GTACCATTCA GCCCGAGTAT CTGAACGAGG TCCCGTCCTC CAGCAACTTC 3360

CCATTCACTC CCAACACGCA GAAATATGCC CCCCAAAACA GCATAGACAA CCCAGACTAT 3420

CAACAGGATT TCACCCCCAC CTTCAAGACT CACACCAATG GACACATCCC AGCAGCAGAA 3480

AACACAGAGT ACACCTCGGT CCGGACTGAC 3510

Domain Profile

S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60

         +kk+kvlGsGafGtvykG+w+pege+vkipvaikvl+e+t++kank++ldea+v+as++h

Q: 685   FKKIKVLGSGAFGTVYKGLWVPEGEDVKIPVAIKVLREATSPKANKDILDEAYVMASVEH  744

         59**********************************************************

S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120

         ++++rllg+cl+st+ql+tql+p+Gclldyv+e+kd++Gsq+llnwcvqiakGm+ylee+

Q: 745   PHVCRLLGICLTSTVQLITQLMPFGCLLDYVKENKDNVGSQYLLNWCVQIAKGMNYLEER  804

         ************************************************************

S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggk.vpikwlalesilkrk  179

         +lvhrdlaarnvlvk+p+hvkitdfGlakll+adeke++a+ggk vpikw+alesil+r+

Q: 805   HLVHRDLAARNVLVKTPQHVKITDFGLAKLLNADEKEYHADGGKeVPIKWMALESILNRT  864

         *******************************************979**************

S: 180   ythqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkc  239

         ythqsdvwsyGvtvwel+tfG+kpydgipa+ei  +lekGerl+qppictidvym++vkc

Q: 865   YTHQSDVWSYGVTVWELMTFGTKPYDGIPASEIAGILEKGERLPQPPICTIDVYMIMVKC  924

         ************************************************************

S: 240   wmidaesrpkfkelaeef  257

         wmi+a  rp+f+el++ef

Q: 925   WMINAVNRPRFRELIAEF  942

         ****************99

Domain Sequence
(FASTA)

FKKIKVLGSG AFGTVYKGLW VPEGEDVKIP VAIKVLREAT SPKANKDILD EAYVMASVEH 60

PHVCRLLGIC LTSTVQLITQ LMPFGCLLDY VKENKDNVGS QYLLNWCVQI AKGMNYLEER 120

HLVHRDLAAR NVLVKTPQHV KITDFGLAKL LNADEKEYHA DGGKEVPIKW MALESILNRT 180

YTHQSDVWSY GVTVWELMTF GTKPYDGIPA SEIAGILEKG ERLPQPPICT IDVYMIMVKC 240

WMINAVNRPR FRELIAEF 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR000494	; EGF_rcpt_L.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00261	; FU; 5.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013