EKS-TEN-00367

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00367

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	354.6	4.3E-106	192	479	288

Status

Unreviewed

Ensembl Protein

ENSTNIP00000017914

UniProt Accession

H3DBM1;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR2B

Gene Synonyms/Alias

ACVR2B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000014872	ENSTNIP00000017914	ENSTNIT00000018138

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

513

Protein Sequence
(FASTA)

MSFSWLTCSL LLGTLCAGYS LGEAETRECV YYNDNWRTER TNQSGFERCE GEKDKRLHCY 60

ASWLNSSGTI KLVKKGCWLD DFNCYDRQEC VSMEENPQVF FCCCEGNYCN ERFTHLPDII 120

GSGNRVKIRP PPRVPSLLNV LVYSLLPLCV LSLALLLALW MYRHRKPPYG HVDLSEDPGP 180

APPSPLVGLK PLQLLEIKAR GRFGCVWKAQ LMSEYVAVKI FPVQNKQSWQ NERDIFITPG 240

MRHENLLRYI AAEKHGTNLE TELWLITEFH ERGSLTDHLK GNAVSWNELC HIAETMSRGL 300

HLHEDIPSYK GEGPNPPLHT GTSRVRMLLL RDDLTAVIGD FGLAVRFEPG KPPGDTHGQV 360

GTRRYMAPEV LEGAINFQRD SFLRIDMYAM GLVLWELVSR CSEADGTIGE YMLPFEDEVG 420

QHPSLEDLQD VVVHKKMRPV MKDCWLKHPG LSQMCETIEE CWDHDAEARL SAGCVEERIG 480

QIARTVSSTT SDSPISIVTS LTNEDLPPKE SST 513

Nucleotide Sequence
(FASTA)

ATGTCTTTTT CATGGCTGAC TTGTTCACTT CTTCTAGGAA CTTTATGCGC AGGGTACAGT 60

CTGGGCGAAG CAGAGACCCG GGAATGTGTG TACTACAATG ATAACTGGCG CACGGAGAGG 120

ACCAACCAGA GCGGCTTTGA GCGCTGCGAG GGTGAAAAGG ACAAGCGGCT GCATTGCTAC 180

GCCTCTTGGC TCAACTCCTC AGGGACCATC AAGCTGGTGA AGAAAGGCTG CTGGCTGGAC 240

GACTTCAACT GCTATGACAG GCAAGAGTGT GTCTCCATGG AGGAAAACCC TCAGGTGTTC 300

TTCTGCTGCT GCGAGGGGAA CTACTGCAAC GAACGATTCA CTCACCTTCC TGACATCATC 360

GGCAGCGGCA ACCGAGTGAA AATCCGACCT CCTCCTCGAG TGCCATCTTT ACTCAACGTG 420

CTAGTGTACT CGCTGCTGCC TCTGTGCGTC CTTTCACTGG CCCTTCTGCT AGCTCTGTGG 480

ATGTATCGCC ATCGCAAACC TCCCTATGGC CACGTAGACC TGAGCGAGGA TCCTGGACCA 540

GCACCTCCAT CTCCCTTAGT GGGGCTTAAA CCATTGCAGT TGCTGGAAAT CAAAGCTAGG 600

GGGCGCTTTG GTTGCGTTTG GAAGGCTCAG TTAATGAGCG AATATGTCGC TGTAAAGATC 660

TTTCCTGTGC AGAATAAGCA GTCGTGGCAG AACGAACGGG ACATTTTCAT TACCCCGGGG 720

ATGAGGCACG AAAATCTCCT GCGTTACATT GCGGCTGAGA AGCACGGAAC TAACCTGGAG 780

ACCGAGCTGT GGCTCATCAC CGAGTTTCAT GAGAGGGGCT CCCTGACGGA CCATCTGAAG 840

GGGAACGCTG TGAGCTGGAA CGAGCTGTGT CACATCGCAG AGACCATGTC TCGCGGGCTG 900

CACCTCCATG AAGACATTCC CAGCTACAAG GGAGAGGGCC CAAACCCACC ATTGCACACA 960

GGGACTTCAA GAGTAAGAAT GTTATTGCTA CGCGATGATC TGACTGCGGT CATTGGAGAT 1020

TTCGGGCTCG CTGTGAGATT CGAACCTGGA AAACCTCCAG GAGATACACA CGGTCAGGTG 1080

GGTACGAGGC GTTACATGGC TCCAGAGGTG CTAGAGGGAG CCATCAACTT CCAGCGGGAC 1140

TCTTTCTTGA GGATAGACAT GTACGCGATG GGCCTTGTGC TGTGGGAGCT GGTGTCTCGC 1200

TGCTCCGAGG CTGACGGTAC GATCGGCGAA TACATGCTGC CATTCGAGGA TGAAGTGGGC 1260

CAGCATCCAT CCCTGGAGGA TCTGCAGGAT GTGGTTGTGC ACAAAAAGAT GCGTCCAGTC 1320

ATGAAGGACT GTTGGCTCAA ACACCCGGGT CTGAGCCAGA TGTGTGAGAC CATTGAGGAA 1380

TGCTGGGACC ACGACGCGGA GGCGCGCTTG TCGGCAGGCT GCGTGGAAGA GCGCATCGGT 1440

CAGATAGCCA GGACGGTCAG CAGCACTACC TCAGACAGCC CCATCTCCAT TGTGACGTCT 1500

CTCACTAACG AGGACCTACC TCCCAAAGAG TCCAGCACCT GA 1542

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         l+lle+ ++Gr+g+Vwka+l+ e+vAvKif+ ++++sw++E++i+ t+ +rhen+l++ia

Q: 192   LQLLEIKARGRFGCVWKAQLMSEYVAVKIFPVQNKQSWQNERDIFITPGMRHENLLRYIA  251

         6899********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         a+k+ ++++tel+l+te+he+gsL+d+Lk + ++++el+++a+++++Gl hLHe+i+  k

Q: 252   AEKHGTNLETELWLITEFHERGSLTDHLKGNAVSWNELCHIAETMSRGL-HLHEDIPSYK  310

         ************************************************9.9******999

S: 121   g.kkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaP  179

         g    p +     + + +l+++dlt++i+D+GLa+++e  k   d  ++ qvGt+RYmaP

Q: 311   GeGPNPPLHTGTSRVRMLLLRDDLTAVIGDFGLAVRFEPGKPPGD--THGQVGTRRYMAP  368

         9778888888888999**************************888..79***********

S: 180   EvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPslee  239

         Evle+a+n+++ ++f r+D+Y++gLvlWE++sRc+e+d+++ ey+lpfe++vg++Psle+

Q: 369   EVLEGAINFQR-DSFLRIDMYAMGLVLWELVSRCSEADGTIGEYMLPFEDEVGQHPSLED  427

         **********9.9***********************************************

S: 240   mkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         +++vvv+kk+rP +++ w k++ l+++++++eecWd+d+eaRl+a +v++r+

Q: 428   LQDVVVHKKMRPVMKDCWLKHPGLSQMCETIEECWDHDAEARLSAGCVEERI  479

         *************************************************985

Domain Sequence
(FASTA)

LQLLEIKARG RFGCVWKAQL MSEYVAVKIF PVQNKQSWQN ERDIFITPGM RHENLLRYIA 60

AEKHGTNLET ELWLITEFHE RGSLTDHLKG NAVSWNELCH IAETMSRGLH LHEDIPSYKG 120

EGPNPPLHTG TSRVRMLLLR DDLTAVIGDF GLAVRFEPGK PPGDTHGQVG TRRYMAPEVL 180

EGAINFQRDS FLRIDMYAMG LVLWELVSRC SEADGTIGEY MLPFEDEVGQ HPSLEDLQDV 240

VVHKKMRPVM KDCWLKHPGL SQMCETIEEC WDHDAEARLS AGCVEERI 288

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0017002	; F:activin-activated receptor activity
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR015768	; Activin_II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS50011

; PROTEIN_KINASE_DOM; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013