EKS-TEN-00216

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00216

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKC	442.7	5.5E-133	256	524	269

Status

Unreviewed

Ensembl Protein

ENSTNIP00000017955

UniProt Accession

H3DBR2;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKCI

Gene Synonyms/Alias

PRKCI;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000014911	ENSTNIP00000017955	ENSTNIT00000018179

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

598

Protein Sequence
(FASTA)

MPTLRDSTMS HPGENSHQVR VKAYYKGDIM ITHFEPSISY EGLYGEVRDM CSMDNDQLFT 60

MKWIDEEGDP CTVSSQLELE EALRLYELNK DSELIIHVFP CVPENPGMPC PGEDISQSEI 120

YRRGARRWRK LYYASGHAFQ AKRFNPEQRA HCAICADRIW GLGRQGYKCI NCKLLVHKKC 180

HKLVTVECGR PVIQDPVMHD TPSSPGDPSE QPGVPTTQGP RTKDSRENLP DEGEEKEAWR 240

SREAGKSPSS LGLADFELLR VIGRGSYAKV LLVQLKKTER IYAMKVVKKE LVNDDEDIDW 300

VQTEKHVFEQ ASNHPFLVGL HSCFQTESRL FFVIEYVNGG DLMFHMQRQR KLPEEHARFY 360

SAEISLALNY LHERGIIYRD LKLDNVLLDS EGHIKLTDYG MCKEGLRPGD TTSTFCGTPN 420

YIAPEILRGE DYGFSVDWWA LGVLMFEMMA GRSPFDIVGS SDNPDQNTED YLFQVILEKQ 480

IRIPRSLSVK AASVLKGFLN KDPKERLGCH PQTGFADIMG HPFFRNVDWD LLEQKQMVPP 540

FKPNISGEFG LDNFDAQFTN EPIQLTPDDD DVVKKIDQSE FEGFEYINPL LMSAEECV 598

Nucleotide Sequence
(FASTA)

ATGCCGACGT TGCGGGACAG CACCATGTCC CACCCCGGCG AGAATTCCCA CCAAGTTCGG 60

GTTAAAGCTT ATTACAAAGG GGACATCATG ATCACTCACT TTGAGCCGTC CATCTCCTAC 120

GAGGGTCTCT ATGGGGAAGT TAGAGACATG TGTTCCATGG ACAACGACCA GCTTTTCACC 180

ATGAAGTGGA TCGACGAGGA AGGTGACCCC TGCACCGTGT CCTCTCAGCT GGAGCTGGAA 240

GAAGCTCTAC GGCTCTATGA ACTCAACAAA GATTCCGAGC TCATCATTCA CGTGTTCCCG 300

TGTGTACCAG AGAATCCTGG CATGCCCTGT CCAGGAGAAG ACATTTCACA GAGTGAGATA 360

TATCGGCGTG GAGCACGGCG CTGGAGGAAA CTTTATTACG CCAGTGGCCA CGCTTTCCAA 420

GCCAAGCGCT TTAACCCGGA GCAGCGAGCC CACTGTGCCA TCTGTGCAGA TCGTATCTGG 480

GGTTTAGGAC GACAAGGCTA CAAATGCATC AACTGCAAAC TCCTGGTGCA TAAAAAGTGC 540

CATAAACTGG TCACGGTGGA GTGTGGCAGG CCAGTGATTC AGGATCCGGT GATGCACGAC 600

ACACCCTCGA GTCCCGGAGA CCCAAGTGAA CAGCCAGGTG TGCCAACCAC GCAAGGTCCC 660

CGGACAAAAG ACTCGAGAGA AAATTTGCCT GATGAAGGAG AAGAAAAAGA GGCGTGGCGA 720

AGTAGGGAAG CTGGGAAATC GCCTTCCAGC CTGGGTCTGG CGGACTTTGA GCTGCTGAGG 780

GTGATCGGAC GAGGCAGCTA CGCAAAGGTG CTGTTGGTGC AGCTGAAGAA GACGGAGCGC 840

ATCTACGCCA TGAAAGTGGT GAAGAAAGAG CTGGTCAACG ACGACGAGGA TATCGATTGG 900

GTCCAAACAG AGAAGCACGT ATTTGAACAG GCCTCTAATC ACCCCTTCCT GGTTGGCCTA 960

CATTCCTGTT TTCAGACAGA AAGCAGACTT TTCTTTGTTA TCGAATATGT AAACGGCGGT 1020

GATCTCATGT TCCACATGCA GAGACAAAGG AAGCTCCCCG AGGAACATGC CAGGTTCTAC 1080

TCAGCAGAGA TCAGTTTGGC GCTCAACTAC CTTCACGAGC GAGGAATCAT CTACAGGGAT 1140

TTGAAACTGG ACAACGTGCT TTTGGACTCA GAAGGACACA TCAAGCTCAC AGACTACGGC 1200

ATGTGCAAGG AGGGATTGAG ACCTGGTGAC ACAACAAGCA CTTTCTGCGG GACTCCTAAT 1260

TACATTGCCC CTGAAATACT CCGAGGAGAG GATTACGGGT TCAGTGTGGA CTGGTGGGCC 1320

CTGGGAGTGT TGATGTTTGA AATGATGGCG GGCCGGTCGC CTTTCGACAT CGTGGGGAGC 1380

TCCGACAACC CCGATCAGAA CACAGAAGAC TACCTCTTCC AAGTTATATT GGAAAAACAG 1440

ATCCGAATCC CCCGCTCGTT GTCGGTCAAA GCGGCCAGCG TCCTCAAGGG ATTCCTCAAC 1500

AAGGATCCCA AGGAGCGTCT GGGCTGCCAC CCTCAGACGG GCTTCGCTGA CATCATGGGT 1560

CACCCCTTCT TCAGAAACGT TGACTGGGAC CTTCTGGAGC AGAAGCAGAT GGTCCCTCCT 1620

TTTAAGCCCA ACATCTCAGG GGAGTTCGGA TTGGACAACT TCGACGCCCA GTTCACCAAC 1680

GAACCCATTC AGCTCACCCC GGACGACGAC GACGTCGTCA AGAAGATCGA CCAGTCGGAG 1740

TTTGAAGGAT TCGAGTACAT CAACCCACTC CTGATGTCAG CGGAGGAGTG CGTGTGA 1797

Domain Profile

S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60

         fell+v+G+Gs++kvll++lkkt+++ya+kv+kk++v++d+d++++++ek+v+++as++p

Q: 256   FELLRVIGRGSYAKVLLVQLKKTERIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHP  315

         89**********************************************************

S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120

         flv l+scfqte+rlffv+eyvnGGdlmfh+q++rkl+ee+arfy+aei+lal++lhe+g

Q: 316   FLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERG  375

         ************************************************************

S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180

         iiyrdlkldnvlld+eGhikl+d+G+cke++  g+ttstfcGtP+yiaPeil++e+yg+s

Q: 376   IIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFS  435

         ************************************************************

S: 181   vdwwalGvllyemlagqsPfe.........gededelfesilekevlyPkslskeaveil  231

         vdwwalGvl++em+ag+sPf+         +++ed+lf++ilek++++P+sls++a+++l

Q: 436   VDWWALGVLMFEMMAGRSPFDivgssdnpdQNTEDYLFQVILEKQIRIPRSLSVKAASVL  495

         *****************************99*****************************

S: 232   kglltkdpekrlGvk.eegeedikehaff  259

         kg+l+kdp++rlG++ ++g +di+ h+ff

Q: 496   KGFLNKDPKERLGCHpQTGFADIMGHPFF  524

         **************989***********9

Domain Sequence
(FASTA)

FELLRVIGRG SYAKVLLVQL KKTERIYAMK VVKKELVNDD EDIDWVQTEK HVFEQASNHP 60

FLVGLHSCFQ TESRLFFVIE YVNGGDLMFH MQRQRKLPEE HARFYSAEIS LALNYLHERG 120

IIYRDLKLDN VLLDSEGHIK LTDYGMCKEG LRPGDTTSTF CGTPNYIAPE ILRGEDYGFS 180

VDWWALGVLM FEMMAGRSPF DIVGSSDNPD QNTEDYLFQV ILEKQIRIPR SLSVKAASVL 240

KGFLNKDPKE RLGCHPQTGF ADIMGHPFF 269

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0031226	; C:intrinsic to plasma membrane
GO:0005915	; C:zonula adherens
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0008270	; F:zinc ion binding
GO:0034334	; P:adherens junction maintenance
GO:0045217	; P:cell-cell junction maintenance
GO:0007502	; P:digestive tract mesoderm development
GO:0048546	; P:digestive tract morphogenesis
GO:0021744	; P:dorsal motor nucleus of vagus nerve development
GO:0035050	; P:embryonic heart tube development
GO:0000132	; P:establishment of mitotic spindle orientation
GO:0016332	; P:establishment or maintenance of polarity of embryonic epithelium
GO:0035556	; P:intracellular signal transduction
GO:0045199	; P:maintenance of epithelial cell apical/basal polarity
GO:0008078	; P:mesodermal cell migration
GO:0001738	; P:morphogenesis of a polarized epithelium
GO:0001841	; P:neural tube formation
GO:0007405	; P:neuroblast proliferation
GO:0007097	; P:nuclear migration
GO:0042476	; P:odontogenesis
GO:0060042	; P:retina morphogenesis in camera-type eye

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR000270	; OPR_PB1.
IPR012233	; PKC_zeta.
IPR017892	; Pkinase_C.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00130	; C1_1; 1.
PF00564	; PB1; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 1.
SM00666	; PB1; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

PR00008

; DAGPEDOMAIN.

Created Date

20-Feb-2013