EKS-TEN-00389

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00389

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/EGFR	415.1	1.2E-124	707	963	257

Status

Unreviewed

Ensembl Protein

ENSTNIP00000018114

UniProt Accession

H3DC71;

Protein Name

Protein Synonyms/Alias

Gene Name

ERBB3 (1 of 2)

Gene Synonyms/Alias

ERBB3 (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000015062	ENSTNIP00000018114	ENSTNIT00000018338

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

1333

Protein Sequence
(FASTA)

MVLWRLLMMC LTSALPAASS QRQEAVCPGT QNGLSSTGSQ ENQYNLTKDR YNGCEIIMGN 60

LEITQIESDW DFSFLKTIRE VTGYVLIAMN HFQEIPLEQL RVIRGNSLYE RRFALSVFLN 120

YPKDGSSGMN RLSLMNLTEI LDGGVQIINN KYLRYGPWVY WQDIIRNNDA PIEIQFNGAR 180

GGCHKSCGDY CWGPDKDQCQ ILTKTVCAPQ CNDRCFGTSP RDCCHVECAA GCKGPLDTDC 240

FACRHFNDSG ACVPQCPLTL IYNKQTFQME TNPNAKYQYG SICVSQCPTH FVVDGRSCVS 300

VCPPGKTEVE RGGQRQCELC SGLCPKVCEG TGAEHRQTVD SSNIDSFVNC TKIQGSLHFL 360

VTGILGDEFK NVPPLDAKKL EVFRTVREIT DILNIQSWPR QLNDLSVFSS LTTIQGRSLH 420

KRFSLMVMRI PTLTSLGLRS LREISDGSVY ISQNANLCYH HTVNWTQLFR GGRDRANSLS 480

SNRPLTDCVA DGRVCDPLCS DSGCWGPGPD QCLSCRKYSR HGTCVADCFF YSGFSREFAA 540

LDGECVACHP ECKPQTGRVS CTGPGADKCV ECTNFQDGPY CMPSCPNGVN DGQRGLIFKF 600

PNREGHCEPC HQNCTQGCSG PGLNDCLEAA RLAVSSGQIT GIALGVPAGL IFCLVLFFLG 660

MLYHRGLAIR RKRAMRRYLE SGESFEPLGP GEKGTKVYAR VLKPSELRKI KSLGSGVFGT 720

VNKGFWTPEG ETVKIPVAIK TIQDSSGRRT FTEITDHMLS MGSLDHPYIV RLLGICPGPS 780

LQLVTQLSSH GSLLEHIRQH KTSLDPQRLL NWCVQIAKGM YYLEEHRMVH RNLAARNILL 840

KNDYQVQISD YGVADLLYPD DKKYIYTETK TPIKWMALES ILFRRYSHQS DVWSYGVTVW 900

EMMSFGAEPY ASVQPQEVPS LLEKGERLSQ PPICTIDVYM VMVKCWMIDE NIRPTFKELA 960

SDFTRMARDP PRYLVIRMEG EEPGTAEIHR RGSGRGLLEA DLEEDEEEGL GASFATPPLQ 1020

HSPPWTSRSR INSYMVTTHS SEFQSAASQV GHIGYLPMTP SPVDTIRQLW YRRSRLSSVR 1080

TLPDRSEFRG SSREAELCED APRCAGIFRV RFGSETGNPQ RFTGCQRKLS TASSPSSFKT 1140

WGADEEEEDP FGYVLAGSPV VPERVCRVSQ RSSRFKNNLS SAAMKHQQEY EIMRKGTPGS 1200

GTKAVDEQGE AAQGICGYEY MDIRCASSAE EDNPAKKTPA TCAGEAEETD QMVAELKEEL 1260

REVEEEEDKC HNTDDEEPVQ YEEMTIQCVV PIGWEQADYQ NVPVKGRTCR NTSFDNPDYW 1320

HSRLFLQPDA VRT 1333

Nucleotide Sequence
(FASTA)

ATGGTCCTGT GGCGGCTCCT GATGATGTGC CTGACTTCAG CCCTGCCAGC AGCTTCGTCC 60

CAAAGGCAAG AAGCCGTGTG CCCCGGCACG CAGAACGGGC TGAGCTCCAC CGGTTCTCAG 120

GAGAACCAGT ACAATCTGAC TAAAGACCGT TACAACGGCT GCGAGATCAT CATGGGCAAC 180

CTGGAGATCA CTCAGATCGA GAGCGACTGG GACTTCTCCT TCCTCAAGAC CATCCGCGAG 240

GTGACTGGAT ACGTCCTCAT CGCGATGAAT CACTTTCAGG AGATTCCTCT GGAGCAGCTG 300

CGAGTCATCA GAGGAAACAG CCTGTACGAG CGGCGCTTCG CCCTCTCCGT CTTCCTCAAC 360

TACCCCAAGG ACGGCTCCAG CGGCATGAAT CGGCTCAGCC TCATGAATCT AACAGAAATT 420

CTAGACGGAG GAGTGCAGAT AATCAACAAC AAGTACCTGA GATATGGCCC CTGGGTCTAC 480

TGGCAGGACA TCATCCGGAA CAATGACGCA CCCATTGAAA TCCAGTTCAA CGGAGCGAGA 540

GGCGGGTGTC ACAAGTCCTG TGGAGACTAC TGCTGGGGCC CAGACAAGGA CCAGTGTCAG 600

ATCTTGACGA AGACGGTGTG CGCGCCGCAG TGTAATGACC GCTGTTTTGG GACCAGCCCC 660

AGGGACTGCT GTCACGTAGA ATGCGCGGCG GGATGTAAAG GCCCCCTGGA CACCGACTGC 720

TTTGCGTGTC GCCATTTCAA CGACTCTGGG GCCTGCGTTC CTCAGTGTCC CCTGACTCTG 780

ATCTACAACA AGCAGACATT CCAAATGGAA ACCAACCCCA ATGCTAAATA CCAGTATGGG 840

TCCATCTGTG TTTCCCAGTG CCCCACTCAT TTTGTGGTGG ATGGAAGGTC CTGCGTGAGC 900

GTTTGCCCCC CAGGCAAGAC GGAGGTGGAG CGAGGCGGCC AGAGGCAGTG TGAACTCTGC 960

AGTGGACTCT GCCCAAAAGT GTGTGAAGGC ACAGGCGCAG AGCACAGACA GACAGTGGAC 1020

TCAAGCAACA TCGACAGCTT CGTCAACTGC ACCAAGATCC AGGGCAGCCT CCACTTCCTG 1080

GTGACGGGGA TCCTGGGAGA TGAGTTTAAA AATGTTCCAC CTCTGGATGC CAAAAAGTTG 1140

GAGGTGTTCC GCACTGTCAG GGAGATCACA GATATCCTAA ACATCCAGTC GTGGCCCAGA 1200

CAGCTGAACG ATCTGTCTGT TTTTTCAAGT CTCACCACCA TCCAAGGAAG ATCTCTGCAC 1260

AAGCGATTTT CCCTCATGGT GATGCGCATC CCCACCCTGA CCTCGCTGGG GCTGCGCTCC 1320

CTCCGGGAGA TCAGCGACGG CAGCGTGTAC ATCAGTCAGA ACGCCAACCT GTGCTACCAC 1380

CACACGGTGA ACTGGACGCA GCTGTTCCGG GGCGGCAGAG ACCGGGCCAA CAGCCTCAGC 1440

AGCAACAGGC CGCTGACAGA CTGTGTTGCA GACGGCCGGG TGTGTGACCC GCTGTGTTCA 1500

GACTCCGGCT GTTGGGGCCC GGGACCTGAC CAGTGCCTCT CCTGCAGGAA GTACAGTCGC 1560

CACGGCACAT GTGTTGCCGA CTGTTTTTTT TACTCTGGAT TTTCAAGGGA ATTTGCAGCA 1620

CTTGATGGGG AATGCGTTGC CTGCCACCCA GAGTGTAAGC CGCAGACCGG GAGAGTCAGC 1680

TGTACTGGAC CGGGCGCAGA CAAGTGTGTG GAATGCACCA ACTTTCAAGA TGGACCCTAC 1740

TGTATGCCGT CTTGTCCTAA TGGGGTGAAC GACGGCCAGA GGGGCCTGAT CTTTAAATTC 1800

CCCAACAGAG AGGGTCACTG TGAGCCGTGT CACCAAAACT GCACACAGGG ATGTTCGGGC 1860

CCAGGGTTAA ATGACTGTTT GGAGGCTGCC AGGTTGGCGG TTAGTAGTGG TCAGATTACA 1920

GGTATAGCCC TAGGGGTCCC TGCTGGCTTG ATATTCTGCT TGGTGTTGTT TTTCCTGGGC 1980

ATGCTGTACC ATCGCGGTCT AGCCATTCGC CGCAAGAGAG CCATGAGGAG GTACCTGGAG 2040

AGTGGAGAGA GCTTTGAGCC ACTGGGGCCC GGGGAGAAAG GTACCAAAGT TTATGCTCGC 2100

GTCTTGAAGC CCTCAGAGTT GAGGAAAATT AAATCCCTGG GTTCAGGAGT TTTTGGAACA 2160

GTTAACAAGG GGTTTTGGAC CCCAGAGGGA GAAACGGTGA AGATCCCTGT GGCCATCAAG 2220

ACCATCCAGG ACAGCTCAGG TCGACGGACC TTCACCGAGA TTACCGATCA TATGCTGTCC 2280

ATGGGCAGTC TGGACCATCC GTACATCGTT AGACTCCTGG GTATCTGCCC AGGTCCCAGT 2340

CTGCAACTGG TGACCCAGCT CAGTTCACAC GGCTCCTTGT TGGAACATAT CAGACAGCAC 2400

AAGACCAGCC TGGACCCCCA GCGTCTTCTC AACTGGTGTG TCCAGATCGC CAAAGGCATG 2460

TACTACCTAG AGGAGCACCG CATGGTCCAC AGGAACCTGG CTGCTCGCAA TATCCTGCTG 2520

AAGAACGACT ACCAGGTCCA GATCTCTGAC TACGGCGTGG CGGACCTGCT TTACCCAGAC 2580

GACAAGAAAT ACATCTACAC TGAAACTAAG ACTCCCATAA AATGGATGGC GCTTGAAAGC 2640

ATTTTATTCC GAAGATACAG CCATCAAAGT GATGTCTGGA GTTACGGAGT GACGGTGTGG 2700

GAGATGATGT CATTTGGGGC AGAGCCATAT GCGTCCGTGC AGCCTCAGGA GGTTCCCAGT 2760

CTGCTGGAGA AGGGCGAGAG ACTGTCCCAG CCGCCCATCT GTACCATAGA TGTATACATG 2820

GTTATGGTTA AATGCTGGAT GATCGACGAA AACATAAGGC CGACTTTCAA AGAGCTAGCC 2880

AGCGACTTCA CCCGCATGGC AAGAGACCCG CCGAGATATC TGGTCATCAG GATGGAAGGA 2940

GAAGAACCAG GAACGGCAGA GATTCACCGA AGGGGATCGG GGCGAGGTCT TCTGGAAGCA 3000

GACTTGGAGG AGGACGAAGA GGAGGGACTG GGGGCCAGTT TTGCCACCCC TCCCCTTCAG 3060

CACTCTCCCC CCTGGACGTC TCGGTCACGG ATAAACTCCT ACATGGTAAC GACTCACAGC 3120

TCAGAATTTC AGAGTGCTGC CTCTCAGGTT GGACATATTG GATACCTGCC CATGACCCCT 3180

AGTCCAGTGG ACACCATCCG CCAGCTGTGG TATCGAAGGT CCCGCCTGAG CTCGGTGAGG 3240

ACACTCCCCG ACAGGTCAGA GTTCAGGGGG AGCAGCAGGG AGGCGGAGCT GTGTGAAGAC 3300

GCCCCACGGT GCGCTGGTAT CTTCAGGGTC CGGTTCGGCT CAGAGACGGG GAATCCTCAG 3360

AGATTCACAG GCTGTCAGAG GAAACTCTCA ACAGCATCGA GTCCCTCATC GTTTAAGACG 3420

TGGGGGGCAG ATGAGGAGGA GGAGGACCCG TTCGGCTACG TTCTGGCTGG GTCACCTGTC 3480

GTTCCAGAGA GAGTCTGTAG AGTCTCACAA AGAAGCTCAA GATTCAAGAA TAACCTGTCT 3540

TCCGCAGCGA TGAAACACCA ACAGGAGTAT GAAATCATGA GAAAAGGGAC CCCTGGGAGC 3600

GGGACAAAGG CTGTTGATGA ACAAGGAGAG GCAGCACAAG GGATATGCGG GTACGAATAC 3660

ATGGACATCA GGTGTGCCAG CTCTGCAGAA GAAGACAATC CAGCAAAGAA GACTCCTGCA 3720

ACATGTGCAG GAGAAGCTGA GGAGACCGAT CAAATGGTGG CGGAGTTAAA AGAAGAGCTC 3780

AGGGAGGTTG AAGAAGAAGA GGACAAATGC CACAACACAG ATGATGAAGA GCCAGTGCAG 3840

TATGAGGAAA TGACGATACA GTGTGTGGTT CCCATCGGAT GGGAGCAGGC AGATTACCAG 3900

AACGTCCCAG TGAAAGGAAG GACCTGTCGT AACACATCAT TTGACAACCC AGACTACTGG 3960

CACAGTAGAC TGTTCCTCCA GCCAGATGCT GTCCGCACCT GA 4002

Domain Profile

S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60

         l+k+k lGsG+fGtv kG w pege+vkipvaik +++++g+++++e++d++l ++sldh

Q: 707   LRKIKSLGSGVFGTVNKGFWTPEGETVKIPVAIKTIQDSSGRRTFTEITDHMLSMGSLDH  766

         69**********************************************************

S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120

         +++vrllg+c   +lqlvtql  +G+ll+++r+hk +l +q llnwcvqiakGm+ylee+

Q: 767   PYIVRLLGICPGPSLQLVTQLSSHGSLLEHIRQHKTSLDPQRLLNWCVQIAKGMYYLEEH  826

         ************************************************************

S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180

         r+vhr+laarn+l+k+  +v+i+d+G+a+ll  d+k++ + ++k+pikw+alesil+r+y

Q: 827   RMVHRNLAARNILLKNDYQVQISDYGVADLLYPDDKKYIYTETKTPIKWMALESILFRRY  886

         ************************************************************

S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240

         +hqsdvwsyGvtvwe+++fGa+py++++ +e+p+llekGerl+qppictidvymv+vkcw

Q: 887   SHQSDVWSYGVTVWEMMSFGAEPYASVQPQEVPSLLEKGERLSQPPICTIDVYMVMVKCW  946

         ************************************************************

S: 241   midaesrpkfkelaeef  257

         mid+++rp+fkela++f

Q: 947   MIDENIRPTFKELASDF  963

         **************998

Domain Sequence
(FASTA)

LRKIKSLGSG VFGTVNKGFW TPEGETVKIP VAIKTIQDSS GRRTFTEITD HMLSMGSLDH 60

PYIVRLLGIC PGPSLQLVTQ LSSHGSLLEH IRQHKTSLDP QRLLNWCVQI AKGMYYLEEH 120

RMVHRNLAAR NILLKNDYQV QISDYGVADL LYPDDKKYIY TETKTPIKWM ALESILFRRY 180

SHQSDVWSYG VTVWEMMSFG AEPYASVQPQ EVPSLLEKGE RLSQPPICTI DVYMVMVKCW 240

MIDENIRPTF KELASDF 257

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Danio rerio"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Loxodonta africana"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Rattus norvegicus"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004716	; F:receptor signaling protein tyrosine kinase activity
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0023014	; P:signal transduction by phosphorylation
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR000494	; EGF_rcpt_L.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR020635	; Tyr_kinase_cat_dom.
IPR016245	; Tyr_kinase_EGF/ERB/XmrK_rcpt.

Pfam

PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00261	; FU; 4.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013