EKS-TEN-00355

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00355

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	452.5	6.7E-136	190	477	288

Status

Unreviewed

Ensembl Protein

ENSTNIP00000018123

UniProt Accession

H3DC80;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR1B (3 of 3)

Gene Synonyms/Alias

ACVR1B (3 of 3);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000015070	ENSTNIP00000018123	ENSTNIT00000018347

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

488

Protein Sequence
(FASTA)

YTSHWAAPSQ PVCLALRCNC TNCETNGYEC ETDGACMAST YYVEGKEQHI RICINRDSLV 60

PPGHPFYCVS AEGLLNTHCC YEDYCNSIDL KVPGEEGLVV GSSWGPVELV AVIAGPVFLL 120

CVLLMVGVFL FQYHQRAYSH RQRLEVEDPS CDHIYLPKDK TLQDLIYDMS TSGSGSGLPL 180

FVQRTVARTI VLQEIIGKGR FGEVWRGKWR GGDVAVKIFS SREERSWFRE AEIYQTIMLR 240

HENILGFIAA DNKDNGTWTQ LWLVSDYHEH GSLFDYLNRY SVTIEGMIKL ALSAASGLAH 300

LHMEILGTQG KPGIAHRDLK SKNILVKKNG MCAIADLGLA VRHESITDTI DIAPNQRVGT 360

KRYMAPEVLD ETINMKHFDS FKCADIYALG LVYWEIARRC NAGGIHEEYQ LPYYDLVPSD 420

PSIDEMRRVV CEQKLRPNVP NWWQSYEALR VMGKIMRECW YANGAARLTA LRIKKTLSQL 480

SVEEDVKI 488

Nucleotide Sequence
(FASTA)

TATACCTCCC ACTGGGCCGC TCCATCGCAG CCTGTGTGTT TGGCGCTACG TTGCAACTGC 60

ACCAACTGTG AGACCAACGG TTATGAGTGC GAGACGGACG GCGCCTGCAT GGCCTCCACG 120

TATTACGTGG AGGGGAAGGA GCAACACATA CGCATCTGCA TCAACCGGGA CAGCCTGGTC 180

CCCCCCGGAC ACCCCTTCTA CTGCGTGAGT GCCGAGGGTC TGCTGAACAC ACACTGCTGC 240

TATGAAGATT ACTGCAACAG CATCGACCTG AAGGTTCCCG GTGAGGAAGG GCTGGTGGTC 300

GGCAGCTCCT GGGGACCCGT GGAGCTGGTG GCGGTCATCG CCGGGCCGGT GTTCCTCCTC 360

TGCGTGCTGC TGATGGTGGG CGTGTTCCTC TTTCAGTACC ACCAGAGAGC CTACAGCCAC 420

AGGCAGAGGC TGGAGGTGGA GGACCCCTCC TGTGACCACA TCTACCTGCC CAAAGACAAG 480

ACGCTGCAGG ACCTCATCTA CGACATGTCC ACCTCCGGCT CCGGCTCCGG TCTGCCCCTG 540

TTTGTGCAGC GGACGGTGGC CAGGACCATC GTCCTGCAGG AGATCATCGG GAAAGGACGC 600

TTCGGCGAGG TGTGGAGGGG GAAGTGGAGG GGCGGCGACG TGGCCGTGAA GATCTTCTCG 660

TCCAGAGAGG AGCGCTCCTG GTTCCGAGAG GCGGAAATCT ACCAGACCAT CATGCTGCGG 720

CACGAGAACA TCCTGGGCTT CATCGCGGCG GACAACAAAG ACAACGGCAC CTGGACGCAG 780

CTGTGGCTGG TGTCTGACTA CCACGAGCAC GGCTCCCTCT TCGACTACCT GAACCGCTAC 840

TCGGTCACCA TCGAGGGCAT GATCAAACTG GCGCTGTCGG CCGCCAGCGG CCTGGCCCAC 900

CTGCACATGG AGATCCTCGG CACCCAGGGT AAACCCGGCA TCGCTCACCG CGACCTCAAG 960

TCCAAGAACA TCCTGGTTAA GAAGAACGGC ATGTGCGCCA TCGCTGACCT GGGCCTGGCC 1020

GTCCGCCACG AATCCATCAC CGACACCATC GATATCGCCC CCAACCAGCG CGTGGGCACC 1080

AAGAGGTACA TGGCCCCGGA GGTCCTGGAC GAGACCATCA ACATGAAACA CTTTGACTCC 1140

TTCAAGTGTG CGGACATTTA CGCGCTGGGC CTGGTCTACT GGGAGATCGC CCGCCGCTGC 1200

AACGCTGGAG GGATCCACGA GGAGTACCAG CTTCCATACT ACGACCTCGT GCCCTCCGAC 1260

CCCTCCATAG ACGAAATGAG GAGGGTGGTG TGTGAGCAGA AACTCAGGCC CAACGTTCCC 1320

AACTGGTGGC AGAGCTACGA GGCCCTGCGC GTCATGGGGA AGATCATGAG GGAGTGCTGG 1380

TACGCCAACG GAGCGGCCAG ACTGACGGCG CTGCGCATCA AGAAGACCCT GTCCCAGCTC 1440

AGCGTGGAGG AGGACGTCAA GATCTGA 1467

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e+igkGr+geVw++k+rg +vAvKifs+++e+sw+rE+eiyqt++lrhenil+fia

Q: 190   IVLQEIIGKGRFGEVWRGKWRGGDVAVKIFSSREERSWFREAEIYQTIMLRHENILGFIA  249

         5789********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lv++yhe+gsL+dyL+r+ +++e +++lals+asGlahLH+ei gt+

Q: 250   ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYSVTIEGMIKLALSAASGLAHLHMEILGTQ  309

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  Kp iaHRDlkskNilvkk+++c+iaDlGLa+++e+ ++++d+a n++vGtkRYmaPE

Q: 310   G--KPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHESITDTIDIAPNQRVGTKRYMAPE  367

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e++n+k+f++fk+aD+Y+lgLv+WE+a+Rc++ ++++eey+lp+++ v+sdPs++em

Q: 368   VLDETINMKHFDSFKCADIYALGLVYWEIARRCNA-GGIHEEYQLPYYDLVPSDPSIDEM  426

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+e+klrP++p+ w++ eal+++ k+++ecW+a+++aRltalr+kk+l

Q: 427   RRVVCEQKLRPNVPNWWQSYEALRVMGKIMRECWYANGAARLTALRIKKTL  477

         *************************************************97

Domain Sequence
(FASTA)

IVLQEIIGKG RFGEVWRGKW RGGDVAVKIF SSREERSWFR EAEIYQTIML RHENILGFIA 60

ADNKDNGTWT QLWLVSDYHE HGSLFDYLNR YSVTIEGMIK LALSAASGLA HLHMEILGTQ 120

GKPGIAHRDL KSKNILVKKN GMCAIADLGL AVRHESITDT IDIAPNQRVG TKRYMAPEVL 180

DETINMKHFD SFKCADIYAL GLVYWEIARR CNAGGIHEEY QLPYYDLVPS DPSIDEMRRV 240

VCEQKLRPNV PNWWQSYEAL RVMGKIMREC WYANGAARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013