EKS-TEN-00571

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00571

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	433.9	2.8E-130	25	308	284

Status

Unreviewed

Ensembl Protein

ENSTNIP00000022803

UniProt Accession

H3DCD0;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK14 (2 of 2)

Gene Synonyms/Alias

MAPK14 (2 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000015118	ENSTNIP00000022803	ENSTNIT00000023044
ENSTNIG00000015118	ENSTNIP00000004469	ENSTNIT00000004610
ENSTNIG00000015118	ENSTNIP00000018173	ENSTNIT00000018397

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

359

Protein Sequence
(FASTA)

MSLEERPSFY RQEVNKTIWE VPERYQNLSP VGSGAYGSVC SADDIKTGLK VAVKKLSRPF 60

QSIIHAKRTY RELRLLKHMK HENVIGLLDV FSPASCLKEF KDVYLVTHLM GADLNNIVKC 120

QKLTDDHVQF LIYQILRGLK YIHSADIIHR DLKPGNLAVN EDCELKILDF GLARHTDDEM 180

TGYVATRWYR APEIMLNWMH YNMTVDIWSV GCIMAELLGR TLFPGTDHID QLKLIMLLVG 240

TPGPELLKKL SSESARNYIH SLPHMPKRNF ADVFLGANPH AVDLLEKMLV LDTDKRITAA 300

EALAHPYFTQ YHDPEDEPVA EPLDQSFESR DLKIEEWKRL TYEEVCSFEP PLFDENDME 359

Nucleotide Sequence
(FASTA)

ATGTCGCTTG AAGAAAGACC CAGCTTTTAC CGACAGGAAG TCAACAAGAC CATATGGGAA 60

GTCCCGGAAC GATACCAAAA CCTGTCCCCG GTTGGTTCTG GTGCTTATGG ATCCGTGTGT 120

TCTGCAGATG ATATCAAGAC TGGGCTGAAG GTGGCTGTGA AGAAGCTCTC GCGTCCATTT 180

CAGTCCATCA TCCACGCCAA GAGGACGTAC AGAGAGCTGC GGCTACTAAA GCACATGAAA 240

CACGAAAATG TGATTGGCCT CCTAGACGTC TTCTCTCCAG CTTCTTGTCT GAAGGAATTC 300

AAGGACGTGT ATCTGGTGAC CCATTTGATG GGGGCAGATC TCAACAACAT CGTCAAATGT 360

CAGAAACTCA CAGACGACCA CGTGCAGTTC CTCATTTATC AGATCCTCCG GGGACTAAAG 420

TACATCCACT CTGCAGATAT CATTCATAGA GATTTGAAAC CTGGTAATCT GGCGGTGAAT 480

GAAGACTGTG AGCTGAAGAT TTTGGACTTT GGTTTGGCCC GGCACACCGA CGATGAGATG 540

ACCGGCTACG TGGCCACTCG CTGGTACCGT GCGCCGGAGA TCATGTTAAA CTGGATGCAT 600

TACAACATGA CAGTGGATAT TTGGTCGGTG GGGTGTATAA TGGCTGAACT CCTTGGAAGA 660

ACTCTGTTTC CTGGTACTGA CCACATTGAT CAGTTGAAGC TTATCATGCT CCTCGTGGGA 720

ACACCCGGTC CTGAGCTCTT GAAGAAACTC TCTTCAGAGT CTGCCAGGAA CTACATCCAC 780

TCCCTGCCAC ACATGCCCAA GAGGAACTTT GCTGATGTGT TTCTTGGTGC TAACCCACAT 840

GCTGTGGACC TTCTAGAGAA AATGCTGGTT CTGGACACGG ACAAGAGAAT AACAGCCGCC 900

GAAGCTCTGG CTCACCCCTA TTTCACCCAG TACCACGACC CAGAGGACGA GCCTGTGGCC 960

GAGCCGTTGG ACCAGAGCTT TGAGAGTCGG GACTTGAAGA TCGAAGAATG GAAACGATTG 1020

ACCTACGAGG AGGTTTGCAG TTTTGAGCCG CCACTTTTTG ACGAGAACGA CATGGAATGA 1080

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++l+p+g+Gayg v+sa d +t+ +va+kklsrpfq+ ++akrt+REl+llk++kheN+

Q: 25    YQNLSPVGSGAYGSVCSADDIKTGLKVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENV  84

         899*********************************************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120

         i lldvf p++ l+e+kdvYlvt+lm++dL++++k qkl+d+h+++l+yqilrglky+Hs

Q: 85    IGLLDVFSPASCLKEFKDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHS  144

         ************************************************************

S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslke  180

         a++iHrDlKP+Nl+vnedcelkildFGlar++d+e    +t+yvatrwYraPei+l++++

Q: 145   ADIIHRDLKPGNLAVNEDCELKILDFGLARHTDDE----MTGYVATRWYRAPEIMLNWMH  200

         **********************************9....*********************

S: 181   ytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyi  240

         y+ +vDiWsvGCI+aEll g++lfpg+d+idql++i+ ++gtp  e lkk++se+arnyi

Q: 201   YNMTVDIWSVGCIMAELL-GRTLFPGTDHIDQLKLIMLLVGTPGPELLKKLSSESARNYI  259

         ****************98.789**************************************

S: 241   kslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         +slp+++k++f+++f  a+++a+dLlek+Lvld+dkRi+++eaL+hpY+

Q: 260   HSLPHMPKRNFADVFLGANPHAVDLLEKMLVLDTDKRITAAEALAHPYF  308

         ************************************************6

Domain Sequence
(FASTA)

YQNLSPVGSG AYGSVCSADD IKTGLKVAVK KLSRPFQSII HAKRTYRELR LLKHMKHENV 60

IGLLDVFSPA SCLKEFKDVY LVTHLMGADL NNIVKCQKLT DDHVQFLIYQ ILRGLKYIHS 120

ADIIHRDLKP GNLAVNEDCE LKILDFGLAR HTDDEMTGYV ATRWYRAPEI MLNWMHYNMT 180

VDIWSVGCIM AELLGRTLFP GTDHIDQLKL IMLLVGTPGP ELLKKLSSES ARNYIHSLPH 240

MPKRNFADVF LGANPHAVDL LEKMLVLDTD KRITAAEALA HPYF 284

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008352	; MAPK_p38.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

PR01773

; P38MAPKINASE.

Created Date

20-Feb-2013