EKS-TEN-00324

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00324

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	250.2	2.1E-74	50	310	261

Status

Unreviewed

Ensembl Protein

ENSTNIP00000018374

UniProt Accession

H3DCY1;

Protein Name

Protein Synonyms/Alias

Gene Name

STK11

Gene Synonyms/Alias

STK11;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000015311	ENSTNIP00000018374	ENSTNIT00000018599

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

441

Protein Sequence
(FASTA)

EAAMSTGELH QLDYLNENEL MEMDTFIHRI DSTEVIYQPR RKRAKLIGKY LMGDLLGEGS 60

YGKVKEMLDS ETLCRRAVKI LKKKKLRRIP NGEANVKKEI QLLRRLQHKN VIQLVDVLYN 120

EEKQKMYMVM EYCVCGMQEM LDSVPEKRFP VFQAHGYFCQ LLDGLEYLHS QGIVHKDIKP 180

GNLLLTTDGA LKISDLGVAE ALHPFAEDDT CRTSQGSPAF QPPEIANGLD TFSGFKVDIW 240

SAGVTLYNIT TSLYPFEGDN IYKLFENIGK GDYTIPEECG PLLSDLLRGM LEYDPAKRFS 300

IQKIRQHSWV RKKHPPSEPP VPIPASADSR DPWRSMTVVP YLEDLHGYTE EEDDELYDRE 360

DEIIYTQDFT VPGQVVEDQL DEGSAEHSPA LAKPVCVNGT EAAALNSKAK AERRSSSSSN 420

PSRKGVSTAS KIRKLSTCKQ Q 441

Nucleotide Sequence
(FASTA)

GAAGCAGCCA TGAGCACCGG CGAGCTGCAT CAACTGGATT ACCTGAACGA GAACGAACTG 60

ATGGAGATGG ACACGTTCAT CCACCGCATC GACTCCACGG AGGTGATCTA CCAGCCCAGG 120

AGGAAGCGGG CCAAGCTGAT AGGGAAGTAC CTGATGGGGG ACCTGCTCGG GGAGGGCTCC 180

TACGGCAAGG TGAAGGAGAT GCTGGACTCA GAGACCCTCT GCCGCAGGGC CGTTAAGATA 240

CTGAAGAAGA AGAAGCTGAG GAGGATTCCT AACGGAGAAG CCAACGTGAA AAAGGAAATC 300

CAGCTGCTAA GGAGACTCCA GCACAAGAAT GTGATTCAGC TGGTGGACGT TCTCTACAAC 360

GAAGAGAAGC AGAAAATGTA TATGGTGATG GAGTATTGTG TTTGTGGGAT GCAAGAAATG 420

TTGGACAGTG TCCCAGAAAA GAGGTTTCCA GTATTCCAAG CTCACGGGTA CTTTTGCCAA 480

CTTCTAGATG GCCTTGAATA TTTGCACAGC CAGGGAATCG TTCACAAAGA CATTAAACCA 540

GGAAATCTGC TGCTGACCAC AGACGGGGCG CTCAAAATCT CCGACCTGGG AGTAGCAGAG 600

GCCCTCCATC CGTTTGCGGA GGATGACACG TGTCGGACCA GCCAGGGCTC CCCGGCCTTC 660

CAGCCGCCCG AGATCGCCAA CGGCTTGGAC ACCTTTTCAG GGTTTAAAGT GGACATCTGG 720

TCCGCTGGAG TAACACTATA CAATATCACC ACAAGTCTGT ATCCATTCGA GGGGGACAAC 780

ATCTATAAGC TATTTGAGAA TATCGGAAAA GGAGATTACA CTATTCCAGA GGAATGCGGA 840

CCCCTCCTGT CGGACCTGCT GCGAGGTATG CTGGAGTACG ACCCTGCAAA GAGGTTTTCC 900

ATACAGAAAA TAAGGCAACA CAGCTGGGTG CGTAAGAAAC ACCCCCCGTC CGAGCCGCCC 960

GTGCCCATCC CTGCCAGCGC GGACAGCAGG GACCCGTGGC GGAGCATGAC GGTGGTGCCC 1020

TACCTGGAGG ACCTGCACGG CTACACGGAG GAGGAGGACG ACGAGCTCTA CGACAGGGAG 1080

GACGAGATCA TTTACACTCA GGACTTCACG GTGCCAGGAC AAGTGGTTGA AGATCAGCTG 1140

GATGAGGGGA GCGCGGAGCA CAGCCCAGCT CTGGCCAAGC CCGTGTGTGT GAACGGGACA 1200

GAAGCGGCGG CCCTGAACAG CAAAGCCAAG GCTGAACGCC GGTCCTCCTC GTCATCCAAC 1260

CCTTCACGCA AAGGAGTTTC CACAGCCAGC AAGATCCGCA AGCTCTCCAC CTGCAAGCAG 1320

CAGTGA 1326

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkkl..seeslekikrEieilkklkhp  58

         y +++ lGegs+gkVk++ ++et  + avKi+kkkkl    +   ++k+Ei++l++l+h+

Q: 50    YLMGDLLGEGSYGKVKEMLDSETLCRRAVKILKKKKLrrIPNGEANVKKEIQLLRRLQHK  109

         778999******************************965334567***************

S: 59    niikllevi..etkkklylvleyasgg..eLfdyieekgrlkekearklfkqlvsavkYl  114

         n+i+l++v+  e+k+k+y+v+ey+  g  e++d +  ++r++  +a+ +f ql+++++Yl

Q: 110   NVIQLVDVLynEEKQKMYMVMEYCVCGmqEMLDSV-PEKRFPVFQAHGYFCQLLDGLEYL  168

         ********9888999********998888*****6.8899********************

S: 115   hskgivHrDlKpeNllldkkenikiaDFGlan...lfkegklletfcGsppYaaPellkg  171

         hs+givH+D+Kp Nlll++++ +ki+D+G+a+    f e+++++t++Gsp++++Pe+ +g

Q: 169   HSQGIVHKDIKPGNLLLTTDGALKISDLGVAEalhPFAEDDTCRTSQGSPAFQPPEIANG  228

         *******************************966567788******************99

S: 172   .kkYegpkvDvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlr  230

          ++++g kvD+Ws+Gv+Ly++ t  +Pf+++n+ +l+e+i kg+++ip+++ + l++Llr

Q: 229   lDTFSGFKVDIWSAGVTLYNITTSLYPFEGDNIYKLFENIGKGDYTIPEECGPLLSDLLR  288

         899*********************************************************

S: 231   klLvvdpekRatieeilkhewl  252

          +L+ dp+kR++i++i++h+w+

Q: 289   GMLEYDPAKRFSIQKIRQHSWV  310

         *********************7

Domain Sequence
(FASTA)

YLMGDLLGEG SYGKVKEMLD SETLCRRAVK ILKKKKLRRI PNGEANVKKE IQLLRRLQHK 60

NVIQLVDVLY NEEKQKMYMV MEYCVCGMQE MLDSVPEKRF PVFQAHGYFC QLLDGLEYLH 120

SQGIVHKDIK PGNLLLTTDG ALKISDLGVA EALHPFAEDD TCRTSQGSPA FQPPEIANGL 180

DTFSGFKVDI WSAGVTLYNI TTSLYPFEGD NIYKLFENIG KGDYTIPEEC GPLLSDLLRG 240

MLEYDPAKRF SIQKIRQHSW V 261

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0097009	; P:energy homeostasis
GO:0060575	; P:intestinal epithelial cell differentiation

KEGG

InterPros

IPR020636	; Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013