EKS-TEN-00574

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00574

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	426.0	7.0E-128	32	320	289

Status

Unreviewed

Ensembl Protein

ENSTNIP00000018415

UniProt Accession

H3DD22;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK1

Gene Synonyms/Alias

MAPK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000015351	ENSTNIP00000018415	ENSTNIT00000018641

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

367

Protein Sequence
(FASTA)

IMATAAPAGC GPSPGSGTEL VRGQAFDVGP RYSNLSYIGE GAYGMVCSAY DRDNKIRVAI 60

KKISPFEHQT YCQRTLREIK ILLRFKHENI IGINDIIRAP TIDQMKDVYI VQDLMETDLY 120

KLLKTQHLSN DHICYFLYQI LRGLKYIHSA NVLHRDLKPS NLLLNTTCDL KICDFGLARV 180

ADPDHDHTGF LTEYVATRWY RAPEIMLNSK GYTKSIDIWS VGCILAEMLS NRPIFPGKHY 240

LDQLSHILGI LGSPCQEDLN CIINIKARNY LLSLPMRCKV PWNRLFPNAD PKALDLLDKM 300

LTFNPYKRIE VEEALAHPYL EQYYDPTDEP VAEAPFKFDM ELDDLPKETL KELIFEETAR 360

FQPGFRS 367

Nucleotide Sequence
(FASTA)

ATAATGGCGA CAGCTGCCCC CGCTGGCTGC GGACCCAGCC CTGGGTCAGG AACGGAGCTA 60

GTCCGCGGGC AGGCCTTCGA CGTCGGGCCT CGGTACAGCA ACCTCTCCTA CATCGGGGAA 120

GGAGCCTACG GGATGGTGTG TTCTGCCTAC GACCGGGACA ACAAAATCCG AGTGGCCATC 180

AAGAAGATCA GCCCGTTTGA GCACCAGACC TACTGCCAAC GCACCCTGAG AGAGATCAAG 240

ATCCTCCTGC GCTTCAAACA CGAGAACATC ATCGGCATCA ATGACATCAT CCGTGCGCCG 300

ACCATTGACC AGATGAAGGA CGTATATATT GTGCAGGACC TGATGGAGAC GGACCTGTAC 360

AAACTCCTGA AGACTCAGCA CCTGAGCAAC GACCACATCT GCTATTTCCT CTACCAGATC 420

CTGCGAGGAC TCAAGTACAT CCACTCTGCC AACGTCCTGC ACCGCGACCT AAAGCCCTCC 480

AACCTCCTGC TCAACACCAC CTGTGATCTA AAGATCTGTG ATTTCGGCTT GGCTCGCGTG 540

GCCGACCCTG ACCACGATCA CACTGGGTTC CTAACAGAGT ACGTAGCCAC CCGCTGGTAC 600

CGAGCACCTG AGATCATGCT CAACTCTAAG GGCTACACCA AGTCCATAGA CATCTGGTCA 660

GTAGGTTGCA TCCTGGCAGA GATGTTGTCC AACAGGCCAA TCTTTCCTGG GAAACACTAC 720

CTGGACCAGC TCAGTCACAT TTTGGGCATC CTGGGGTCTC CGTGTCAGGA GGATCTCAAC 780

TGCATCATCA ACATCAAGGC CAGGAACTAT CTTTTGTCGC TGCCAATGCG CTGCAAAGTG 840

CCATGGAACC GCCTCTTTCC CAACGCGGAC CCCAAAGCTC TGGATCTGCT GGACAAGATG 900

CTGACCTTCA ACCCTTACAA AAGGATTGAA GTGGAGGAGG CTCTGGCTCA TCCCTACCTG 960

GAACAATATT ATGACCCTAC AGATGAGCCT GTTGCTGAAG CCCCGTTCAA GTTTGACATG 1020

GAGTTGGATG ACCTGCCCAA AGAGACACTG AAGGAGCTCA TCTTTGAAGA AACTGCACGT 1080

TTCCAGCCTG GCTTCAGGTC CTAA 1104

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++l+++geGayg+v+sa+d++++ rvaikk+s pf+++t ++rtlRE+k+l ++kheNi

Q: 32    YSNLSYIGEGAYGMVCSAYDRDNKIRVAIKKIS-PFEHQTYCQRTLREIKILLRFKHENI  90

         78999***************************9.**************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120

         i + d++++ + ++++kdvY+v++lmetdL+k++k+q+ls++hi ++lyqilrglky+Hs

Q: 91    IGINDIIRAPT-IDQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHS  149

         ********999.************************************************

S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekk..lteyvatrwYraPeillsl  178

         anv+HrDlKPsNll+n++c+lki+dFGlar+ad++++++  lteyvatrwYraPei+l++

Q: 150   ANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTgfLTEYVATRWYRAPEIMLNS  209

         ***********************************999999*******************

S: 179   keytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearn  238

         k ytk++DiWsvGCIlaE+l+++p+fpgk+++dql++il +lg+p +e+l++i + +arn

Q: 210   KGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLSHILGILGSPCQEDLNCIINIKARN  269

         ************************************************************

S: 239   yikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         y+ slp++ k ++++lfp+a+++aldLl+k+L+++p kRi+veeaL+hpYl

Q: 270   YLLSLPMRCKVPWNRLFPNADPKALDLLDKMLTFNPYKRIEVEEALAHPYL  320

         **************************************************7

Domain Sequence
(FASTA)

YSNLSYIGEG AYGMVCSAYD RDNKIRVAIK KISPFEHQTY CQRTLREIKI LLRFKHENII 60

GINDIIRAPT IDQMKDVYIV QDLMETDLYK LLKTQHLSND HICYFLYQIL RGLKYIHSAN 120

VLHRDLKPSN LLLNTTCDLK ICDFGLARVA DPDHDHTGFL TEYVATRWYR APEIMLNSKG 180

YTKSIDIWSV GCILAEMLSN RPIFPGKHYL DQLSHILGIL GSPCQEDLNC IINIKARNYL 240

LSLPMRCKVP WNRLFPNADP KALDLLDKML TFNPYKRIEV EEALAHPYL 289

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Echinops telfairi"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0007369	; P:gastrulation
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008349	; MAPK_ERK1/2.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01770

; ERK1ERK2MAPK.

Created Date

20-Feb-2013