EKS-TEN-00093

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00093

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	347.3	6.7E-104	12	295	284

Status

Unreviewed

Ensembl Protein

ENSTNIP00000018475

UniProt Accession

H3DD82;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK7

Gene Synonyms/Alias

CDK7;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000015407	ENSTNIP00000018475	ENSTNIT00000018701

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

344

Protein Sequence
(FASTA)

MALDVKSRSK RYEKLDFLGE GQFATVYKAR DKTTDTIVAI KKIKVRHITE AKDGINRTAL 60

REIKLLQELH HPNIIGLLDA FGHKSNISLV FDFMETDLEV IIKDTSLVLT PANIKAYILM 120

TLQGLEYMHQ HWVLHRDLKP NNLLLDGNGV LKLADFGLAK AFGSPNRVYT HQVVTRWYRS 180

PELLFGARMY GVGVDMWAVG CILAELLLRL PFLAGDSDLD QLTKIFEALG TPTEESWPGL 240

TSLPDYVSFK IFPGTPLEHI FSAAGDDLLE LLQGFFTFNP LMRSTATQAL KMRYFSNRPG 300

PTPGPQLPRP NCSVEALREK ETVGLKRKIE GLDSNLMMKK KLIF 344

Nucleotide Sequence
(FASTA)

ATGGCGCTCG ATGTCAAATC CAGGTCCAAA CGATACGAAA AACTCGATTT TCTTGGCGAG 60

GGTCAGTTTG CCACAGTATA TAAAGCCAGG GATAAAACCA CGGACACGAT AGTCGCTATT 120

AAAAAGATTA AAGTTCGCCA CATAACGGAG GCAAAAGATG GTATTAACAG GACTGCCCTT 180

AGAGAGATCA AACTTTTGCA AGAACTGCAT CATCCAAACA TTATCGGGCT TCTGGATGCT 240

TTTGGACACA AATCCAACAT CAGCCTGGTG TTTGATTTTA TGGAAACAGA CCTGGAGGTG 300

ATCATAAAAG ACACCAGCCT AGTTTTGACT CCAGCTAATA TCAAAGCCTA CATCCTCATG 360

ACCCTGCAGG GACTGGAGTA CATGCACCAA CACTGGGTCC TACACAGGGA TCTGAAGCCT 420

AATAACCTCC TGTTAGACGG TAATGGAGTT TTGAAGTTGG CTGATTTTGG ATTAGCTAAG 480

GCCTTTGGGA GCCCGAACAG AGTCTACACG CATCAAGTGG TCACGAGGTG GTACCGCTCC 540

CCTGAACTTC TGTTTGGGGC CAGGATGTAC GGTGTGGGTG TTGACATGTG GGCAGTGGGA 600

TGCATCCTGG CAGAATTACT GCTGCGGCTA CCGTTCCTCG CTGGAGACTC GGATCTTGAC 660

CAGCTGACTA AGATCTTCGA GGCTCTGGGG ACGCCCACAG AGGAGTCCTG GCCTGGCCTC 720

ACTAGTTTAC CGGACTACGT GTCCTTCAAA ATCTTTCCTG GCACTCCGCT GGAACATATA 780

TTCAGTGCAG CTGGCGATGA CCTACTGGAG CTCCTACAAG GCTTCTTCAC CTTTAACCCT 840

TTGATGAGGT CCACCGCAAC GCAGGCTCTC AAGATGAGGT ATTTCAGTAA CCGACCTGGT 900

CCCACCCCCG GGCCTCAGCT TCCCCGGCCC AACTGTTCAG TTGAGGCCCT GAGAGAGAAG 960

GAAACCGTAG GTCTCAAGAG GAAAATCGAA GGCCTGGACT CAAATCTGAT GATGAAGAAG 1020

AAGCTCATTT TTTGA 1035

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlek...ekegvpitalrEisllkelkh  57

         yekl+ +geG++++vyka+dk+t+++vA+Kki++ +    k+g++ talrEi+ll+el+h

Q: 12    YEKLDFLGEGQFATVYKARDKTTDTIVAIKKIKVRHiteAKDGINRTALREIKLLQELHH  71

         99******************************9876111557******************

S: 58    knivkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylH  117

         +ni+ Ll+ +  +k+++ Lvf+f+e+dL+ ++k+++   l+++++k ++l+ l+gl+y+H

Q: 72    PNIIGLLDAFG-HKSNISLVFDFMETDLEVIIKDTSL-VLTPANIKAYILMTLQGLEYMH  129

         ***********.99***********************.**********************

S: 118   snkilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgake  177

         ++++lHRDlKp+NlL++ +g+lklaDfGla+af+sp++ yt++vvT+wYr+PelL+ga+

Q: 130   QHWVLHRDLKPNNLLLDGNGVLKLADFGLAKAFGSPNRVYTHQVVTRWYRSPELLFGARM  189

         ************************************************************

S: 178   YstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeykks  237

         Y+  vD+W+vgcilaell r p++ g+s+ dql++if+ lgtp+e++wp++++lp+y  s

Q: 190   YGVGVDMWAVGCILAELLLRLPFLAGDSDLDQLTKIFEALGTPTEESWPGLTSLPDYV-S  248

         *********************************************************8.9

S: 238   fpkkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         f+  + + l++ ++++ ++ l+ll+ +++++p  R +a++al+ +yf

Q: 249   FKIFPGTPLEHIFSAAGDDLLELLQGFFTFNPLMRSTATQALKMRYF  295

         999999********999****************************98

Domain Sequence
(FASTA)

YEKLDFLGEG QFATVYKARD KTTDTIVAIK KIKVRHITEA KDGINRTALR EIKLLQELHH 60

PNIIGLLDAF GHKSNISLVF DFMETDLEVI IKDTSLVLTP ANIKAYILMT LQGLEYMHQH 120

WVLHRDLKPN NLLLDGNGVL KLADFGLAKA FGSPNRVYTH QVVTRWYRSP ELLFGARMYG 180

VGVDMWAVGC ILAELLLRLP FLAGDSDLDQ LTKIFEALGT PTEESWPGLT SLPDYVSFKI 240

FPGTPLEHIF SAAGDDLLEL LQGFFTFNPL MRSTATQALK MRYF 284

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013