EKS-TEN-00182

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00182

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Csk	393.9	2.6E-118	196	440	245

Status

Unreviewed

Ensembl Protein

ENSTNIP00000018577

UniProt Accession

H3DDI4;

Protein Name

Protein Synonyms/Alias

Gene Name

MATK

Gene Synonyms/Alias

MATK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000015506	ENSTNIP00000018577	ENSTNIT00000018804

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

441

Protein Sequence
(FASTA)

RRLAEMSWSA GTQWVAKRAH TKPKPGELAY HKGEMFTILD VSPKKGYYKA KHNTTGEEGL 60

VNSEHMCERQ ALRLVPCLSL MPWFHGKISG PEAVCKLQPA EDGLFLVRES IRHPGDYVLC 120

VSVSGEVIHY RVIYQDNKLT IDNQEYFYNL IDMVEFYSKN KGSIATTLLK PKPKQGAKSA 180

EEELSKSGWL LDIKKLQLGE KIGDGEFGAV YKGEYLGQQV AVKVIKCDVT AQSFLLETAV 240

MTKLQHKNLV RLLGVIPQKG LHIITELMKK GSLVNFLRTR GRSLVPAPQL LRFALDVCEG 300

MEYLESKKLV HRDLAARNVL VSDDIVAKIS DFGLTKAHAN LSDDAKLPIK WTAPEALRKE 360

KLSSKSDVWS YGVLLWEIFS YGRQPYPQDD SLREVKERVE QGYRMEAPED CPPALYALMR 420

ACWEQDPRRR PTFHKLREKL E 441

Nucleotide Sequence
(FASTA)

CGTCGTCTGG CAGAGATGAG CTGGTCTGCG GGGACTCAGT GGGTGGCCAA GCGAGCCCAC 60

ACCAAGCCCA AACCAGGAGA ACTGGCCTAC CACAAAGGAG AAATGTTCAC CATCTTGGAC 120

GTGAGCCCGA AGAAAGGATA TTATAAAGCC AAACATAACA CCACGGGGGA GGAAGGGCTC 180

GTCAACTCTG AGCATATGTG TGAAAGACAG GCCCTGCGTT TGGTTCCTTG TCTCAGCCTC 240

ATGCCCTGGT TTCATGGGAA GATCTCTGGT CCTGAGGCGG TGTGTAAGCT GCAGCCGGCT 300

GAAGACGGCC TGTTCCTGGT TCGAGAATCC ATTCGCCACC CCGGCGACTA CGTGCTGTGT 360

GTGAGCGTGT CGGGGGAGGT CATCCATTAC AGGGTGATTT ATCAAGACAA CAAGCTCACC 420

ATTGACAACC AGGAGTATTT CTACAACCTC ATTGACATGG TGGAGTTTTA CTCCAAGAAC 480

AAAGGCTCCA TTGCTACAAC TCTCCTGAAA CCAAAACCCA AACAAGGAGC AAAGTCTGCT 540

GAGGAGGAGC TGTCCAAAAG TGGATGGCTG TTGGATATTA AAAAGCTTCA GTTGGGAGAG 600

AAAATAGGTG ATGGCGAGTT TGGAGCCGTT TATAAAGGAG AGTATCTGGG CCAGCAGGTG 660

GCGGTGAAGG TCATCAAATG TGATGTCACA GCTCAGTCCT TCCTTCTGGA AACTGCAGTC 720

ATGACGAAGC TGCAGCATAA AAACCTGGTG CGACTGCTGG GGGTCATTCC TCAGAAAGGG 780

CTGCACATCA TCACCGAACT GATGAAAAAG GGAAGCCTGG TGAACTTTCT GAGGACCAGG 840

GGCCGTTCGC TCGTCCCTGC GCCCCAGCTG CTGCGATTTG CCCTTGATGT GTGTGAAGGG 900

ATGGAGTACC TGGAGTCCAA GAAGCTGGTT CACAGAGATT TGGCAGCTCG TAACGTGCTG 960

GTGTCTGATG ACATCGTGGC AAAGATCAGC GATTTTGGCC TGACCAAGGC CCACGCAAAC 1020

CTGTCCGATG ATGCCAAACT GCCCATCAAA TGGACGGCCC CAGAAGCTCT GAGGAAAGAG 1080

AAACTGTCCA GCAAGTCTGA TGTTTGGAGC TACGGCGTTC TGCTGTGGGA GATCTTCTCG 1140

TACGGCCGTC AACCGTACCC CCAAGATGAT TCTCTCAGGG AGGTAAAGGA AAGAGTGGAG 1200

CAAGGCTATC GCATGGAGGC TCCGGAGGAC TGCCCCCCTG CTCTTTACGC CCTGATGAGG 1260

GCTTGCTGGG AGCAGGACCC ACGCAGGAGA CCCACCTTCC ACAAACTGAG GGAGAAACTG 1320

GAGTAG 1326

Domain Profile

S: 1     lklgetigkgefgdvllgeyrgekvavkvikndataqafldeasvmtklehenlvkllgv  60

         l+lge+ig+gefg+v +gey g++vavkvik+d+taq+fl e++vmtkl+h+nlv+llgv

Q: 196   LQLGEKIGDGEFGAVYKGEYLGQQVAVKVIKCDVTAQSFLLETAVMTKLQHKNLVRLLGV  255

         789********************************************************9

S: 61    ileekglylvteyvakgslvdylrsrgrallekkqllkfaldvaegmeyleskklvhrdl  120

         i ++ gl+++te + kgslv++lr+rgr+l+   qll+faldv+egmeyleskklvhrdl

Q: 256   IPQK-GLHIITELMKKGSLVNFLRTRGRSLVPAPQLLRFALDVCEGMEYLESKKLVHRDL  314

         9766.*******************************************************

S: 121   aarnvlvsedlvakvsdfglakeeskdldsgklpvkwtapealkekkfstksdvwsfgil  180

         aarnvlvs+d+vak+sdfgl+k++++ +d +klp+kwtapeal+++k+s+ksdvws+g+l

Q: 315   AARNVLVSDDIVAKISDFGLTKAHANLSDDAKLPIKWTAPEALRKEKLSSKSDVWSYGVL  374

         ************************************************************

S: 181   lweifsfgrvpypri.plkdvvkavekgykmeapegcppevyelmkeaweleaakrpsfa  239

         lweifs+gr pyp+  +l++v ++ve+gy+meape cpp++y lm+ +we ++ +rp+f+

Q: 375   LWEIFSYGRQPYPQDdSLREVKERVEQGYRMEAPEDCPPALYALMRACWEQDPRRRPTFH  434

         *************9538*******************************************

S: 240   klkekl  245

         kl+ekl

Q: 435   KLREKL  440

         ****97

Domain Sequence
(FASTA)

LQLGEKIGDG EFGAVYKGEY LGQQVAVKVI KCDVTAQSFL LETAVMTKLQ HKNLVRLLGV 60

IPQKGLHIIT ELMKKGSLVN FLRTRGRSLV PAPQLLRFAL DVCEGMEYLE SKKLVHRDLA 120

ARNVLVSDDI VAKISDFGLT KAHANLSDDA KLPIKWTAPE ALRKEKLSSK SDVWSYGVLL 180

WEIFSYGRQP YPQDDSLREV KERVEQGYRM EAPEDCPPAL YALMRACWEQ DPRRRPTFHK 240

LREKL 245

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013