EKS-TEN-00050
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TEN-00050
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Jak323.61.2E-96418678261
StatusUnreviewed
Ensembl ProteinENSTNIP00000018644
UniProt AccessionH3C837;
Protein Name
Protein Synonyms/Alias
Gene NameJAK2 (2 of 2)
Gene Synonyms/Alias JAK2 (2 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTNIG00000015572ENSTNIP00000004409ENSTNIT00000004548
ENSTNIG00000015572ENSTNIP00000018644ENSTNIT00000018871
OrganismTetraodon nigroviridis
Functional Description
Protein Length974
Protein Sequence
(FASTA)
IRYYFPGWYS GGASRAYRYG VAKGSESPVF DDCVMSYLFS QWRNDFVNGF VKIPSSHEIQ 60
EECLGMAVLD MTRTAKERQL SPLDIYHTMS YKSFLPKEIR AQIQDCNFLT RKRIRFRFKR 120
FIQQFSQCRT TVRDLKLKYL ISMESLEKAF YTETFQVREL SRGQLIMTGC SNGIQWCQEK 180
LKDSDEELQI LCDFPDVTDI SIKQASKEGA TESRVVTINK QDGKNLELEF PSLSEALSFV 240
SLIDGYYRLT TDAHHYLCKE VAPPRLVEAI TSHCHGPISL EFAINQLQKC GNKQGLFILQ 300
CSPKDFNKYF LTFPVEVYGT VEFKHCQITR SECGQFNLSG TKRNFSSLHE LLSCYKNETV 360
RSDSVVFQFS KCCPPKAKER SCLLVCRTNK GPEVPLSPST NRHNISQMVF HKIRKEDLEF 420
NESLGQGTFT KIFKGVRKEL GDYGLMHQTE VVMKVLDQAH RNYSESFFEA ASMMTQLSHV 480
HLILNYGVCV CGEENIMVQE YVKFGSLDTY LKKNKNSVNI LWKLEVAKQL AQAMNFLEEK 540
NLVHGNVCAK NVLLIREDDW RAGNPPFIKL SDPGISITVL PKEILVERIP WVPPECVNDP 600
ANLSLAADKW SFGTTLWEIC SGGEKPLASL DNTNKTLFYE DRHQLPAPKW IELANLITSC 660
MDYEPTFRPT FRAIIRDLHS LFTPGWFSNM VLFKQQLGKG NFGSVEMCRY DPLQDNTGEV 720
VAVKKLQHGT AEHIRDFERE IEILKSLQHE NIVKYKGVCY SAGRRNLRLV MEYLPFGSLR 780
DYLIKNKERI DHKKLVHYSS QICKGMEYLS GKRYIHRDLA TRNILVESES RVKIGDFGLT 840
KILPQDKEYY MVREPGESPI FWYAPESLTE SKFSVASDVW SFGVVLYELF THSSRNSSPP 900
TVFMSMMGND KQGQLIVYHL IELLKSGSRL PQPLDCPTEI HEIMEQCWDN DPYLRPSFKE 960
LALSIDLFRE HKEF 974
Nucleotide Sequence
(FASTA)
ATCAGGTACT ATTTTCCTGG CTGGTACAGT GGCGGGGCAT CTCGAGCGTA TCGATATGGG 60
GTGGCCAAGG GGTCAGAGAG CCCCGTTTTT GATGACTGTG TAATGTCATA CCTTTTCTCT 120
CAGTGGAGGA ACGACTTTGT CAATGGCTTT GTGAAGATTC CCAGTTCTCA TGAAATTCAG 180
GAAGAATGCC TTGGTATGGC TGTACTCGAC ATGACACGAA CAGCCAAAGA AAGACAGCTG 240
TCCCCTTTGG ACATTTACCA CACTATGAGC TACAAGTCTT TCTTACCAAA AGAGATTAGA 300
GCTCAGATTC AGGACTGCAA TTTTTTGACA CGCAAGCGGA TCCGCTTCCG TTTCAAGCGC 360
TTCATCCAGC AGTTCAGTCA GTGTCGGACC ACCGTGCGCG ACCTCAAACT GAAATACCTC 420
ATCAGCATGG AGTCCTTGGA GAAAGCGTTC TACACAGAGA CTTTCCAGGT CAGGGAACTG 480
TCCCGTGGCC AGCTCATCAT GACTGGTTGT AGCAATGGCA TCCAGTGGTG TCAAGAGAAA 540
TTAAAAGATT CAGATGAGGA GCTGCAAATC TTGTGTGATT TTCCTGATGT CACTGACATC 600
AGCATCAAAC AGGCCAGCAA AGAGGGTGCG ACAGAGAGCC GGGTGGTCAC CATCAACAAA 660
CAAGATGGCA AGAACCTGGA ACTGGAGTTC CCCAGCCTGT CTGAAGCCCT GTCCTTTGTG 720
TCCCTCATTG ATGGCTATTA TCGGTTGACC ACAGATGCTC ATCACTATCT GTGTAAAGAA 780
GTGGCTCCTC CGAGGCTTGT GGAGGCCATC ACGTCCCATT GCCATGGCCC CATTTCGTTG 840
GAGTTTGCTA TCAATCAACT TCAGAAGTGT GGAAACAAGC AGGGGTTGTT TATTTTGCAG 900
TGTAGCCCTA AAGACTTTAA CAAATATTTC TTGACATTTC CTGTGGAGGT GTATGGCACT 960
GTAGAATTCA AACATTGCCA GATAACCAGG TCTGAGTGCG GACAGTTTAA CCTCAGTGGA 1020
ACCAAAAGAA ATTTCAGCAG CTTGCACGAG CTCCTTAGCT GTTACAAAAA TGAAACTGTG 1080
CGCTCAGACA GTGTTGTTTT TCAGTTCAGC AAGTGCTGTC CTCCTAAAGC CAAAGAAAGG 1140
TCTTGCCTCC TTGTGTGCAG GACCAACAAA GGCCCTGAAG TGCCTCTGTC TCCATCAACC 1200
AACAGACACA ACATCAGTCA AATGGTCTTT CACAAAATCA GGAAAGAAGA TCTTGAATTT 1260
AATGAAAGTT TGGGTCAAGG GACTTTTACC AAAATCTTCA AAGGGGTTCG TAAAGAGCTG 1320
GGAGATTATG GTCTCATGCA TCAGACCGAA GTAGTCATGA AGGTCCTAGA CCAGGCCCAC 1380
CGGAACTACT CTGAGTCTTT CTTTGAAGCT GCCAGCATGA TGACACAGTT GTCCCATGTA 1440
CACCTGATCC TGAACTATGG CGTGTGTGTC TGCGGAGAGG AAAATATAAT GGTACAGGAG 1500
TATGTCAAAT TTGGTTCTCT GGACACCTAC CTGAAGAAGA ACAAGAACTC TGTAAACATC 1560
CTTTGGAAGC TGGAGGTGGC TAAGCAGCTT GCTCAGGCCA TGAACTTCCT GGAAGAAAAG 1620
AATCTTGTCC ACGGCAATGT GTGTGCTAAA AATGTTCTCC TGATCAGAGA GGATGACTGG 1680
AGGGCTGGAA ACCCTCCCTT CATCAAACTG AGCGACCCTG GCATCAGCAT CACTGTCCTG 1740
CCTAAGGAGA TCCTAGTTGA GAGGATCCCC TGGGTACCTC CTGAGTGTGT CAATGATCCC 1800
GCCAACCTGA GCCTGGCAGC AGACAAATGG AGCTTTGGCA CAACACTTTG GGAGATCTGC 1860
AGTGGTGGAG AGAAGCCTTT AGCATCGCTG GACAACACTA ATAAAACCCT GTTCTATGAG 1920
GACCGACACC AGCTCCCAGC TCCTAAGTGG ATTGAACTGG CAAATTTAAT AACCAGCTGC 1980
ATGGATTACG AGCCTACGTT CAGGCCCACG TTTCGTGCCA TTATTCGTGA CCTCCACAGC 2040
CTCTTCACAC CAGGTTGGTT CAGCAATATG GTACTATTCA AACAGCAGCT GGGCAAGGGA 2100
AATTTTGGCA GCGTGGAGAT GTGCCGATAC GATCCACTTC AGGACAACAC CGGCGAGGTC 2160
GTGGCCGTGA AAAAACTGCA GCACGGGACC GCAGAACACA TTCGAGACTT TGAGCGGGAA 2220
ATTGAGATCT TGAAATCTCT GCAGCACGAG AACATCGTCA AGTACAAAGG TGTCTGCTAC 2280
AGCGCAGGTC GGCGGAATCT TCGCCTTGTC ATGGAATATC TTCCCTTTGG AAGTCTGCGA 2340
GACTACCTCA TAAAAAACAA GGAGAGGATC GACCATAAGA AGCTCGTGCA TTACTCTTCT 2400
CAGATCTGCA AGGGAATGGA GTACCTGTCC GGTAAGCGCT ACATTCACAG AGACCTGGCA 2460
ACGCGGAATA TTCTCGTGGA GAGTGAATCG AGGGTGAAGA TTGGAGATTT TGGCCTTACC 2520
AAAATTCTGC CTCAGGATAA AGAATACTAC ATGGTCAGAG AGCCGGGAGA GAGCCCCATA 2580
TTCTGGTACG CGCCTGAGTC CCTGACTGAG AGCAAGTTCT CAGTGGCTTC AGATGTCTGG 2640
AGCTTCGGGG TGGTGCTCTA TGAGCTCTTC ACCCACAGCA GCAGAAACAG CAGCCCTCCC 2700
ACAGTCTTTA TGTCCATGAT GGGAAACGAC AAGCAGGGAC AGCTGATTGT GTATCACCTG 2760
ATTGAACTTC TAAAGTCAGG CAGCCGGCTG CCTCAACCAT TGGATTGTCC TACAGAGATA 2820
CACGAGATCA TGGAGCAGTG CTGGGACAAC GATCCCTACC TTCGTCCTTC TTTCAAAGAG 2880
CTCGCTTTGA GCATTGATCT GTTCAGGGAA CATAAAGAGT TTTAG 2925
Domain Profile
S: 1     lkqiesLgkgtftkvfevred...aegdsteeevalkvLkesgedisrdfkreaeilsql  57
         l+++esLg+gtftk+f++ ++   ++g  +++ev++kvL+++++++s++f+++a++++ql
Q: 418   LEFNESLGQGTFTKIFKGVRKelgDYGLMHQTEVVMKVLDQAHRNYSESFFEAASMMTQL  477
         6789**************997566888899******************************
S: 58    shehivklkgvcvaegenrlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYL  117
         sh h++ ++gvcv+++en++V+eyv+ GsLd+yL+k+k+++++ ++l+vakqla+am++L
Q: 478   SHVHLILNYGVCVCGEENIMVQEYVKFGSLDTYLKKNKNSVNILWKLEVAKQLAQAMNFL  537
         ************************************************************
S: 118   edkklvhrdvaarnvLveresn..egtppfvklsdpglakavnqdeYylvreerdsripw  175
         e+k+lvh++v+a+nvL+ re++   g+ppf+klsdpg++ +v      l++e   +ripw
Q: 538   EEKNLVHGNVCAKNVLLIREDDwrAGNPPFIKLSDPGISITV------LPKEILVERIPW  591
         *********************9999*****************......************
S: 176   lapeclseaknlstasdvWsFgvtlyelltcskgesplrseslerklelleekerlpkpk  235
         ++pec+++  nls+a+d+WsFg+tl+e+  cs ge+pl s ++++k+ ++e++++lp+pk
Q: 592   VPPECVNDPANLSLAADKWSFGTTLWEI--CSGGEKPLASLDNTNKTLFYEDRHQLPAPK  649
         ****************************..******************************
S: 236   cpaelaelmtnclsyepsqrpsFrailedl  265
         +  ela+l+t c++yep++rp+Frai++dl
Q: 650   WI-ELANLITSCMDYEPTFRPTFRAIIRDL  678
         **.*************************98
Domain Sequence
(FASTA)
LEFNESLGQG TFTKIFKGVR KELGDYGLMH QTEVVMKVLD QAHRNYSESF FEAASMMTQL 60
SHVHLILNYG VCVCGEENIM VQEYVKFGSL DTYLKKNKNS VNILWKLEVA KQLAQAMNFL 120
EEKNLVHGNV CAKNVLLIRE DDWRAGNPPF IKLSDPGISI TVLPKEILVE RIPWVPPECV 180
NDPANLSLAA DKWSFGTTLW EICSGGEKPL ASLDNTNKTL FYEDRHQLPA PKWIELANLI 240
TSCMDYEPTF RPTFRAIIRD L 261
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pelodiscus sinensis"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00026
EKS-DAR-00042
EKS-DRM-00011
EKS-GAM-00013
EKS-GAA-00046
EKS-HOS-00032
EKS-ORN-00046
EKS-ORA-00025
EKS-ORC-00031
EKS-ORL-00043
EKS-PES-00027
EKS-SUS-00028
EKS-TAR-00046
EKS-XIM-00044
Gene Ontology
GO:0005856; C:cytoskeleton
GO:0016020; C:membrane
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0007243; P:intracellular protein kinase cascade
KEGG
InterPros
IPR019748; FERM_central.
IPR000299; FERM_domain.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016251; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020693; Tyr_kinase_non-rcpt_Jak2.
Pfam
PF07714; Pkinase_Tyr; 2.
SMARTs
SM00252; SH2; 1.
SM00219; TyrKc; 2.
Prosites
PS50057; FERM_3; 1.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
Prints
PR01823; JANUSKINASE.
PR01825; JANUSKINASE2.
PR00109; TYRKINASE.
Created Date20-Feb-2013