EKS-TEN-00524

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00524

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/DAPK	447.3	1.7E-134	14	273	260

Status

Unreviewed

Ensembl Protein

ENSTNIP00000018708

UniProt Accession

H3DDW5;

Protein Name

Protein Synonyms/Alias

Gene Name

DAPK1

Gene Synonyms/Alias

DAPK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000015634	ENSTNIP00000018708	ENSTNIT00000018935

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

1441

Protein Sequence
(FASTA)

MTIFNQENVE EFYEIGNELG SGQFAVVRRC RHRSTGVEYA AKFIKKRRSK SSRRGVSRED 60

IEREVNILKE IQHANIITLH EVFENKAEVI LILELVAGGE LFDFLAEKES LSEDTQFLKQ 120

ILDGVFYLHS KQIAHFDLKP ENIMLLNRSV PHPRIKIIDF GLAHKIDFGN DFKNIFGTPE 180

FVAPEVVNYE PLGLEADMWS VGVITYILLS GASPFLGDNK QETLANVSAV DYTFDEEFFS 240

NTSILAKDFI ARLLVKDPKK RMAIQDSLQH PWIKPKDTQQ ALSRKESAVN MEKFKKFAAR 300

RKWKQSVRLI SLCNRLSRSF LSRSNISVAR SDDTLDEEDS FVMKAIIHAI NDDNVPGLTH 360

LLGSLNSYDV NQPNKHGIPP LLIAAGCGNI QIIEVLMRKG AEIQAGDKNH QSGANAIYYA 420

ARHGHVDTLK FLHEKNCPLD IQDKSGETAL HVAARYGNVD VVGYLCSIRA NPDLADREQE 480

TPLHCAAWHG YSTVARALCQ AGCRVDAKNR EGESPLLTAS ARGFVDIVEC LVEHRANLET 540

CDKDGHTALH LAVRRCQVEV VRCLLRHHCH LDQQDRHGNT ALHIACKDGN LPIVIALCNA 600

KANLDLPNKY GRTPLHLAAS NGSLEVVRHL CLAGVNIDAV TNDGKTAEEL ANADHHEQIV 660

SLLVRLKKDN HKLSYIQQLR PTQTIQPRKL KLFGHPGAGK STLLESLKCG ILRSFFRRRR 720

TRMTNTARQP NSPVNSKPPV SVSISNLYPG CENVSVRSRS MMFEPSLTKG VLEVFSPVHS 780

TLSTADEQAT KAIDIQHANI HSVGDFSVWE FSGNPVYYCS YDYFAANDNT AIHLVLFSLE 840

EPYETQLSHV TYWLNLLKAL TLPQDNIGFG GRIQQPLLVV LVATHADLAD IPRAFSGEFT 900

YDKEKVLLKE VRNRFGLDLQ ISEKLFVMDA GASNSKDLKL LRSHLLELRS SIISKCSPMT 960

QLTERLLNTL PAWRKLSGPN QLTSWQQFVS DVQEHINPLV SQDHLRALTM QLHSMGEINI 1020

MQSETVQDVV LLEPRWLCSS ILGKLLSVET PKAIHHYRGR YRLEEVQALV PESDVEELLQ 1080

ILDAMDICAR DTTNPFMVDV PTLIKTSGLH RSWTEEDEED EALIYGGVRL VPAEHLTPFP 1140

CGLFHKLQVN LCRWSHQQKS EEEGGDDFDG DIHLWTNGAK VSQTGVEALV LLVNHGQGVE 1200

IQVRGHDSER AKCYTLLDTI CSITENLLTS TLPGLLTAKY YLSPQQLRER HTPIMIYQPK 1260

DFFRAQAQRE TSLTNTMGGY RESFSSILSF GCAEVYQQGT LGTDVHISDV PLLARRKLCR 1320

MLDPPDAMGK DWCLLAMNLG LTELVAKHSN GTSNGAAEPD SPQPSPTAAL LQEWSGRADS 1380

TVGVLMGKLR ELGRRDAADF LLKASPVFRV NVEAIGRAAN GYPPICNGGT SYNSISSVIS 1440

R 1441

Nucleotide Sequence
(FASTA)

ATGACCATTT TTAATCAGGA AAATGTCGAG GAATTTTATG AAATCGGAAA CGAGCTGGGG 60

AGTGGACAGT TTGCGGTGGT CAGAAGATGC CGGCACAGGA GCACGGGTGT GGAGTATGCT 120

GCCAAGTTCA TCAAGAAGAG GCGCAGCAAA TCGAGCCGCC GAGGGGTGTC CAGGGAGGAC 180

ATTGAGCGGG AGGTGAACAT CCTGAAGGAG ATCCAGCACG CAAACATCAT AACCCTTCAT 240

GAGGTTTTTG AAAACAAAGC AGAGGTCATT CTGATCCTAG AGCTTGTGGC TGGCGGCGAG 300

CTCTTCGATT TTCTGGCAGA GAAGGAGTCG CTGAGTGAAG ATACTCAGTT CCTGAAGCAG 360

ATCCTGGATG GAGTCTTTTA CCTGCACTCC AAACAAATCG CTCACTTTGA CCTTAAGCCA 420

GAGAACATCA TGCTGCTGAA CCGCTCAGTG CCTCACCCAC GCATCAAAAT CATTGACTTT 480

GGCCTGGCCC ATAAGATAGA CTTTGGCAAT GATTTTAAAA ACATTTTTGG AACTCCAGAA 540

TTTGTAGCTC CTGAAGTAGT CAACTATGAG CCCCTGGGCC TGGAGGCAGA CATGTGGAGT 600

GTCGGTGTGA TAACCTACAT CCTCCTGAGT GGTGCGTCTC CCTTCCTGGG GGACAACAAG 660

CAGGAGACAT TAGCCAACGT CTCAGCTGTG GACTACACCT TTGATGAGGA GTTCTTCAGC 720

AACACCAGTA TCCTGGCCAA AGACTTCATA GCAAGGCTTC TCGTGAAAGA CCCCAAAAAG 780

AGAATGGCAA TTCAGGACAG CCTTCAACAT CCTTGGATTA AGCCAAAAGA TACTCAACAG 840

GCACTAAGTA GAAAAGAGTC AGCAGTCAAC ATGGAGAAGT TCAAGAAGTT TGCAGCTCGA 900

AGAAAATGGA AACAATCCGT CCGACTTATC TCCTTATGTA ACCGTTTGTC CCGCTCCTTC 960

CTGTCCAGAA GCAACATAAG TGTGGCGCGC AGCGATGACA CTTTGGACGA GGAAGACTCC 1020

TTTGTGATGA AGGCCATAAT CCATGCCATA AATGACGATA ATGTACCTGG TCTCACGCAT 1080

TTACTCGGCT CCCTAAACAG TTATGACGTC AACCAGCCCA ACAAGCATGG GATTCCACCC 1140

CTTCTGATTG CAGCTGGCTG TGGCAACATT CAGATCATTG AGGTGCTGAT GAGAAAAGGT 1200

GCAGAGATCC AGGCCGGTGA TAAGAACCAT CAGAGCGGAG CCAATGCTAT CTACTACGCA 1260

GCGAGACACG GCCATGTGGA CACCCTGAAA TTCCTCCATG AAAAGAACTG TCCTCTGGAT 1320

ATTCAAGATA AGTCTGGAGA GACTGCTCTG CACGTGGCAG CTCGCTATGG CAACGTGGAC 1380

GTGGTGGGCT ATCTGTGCAG CATCCGCGCC AACCCAGATC TGGCTGACAG GGAGCAGGAA 1440

ACTCCGCTGC ATTGTGCCGC TTGGCACGGC TACTCCACAG TTGCCAGAGC TCTCTGCCAG 1500

GCGGGCTGCC GCGTCGACGC AAAGAACCGG GAAGGCGAGA GTCCATTGCT GACGGCATCT 1560

GCTCGGGGTT TTGTGGACAT TGTCGAGTGC CTGGTGGAGC ATCGGGCCAA TCTAGAAACG 1620

TGTGACAAGG ATGGACACAC AGCCCTCCAC CTGGCCGTAC GGAGGTGTCA GGTTGAAGTG 1680

GTGCGTTGCC TCCTTAGACA CCACTGTCAC CTCGACCAAC AGGATCGCCA TGGTAACACA 1740

GCGCTACACA TTGCTTGCAA GGATGGAAAC CTTCCCATTG TTATAGCTCT TTGCAATGCC 1800

AAGGCCAATC TTGACCTCCC TAACAAGTAT GGCAGGACTC CTCTTCACCT GGCTGCCAGC 1860

AATGGGAGCC TGGAGGTGGT TCGTCACCTG TGTCTGGCTG GAGTTAACAT TGACGCTGTC 1920

ACCAATGATG GGAAAACAGC TGAGGAACTA GCCAATGCTG ATCATCACGA GCAAATTGTT 1980

TCTTTGTTGG TGCGGCTTAA GAAGGACAAC CACAAACTGA GCTACATCCA GCAGCTGCGG 2040

CCCACTCAGA CCATCCAGCC CAGGAAGCTG AAACTGTTTG GGCACCCTGG AGCTGGGAAG 2100

AGCACCCTGC TGGAGTCCCT CAAGTGTGGC ATCCTGCGTA GTTTCTTCAG GAGGAGGAGG 2160

ACGCGCATGA CCAACACGGC TCGCCAACCC AACTCTCCAG TCAACTCCAA ACCGCCCGTC 2220

TCGGTGAGCA TTTCCAATCT GTACCCGGGC TGTGAGAATG TGAGTGTGCG GAGTCGCAGC 2280

ATGATGTTCG AGCCGAGCCT GACCAAAGGA GTCCTGGAGG TCTTCTCTCC CGTCCACAGC 2340

ACTCTGTCCA CAGCTGATGA ACAGGCTACA AAGGCCATCG ACATCCAGCA CGCCAACATT 2400

CACAGCGTGG GGGATTTCAG CGTATGGGAG TTTTCCGGAA ACCCCGTCTA TTACTGCTCC 2460

TACGACTACT TTGCAGCCAA TGACAACACC GCCATCCACC TGGTCCTCTT CAGCCTGGAG 2520

GAGCCGTATG AAACCCAGCT GAGCCATGTC ACCTACTGGC TGAACCTGCT GAAAGCTCTC 2580

ACTCTGCCGC AGGACAACAT CGGTTTCGGA GGTCGCATCC AGCAGCCTCT GCTGGTCGTC 2640

CTAGTGGCAA CCCATGCCGA CCTCGCCGAC ATTCCCAGGG CTTTTTCTGG AGAGTTCACT 2700

TATGACAAGG AGAAGGTGCT TCTTAAGGAA GTGCGGAACA GGTTCGGGCT TGACCTGCAG 2760

ATCAGTGAAA AATTGTTTGT GATGGATGCC GGCGCCTCAA ACTCCAAAGA CCTCAAGCTC 2820

CTGAGGAGTC ACCTGCTGGA ACTTCGCAGC AGCATCATCT CTAAGTGTAG TCCCATGACA 2880

CAGCTGACGG AGCGCCTGCT GAATACCCTG CCGGCCTGGC GGAAGCTGAG CGGACCCAAC 2940

CAGCTGACAT CGTGGCAGCA GTTTGTCAGC GATGTCCAGG AGCACATCAA CCCGCTGGTC 3000

AGCCAGGATC ATCTGCGCGC ACTGACCATG CAGCTCCACA GCATGGGAGA GATCAATATC 3060

ATGCAGAGTG AGACGGTGCA GGATGTTGTT CTCCTGGAGC CCCGATGGCT CTGCAGCAGC 3120

ATCCTGGGCA AACTGCTCTC TGTGGAGACT CCCAAGGCCA TCCACCACTA CCGGGGCCGC 3180

TACAGGCTGG AGGAGGTGCA GGCCCTCGTT CCAGAGAGCG ACGTGGAGGA GCTGCTACAG 3240

ATCCTGGACG CCATGGATAT CTGTGCCCGT GACACCACCA ACCCCTTCAT GGTGGATGTA 3300

CCCACTCTCA TCAAGACCAG CGGTCTCCAC CGCTCCTGGA CCGAAGAGGA CGAGGAGGAC 3360

GAGGCGCTGA TCTACGGCGG CGTGCGCCTG GTCCCTGCAG AGCACCTCAC TCCTTTCCCG 3420

TGTGGCCTGT TTCACAAGCT GCAGGTGAAC TTGTGTCGCT GGAGCCACCA GCAGAAGTCC 3480

GAAGAGGAGG GCGGGGACGA TTTCGACGGT GACATCCATC TGTGGACAAA TGGCGCCAAA 3540

GTCAGCCAGA CAGGCGTGGA GGCTCTTGTC CTGCTGGTCA ACCACGGGCA GGGGGTGGAA 3600

ATCCAGGTGC GCGGGCACGA CTCCGAGCGG GCCAAGTGCT ACACCTTGTT GGACACCATC 3660

TGTAGTATCA CGGAGAACCT GCTGACCTCC ACCCTTCCCG GCCTGCTGAC AGCCAAATAC 3720

TACCTTAGTC CTCAGCAGCT GCGGGAACGT CACACCCCCA TCATGATCTA CCAACCCAAA 3780

GATTTCTTCC GCGCCCAAGC GCAGCGGGAA ACCTCCCTCA CCAACACCAT GGGCGGCTAC 3840

AGAGAGAGCT TCAGCAGCAT CCTGTCGTTC GGCTGTGCCG AGGTTTACCA GCAGGGGACC 3900

CTGGGAACAG ACGTCCACAT ATCCGACGTC CCCCTGCTGG CTCGCAGGAA GCTCTGTCGC 3960

ATGCTGGACC CGCCGGACGC CATGGGAAAA GACTGGTGCC TGTTGGCCAT GAACCTTGGC 4020

CTCACAGAAC TGGTGGCCAA ACACAGCAAC GGCACCTCCA ACGGCGCCGC CGAGCCGGAC 4080

TCTCCGCAGC CCAGCCCCAC CGCGGCGCTG CTGCAGGAGT GGAGCGGCCG AGCGGACAGC 4140

ACCGTCGGCG TGCTCATGGG CAAACTGAGG GAGCTGGGCC GCAGAGACGC TGCCGACTTT 4200

CTGCTCAAGG CTTCCCCCGT TTTCAGGGTG AACGTGGAGG CCATCGGCAG GGCTGCTAAC 4260

GGATACCCGC CCATCTGCAA CGGCGGCACC TCGTACAACT CCATCAGCTC GGTCATCTCA 4320

CGCTGA 4326

Domain Profile

S: 2     etgkelgsGkfavvrkcrekstGkeyaakflkkrrlkssrrgvsreeierevavlkeirs  61

         e+g+elgsG+favvr+cr++stG eyaakf+kkrr+kssrrgvsre+ierev++lkei+

Q: 14    EIGNELGSGQFAVVRRCRHRSTGVEYAAKFIKKRRSKSSRRGVSREDIEREVNILKEIQ-  72

         6799*******************************************************.

S: 62    epnvinlhevyenksdvililelvaGGelfdllaekeslseeeatellkqilegvkylhs  121

         + n+i+lhev+enk++vililelvaGGelfd+laekeslse+  t++lkqil+gv ylhs

Q: 73    HANIITLHEVFENKAEVILILELVAGGELFDFLAEKESLSED--TQFLKQILDGVFYLHS  130

         ***************************************997..79**************

S: 122   kkivhldlkPenillldkkvpkgdiklidfGlsrkieegaelkeilGtPefvaPeivnye  181

         k+i+h+dlkPeni+ll+++vp+++ik+idfGl++ki+ g+++k+i+GtPefvaPe+vnye

Q: 131   KQIAHFDLKPENIMLLNRSVPHPRIKIIDFGLAHKIDFGNDFKNIFGTPEFVAPEVVNYE  190

         ************************************************************

S: 182   plsletdmwsiGvityillsgasPflGdtkqetllnisavnldfseelfssvselakdfi  241

         pl+le+dmws+GvityillsgasPflGd+kqetl+n+sav+++f+ee+fs++s lakdfi

Q: 191   PLGLEADMWSVGVITYILLSGASPFLGDNKQETLANVSAVDYTFDEEFFSNTSILAKDFI  250

         ************************************************************

S: 242   rrllvkdpekrltieeclehswl  264

          rllvkdp+kr++i+++l+h+w+

Q: 251   ARLLVKDPKKRMAIQDSLQHPWI  273

         **********************8

Domain Sequence
(FASTA)

EIGNELGSGQ FAVVRRCRHR STGVEYAAKF IKKRRSKSSR RGVSREDIER EVNILKEIQH 60

ANIITLHEVF ENKAEVILIL ELVAGGELFD FLAEKESLSE DTQFLKQILD GVFYLHSKQI 120

AHFDLKPENI MLLNRSVPHP RIKIIDFGLA HKIDFGNDFK NIFGTPEFVA PEVVNYEPLG 180

LEADMWSVGV ITYILLSGAS PFLGDNKQET LANVSAVDYT FDEEFFSNTS ILAKDFIARL 240

LVKDPKKRMA IQDSLQHPWI 260

Keyword

ANK repeat; ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome; Repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007165	; P:signal transduction

KEGG

InterPros

IPR002110	; Ankyrin_rpt.
IPR020683	; Ankyrin_rpt-contain_dom.
IPR000488	; Death.
IPR020676	; Death-assoc_prot_kinase.
IPR011029	; DEATH-like.
IPR011009	; Kinase-like_dom.
IPR020675	; Myosin_light_ch_kinase-rel.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00023	; Ank; 3.
PF12796	; Ank_2; 2.
PF00531	; Death; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00248	; ANK; 9.
SM00005	; DEATH; 1.
SM00220	; S_TKc; 1.

Prosites

PS50297	; ANK_REP_REGION; 1.
PS50088	; ANK_REPEAT; 8.
PS50017	; DEATH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013