EKS-TEN-00126

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00126

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Tec	441.9	6.5E-133	377	628	252

Status

Unreviewed

Ensembl Protein

ENSTNIP00000018826

UniProt Accession

H3C0T3;

Protein Name

Protein Synonyms/Alias

Gene Name

BTK

Gene Synonyms/Alias

BTK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000015750	ENSTNIP00000001814	ENSTNIT00000003348
ENSTNIG00000015750	ENSTNIP00000001849	ENSTNIT00000003695
ENSTNIG00000015750	ENSTNIP00000018826	ENSTNIT00000019054

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

635

Protein Sequence
(FASTA)

MSDFILEEIF IKRSQQKKKT SPLNYKERLF VLTQEKIAYY DFDAEKRKRK GLRGSVDLEK 60

IKCVETVEPE PNAPQERMYA FQIVYDEGPL YVFAKTEEAR SRWIKTLKDM VRCNKDLLQK 120

YHPCSWMDGV WLCCHQEVKQ AMGCKVLDNK NGFTWNSNRR ASRKPLPPTP TEEKPGWTLP 180

PQPPEPQGPS VGMTVTAEYN YAPMTPQDLE LKKEEQYTIL EMSDPNWWRA RDKYGNEGYI 240

PSNYVVEAEK GLERFDWFCK NTNRSQAEKL LRTENKDGGF LVRESSRAGK YTVSLLSKVG 300

GETGGSCRHY NICTTSQGHF YLAEKHYFST IPELINYHQH NAAGMVSRLK YIVSTRTRPP 360

STVGLGYGVW EIDPRHLTFI KDLGTGQFGL VKYGKWQGKH DVAIKMIKEG SMSEDDFIEE 420

AKIMMKLHHE NLVQLYGVCT KQRPIYIVTE FLSNGCLLTY LREGLKQHPT MVQLLEMCKD 480

ISEGMAYLES KQYIHRDLAA RNCLVDGNGT VKVTDFGLSR YVLDDEYTSS VGAKFPVRWS 540

PPEVLLYCKF SSKSDVWAYG VLMWEVYTLG KLPYERLNNQ EIVDKLSSGQ RLYRPQLANE 600

KVYAVMTSCW LEKPDDRPAF EELVLTVQDL LDGLQ 635

Nucleotide Sequence
(FASTA)

ATGTCAGATT TCATCCTGGA GGAGATCTTC ATTAAACGCT CCCAGCAGAA GAAGAAAACC 60

TCCCCGCTCA ACTACAAGGA GAGGCTGTTT GTGCTCACGC AGGAGAAAAT CGCCTACTAT 120

GATTTTGATG CTGAGAAGCG GAAGCGAAAA GGTCTAAGAG GATCCGTGGA CCTGGAGAAA 180

ATCAAGTGCG TGGAGACGGT TGAACCCGAG CCCAACGCCC CGCAGGAGCG CATGTATGCC 240

TTCCAGATCG TGTACGACGA GGGGCCTTTG TACGTTTTTG CAAAGACTGA GGAAGCCCGT 300

TCCCGATGGA TAAAGACCCT TAAAGACATG GTGCGCTGCA ACAAGGACCT CCTGCAGAAG 360

TACCATCCCT GTTCCTGGAT GGACGGGGTC TGGCTGTGCT GCCACCAGGA GGTCAAACAG 420

GCCATGGGCT GCAAGGTGCT GGATAATAAA AACGGGTTTA CCTGGAACTC CAACCGAAGG 480

GCCTCCAGGA AGCCTCTTCC ACCCACCCCG ACAGAGGAGA AACCTGGCTG GACTTTACCT 540

CCTCAGCCGC CGGAGCCGCA GGGACCCTCT GTAGGTATGA CGGTCACGGC AGAGTACAAT 600

TACGCACCCA TGACGCCACA AGACTTGGAG CTGAAGAAGG AGGAGCAGTA CACCATCCTG 660

GAGATGTCCG ACCCCAACTG GTGGAGGGCC AGAGACAAAT ATGGGAATGA AGGCTACATC 720

CCCAGCAATT ACGTTGTGGA GGCTGAAAAG GGGTTAGAAC GTTTCGACTG GTTTTGTAAG 780

AACACAAATC GCAGCCAAGC AGAAAAACTG TTAAGGACTG AGAACAAAGA TGGAGGCTTC 840

TTGGTGCGGG AATCAAGCAG AGCTGGAAAA TACACAGTGT CATTGTTGAG CAAGGTTGGA 900

GGAGAAACGG GTGGAAGCTG CAGACACTAT AACATCTGCA CCACTTCCCA GGGACACTTT 960

TACCTGGCTG AGAAGCACTA TTTCAGCACC ATCCCTGAGC TCATCAACTA CCACCAGCAC 1020

AACGCAGCAG GAATGGTTAG CAGGCTGAAA TATATCGTAT CCACCCGGAC GCGGCCTCCC 1080

TCCACAGTGG GGCTGGGCTA CGGTGTGTGG GAGATCGACC CTCGTCACCT CACCTTCATC 1140

AAAGACCTGG GCACCGGCCA GTTTGGACTG GTGAAGTACG GAAAGTGGCA GGGAAAACAC 1200

GACGTGGCCA TTAAGATGAT AAAAGAGGGC TCCATGTCTG AGGATGACTT CATAGAGGAA 1260

GCAAAAATCA TGATGAAGCT CCACCATGAA AACCTGGTCC AGTTGTACGG GGTGTGCACC 1320

AAACAAAGAC CTATTTACAT CGTGACCGAG TTCCTCTCCA ACGGCTGCTT GCTGACGTAC 1380

CTCAGGGAAG GGCTGAAGCA GCACCCGACG ATGGTCCAGC TGCTGGAGAT GTGCAAGGAC 1440

ATCTCTGAGG GCATGGCCTA CCTGGAGTCC AAGCAGTACA TCCACAGAGA CCTGGCTGCC 1500

AGGAACTGCT TAGTAGATGG CAACGGCACC GTCAAAGTCA CAGATTTTGG GTTATCAAGG 1560

TATGTGTTAG ATGATGAGTA CACAAGTTCA GTAGGGGCCA AGTTTCCTGT TCGCTGGTCC 1620

CCTCCTGAGG TCCTCCTCTA CTGCAAATTC AGCAGCAAGT CGGACGTATG GGCATATGGG 1680

GTCCTCATGT GGGAGGTGTA CACTTTGGGA AAGCTTCCGT ATGAGCGCCT CAACAACCAG 1740

GAGATTGTGG ACAAGCTGTC GAGTGGTCAG CGCCTCTACC GCCCACAACT GGCCAATGAG 1800

AAGGTCTACG CTGTCATGAC CAGCTGCTGG CTCGAAAAAC CGGATGACAG GCCTGCATTT 1860

GAGGAGCTAG TTCTGACTGT TCAGGATCTT CTGGATGGGC TCCAGTAG 1908

Domain Profile

S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60

         lt++k+lg+gqfg+vk+gkw++k+dvaik+ikeg+mse+dfieeak+mmkl h++lvqly

Q: 377   LTFIKDLGTGQFGLVKYGKWQGKHDVAIKMIKEGSMSEDDFIEEAKIMMKLHHENLVQLY  436

         79**********************************************************

S: 61    gvclkqkpiyivteylengcllnylrekkkkl.ekelllemckdvcegmeylerksfihr  119

         gvc+kq+piyivte+l+ngcll ylre  k+  +  +llemckd++egm+yle+k++ihr

Q: 437   GVCTKQRPIYIVTEFLSNGCLLTYLREGLKQHpTMVQLLEMCKDISEGMAYLESKQYIHR  496

         **************************98666515678***********************

S: 120   dlaarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdv  179

         dlaarnclvd + +vkv+dfgl+ryvldd+y+ssvgakfpv+wsppevl y k+ssksdv

Q: 497   DLAARNCLVDGNGTVKVTDFGLSRYVLDDEYTSSVGAKFPVRWSPPEVLLYCKFSSKSDV  556

         ************************************************************

S: 180   wafgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpee  239

         wa+gvlmwev+++gklpye+ +n+e+v+k+s g rlyrp+la++kvy vm+scw ekp++

Q: 557   WAYGVLMWEVYTLGKLPYERLNNQEIVDKLSSGQRLYRPQLANEKVYAVMTSCWLEKPDD  616

         ************************************************************

S: 240   rptfkellsale  251

         rp+f+el+ +++

Q: 617   RPAFEELVLTVQ  628

         *******98775

Domain Sequence
(FASTA)

LTFIKDLGTG QFGLVKYGKW QGKHDVAIKM IKEGSMSEDD FIEEAKIMMK LHHENLVQLY 60

GVCTKQRPIY IVTEFLSNGC LLTYLREGLK QHPTMVQLLE MCKDISEGMA YLESKQYIHR 120

DLAARNCLVD GNGTVKVTDF GLSRYVLDDE YTSSVGAKFP VRWSPPEVLL YCKFSSKSDV 180

WAYGVLMWEV YTLGKLPYER LNNQEIVDKL SSGQRLYRPQ LANEKVYAVM TSCWLEKPDD 240

RPAFEELVLT VQ 252

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0005543	; F:phospholipid binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0009952	; P:anterior/posterior pattern specification
GO:0035556	; P:intracellular signal transduction
GO:0030178	; P:negative regulation of Wnt receptor signaling pathway
GO:0060828	; P:regulation of canonical Wnt receptor signaling pathway

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR001849	; Pleckstrin_homology.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR001562	; Znf_Btk_motif.

Pfam

PF00779	; BTK; 1.
PF00169	; PH; 1.
PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00107	; BTK; 1.
SM00233	; PH; 1.
SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.
PS51113	; ZF_BTK; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013