EKS-TEN-00201

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00201

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/RSKb	477.0	1.5E-143	399	656	258

Status

Unreviewed

Ensembl Protein

ENSTNIP00000018850

UniProt Accession

H3C6P2;

Protein Name

Ribosomal protein S6 kinase

Protein Synonyms/Alias

Gene Name

RPS6KA6

Gene Synonyms/Alias

RPS6KA6;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000015774	ENSTNIP00000008277	ENSTNIT00000008443
ENSTNIG00000015774	ENSTNIP00000018850	ENSTNIT00000019078
ENSTNIG00000015774	ENSTNIP00000003913	ENSTNIT00000000926
ENSTNIG00000015774	ENSTNIP00000002055	ENSTNIT00000003899
ENSTNIG00000015774	ENSTNIP00000018852	ENSTNIT00000019080
ENSTNIG00000015774	ENSTNIP00000018851	ENSTNIT00000019079

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

718

Protein Sequence
(FASTA)

NGHQVMDEPM EEGESFSHCD EGTYKEIPIT HHVKEGCEKA DPSQFELLKV LGQGSFGKVF 60

LVRKILGPDA GQLYAMKVLK KASLKVRDRV RTKMERDILV EVNHPFIVKL HYAFQTEGKL 120

YLILDFLRGG DVFTRLSKEV MFTEEDVKFY LAELALALDH LHNLGIVYRD LKPENILLDE 180

AGHIKLTDFG LSKESVDADK KAYSFCGTVE YMAPEVVNRR GHTQSADWWS LGVLMFEMLT 240

GTLPFQGKDR NETMNMILKA KLGMPQFLSL EAQSLLRMLF KRNPANRLGA GPDGVEEIKR 300

HSFFSTIDWN KLYRRELQPP FKPAAGKPDD TFCFDPEFTA KTPKDSPGIP PSANAHQLFK 360

GFSFVAPAPM DENKGSPLLS ILPIVQNMHG GSAKFSDLYE LQEDIGVGSY SICKRCVHRV 420

SAVDYAVKII DKIKRDPSEE IEILMRYGQH PNIITLKDVY DEGRYVYLVM ELMKGGELLD 480

KILRQKFFSE REASAVLYTI TKTVHYLHCQ GVVHRDLKPS NILYMDDSGN PDSIRICDFG 540

FAKQLRGGNG LLLTPCYTAN FVAPEVLMRQ GYDAACDIWS LGVLLYTMLA GYTPFANGPN 600

DTPEEILLRI GSGKFSLTGG NWDTVSDTSK DLLSHMLHVD PHQRYSAEQV LKHSWITCRD 660

TLPHFQLTRH DAPHLVKGAM AATYSALSQK TSQPVLEPVA ASSLAQRRSM KKLTSTDM 718

Nucleotide Sequence
(FASTA)

AATGGGCATC AGGTCATGGA CGAGCCCATG GAGGAGGGAG AGTCTTTCTC ACACTGCGAT 60

GAAGGGACCT ATAAGGAGAT TCCAATCACC CATCATGTGA AAGAGGGTTG TGAGAAAGCC 120

GATCCGTCTC AGTTCGAACT GCTCAAAGTC CTCGGCCAGG GTTCGTTTGG CAAGGTATTT 180

CTGGTCAGGA AGATTCTGGG TCCAGACGCT GGTCAGTTAT ATGCAATGAA AGTGCTAAAA 240

AAGGCATCTT TGAAGGTCAG GGACAGAGTT CGGACCAAGA TGGAAAGAGA CATTTTAGTC 300

GAAGTCAATC ATCCCTTCAT AGTGAAATTG CACTACGCCT TTCAAACAGA AGGGAAACTG 360

TATTTAATAC TGGACTTTCT CAGGGGAGGG GATGTATTCA CTCGCTTATC CAAAGAGGTT 420

ATGTTTACAG AGGAAGATGT GAAATTCTAC CTTGCAGAGC TGGCCCTGGC CCTCGACCAT 480

CTGCACAACC TGGGCATAGT TTACAGAGAT CTCAAGCCAG AGAACATCTT ACTTGATGAA 540

GCTGGACATA TAAAGTTAAC AGACTTTGGC CTGAGCAAAG AGTCGGTGGA TGCTGACAAG 600

AAGGCGTATT CCTTCTGTGG TACGGTGGAG TATATGGCCC CCGAGGTGGT CAACAGGAGA 660

GGACACACAC AGAGTGCAGA CTGGTGGTCT TTGGGAGTAC TCATGTTTGA GATGCTAACA 720

GGAACATTAC CATTTCAAGG GAAAGACCGC AACGAGACCA TGAACATGAT CCTCAAAGCA 780

AAGTTGGGAA TGCCCCAGTT CCTCAGTTTG GAGGCCCAGA GTTTGCTCCG CATGCTTTTC 840

AAACGCAACC CCGCTAACAG ACTAGGGGCT GGGCCTGATG GAGTGGAGGA GATCAAGCGG 900

CACTCGTTCT TTTCCACCAT CGACTGGAAT AAACTCTACA GGAGAGAGCT CCAGCCCCCG 960

TTTAAACCTG CAGCAGGCAA ACCGGATGAC ACGTTCTGCT TTGACCCAGA GTTCACCGCT 1020

AAAACACCTA AAGACTCCCC AGGTATCCCT CCCAGTGCAA ATGCCCACCA GCTCTTCAAA 1080

GGCTTCAGTT TTGTTGCTCC AGCACCAATG GATGAAAACA AGGGCTCCCC GCTGCTCAGT 1140

ATCCTCCCCA TAGTTCAGAA TATGCATGGC GGCTCGGCCA AGTTCTCCGA TCTGTACGAG 1200

CTGCAGGAGG ACATCGGAGT GGGCTCCTAC TCCATTTGTA AACGCTGTGT ACATCGAGTG 1260

TCGGCCGTGG ACTATGCTGT GAAGATTATT GATAAAATCA AGAGGGACCC CTCTGAGGAA 1320

ATTGAAATCC TGATGCGATA CGGCCAGCAT CCCAACATCA TCACCCTGAA AGACGTTTAT 1380

GACGAGGGCA GGTACGTGTA CCTGGTGATG GAGCTGATGA AAGGAGGTGA GCTGCTGGAC 1440

AAGATCCTCA GGCAGAAGTT CTTCTCTGAG AGAGAGGCCA GTGCTGTGCT CTACACCATC 1500

ACCAAGACTG TTCACTACCT CCACTGCCAA GGGGTGGTAC ACCGAGACCT GAAGCCCAGT 1560

AACATCCTCT ACATGGACGA CTCGGGAAAT CCCGACTCTA TCAGGATATG CGACTTTGGG 1620

TTTGCCAAGC AGCTTCGCGG AGGGAACGGC TTGCTCCTCA CCCCCTGTTA CACCGCCAAC 1680

TTTGTGGCAC CAGAGGTACT AATGCGGCAA GGTTATGATG CGGCCTGTGA CATCTGGAGT 1740

CTAGGAGTTC TACTCTATAC CATGCTAGCA GGGTACACGC CGTTTGCTAA CGGGCCAAAT 1800

GATACACCAG AGGAGATTCT TCTCAGAATT GGATCTGGAA AGTTTTCTCT GACTGGAGGC 1860

AACTGGGATA CTGTGTCAGA CACCTCAAAG GACCTGCTGT CACACATGCT CCATGTGGAC 1920

CCTCACCAGC GATACTCAGC AGAGCAGGTT CTAAAACATT CCTGGATCAC CTGCAGAGAC 1980

ACATTACCAC ACTTCCAGCT CACACGCCAT GATGCACCTC ACCTTGTCAA GGGAGCCATG 2040

GCTGCTACGT ATTCAGCACT GAGCCAGAAA ACAAGTCAGC CTGTGCTGGA GCCCGTAGCA 2100

GCCTCCAGTC TGGCCCAGAG ACGCAGTATG AAGAAACTCA CCTCGACAGA CATGTAG 2157

Domain Profile

S: 1     yevkedlGvGsysvckrcvhkatnqefavkiidkskrdtseeieillryeqhpnivtlkd  60

         ye++ed+GvGsys+ckrcvh+ +  ++avkiidk krd+seeieil+ry+qhpni+tlkd

Q: 399   YELQEDIGVGSYSICKRCVHRVSAVDYAVKIIDKIKRDPSEEIEILMRYGQHPNIITLKD  458

         6899********************************************************

S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120

         vyd+g+yvylv+el+kGGelld+i+++kffsereasa+l+t++k+v+ylh+qGvvhrdlk

Q: 459   VYDEGRYVYLVMELMKGGELLDKILRQKFFSEREASAVLYTITKTVHYLHCQGVVHRDLK  518

         ************************************************************

S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180

         p+nily+d+s+n++si+i+dfGfak++r  ngll tpcyt+nfvapevl+rqGyd+acd+

Q: 519   PSNILYMDDSGNPDSIRICDFGFAKQLRGGNGLLLTPCYTANFVAPEVLMRQGYDAACDI  578

         ************************************************************

S: 181   wslGvllytmlaGyvpfangpedtaeeilakikeGkfslsGeawdsvseeakdlvskllt  240

         wslGvllytmlaGy+pfangp+dt+eeil +i++Gkfsl G++wd+vs+++kdl+s++l+

Q: 579   WSLGVLLYTMLAGYTPFANGPNDTPEEILLRIGSGKFSLTGGNWDTVSDTSKDLLSHMLH  638

         ************************************************************

S: 241   vdpakrlkleqllkhswl  258

         vdp++r+ +eq+lkhsw+

Q: 639   VDPHQRYSAEQVLKHSWI  656

         *****************8

Domain Sequence
(FASTA)

YELQEDIGVG SYSICKRCVH RVSAVDYAVK IIDKIKRDPS EEIEILMRYG QHPNIITLKD 60

VYDEGRYVYL VMELMKGGEL LDKILRQKFF SEREASAVLY TITKTVHYLH CQGVVHRDLK 120

PSNILYMDDS GNPDSIRICD FGFAKQLRGG NGLLLTPCYT ANFVAPEVLM RQGYDAACDI 180

WSLGVLLYTM LAGYTPFANG PNDTPEEILL RIGSGKFSLT GGNWDTVSDT SKDLLSHMLH 240

VDPHQRYSAE QVLKHSWI 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016239	; Ribosomal_S6_kinase_II.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 2.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 2.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 2.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00108	; PROTEIN_KINASE_ST; 2.

Prints

Created Date

20-Feb-2013