EKS-TEN-00358

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00358

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	447.8	1.7E-134	235	522	288

Status

Unreviewed

Ensembl Protein

ENSTNIP00000018885

UniProt Accession

H3DEE2;

Protein Name

Protein Synonyms/Alias

Gene Name

BMPR1B (2 of 2)

Gene Synonyms/Alias

BMPR1B (2 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000015803	ENSTNIP00000018885	ENSTNIT00000019113

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

533

Protein Sequence
(FASTA)

VTQRYTKSLL KGSSLMLCKT FFLLGNILDS MLLKASNKEA AGSRKETSGS AAPAPSAQRL 60

LWCHCYHYCP EDSTNNTCRT DGYCFTMVEE EAVGVPVQTA GCLGLGGSVF QCRDTVGSRQ 120

RRSIECCTDE DYCNKNLHPT LPPLKPPLYM DGKIHHLALL ISVTVCSLIL VAIITFCYIR 180

YRRQESRPRY SIGLEQDESY SLPGESLKDL IEQSQSSGSG SGLPLLVQRT IAKQIQMVKQ 240

IGKGRYGEVW MGKWRGEKVA VKVFFTTDEA SWSRETEIYQ TVLMRHENIL GFIAADIKGT 300

GSWTQLYLIT DYHENGSLYD YLKSTTLDNK AMLRLAYSSV SGLCHLHTEI FGTQGKPAIA 360

HRDLKSKNIL VKRNGTCCIA DLGLAVKFIS DTNEVDIPPN TKVGTKRYMP PEVLDETLNK 420

SHFQSYIMAD VYSFGLILWE IARRCISGGI LEEYQLPYHE LVPTDPSYED MKEVVCTKRL 480

RPSFPNRWTS DECLRQMGKL MTECWAHNPG SRLTALRVKK TLAKMSESQD IKL 533

Nucleotide Sequence
(FASTA)

GTTACACAAA GATACACAAA GTCACTCCTG AAAGGAAGTT CTTTGATGTT GTGTAAAACT 60

TTTTTTTTAC TAGGCAACAT ATTGGACAGC ATGCTGCTGA AAGCGTCCAA TAAGGAGGCG 120

GCGGGGAGCC GGAAGGAGAC CAGTGGCAGC GCAGCTCCGG CGCCATCCGC CCAAAGACTG 180

CTGTGGTGTC ACTGTTATCA CTACTGCCCC GAAGACTCCA CCAACAACAC GTGCAGGACG 240

GATGGCTACT GTTTCACCAT GGTGGAAGAG GAGGCAGTGG GGGTTCCGGT CCAGACTGCG 300

GGCTGCCTGG GGCTGGGCGG CTCAGTGTTT CAGTGTCGGG ACACGGTGGG CTCGCGACAA 360

AGGAGATCCA TCGAGTGCTG CACAGATGAG GATTACTGCA ACAAAAACCT GCATCCCACG 420

CTGCCACCGC TCAAACCTCC CCTCTACATG GATGGGAAGA TCCACCATTT GGCCCTGTTG 480

ATCTCAGTTA CTGTGTGCAG CCTCATACTG GTCGCCATCA TCACCTTCTG CTACATTAGG 540

TACAGACGTC AGGAGTCTCG TCCCCGGTAC AGTATTGGAC TGGAGCAGGA TGAGAGTTAC 600

AGCCTGCCTG GAGAATCCTT GAAGGACCTG ATTGAACAGT CCCAAAGCTC TGGCTCAGGC 660

TCGGGGCTCC CTCTGTTGGT ACAGAGAACT ATAGCTAAGC AGATCCAGAT GGTAAAGCAG 720

ATAGGCAAGG GCCGCTATGG AGAGGTGTGG ATGGGAAAGT GGAGGGGTGA AAAGGTTGCC 780

GTCAAAGTGT TCTTCACCAC GGACGAGGCC AGTTGGTCCA GAGAGACCGA GATCTATCAG 840

ACCGTCTTGA TGAGACATGA GAACATTCTG GGTTTCATAG CCGCTGACAT TAAAGGCACT 900

GGCTCCTGGA CCCAGCTCTA CCTGATCACC GACTACCATG AAAACGGCTC CTTGTACGAC 960

TACCTCAAAT CCACCACGCT GGACAACAAA GCCATGCTAA GGCTGGCGTA TTCCTCGGTG 1020

TCAGGCCTCT GTCACCTCCA CACTGAGATC TTTGGTACCC AAGGCAAGCC GGCCATCGCT 1080

CACAGAGACC TGAAGAGCAA AAACATCCTG GTGAAAAGAA ACGGGACCTG CTGCATCGCC 1140

GACCTCGGAC TGGCGGTCAA GTTTATTAGT GACACCAATG AGGTCGACAT CCCTCCCAAC 1200

ACAAAGGTTG GTACCAAGCG CTACATGCCG CCGGAGGTTC TGGATGAGAC GCTGAACAAA 1260

AGTCACTTTC AGTCGTACAT CATGGCGGAC GTGTACAGCT TTGGGCTCAT TCTCTGGGAG 1320

ATCGCTCGGC GTTGCATCTC AGGAGGGATC CTTGAGGAGT ACCAACTGCC CTACCACGAG 1380

TTGGTTCCAA CAGACCCTTC GTATGAGGAT ATGAAAGAGG TGGTCTGCAC CAAGAGACTA 1440

CGGCCATCTT TTCCTAACCG ATGGACCAGC GATGAATGTT TGAGACAGAT GGGGAAGCTG 1500

ATGACAGAAT GCTGGGCTCA CAACCCTGGC TCCCGCCTCA CGGCCCTCAG AGTGAAAAAA 1560

ACACTGGCCA AGATGTCAGA ATCACAAGAC ATCAAGCTGT GA 1602

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         ++++++igkGrygeVw++k+rge+vAvK+f+t+deasw rE+eiyqtvl+rhenil+fia

Q: 235   IQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTDEASWSRETEIYQTVLMRHENILGFIA  294

         799*********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k ++s+t+l+l+t+yhe+gsL+dyLk++tld + +lrla+s +sGl+hLH+ei+gt+

Q: 295   ADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDNKAMLRLAYSSVSGLCHLHTEIFGTQ  354

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvk+++tcciaDlGLa+k+ ++++e+d+  n++vGtkRYm PE

Q: 355   G--KPAIAHRDLKSKNILVKRNGTCCIADLGLAVKFISDTNEVDIPPNTKVGTKRYMPPE  412

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e+ln ++f+++ +aDvYs+gL+lWE+a+Rc + +++ eey+lp++e v++dPs+e+m

Q: 413   VLDETLNKSHFQSYIMADVYSFGLILWEIARRCIS-GGILEEYQLPYHELVPTDPSYEDM  471

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         kevv++k+lrP++p++w+++e+l+++ kl++ecW+++p +Rltalrvkk+l

Q: 472   KEVVCTKRLRPSFPNRWTSDECLRQMGKLMTECWAHNPGSRLTALRVKKTL  522

         *************************************************97

Domain Sequence
(FASTA)

IQMVKQIGKG RYGEVWMGKW RGEKVAVKVF FTTDEASWSR ETEIYQTVLM RHENILGFIA 60

ADIKGTGSWT QLYLITDYHE NGSLYDYLKS TTLDNKAMLR LAYSSVSGLC HLHTEIFGTQ 120

GKPAIAHRDL KSKNILVKRN GTCCIADLGL AVKFISDTNE VDIPPNTKVG TKRYMPPEVL 180

DETLNKSHFQ SYIMADVYSF GLILWEIARR CISGGILEEY QLPYHELVPT DPSYEDMKEV 240

VCTKRLRPSF PNRWTSDECL RQMGKLMTEC WAHNPGSRLT ALRVKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0030509	; P:BMP signaling pathway
GO:0048263	; P:determination of dorsal identity
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013