EKS-TEN-00516

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00516

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/IRAK	295.3	5.4E-88	190	454	265

Status

Unreviewed

Ensembl Protein

ENSTNIP00000019071

UniProt Accession

H3DEX7;

Protein Name

Protein Synonyms/Alias

Gene Name

IRAK4

Gene Synonyms/Alias

IRAK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000015983	ENSTNIP00000019071	ENSTNIT00000019299

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

465

Protein Sequence
(FASTA)

MSNSVTSATY IRNLSYSLRR QLSDILDPQE RWKEIIVSIR KPNGDFRYSQ HHVRRFAGLP 60

AQGKSPTEEL LADWGTTNCT VGELVDMLKN NSLLAAVTLL LPGLKDAIPA ETLQPGPPSG 120

ETYSALPTRL LDDAGALAGS SSASTHILPD SREPEPSGEP FRNFRLRSVP YNDLIRITND 180

FDDRPVSDGG CRLGEGGFGA VYKGVLNQIP VAVKKLVPIE DISLEELRVQ FHQEVQTLRV 240

LKHENLVDMV GFSCDGQYPC VIYPLMSNGS LLNCLACLEG SPPLSWKQRC SIAEGTANGL 300

DYLHSNHHVH RDVKSANILL DEKRVAKISD FGLTRASPKG TSTTMMTERI VGTCAYMAPE 360

ALRGQVTPKS DIFSFGVVLL EILSGLPPAD ENREPQFLME VTFTIDDEDE ELTLEGFLDK 420

KMEDVDFSQA ESVYTLACSC LQDRKNQRPL SKQVGRGRTH SLTWS 465

Nucleotide Sequence
(FASTA)

ATGAGTAATT CGGTAACTTC CGCTACTTAC ATTCGTAATC TCAGTTATAG TTTACGACGA 60

CAATTATCCG ATATTTTAGA TCCTCAGGAG AGGTGGAAAG AGATTATTGT CTCCATACGG 120

AAGCCGAATG GGGACTTCAG ATATTCCCAA CATCATGTCA GGAGGTTCGC AGGTCTGCCT 180

GCGCAGGGAA AAAGCCCCAC AGAGGAGCTG CTGGCTGACT GGGGCACCAC CAACTGTACA 240

GTGGGAGAAC TGGTGGACAT GCTGAAGAAT AATAGCTTAT TAGCTGCTGT TACTCTTCTG 300

CTGCCTGGTT TGAAAGATGC CATCCCAGCA GAAACACTGC AGCCAGGCCC TCCATCAGGG 360

GAAACCTACA GCGCTCTCCC AACCAGACTG CTGGACGACG CAGGGGCGCT GGCAGGTTCC 420

AGCTCCGCGT CCACACACAT TCTGCCAGAC AGCAGAGAAC CAGAGCCCTC AGGTGAACCT 480

TTCAGGAACT TTAGGCTCAG AAGTGTCCCA TACAACGATC TGATTAGGAT TACCAATGAC 540

TTTGACGACC GTCCTGTATC AGACGGGGGC TGCAGGCTGG GAGAAGGAGG CTTCGGCGCT 600

GTCTACAAAG GTGTCCTAAA CCAGATACCG GTGGCTGTGA AAAAGCTCGT TCCCATAGAG 660

GACATCTCCC TGGAGGAGCT ACGAGTCCAG TTCCACCAGG AGGTCCAAAC TCTGAGAGTT 720

TTAAAACACG AGAACCTGGT GGACATGGTT GGATTCTCCT GTGATGGACA GTACCCGTGT 780

GTGATCTACC CGTTAATGTC CAACGGTTCG CTGCTGAACT GTTTGGCCTG CCTGGAAGGA 840

AGTCCACCAT TGTCTTGGAA ACAGAGATGT TCGATAGCTG AAGGGACCGC AAACGGTTTG 900

GACTACCTGC ACAGTAACCA CCATGTTCAT AGAGATGTAA AAAGCGCAAA TATCCTGTTA 960

GATGAAAAAC GGGTGGCGAA GATCTCAGAT TTCGGGTTGA CCAGAGCTTC TCCCAAGGGG 1020

ACTTCGACGA CCATGATGAC AGAGAGGATT GTGGGTACCT GCGCGTACAT GGCGCCTGAG 1080

GCCCTGAGGG GGCAGGTTAC ACCTAAATCT GATATCTTCA GTTTTGGAGT GGTGCTCTTG 1140

GAAATATTGT CTGGGCTTCC TCCAGCCGAT GAAAACCGTG AGCCTCAGTT CTTGATGGAG 1200

GTGACCTTTA CAATAGACGA TGAAGACGAG GAGCTGACTT TAGAGGGGTT CCTGGACAAG 1260

AAGATGGAGG ATGTGGACTT CAGCCAGGCT GAGAGTGTCT ACACGTTGGC CTGCAGCTGC 1320

CTCCAGGACA GGAAAAACCA ACGGCCGCTC AGCAAACAGG TGGGGCGAGG AAGGACACAC 1380

TCGCTCACCT GGTCC 1395

Domain Profile

S: 4     dnrigeGgfgevyrgelkntavavkklkeeadlslkelkqsfltElkvlarfrHdnilel  63

         + r+geGgfg vy+g l++  vavkkl   +d+sl+el+ +f++E+++l  ++H+n++++

Q: 190   GCRLGEGGFGAVYKGVLNQIPVAVKKLVPIEDISLEELRVQFHQEVQTLRVLKHENLVDM  249

         579*********************************************************

S: 64    lgysaeseklcLvYqymknGsLedrLqcqkgsepLsWpqRlsillGtaraiefLHeasps  123

         +g+s +++ +c++Y++m+nGsL + L c +gs+pLsW+qR+si+ Gta+++++LH++  +

Q: 250   VGFSCDGQYPCVIYPLMSNGSLLNCLACLEGSPPLSWKQRCSIAEGTANGLDYLHSN--H  307

         *********************************************************..*

S: 124   lihgdiksaNiLLDekltpKlgDfglarfapesekqsstvlrtskvrgtlaYlpeefirv  183

         ++h+d+ksaNiLLDek  +K++Dfgl+r   +s+k +st ++t++++gt aY+++e++r

Q: 308   HVHRDVKSANILLDEKRVAKISDFGLTR---ASPKGTSTTMMTERIVGTCAYMAPEALR-  363

         ****************************...89999999999*****************.

S: 184   gqltvkvDvySfGiVllEvltGlravdedrktkyLkdllkeeieeekveilekfldkkag  243

         gq+t k+D++SfG+VllE+l+Gl+  de+r+++ L ++     +e++  +le fldkk+

Q: 364   GQVTPKSDIFSFGVVLLEILSGLPPADENREPQFLMEVTFTIDDEDEELTLEGFLDKKME  423

         *************************************975555555556899********

S: 244   kleeellealielalaclaekakkrPtmsqv  274

         +++ + +e++++la+ cl++++++rP  +qv

Q: 424   DVDFSQAESVYTLACSCLQDRKNQRPLSKQV  454

         **************************99887

Domain Sequence
(FASTA)

GCRLGEGGFG AVYKGVLNQI PVAVKKLVPI EDISLEELRV QFHQEVQTLR VLKHENLVDM 60

VGFSCDGQYP CVIYPLMSNG SLLNCLACLE GSPPLSWKQR CSIAEGTANG LDYLHSNHHV 120

HRDVKSANIL LDEKRVAKIS DFGLTRASPK GTSTTMMTER IVGTCAYMAP EALRGQVTPK 180

SDIFSFGVVL LEILSGLPPA DENREPQFLM EVTFTIDDED EELTLEGFLD KKMEDVDFSQ 240

AESVYTLACS CLQDRKNQRP LSKQV 265

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0045893	; P:positive regulation of transcription, DNA-dependent
GO:0009617	; P:response to bacterium
GO:0007165	; P:signal transduction

KEGG

InterPros

IPR011029	; DEATH-like.
IPR017428	; Interleukin-1_rcpt-assoc_kin4.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013