EKS-TEN-00142
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TEN-00142
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Met448.39.2E-13510851342258
StatusUnreviewed
Ensembl ProteinENSTNIP00000019147
UniProt AccessionH3DF54;
Protein Name
Protein Synonyms/Alias
Gene NameMET
Gene Synonyms/Alias MET;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTNIG00000016058ENSTNIP00000019147ENSTNIT00000019375
ENSTNIG00000016058ENSTNIP00000019148ENSTNIT00000019376
OrganismTetraodon nigroviridis
Functional Description
Protein Length1343
Protein Sequence
(FASTA)
MNLCCLPAVP LLLLLLWALS ASAEGHCDKS PETNKLNLSV SYELPTFTAD SPIQNMVTLD 60
GIIYVGAVNR IYALAPDLTK LSEYHTGPLL ANQTCGQKFA NTSFGGGRKD NVNVALVLEN 120
IYDKGLFSCG SADNGVCRRH VLEDDVSQKS VDEQVYCFTD LKQDKGQPRD SDVVVSPSGS 180
QVLNVESNMI MFFVGNSEIP GLGNGIGSAT HPHTMSLRKM KTSQNGFTFL SSQSYMDLIP 240
PLRGSYYLRY VYSFHSGPFT YFLTVQQVSK DSQAYHTRIV RMCSFDHDIR RYVEMPLECI 300
STDKRRRRST EDVKVFNILQ AANVTKVGSD VELQRQLKVE EDDDVLFAAF ARGKPNSPEP 360
TPNSAICIMS LKHINDMFKM YMKKCNTVDL YHFTGSDTKS CYNVVCLHMS TCCAGKEGKY 420
RLQVTQFVQR LEYWHKELTN TLVTSINVVP VHGRAVAYLG TADGRHIQVV FSRSLRPHVN 480
IRLDSRPVSA GVVLPGQNLS EGALLLATGN KITKVPLIGP GCDQLTTCTS CLLSSRVTEC 540
GWCDGRCTRA NQCPSSIWTQ EYCTPVITKV FPTSGPIRGS TTVTICGLNF GFVKTESFKV 600
PLVTVEVAGA HCKLLRQDYI NRWTEIQCSP MSAGNFTPSG HTVKVTSGHM VAKMDGFTFV 660
DPVISEIFPT FGPKSGSTML TIRGASLDTG NKLEVTVGKA ACNIQSLSPT MLTCKTSPYA 720
VPCKQPVKLT VDSVERQAPL LFTYNRDPII SSIQPSRSFV SGGCTVVAHG LFLQSGLQPQ 780
MILTTGQDAE VFHVSCVYGE NGTSIHCTTP SLAKLALQPP VVTKVAFVLD GYMTEQKDLI 840
YVEDPLFQDP KLTSKDNKSI VELKGDRMDR EAMKCQVLTV SNHSCESLTL VGNTLECTIP 900
TELQTTTSKE LQVEWRQADS VIHLGNLMLA QEQDYTGLVV GSVCVSLLLL LLGSLLMWRR 960
NKNIDVVDLS EVWYDGRGHI QHLDRLANAR SVSPTNEMVS HESVDYRTNL LEGSELTPWS 1020
SDDVTFNSLN VLLVTLGSGM GLGMEGELVS PLLMAPVHID PSCLHPDLLT EVQHVVIARE 1080
QLLLHLNQVI GRGHFGCVFH GTLLEPDGQK QHCAVKSLNR ITDLEEVSQF LKEGIIMKDF 1140
SHPNVLSLLG ICLPPEGSPL MVLPYMKHGD LRNFIRDEAH NPTVKDLMGF GLQVARGMEY 1200
LASKKFVHRD LAARNCMLDE SYTVKVADFG LARDVYDKEY YSVHNKSGVK LPVKWMALES 1260
LQTHKFTTKS DVWSFGVLLW ELMTRGAPPY SDVNSFDITV FLLQGRRLLQ PEFCPDALYT 1320
VMIECWHPNP ERRHSYSELV SRL 1343
Nucleotide Sequence
(FASTA)
ATGAATCTCT GCTGCCTTCC TGCCGTCCCC CTGCTGCTGC TGCTGCTTTG GGCCCTGAGC 60
GCCAGCGCAG AGGGCCACTG CGATAAATCA CCCGAGACCA ACAAACTAAA CCTCTCCGTC 120
AGCTACGAGC TGCCGACGTT CACTGCAGAC TCCCCCATCC AGAACATGGT GACGCTCGAC 180
GGGATCATCT ACGTCGGGGC CGTGAACAGG ATCTATGCTT TGGCCCCGGA CCTCACCAAA 240
CTCTCGGAGT ACCACACCGG GCCGCTTCTC GCCAACCAGA CTTGCGGTCA GAAGTTTGCC 300
AACACCAGCT TCGGCGGCGG CAGGAAGGAC AACGTCAACG TCGCCCTGGT GCTGGAAAAC 360
ATCTACGACA AAGGGCTGTT CAGCTGCGGT TCGGCCGACA ACGGCGTTTG CCGCCGCCAC 420
GTCCTGGAAG ACGACGTCAG CCAGAAGAGT GTGGACGAGC AGGTCTACTG CTTCACCGAC 480
CTGAAGCAAG ACAAAGGCCA ACCCAGAGAC TCCGATGTTG TGGTCAGCCC TTCAGGTTCT 540
CAGGTGCTTA ACGTGGAGAG CAACATGATC ATGTTTTTCG TTGGAAACTC CGAAATTCCT 600
GGTTTGGGAA ATGGAATAGG CTCTGCCACG CATCCCCACA CCATGTCTCT GCGGAAGATG 660
AAGACGAGCC AGAACGGGTT CACCTTTTTG TCAAGCCAGT CTTACATGGA CCTGATTCCA 720
CCTCTCCGCG GCAGTTACTA CCTGCGATAC GTCTACTCCT TCCACAGTGG ACCCTTCACC 780
TACTTCCTCA CTGTGCAGCA GGTGAGCAAG GACTCCCAGG CCTACCACAC GCGCATCGTG 840
CGCATGTGCT CCTTCGATCA CGACATCCGG CGCTACGTGG AGATGCCGCT CGAGTGCATC 900
AGCACAGACA AACGGCGGCG GCGCTCCACG GAAGACGTGA AGGTCTTCAA CATCCTCCAG 960
GCGGCCAACG TCACCAAGGT GGGCAGTGAC GTGGAGCTGC AGAGGCAGCT GAAAGTGGAG 1020
GAAGACGACG ACGTGCTCTT CGCCGCCTTC GCCCGGGGAA AGCCCAACTC CCCGGAGCCG 1080
ACCCCGAACT CCGCCATTTG CATCATGTCT CTGAAGCACA TCAACGACAT GTTCAAGATG 1140
TACATGAAGA AGTGCAACAC GGTCGACCTC TATCATTTCA CCGGATCTGA CACGAAGTCC 1200
TGCTACAACG TGGTTTGTTT GCATATGTCC ACCTGCTGTG CAGGCAAAGA AGGCAAGTAC 1260
CGCCTGCAGG TCACCCAGTT TGTCCAGAGG TTGGAGTACT GGCACAAGGA GCTGACCAAC 1320
ACCTTGGTCA CATCTATCAA TGTGGTACCA GTCCACGGGC GCGCGGTAGC GTACCTCGGC 1380
ACCGCAGACG GACGGCACAT CCAGGTGGTG TTTTCACGAT CTCTCCGCCC CCATGTGAAC 1440
ATCCGCTTGG ACTCGAGACC AGTGTCAGCT GGTGTTGTGC TGCCGGGGCA GAACCTCTCC 1500
GAAGGAGCTC TTCTTCTCGC CACAGGAAAC AAGATCACAA AGGTTCCTCT GATTGGCCCT 1560
GGCTGTGATC AGCTGACCAC CTGCACCTCC TGCTTGTTGT CGTCACGTGT TACGGAGTGC 1620
GGTTGGTGTG ACGGACGTTG CACTAGAGCC AACCAGTGTC CCTCCTCAAT CTGGACGCAA 1680
GAGTATTGCA CGCCAGTCAT CACCAAGGTT TTTCCAACAT CTGGACCCAT TCGCGGTTCC 1740
ACAACGGTGA CTATTTGCGG GCTCAACTTT GGTTTCGTCA AGACGGAGAG CTTCAAGGTG 1800
CCCCTGGTGA CGGTGGAGGT GGCGGGGGCT CACTGCAAAC TTCTCAGACA AGACTACATC 1860
AACAGGTGGA CTGAGATCCA GTGTTCCCCC ATGTCTGCTG GGAACTTTAC GCCATCGGGA 1920
CACACGGTGA AGGTGACCAG TGGCCACATG GTAGCCAAGA TGGACGGCTT CACCTTTGTG 1980
GACCCCGTCA TTTCTGAGAT TTTTCCAACA TTTGGGCCGA AATCAGGGAG CACCATGCTG 2040
ACCATCAGAG GAGCTTCACT TGACACTGGA AACAAGCTGG AGGTGACAGT TGGAAAAGCA 2100
GCCTGTAACA TCCAGAGCTT GTCCCCAACG ATGCTAACAT GTAAGACTTC TCCGTACGCC 2160
GTTCCCTGCA AGCAACCCGT GAAGCTGACG GTGGACTCAG TGGAGCGTCA AGCCCCTCTG 2220
CTGTTTACGT ACAACCGAGA CCCCATCATC AGCAGCATCC AACCCTCACG CTCCTTCGTC 2280
AGCGGAGGCT GCACAGTGGT GGCTCACGGC CTCTTCCTCC AGTCTGGCCT GCAGCCCCAG 2340
ATGATCCTCA CCACCGGGCA AGATGCTGAG GTGTTTCATG TGAGCTGTGT GTACGGTGAG 2400
AACGGGACAT CCATCCACTG CACGACACCC TCCCTGGCCA AACTGGCTCT GCAGCCTCCA 2460
GTGGTCACCA AGGTAGCCTT CGTCCTGGAC GGCTACATGA CGGAGCAGAA GGACCTGATA 2520
TACGTGGAGG ACCCCCTTTT CCAGGACCCC AAGCTGACCT CAAAAGACAA CAAGAGCATC 2580
GTAGAGCTCA AAGGTGACAG GATGGACCGG GAGGCGATGA AATGTCAGGT GCTGACCGTT 2640
TCCAACCACA GCTGCGAGAG CCTGACGCTG GTCGGGAACA CGCTGGAGTG CACCATTCCC 2700
ACCGAGCTGC AGACCACCAC CTCCAAGGAG CTGCAGGTGG AGTGGCGGCA GGCGGACTCC 2760
GTTATACATC TGGGCAATCT GATGCTGGCT CAGGAGCAGG ACTACACGGG CCTGGTGGTG 2820
GGCTCTGTGT GCGTCAGTCT GCTGCTGCTG CTGCTGGGAT CTCTGCTGAT GTGGAGGAGA 2880
AACAAGAACA TCGACGTTGT AGATCTGTCT GAGGTGTGGT ATGATGGCCG GGGCCACATC 2940
CAGCATCTGG ACAGGCTGGC TAACGCGAGG AGCGTCAGTC CCACTAATGA AATGGTGTCC 3000
CACGAGTCAG TGGACTATAG AACAAACCTG CTGGAGGGCT CTGAACTAAC ACCATGGTCT 3060
TCAGATGATG TGACCTTTAA CAGTCTAAAT GTTTTACTGG TGACGCTGGG AAGCGGAATG 3120
GGTCTGGGCA TGGAGGGCGA GCTGGTGTCG CCATTACTGA TGGCCCCGGT CCACATTGAC 3180
CCATCCTGCC TGCACCCAGA CTTGCTAACT GAGGTGCAGC ATGTGGTGAT CGCCAGGGAG 3240
CAGCTGCTGC TCCACCTCAA CCAGGTTATC GGCAGAGGTC ACTTTGGCTG CGTGTTCCAT 3300
GGCACCCTGC TTGAACCCGA TGGGCAGAAG CAGCACTGTG CTGTCAAGTC TCTGAACCGC 3360
ATCACAGATC TGGAGGAGGT GTCCCAGTTC CTGAAGGAGG GGATCATCAT GAAGGACTTC 3420
AGTCACCCAA ATGTTCTGTC TCTGCTGGGG ATCTGTCTGC CGCCAGAGGG TTCTCCACTC 3480
ATGGTCCTGC CCTACATGAA GCACGGCGAC CTGCGCAACT TCATCCGTGA CGAGGCACAT 3540
AACCCAACGG TGAAGGACCT GATGGGCTTC GGGCTGCAGG TCGCCAGAGG GATGGAGTAT 3600
CTGGCCAGCA AGAAGTTTGT CCATCGAGAC CTTGCTGCCA GGAACTGCAT GCTGGACGAG 3660
AGCTACACTG TGAAGGTGGC AGACTTTGGC CTGGCCAGAG ATGTTTATGA TAAAGAATAC 3720
TATAGCGTCC ACAACAAGAG CGGAGTCAAG CTGCCCGTCA AGTGGATGGC TCTGGAAAGC 3780
CTCCAGACAC ACAAGTTCAC CACCAAGTCA GACGTGTGGT CATTTGGAGT GTTGCTGTGG 3840
GAACTGATGA CACGTGGGGC CCCGCCGTAC TCCGATGTCA ACTCCTTCGA CATCACCGTG 3900
TTCCTCCTGC AGGGGAGGAG GCTGCTGCAG CCCGAGTTCT GCCCCGATGC TCTCTACACG 3960
GTGATGATCG AGTGCTGGCA CCCCAATCCC GAGCGGCGGC ACTCTTACTC CGAGCTGGTG 4020
TCGCGCCTC 4029
Domain Profile
S: 2     dkeeviGkGhfGvvykgelsdsaskkikvavksleritdiekveeflreglvmkeldhpn  61
         + ++viG+GhfG+v++g+l++++++k+++avksl+ritd+e+v++fl+eg++mk+++hpn
Q: 1085  HLNQVIGRGHFGCVFHGTLLEPDGQKQHCAVKSLNRITDLEEVSQFLKEGIIMKDFSHPN  1144
         789*********************************************************
S: 62    vlsllGialddeglplvvlpymkkGdlksfirneernltvkdllefalqvakgmeylask  121
         vlsllGi+l++eg+pl+vlpymk+Gdl++fir+e +n+tvkdl++f+lqva+gmeylask
Q: 1145  VLSLLGICLPPEGSPLMVLPYMKHGDLRNFIRDEAHNPTVKDLMGFGLQVARGMEYLASK  1204
         ************************************************************
S: 122   kfvhrdlaarnclldekltvkvadfGlardvldkelyvveeerdarlpvkwlaleslqtf  181
         kfvhrdlaarnc+lde++tvkvadfGlardv+dke+y+v+++ + +lpvkw+aleslqt+
Q: 1205  KFVHRDLAARNCMLDESYTVKVADFGLARDVYDKEYYSVHNKSGVKLPVKWMALESLQTH  1264
         ************************************************************
S: 182   kqfttksdvwsfGvllwelltrgatpysevasfdltlylkegrrlrkpeycpdklydvml  241
         k fttksdvwsfGvllwel+trga+pys+v+sfd+t++l +grrl +pe+cpd+ly vm+
Q: 1265  K-FTTKSDVWSFGVLLWELMTRGAPPYSDVNSFDITVFLLQGRRLLQPEFCPDALYTVMI  1323
         *.**********************************************************
S: 242   kcwkakpaerpqfsdlvsi  260
         +cw+++p++r ++s+lvs+
Q: 1324  ECWHPNPERRHSYSELVSR  1342
         *****************97
Domain Sequence
(FASTA)
HLNQVIGRGH FGCVFHGTLL EPDGQKQHCA VKSLNRITDL EEVSQFLKEG IIMKDFSHPN 60
VLSLLGICLP PEGSPLMVLP YMKHGDLRNF IRDEAHNPTV KDLMGFGLQV ARGMEYLASK 120
KFVHRDLAAR NCMLDESYTV KVADFGLARD VYDKEYYSVH NKSGVKLPVK WMALESLQTH 180
KFTTKSDVWS FGVLLWELMT RGAPPYSDVN SFDITVFLLQ GRRLLQPEFC PDALYTVMIE 240
CWHPNPERRH SYSELVSR 258
KeywordATP-binding; Complete proteome; Disulfide bond; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00115
EKS-ANC-00111
EKS-BOT-00123
EKS-CAJ-00125
EKS-CAF-00126
EKS-CAP-00120
EKS-DAR-00379
EKS-EQC-00119
EKS-FEC-00114
EKS-GAG-00103
EKS-GAA-00142
EKS-GOG-00122
EKS-HOS-00125
EKS-LAC-00128
EKS-LOA-00118
EKS-MAM-00119
EKS-MEG-00093
EKS-MOD-00120
EKS-MUM-00124
EKS-MUP-00126
EKS-MYL-00133
EKS-NOL-00115
EKS-OCP-00079
EKS-ORN-00150
EKS-ORA-00101
EKS-ORC-00115
EKS-ORL-00139
EKS-OTG-00126
EKS-PAT-00111
EKS-PES-00105
EKS-POA-00116
EKS-RAN-00120
EKS-SAH-00115
EKS-SUS-00109
EKS-TAG-00152
EKS-TAR-00154
EKS-VIP-00058
EKS-XET-00102
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0004872; F:receptor activity
GO:0021707; P:cerebellar granule cell differentiation
GO:0001889; P:liver development
GO:0001764; P:neuron migration
GO:0021522; P:spinal cord motor neuron differentiation
KEGG
InterPros
IPR013783; Ig-like_fold.
IPR014756; Ig_E-set.
IPR002909; IPT_TIG_rcpt.
IPR011009; Kinase-like_dom.
IPR003659; Plexin-like.
IPR016201; Plexin-like_fold.
IPR002165; Plexin_repeat.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001627; Semaphorin/CD100_Ag.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR015943; WD40/YVTN_repeat-like_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF01437; PSI; 1.
PF01403; Sema; 1.
PF01833; TIG; 3.
SMARTs
SM00429; IPT; 3.
SM00423; PSI; 1.
SM00630; Sema; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS51004; SEMA; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013