EKS-TEN-00538

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00538

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/SGK	532.0	3.2E-160	98	355	258

Status

Unreviewed

Ensembl Protein

ENSTNIP00000019416

UniProt Accession

H3DFX2;

Protein Name

Protein Synonyms/Alias

Gene Name

SGK1

Gene Synonyms/Alias

SGK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000016322	ENSTNIP00000019416	ENSTNIT00000019646

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

431

Protein Sequence
(FASTA)

MTVQTETEQP ALTYSKSKGL VTLVTAFMKQ RRMGLNDFIQ RLATNSYACK HPEVQSILNL 60

NPPQDAELMN ANPSPPPSPS QQINLGPSSN PSAKPNDFHF LKVIGKGSFG KVLLARHRTD 120

DQFYAVKVLQ KKAILKKKEE KHIMSERNVL LKNVKHPFLV GLHYSFQTAD KLYFVLDYIN 180

GGELFYHLQR ERCFLEPRAR FYSAEIASAL GYLHSLNIVY RDLKPENILL DSQGHIILTD 240

FGLCKENIEP NGTTSTFCGT PEYLAPEVLH KQPYDRTVDW WCLGAVLYEM LYGLPPFYSR 300

NTAEMYDNIL NKPLQLKPNI SNAARHLLEG LLQKDRTKRL GCTEDFIEIK NHMFFSPINW 360

DDLNAKKITP PFNPNVTGPN DLRHFDPEFT DEPVPSSIGC SPDSVLITAS IKEAAEAFVG 420

FSYAPSMDSY L 431

Nucleotide Sequence
(FASTA)

ATGACCGTCC AGACGGAAAC AGAGCAGCCT GCGCTGACTT ATTCCAAATC TAAGGGGCTG 60

GTGACTTTAG TCACTGCGTT TATGAAACAG AGGAGGATGG GGCTGAACGA CTTCATTCAG 120

AGGCTGGCCA CAAACTCCTA CGCCTGCAAG CACCCTGAAG TTCAGTCCAT CCTGAACTTG 180

AATCCTCCAC AAGATGCGGA GCTCATGAAC GCGAACCCAT CTCCTCCCCC CAGTCCATCC 240

CAACAGATCA ACCTGGGCCC TTCCTCCAAC CCCTCAGCCA AACCCAACGA CTTCCACTTC 300

CTCAAGGTGA TCGGCAAAGG CAGCTTCGGC AAGGTGCTGC TAGCGCGGCA TCGCACCGAC 360

GACCAGTTTT ACGCCGTCAA GGTCTTGCAG AAAAAGGCCA TCCTGAAGAA GAAGGAGGAG 420

AAACACATCA TGTCTGAGAG GAATGTGCTG CTGAAGAACG TCAAGCACCC GTTTCTGGTG 480

GGCCTGCACT ACTCCTTCCA GACGGCAGAC AAGCTCTACT TCGTCTTGGA CTACATCAAC 540

GGCGGAGAGT TGTTCTACCA CCTTCAGAGA GAGCGCTGCT TCCTGGAGCC CAGGGCCAGG 600

TTCTACTCAG CAGAGATCGC CAGCGCCCTG GGTTACCTCC ACTCCCTCAA CATCGTCTAC 660

AGGGACCTGA AGCCCGAGAA CATCCTGCTG GACTCGCAGG GCCACATCAT CCTCACGGAC 720

TTCGGCCTGT GCAAGGAGAA CATCGAGCCC AACGGCACCA CCTCAACGTT CTGCGGCACC 780

CCGGAGTATT TGGCTCCTGA GGTTCTGCAC AAGCAGCCGT ATGACAGGAC GGTAGACTGG 840

TGGTGCTTGG GAGCAGTCCT CTATGAGATG CTGTACGGCC TGCCTCCGTT CTACAGCCGG 900

AACACAGCGG AGATGTACGA CAACATCCTG AACAAGCCGC TGCAGCTCAA ACCCAACATT 960

TCCAACGCGG CCAGGCATCT GCTGGAGGGC CTGCTGCAGA AGGACAGGAC CAAGCGGCTG 1020

GGATGCACAG AGGACTTCAT TGAGATCAAA AATCACATGT TTTTCTCCCC CATCAACTGG 1080

GATGACCTCA ATGCTAAGAA GATCACCCCT CCGTTTAACC CCAACGTGAC GGGACCAAAC 1140

GACCTGAGAC ATTTCGATCC CGAGTTCACG GATGAGCCGG TGCCCAGCTC CATCGGCTGC 1200

TCCCCAGACA GCGTGCTCAT CACGGCCAGT ATCAAGGAGG CCGCGGAGGC CTTCGTGGGC 1260

TTCTCCTACG CCCCCTCCAT GGACTCCTAC CTATAG 1296

Domain Profile

S: 1     fdflkvigkgsfgkvllakrkadekfyavkvlqkkailkkkeekhimaernvllknvkhp  60

         f+flkvigkgsfgkvlla++++d++fyavkvlqkkailkkkeekhim+ernvllknvkhp

Q: 98    FHFLKVIGKGSFGKVLLARHRTDDQFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHP  157

         9***********************************************************

S: 61    flvglhysfqtaeklyfvldyvnggelffhlqrersfleprarfyaaeiasalgylhsln  120

         flvglhysfqta+klyfvldy+nggelf+hlqrer+fleprarfy+aeiasalgylhsln

Q: 158   FLVGLHYSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYSAEIASALGYLHSLN  217

         ************************************************************

S: 121   ivyrdlkpenilldskghvvltdfglckeeieaedttstfcgtpeylapevlrkkpydrt  180

         ivyrdlkpenillds+gh++ltdfglcke+ie + ttstfcgtpeylapevl+k+pydrt

Q: 218   IVYRDLKPENILLDSQGHIILTDFGLCKENIEPNGTTSTFCGTPEYLAPEVLHKQPYDRT  277

         ************************************************************

S: 181   vdwwclgavlyemlyglppfysrdvaemydnilnkplqlkpgisvaalelleellekdrk  240

         vdwwclgavlyemlyglppfysr++aemydnilnkplqlkp+is+aa++lle+ll+kdr+

Q: 278   VDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNISNAARHLLEGLLQKDRT  337

         ************************************************************

S: 241   krlgakedfleiknhvff  258

         krlg  edf+eiknh+ff

Q: 338   KRLGCTEDFIEIKNHMFF  355

         *****************9

Domain Sequence
(FASTA)

FHFLKVIGKG SFGKVLLARH RTDDQFYAVK VLQKKAILKK KEEKHIMSER NVLLKNVKHP 60

FLVGLHYSFQ TADKLYFVLD YINGGELFYH LQRERCFLEP RARFYSAEIA SALGYLHSLN 120

IVYRDLKPEN ILLDSQGHII LTDFGLCKEN IEPNGTTSTF CGTPEYLAPE VLHKQPYDRT 180

VDWWCLGAVL YEMLYGLPPF YSRNTAEMYD NILNKPLQLK PNISNAARHL LEGLLQKDRT 240

KRLGCTEDFI EIKNHMFF 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0035091	; F:phosphatidylinositol binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007154	; P:cell communication

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR001683	; Phox.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013