EKS-TEN-00387
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TEN-00387
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR459.33.8E-138591833243
StatusUnreviewed
Ensembl ProteinENSTNIP00000019534
UniProt AccessionH3DG90;
Protein Name
Protein Synonyms/Alias
Gene NameERBB4 (2 of 2)
Gene Synonyms/Alias ERBB4 (2 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTNIG00000016436ENSTNIP00000019534ENSTNIT00000019764
OrganismTetraodon nigroviridis
Functional Description
Protein Length1189
Protein Sequence
(FASTA)
TEILNGGVYV DRNKFLCHAD TIHWQDIVKT PRIHPLVVPT NSSITCQKCH RSCNGRCWGP 60
KVDQCQSLTK TVCAEQCDGR CFGPYISDCC HRECAGGCYG PKDTDCFVTC TNFNDSGACV 120
TQCPQPFVYN PITFQLEHNP RAKYTYGAFC VKKCPHNFVV DHSSCVRACP SNKMEVEENG 180
VKMCIPCTDI CPKACDGIGT ASLHMHQTVD SSNIDKFVNC TKINGNLVFL ITGIKGDVYH 240
NIEALDPEKL NVFRTVREVT GFLNIQSWPD NMTDLSVFSN LATIGGRALY SGISLLVLKQ 300
QGISSLQLQS LREISAGNVH IEENSQLCYY NTINWTRLFR TSNQKALIRN NQSPEQCSKK 360
HMVCDPLCSD AGCWGPGPDQ CLSCKYFIRG RTCVDRCNLY EGEIREYANG SMCVECDGQC 420
ELADDDSLTC HGPGPEHCEK CLHFKDGPNC VEKCPDGLQG ANSFIFKYAE ANNECHPCHA 480
NCTQGCHEDN MHKDVLPPWA QNNYIQQILK TPLIAAGVIG VLFMVVIIVL SVAVSMRRKN 540
IKKKRALRRF LETEFFSPLS HFLSSPNKKA LAKLYKKIIE NVKRLKTALN LYKGIWVPEG 600
EKVKIPVAVK ILNEATGPKA NVEFMDEALI MASMEHPHLV RLLGVCLSPT IQLVTQLMPH 660
GCLLDYVHEH KDNIGSQLLL NWCVQIAKGM LYLEERRLVH RDLAARNVLV KSPNHIKITD 720
FGLARLLDVN EKEYNADGGK MAIKWMALEC IHYRKFTHQS DVWSYGVTIW ELMTFGGKPY 780
DGISTRDIPD LLEKGERLPQ PPISTIDVYM VMVKCWMIDA DSRPKFKELA AEFTRMARDP 840
QRYLVIQGDD CMKLPGPNDS KFFQSLLAEE QLEDLMDAEE YLVPQSFNVP PLAYTPRTRM 900
DSNKSIFHHH PAVGYISNNQ FSYQDPSYSM ENMLATLPRG VPGATVSGGC LPTQDLASGG 960
QMGVGFIRSN QDDPRCNGTL RKQASPRAGD DGSAQRYSAD PTGLLSERGA KGDQDGYMAA 1020
ARDRKVADPN YLNSVEENPF VTRRRNDEAH VAMDGASCHT LHIARAAAAP KNQHIHGDDA 1080
YLNEPLYLNT FLNPGHTGHV LHSGTASNTI MKNKKANFDN PEYWQHSLPP KSSLHNPEYL 1140
QDCSTRFFYR QNGRIRPAVA ENQEYLSEAA MKAGNVLPPP PYRQRNTVV 1189
Nucleotide Sequence
(FASTA)
ACAGAAATCC TCAATGGTGG TGTGTATGTT GACCGCAACA AGTTCCTGTG CCACGCAGAC 60
ACAATCCACT GGCAAGATAT TGTCAAAACC CCCCGGATCC ATCCACTAGT GGTGCCCACC 120
AACAGCAGCA TCACATGTCA AAAGTGTCAT CGCTCCTGTA ACGGTCGCTG TTGGGGTCCT 180
AAGGTAGACC AGTGTCAAAG CTTGACAAAA ACGGTGTGTG CTGAGCAGTG CGACGGACGA 240
TGCTTTGGTC CCTACATCAG CGACTGCTGT CATCGGGAGT GTGCAGGTGG CTGCTACGGA 300
CCAAAGGACA CAGACTGCTT TGTAACCTGT ACCAACTTCA ATGACAGTGG GGCATGCGTG 360
ACCCAGTGCC CACAGCCGTT CGTCTACAAC CCCATCACCT TCCAACTAGA GCACAACCCC 420
AGGGCCAAAT ACACCTACGG AGCCTTCTGT GTCAAGAAAT GTCCTCATAA CTTCGTGGTA 480
GACCATAGCT CCTGTGTGAG AGCGTGTCCC AGCAACAAGA TGGAGGTGGA GGAGAACGGC 540
GTTAAAATGT GCATACCTTG TACTGACATC TGCCCCAAAG CTTGTGACGG GATCGGCACA 600
GCCAGCCTAC ACATGCACCA GACGGTAGAC TCCAGCAACA TTGACAAGTT TGTTAACTGC 660
ACCAAAATCA ACGGGAACCT GGTGTTCCTC ATCACTGGGA TCAAAGGAGA CGTCTATCAC 720
AACATTGAAG CCCTGGACCC TGAAAAACTC AATGTGTTTC GGACTGTGCG GGAAGTCACA 780
GGCTTCCTGA ACATTCAGTC TTGGCCCGAC AATATGACCG ACTTGAGCGT GTTTTCCAAT 840
TTGGCGACCA TTGGAGGCAG GGCGTTGTAC AGTGGAATCT CCCTGCTGGT GTTAAAACAG 900
CAGGGCATCT CCTCGCTGCA GCTCCAGTCT CTCAGGGAGA TCAGCGCCGG GAATGTGCAC 960
ATTGAGGAGA ACAGCCAGCT CTGCTACTAC AACACCATCA ACTGGACCAG GCTGTTCCGC 1020
ACCTCCAACC AGAAGGCGTT GATCCGTAAC AACCAAAGCC CAGAACAGTG CTCCAAGAAA 1080
CACATGGTGT GTGACCCACT GTGTTCAGAC GCAGGGTGCT GGGGTCCAGG GCCCGACCAG 1140
TGCCTCTCCT GCAAATACTT TATTCGCGGA CGAACGTGCG TGGACAGATG CAACCTGTAC 1200
GAGGGGGAAA TTCGAGAATA TGCCAACGGG TCGATGTGTG TGGAGTGCGA TGGCCAGTGC 1260
GAACTAGCAG ATGATGACTC TTTGACCTGC CACGGTCCAG GACCAGAGCA TTGTGAGAAA 1320
TGTCTCCATT TCAAGGACGG TCCCAACTGT GTGGAGAAGT GTCCTGATGG CCTTCAGGGT 1380
GCCAACAGCT TCATCTTTAA GTATGCAGAG GCCAACAATG AATGTCATCC CTGTCACGCC 1440
AACTGCACAC AAGGCTGCCA TGAGGATAAC ATGCATAAAG ATGTTCTCCC TCCCTGGGCA 1500
CAGAATAACT ACATCCAGCA GATCCTGAAA ACCCCTCTGA TCGCTGCAGG GGTGATCGGC 1560
GTCCTCTTTA TGGTTGTGAT TATAGTTCTG AGTGTAGCCG TGTCCATGCG TCGCAAGAAT 1620
ATTAAGAAGA AAAGAGCGCT TCGTCGCTTC CTGGAAACAG AGTTCTTCAG TCCTCTCTCA 1680
CACTTTCTAT CTTCCCCGAA TAAGAAAGCT TTGGCAAAGT TATATAAAAA AATAATTGAA 1740
AATGTCAAGA GACTAAAAAC GGCTCTCAAT CTGTACAAAG GGATCTGGGT CCCAGAAGGA 1800
GAGAAAGTGA AGATTCCAGT AGCCGTTAAA ATATTAAATG AGGCGACAGG ACCCAAGGCT 1860
AACGTGGAGT TCATGGACGA GGCCCTCATC ATGGCGAGCA TGGAGCACCC CCACTTGGTG 1920
CGCCTGCTGG GTGTCTGCTT GAGTCCCACC ATCCAGCTGG TCACGCAGCT GATGCCTCAC 1980
GGGTGCCTCC TCGACTATGT CCACGAGCAC AAGGACAACA TTGGCTCCCA ACTGTTGCTC 2040
AACTGGTGTG TCCAGATTGC CAAGGGTATG CTGTATTTGG AGGAGCGGAG GCTTGTTCAC 2100
AGAGACCTGG CTGCACGAAA CGTCCTCGTC AAGTCTCCCA ACCACATCAA GATCACAGAC 2160
TTTGGTCTGG CTCGCTTGCT GGATGTTAAC GAGAAGGAGT ATAACGCTGA TGGAGGAAAG 2220
ATGGCAATTA AATGGATGGC CCTTGAGTGC ATCCACTACA GGAAGTTTAC TCATCAGAGC 2280
GATGTTTGGA GTTACGGAGT CACCATTTGG GAGCTGATGA CCTTTGGAGG GAAGCCATAC 2340
GATGGGATTT CCACCAGAGA CATCCCAGAC CTGCTGGAAA AAGGAGAGCG CCTCCCCCAG 2400
CCCCCCATCA GCACCATCGA CGTTTACATG GTCATGGTCA AATGTTGGAT GATTGATGCT 2460
GACAGTCGTC CCAAATTCAA GGAGCTGGCT GCAGAGTTCA CCCGGATGGC TCGTGATCCC 2520
CAGAGATACC TGGTCATCCA GGGTGACGAC TGCATGAAGT TGCCAGGTCC AAACGACAGC 2580
AAGTTCTTCC AGAGCCTCCT GGCTGAGGAG CAGCTGGAGG ACCTGATGGA TGCCGAAGAG 2640
TACCTGGTGC CCCAGTCTTT CAACGTCCCA CCACTGGCGT ACACCCCACG CACACGCATG 2700
GACTCCAACA AGAGCATATT CCATCATCAC CCTGCAGTTG GATACATTTC TAACAACCAG 2760
TTTAGTTATC AAGACCCCAG TTACAGCATG GAAAACATGC TGGCCACACT GCCAAGGGGG 2820
GTCCCTGGCG CCACGGTGTC CGGAGGCTGT CTGCCCACTC AGGACTTGGC ATCAGGGGGG 2880
CAGATGGGGG TTGGGTTTAT CCGTAGCAAC CAAGATGACC CCCGCTGCAA CGGCACCCTG 2940
AGGAAACAGG CCTCCCCGAG GGCAGGTGAC GATGGCAGTG CTCAGCGCTA CAGTGCCGAT 3000
CCAACCGGTC TGTTATCAGA ACGCGGAGCG AAAGGAGACC AGGATGGCTA CATGGCTGCC 3060
GCGAGGGACA GGAAAGTTGC AGATCCCAAT TATCTCAACT CAGTGGAAGA AAACCCCTTT 3120
GTCACGCGCC GTAGAAATGA CGAGGCACAT GTGGCAATGG ATGGGGCAAG TTGCCACACC 3180
CTGCACATAG CCAGAGCTGC AGCTGCACCC AAGAATCAGC ACATTCACGG GGATGATGCG 3240
TACCTCAATG AGCCCCTGTA CCTGAATACT TTTCTTAACC CTGGCCATAC CGGACACGTT 3300
CTGCACTCAG GCACGGCTAG TAACACCATC ATGAAAAATA AGAAGGCCAA TTTTGACAAT 3360
CCAGAATACT GGCAACACAG TCTACCCCCC AAATCTTCGC TCCACAACCC CGAGTACCTG 3420
CAGGACTGCA GCACGCGCTT CTTCTACCGG CAGAACGGAC GCATTCGCCC CGCTGTTGCT 3480
GAGAACCAGG AGTACTTGTC AGAGGCAGCG ATGAAAGCAG GCAACGTTTT GCCGCCGCCT 3540
CCCTACAGAC AGAGGAACAC TGTAGTGTAG 3570
Domain Profile
S: 15    vykGiwipegenvkipvaikvleektgkkankelldealvlasldhanlvrllglclsst  74
         +ykGiw+pege+vkipva+k+l+e+tg+kan e++deal++as++h++lvrllg+cls t
Q: 591   LYKGIWVPEGEKVKIPVAVKILNEATGPKANVEFMDEALIMASMEHPHLVRLLGVCLSPT  650
         7***********************************************************
S: 75    lqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleekrlvhrdlaarnvlv  134
         +qlvtql+p+Gclldyv+ehkd++Gsq llnwcvqiakGm ylee+rlvhrdlaarnvlv
Q: 651   IQLVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMLYLEERRLVHRDLAARNVLV  710
         ************************************************************
S: 135   kspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrkythqsdvwsyGvtvw  194
         kspnh+kitdfGla+ll+ +eke++a+ggk++ikw+ale+i++rk+thqsdvwsyGvt+w
Q: 711   KSPNHIKITDFGLARLLDVNEKEYNADGGKMAIKWMALECIHYRKFTHQSDVWSYGVTIW  770
         ************************************************************
S: 195   elltfGakpydgipakeipdllekGerlaqppictidvymvlvkcwmidaesrpkfkela  254
         el+tfG kpydgi++++ipdllekGerl+qppi tidvymv+vkcwmida+srpkfkela
Q: 771   ELMTFGGKPYDGISTRDIPDLLEKGERLPQPPISTIDVYMVMVKCWMIDADSRPKFKELA  830
         ************************************************************
S: 255   eef  257
         +ef
Q: 831   AEF  833
         *99
Domain Sequence
(FASTA)
LYKGIWVPEG EKVKIPVAVK ILNEATGPKA NVEFMDEALI MASMEHPHLV RLLGVCLSPT 60
IQLVTQLMPH GCLLDYVHEH KDNIGSQLLL NWCVQIAKGM LYLEERRLVH RDLAARNVLV 120
KSPNHIKITD FGLARLLDVN EKEYNADGGK MAIKWMALEC IHYRKFTHQS DVWSYGVTIW 180
ELMTFGGKPY DGISTRDIPD LLEKGERLPQ PPISTIDVYM VMVKCWMIDA DSRPKFKELA 240
AEF 243
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Oreochromis niloticus"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>
EKS-ORN-00387
EKS-TAR-00389
EKS-XIM-00377
Gene Ontology
GO:0016020; C:membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 1.
SMARTs
SM00261; FU; 4.
SM00219; TyrKc; 1.
Prosites
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013