EKS-TEN-00356

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00356

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	452.2	8.2E-136	207	494	288

Status

Unreviewed

Ensembl Protein

ENSTNIP00000019588

UniProt Accession

H3DGE4;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR1

Gene Synonyms/Alias

ACVR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000016489	ENSTNIP00000019588	ENSTNIT00000019818

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

508

Protein Sequence
(FASTA)

MAAADMFLLV LALLVFPCAG LEEVEIKPLK REEHECVCEG SSCALGNRCM GHQCFSSLMV 60

SAGALVYQKG CFKVYEQSTM TCKTPPSRDQ VVECCYGHLC NLNSSVELPV KAEELPSYSV 120

TMLVIVIMAP IIVLVVLSVA AILVFRRIHH NQMERLTSRD AEYGTIDGLI ASNVGESTLA 180

DLLDHSCTSG SGSGLPFLVQ RTVARQITLN ECVGKGRYGE VWRGQWQGEN VAVKIFSSRD 240

EKSWFRETEI YNTVLLRHEN ILGFIASDMT SRNSSTQLWL ITHFHEMGSL YDYLQLSTLD 300

ASSCLRMALS IASGLAHLHV EIFGTQGKPA IAHRDLKSKN ILVKKNGHCC IADLGLAVMH 360

FQDTNELDVG NNPKVGTKRY MAPEVLDDSI QMDCFESFKR VDIWALGLVL WEVARRTVSN 420

GIVEDYKPPF HDVVPSDPSF EDMKKVVCVD QQRPNIPNRW FSDPTLTSMA KLMKECWYQN 480

PSARLTALRI KKTLTKIDNS LDKIKTDI 508

Nucleotide Sequence
(FASTA)

ATGGCGGCAG CGGACATGTT TCTTCTGGTT TTGGCCCTCC TTGTGTTCCC GTGCGCTGGC 60

TTGGAAGAGG TGGAGATAAA GCCTCTGAAA AGGGAGGAGC ATGAGTGTGT GTGTGAGGGC 120

AGCTCCTGCG CGTTGGGAAA TCGCTGCATG GGCCACCAGT GCTTCTCGTC GTTGATGGTC 180

AGCGCCGGCG CCCTGGTGTA CCAGAAGGGA TGCTTCAAGG TCTACGAGCA GAGCACAATG 240

ACTTGCAAGA CCCCGCCGTC CCGAGACCAG GTGGTGGAAT GCTGCTACGG TCACCTGTGT 300

AACCTGAACA GCTCGGTGGA GCTGCCCGTC AAAGCTGAAG AGCTTCCCAG CTACAGCGTG 360

ACCATGCTGG TTATCGTCAT CATGGCGCCC ATCATCGTCC TCGTTGTTCT CTCTGTCGCC 420

GCCATCCTGG TGTTCAGACG CATCCATCAC AACCAGATGG AGAGACTCAC ATCACGGGAT 480

GCGGAGTACG GAACCATCGA CGGTCTCATA GCCTCCAACG TCGGCGAGAG CACCCTGGCG 540

GATCTGTTGG ACCACTCGTG CACCTCTGGA AGTGGCTCCG GGTTGCCGTT CCTGGTTCAG 600

AGAACCGTTG CCAGACAAAT TACCCTTAAT GAGTGTGTGG GAAAGGGCCG TTACGGCGAA 660

GTGTGGAGGG GTCAGTGGCA GGGAGAGAAC GTCGCGGTCA AGATTTTCTC CTCCAGAGAC 720

GAGAAGTCCT GGTTCAGGGA GACCGAGATC TACAACACGG TGCTGCTGAG GCACGAGAAC 780

ATCCTGGGCT TCATCGCTTC GGACATGACC TCCAGGAACT CCAGCACCCA GCTGTGGCTC 840

ATCACCCACT TCCACGAGAT GGGCTCCCTG TACGACTACC TTCAGCTCAG CACCCTGGAC 900

GCCTCCAGCT GCCTGCGCAT GGCGCTGTCC ATCGCTAGCG GCCTGGCGCA TCTCCACGTG 960

GAGATCTTTG GCACCCAGGG CAAGCCGGCC ATCGCCCACC GGGACCTGAA GAGCAAAAAC 1020

ATCCTGGTGA AGAAGAACGG CCACTGCTGC ATCGCTGACC TCGGACTGGC CGTGATGCAT 1080

TTTCAAGACA CCAACGAGCT GGATGTGGGG AACAATCCCA AAGTGGGCAC GAAGCGCTAC 1140

ATGGCCCCCG AGGTGCTGGA CGACTCCATC CAGATGGACT GTTTCGAGTC CTTCAAGCGG 1200

GTGGACATCT GGGCCCTGGG CCTGGTTCTG TGGGAGGTTG CCAGGAGGAC GGTCAGCAAT 1260

GGTATCGTAG AAGACTACAA GCCGCCGTTC CACGACGTGG TCCCCAGTGA TCCCAGCTTT 1320

GAGGACATGA AGAAGGTGGT GTGCGTGGAC CAGCAGAGAC CAAACATACC AAACCGATGG 1380

TTTTCGGACC CGACTCTGAC CTCCATGGCC AAACTCATGA AGGAGTGCTG GTACCAGAAT 1440

CCGTCGGCCA GGCTAACGGC GCTGCGCATC AAAAAGACTC TCACAAAGAT CGACAACTCT 1500

CTGGACAAAA TCAAAACGGA CATTTGA 1527

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         ++l e++gkGrygeVw+++++ge+vAvKifs++de+sw+rE+eiy+tvllrhenil+fia

Q: 207   ITLNECVGKGRYGEVWRGQWQGENVAVKIFSSRDEKSWFRETEIYNTVLLRHENILGFIA  266

         6899********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         +d+++++s+t+l+l+t++he+gsL+dyL+ +tld++++lr+als+asGlahLH ei+gt+

Q: 267   SDMTSRNSSTQLWLITHFHEMGSLYDYLQLSTLDASSCLRMALSIASGLAHLHVEIFGTQ  326

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvkk++ cciaDlGLa+++ ++++eld+ +n +vGtkRYmaPE

Q: 327   G--KPAIAHRDLKSKNILVKKNGHCCIADLGLAVMHFQDTNELDVGNNPKVGTKRYMAPE  384

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl++++++++fe+fkr+D+++lgLvlWEva+R+ + +++ve+yk+pf++vv+sdPs+e+m

Q: 385   VLDDSIQMDCFESFKRVDIWALGLVLWEVARRTVS-NGIVEDYKPPFHDVVPSDPSFEDM  443

         **********************************9.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         k+vv+++++rP+ip++w ++++l++++kl++ecW+++p+aRltalr+kk+l

Q: 444   KKVVCVDQQRPNIPNRWFSDPTLTSMAKLMKECWYQNPSARLTALRIKKTL  494

         *************************************************97

Domain Sequence
(FASTA)

ITLNECVGKG RYGEVWRGQW QGENVAVKIF SSRDEKSWFR ETEIYNTVLL RHENILGFIA 60

SDMTSRNSST QLWLITHFHE MGSLYDYLQL STLDASSCLR MALSIASGLA HLHVEIFGTQ 120

GKPAIAHRDL KSKNILVKKN GHCCIADLGL AVMHFQDTNE LDVGNNPKVG TKRYMAPEVL 180

DDSIQMDCFE SFKRVDIWAL GLVLWEVARR TVSNGIVEDY KPPFHDVVPS DPSFEDMKKV 240

VCVDQQRPNI PNRWFSDPTL TSMAKLMKEC WYQNPSARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013