EKS-TEN-00377

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00377

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/DDR	432.1	1.1E-129	534	822	289

Status

Unreviewed

Ensembl Protein

ENSTNIP00000003320

UniProt Accession

H3DH64;

Protein Name

Protein Synonyms/Alias

Gene Name

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000016748	ENSTNIP00000019858	ENSTNIT00000020088
ENSTNIG00000016748	ENSTNIP00000003320	ENSTNIT00000000656

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

828

Protein Sequence
(FASTA)

AHCRYALGME DGRIPDEAIT ASSQWYKTTG PQYARLNQEK GDGAWCPEHL DNQYLQVDLG 60

RLTFLTVVGT QGRFARNTGN EFTSAYRLNY SRDGLLWKSW RNRLGNALIE GNKNTYASVI 120

NDLHPPIITR YIRLLPVTKH SPTVCMRVEL YGCPWEDGLI SYSAPEGQYM MPPGSPIACL 180

NDSTYDGVRE RRRLSGGMGQ LTDGVIGLDD FLKTHQYHVW PGYDYLGWKN DSLGTQGYVE 240

MEFVFDRQRN FTSMKVHSNN MFRSGVKIFS AVSCWFKPRL IASWEPEPVV FKTVLDDKNP 300

SARYVTVSLN RRAAKSLRCR FYFADVWMMF SEISFQSVAF YYSKTEFFPA APSPSARSPP 360

EDSNTPVLIG CLVTIILLLV IIIFLILWCQ YVCKVLEKAP RQILDEEVTV RLSSCSDTII 420

LQTPPVPPRS SHAGPANSDP HYERVFLLDP QYQNPAALRN KLPELSQSAE ASGNSNISFD 480

RRYPGEISAP HYAETDIVRL QGVTGSNMYA VPALTVDSLT RKDISAAEFP RQQLIFREKL 540

GEGQFGEVHL CEAEGLPEFL GEGSPLPERD GHSVLVAVKQ LRADATSQAR NDFLKEIKIM 600

SRLNDPNIIR LLCVCVSSDP LCMVTEYMEN GDLNMFLSQR EIESTLTHAN NIPSVSLSDL 660

LHMAVQISSG MKYLASLNFV HRDLATRNCL LDRRLTIKIA DFGMSRNLYS SDYYRIQGRA 720

VLPIRWMAWE SILLGKFTTA SDVWAFGVTL WEIFTLCKEQ PYSLLSDEQV IENTGEFFRN 780

QGRQIFLYAP PLCPPSLFEL MMRCWSRDIH DRPNFEGLYR ALRPHVNQ 828

Nucleotide Sequence
(FASTA)

GCACACTGTC GCTATGCCTT GGGTATGGAG GATGGACGGA TTCCAGATGA GGCCATCACA 60

GCATCCAGCC AATGGTATAA GACCACTGGA CCACAGTATG CAAGGTTGAA TCAGGAGAAA 120

GGAGACGGCG CCTGGTGTCC AGAGCATTTA GACAACCAGT ACCTGCAGGT GGACTTGGGC 180

AGGCTGACCT TCCTGACTGT GGTCGGGACT CAGGGAAGAT TTGCCCGGAA CACTGGGAAC 240

GAATTCACCA GTGCCTACCG CCTAAACTAC AGCCGGGACG GCCTGCTGTG GAAGTCTTGG 300

AGAAACCGTC TGGGAAATGC GTTGATAGAG GGCAACAAAA ACACGTACGC CTCAGTCATC 360

AATGACCTTC ACCCCCCCAT CATCACGCGC TACATCAGGC TGCTTCCTGT CACCAAACAC 420

TCACCCACAG TCTGCATGAG AGTGGAATTG TACGGCTGTC CGTGGGAGGA TGGACTGATC 480

TCCTACAGTG CTCCGGAGGG TCAGTACATG ATGCCCCCCG GCTCCCCCAT CGCCTGTCTC 540

AATGACTCCA CCTACGACGG AGTGCGCGAG AGAAGGAGGC TGTCTGGGGG GATGGGCCAG 600

CTGACGGACG GCGTGATCGG CCTGGACGAC TTCTTGAAGA CTCACCAGTA CCACGTGTGG 660

CCGGGCTACG ACTATCTGGG CTGGAAGAAT GACTCGCTGG GCACTCAGGG ATACGTAGAA 720

ATGGAATTTG TTTTTGACAG GCAGCGCAAC TTCACGTCTA TGAAGGTTCA CAGTAACAAC 780

ATGTTCAGGT CTGGCGTGAA GATCTTTTCC GCCGTCTCCT GTTGGTTTAA GCCCCGCCTC 840

ATTGCCAGCT GGGAGCCGGA GCCGGTGGTG TTCAAGACGG TGCTGGACGA CAAAAACCCG 900

AGTGCCCGCT ACGTGACCGT GTCGCTCAAC CGCCGCGCGG CAAAATCCCT CCGCTGCCGC 960

TTTTACTTTG CCGACGTCTG GATGATGTTC AGCGAGATCT CCTTTCAGTC GGTTGCCTTT 1020

TATTATTCTA AAACTGAATT CTTTCCAGCA GCTCCCAGTC CATCAGCCAG ATCCCCACCG 1080

GAGGACAGCA ACACGCCCGT TCTGATTGGC TGCCTTGTGA CCATTATTCT GCTCTTGGTC 1140

ATCATCATCT TCCTCATCCT CTGGTGCCAG TATGTCTGCA AGGTACTGGA GAAGGCTCCC 1200

AGGCAGATCC TGGATGAGGA GGTGACGGTT CGGCTCTCCT CCTGCAGCGA CACCATCATC 1260

CTCCAGACGC CTCCGGTGCC CCCTCGTTCC AGCCACGCAG GCCCTGCCAA CAGCGATCCT 1320

CACTATGAGC GCGTTTTCCT GCTGGATCCG CAGTACCAGA ACCCGGCAGC TCTGAGGAAC 1380

AAACTGCCAG AGCTGTCACA AAGCGCGGAA GCCTCAGGTA ACTCTAATAT TAGCTTTGAC 1440

CGCCGGTACC CAGGTGAAAT CAGCGCGCCG CACTACGCCG AGACGGACAT CGTGAGGCTG 1500

CAGGGCGTCA CCGGCAGCAA CATGTATGCT GTTCCCGCCC TCACCGTGGA CTCCCTCACC 1560

AGGAAGGACA TCTCGGCCGC TGAGTTCCCG CGACAGCAGC TGATCTTCAG GGAGAAGCTG 1620

GGGGAGGGAC AGTTCGGAGA GGTCCACCTG TGCGAAGCTG AGGGTCTCCC AGAATTCCTC 1680

GGCGAGGGGT CGCCGCTTCC TGAGAGGGAT GGACATTCCG TCCTGGTGGC TGTGAAGCAG 1740

CTGAGGGCCG ATGCCACCAG CCAGGCCAGA AACGACTTCC TGAAGGAAAT TAAGATCATG 1800

TCCCGTCTGA ACGACCCCAA CATCATCCGG CTGCTGTGTG TGTGTGTGTC CTCGGACCCG 1860

TTGTGCATGG TCACGGAATA CATGGAGAAC GGAGACCTCA ATATGTTCCT TTCGCAGCGA 1920

GAGATCGAAA GCACGCTGAC CCACGCCAAC AACATCCCTT CAGTCAGTCT GTCTGACCTC 1980

CTCCACATGG CAGTGCAGAT CTCCTCAGGG ATGAAATACC TGGCGTCTCT GAACTTTGTA 2040

CACCGCGACC TGGCAACCAG GAACTGCCTG CTGGACCGAC GCCTCACCAT CAAGATCGCC 2100

GATTTCGGGA TGAGCCGAAA CCTGTACAGC AGCGACTACT ACCGCATCCA AGGCCGGGCG 2160

GTGCTCCCCA TACGCTGGAT GGCCTGGGAG AGCATCCTCC TGGGTAAGTT CACCACAGCG 2220

AGCGACGTGT GGGCGTTTGG TGTCACCCTG TGGGAGATCT TCACCCTGTG TAAGGAGCAG 2280

CCCTACAGTC TGCTGTCTGA CGAACAGGTC ATAGAGAACA CTGGCGAGTT CTTCAGGAAC 2340

CAGGGCAGAC AGATTTTCCT TTACGCTCCT CCGCTGTGTC CACCGTCTCT CTTCGAGCTG 2400

ATGATGCGTT GTTGGAGTCG CGACATACAC GATCGGCCCA ACTTTGAGGG ACTGTACCGA 2460

GCCCTGAGGC CCCACGTCAA CCAGTGA 2487

Domain Profile

S: 1     LlikeklGeGkfgevklCevegledlkekd.....skgsallvavkslredanknarkdf  55

         L+++eklGeG+fgev+lCe egl ++         ++g+++lvavk+lr+da+++ar+df

Q: 534   LIFREKLGEGQFGEVHLCEAEGLPEFLGEGsplpeRDGHSVLVAVKQLRADATSQARNDF  593

         799*******************999988777899899***********************

S: 56    lkeikilsrlkdPnivrllgvcvrdeplclileyvenGdlnqflseheaeds..elakek  113

         lkeiki+srl+dPni+rll vcv  +plc+++ey+enGdln fls++e e++  ++++ +

Q: 594   LKEIKIMSRLNDPNIIRLLCVCVSSDPLCMVTEYMENGDLNMFLSQREIESTltHANNIP  653

         **********************************************99666511566779

S: 114   tlsyellvsiatqiasglkyLeslnfvhrdlatrnclvgeeftvkiadfglsrslyagdy  173

         ++s + l+++a qi sg+kyL+slnfvhrdlatrncl+++ +t+kiadfg+sr+ly++dy

Q: 654   SVSLSDLLHMAVQISSGMKYLASLNFVHRDLATRNCLLDRRLTIKIADFGMSRNLYSSDY  713

         ************************************************************

S: 174   yrvqGravlPiRwmawesillgkfttasDvWafgvtlweiltlcreqPyeeltdeqvien  233

         yr+qGravlPiRwmawesillgkfttasDvWafgvtlwei+tlc+eqPy+ l+deqvien

Q: 714   YRIQGRAVLPIRWMAWESILLGKFTTASDVWAFGVTLWEIFTLCKEQPYSLLSDEQVIEN  773

         ************************************************************

S: 234   agelfrdqkrkvvlsrPavcpselyelllrCwrrdeseRPsfeelhkll  282

         +ge+fr+q+r+++l  P++cp +l+el++rCw+rd ++RP fe l++ l

Q: 774   TGEFFRNQGRQIFLYAPPLCPPSLFELMMRCWSRDIHDRPNFEGLYRAL  822

         *******************************************998865

Domain Sequence
(FASTA)

LIFREKLGEG QFGEVHLCEA EGLPEFLGEG SPLPERDGHS VLVAVKQLRA DATSQARNDF 60

LKEIKIMSRL NDPNIIRLLC VCVSSDPLCM VTEYMENGDL NMFLSQREIE STLTHANNIP 120

SVSLSDLLHM AVQISSGMKY LASLNFVHRD LATRNCLLDR RLTIKIADFG MSRNLYSSDY 180

YRIQGRAVLP IRWMAWESIL LGKFTTASDV WAFGVTLWEI FTLCKEQPYS LLSDEQVIEN 240

TGEFFRNQGR QIFLYAPPLC PPSLFELMMR CWSRDIHDRP NFEGLYRAL 289

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Danio rerio"; ?>Gallus gallus"; ?>Meleagris gallopavo"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Pelodiscus sinensis"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0007155	; P:cell adhesion
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR000421	; Coagulation_fac_5/8-C_type_dom.
IPR008979	; Galactose-bd-like.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF00754	; F5_F8_type_C; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00231	; FA58C; 1.
SM00219	; TyrKc; 1.

Prosites

PS01285	; FA58C_1; 1.
PS01286	; FA58C_2; 1.
PS50022	; FA58C_3; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013