EKS-TEN-00489

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00489

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	231.6	1.2E-68	2	165	164

Status

Unreviewed

Ensembl Protein

ENSTNIP00000020131

UniProt Accession

H3DHY7;

Protein Name

Protein Synonyms/Alias

Gene Name

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000017006	ENSTNIP00000020131	ENSTNIT00000020362

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

773

Protein Sequence
(FASTA)

PHILVNWAVQ IARGMQYLHE EAVVSIIHRD LKSSNILLLE RIENDDIGRK TLKITDFGLA 60

REWHKTTKMS AAGTYSWMAP EVIKSSLFSK GSDIWGYGVL LWELLTGEVP YRGIDGLAVA 120

YGVAVNKLTL PIPSTCPEPF AKLMEECWDQ DPHVRPSFSC ILEQLSAIEE AVMATMPQDS 180

FHSMQDNWRV EIQEMFDELR TKEKELRSRE EELTRAALQQ KSQEELLKRR EQQLAEREID 240

VLERELNILI FQLNKDKPNV KKRKGKFKRS RLKLKDGNRI SLPSDFQHKI TVQASPSMDK 300

RRSLHSTSSS PPSSPTLIPR LRAIQLTQDE SNRTWGRSSL FRPEEFDDVK KGIKKKGRTW 360

GPSSVQTKER PATAERVRPL SDGSNPWSTS LVKSQKSVPL AALFAEQGGD QSAAQESPDS 420

SSKPKQLKFP NQVYIDLPLW RDEPQGGQSE TADDPSTTTS TSSASTTPQH TPTNSLKRAA 480

AGRRTDSVLY GCGSLLASVV LGYDLREALR ASGPGDDGGE PPRLFQRATR FRRSTSPPGG 540

RSRRDEAPPS HQGSAQPVNL MAMSAIMECN STKCLLQSEA EAESSPGKAD PATAAQPAEP 600

LGAGPEGRGA EAAAKATHTQ SQPPESKNNT GARLRRKKYH SHHSSEHRPR SASEPLTNGQ 660

PTPAPPPTPQ KQDRDAQPRR SRGARLGPDR DPCPSGQAPR LGPAEGTQQE LLAGPLLRGA 720

GGPEPGRVLS SEGCSLLDMD TEGQKRDCTV PLCRIQSSPH VPSVFELEKE FLS 773

Nucleotide Sequence
(FASTA)

CCGCACATCC TGGTCAACTG GGCCGTGCAG ATCGCACGAG GGATGCAGTA CCTGCACGAG 60

GAGGCGGTGG TGTCCATCAT CCACCGCGAC CTCAAGTCCA GCAACATTTT GTTACTTGAA 120

AGGATCGAGA ATGACGACAT CGGGAGGAAG ACCTTGAAGA TCACCGATTT CGGGCTGGCC 180

AGGGAGTGGC ACAAAACCAC CAAGATGTCG GCTGCAGGCA CCTACTCCTG GATGGCCCCT 240

GAAGTCATCA AGTCCTCGCT CTTCTCCAAA GGCAGCGACA TCTGGGGCTA CGGCGTCCTG 300

CTGTGGGAGC TGCTGACTGG GGAGGTGCCC TACCGCGGCA TAGACGGCCT GGCTGTGGCT 360

TACGGCGTGG CTGTCAATAA ACTGACCCTG CCCATCCCCT CCACCTGCCC CGAACCTTTT 420

GCCAAGCTCA TGGAAGAGTG CTGGGACCAG GACCCCCACG TGCGCCCTTC CTTCTCCTGC 480

ATCCTGGAGC AGCTGTCAGC CATCGAGGAG GCGGTGATGG CCACCATGCC CCAGGACTCC 540

TTCCACAGCA TGCAGGACAA CTGGCGTGTG GAGATCCAGG AAATGTTTGA CGAGCTCAGG 600

ACCAAAGAGA AGGAGCTTCG CTCCAGAGAG GAGGAGCTGA CGCGAGCTGC CCTGCAGCAG 660

AAGTCGCAGG AGGAGCTGCT GAAGCGGCGG GAGCAGCAGC TGGCCGAGCG AGAGATCGAC 720

GTGCTGGAGA GGGAGCTCAA CATCCTCATC TTCCAGCTCA ACAAGGACAA ACCCAACGTG 780

AAGAAGAGGA AAGGCAAATT CAAGCGCTCG CGGCTCAAGC TCAAGGATGG CAACCGCATC 840

AGCCTGCCCT CCGACTTCCA GCATAAGATC ACCGTTCAGG CGTCTCCTTC CATGGACAAG 900

AGACGGAGCC TCCACAGCAC CAGCTCCTCC CCTCCCAGCA GCCCCACCCT CATCCCCCGT 960

CTGAGGGCCA TCCAGCTCAC CCAGGACGAG AGCAACCGCA CGTGGGGCCG CAGCTCCCTC 1020

TTCAGGCCGG AGGAGTTTGA CGACGTGAAG AAGGGAATCA AGAAGAAAGG ACGGACCTGG 1080

GGCCCCAGTT CAGTGCAGAC TAAAGAGAGA CCCGCCACCG CAGAGAGGGT TCGTCCTCTG 1140

TCAGACGGCA GCAACCCCTG GTCCACCAGC CTGGTCAAGT CGCAGAAGTC CGTTCCTCTG 1200

GCCGCCCTCT TTGCAGAACA AGGTGGAGAC CAGAGCGCCG CCCAGGAGAG TCCTGACAGC 1260

AGCTCCAAGC CAAAGCAGCT CAAGTTCCCC AACCAGGTGT ACATCGACCT ACCTCTGTGG 1320

AGGGACGAGC CTCAGGGCGG CCAATCGGAG ACCGCGGACG ACCCCTCCAC CACCACGTCC 1380

ACCTCGTCGG CCTCCACCAC CCCTCAGCAC ACCCCCACCA ACAGCCTGAA GCGGGCGGCG 1440

GCTGGGCGGA GGACCGACTC GGTGCTGTAC GGCTGCGGCT CGCTGCTGGC CTCCGTGGTG 1500

CTGGGGTACG ACCTGAGGGA GGCCCTGAGG GCCTCGGGCC CCGGGGACGA TGGCGGCGAG 1560

CCGCCACGTC TGTTTCAGCG CGCCACGCGC TTCCGCCGCA GCACCTCACC GCCGGGCGGT 1620

CGCTCCCGCA GAGACGAAGC TCCGCCCAGC CACCAGGGCT CCGCCCAGCC CGTCAACCTG 1680

ATGGCCATGT CAGCCATCAT GGAGTGCAAC TCCACCAAGT GTCTCCTCCA GTCCGAGGCG 1740

GAGGCGGAGA GCAGCCCCGG GAAGGCCGAC CCGGCCACCG CCGCTCAGCC GGCGGAGCCG 1800

CTCGGGGCGG GACCAGAAGG CCGCGGCGCC GAGGCCGCGG CGAAGGCCAC GCACACCCAA 1860

AGTCAGCCGC CAGAGAGCAA GAACAACACC GGAGCGCGTT TGCGCCGGAA GAAGTACCAC 1920

AGCCACCACA GCAGTGAGCA CCGGCCCCGC TCTGCCTCCG AACCTTTGAC CAATGGTCAG 1980

CCCACTCCGG CCCCTCCACC CACGCCGCAG AAGCAGGACA GGGACGCGCA GCCGAGAAGG 2040

TCCCGGGGGG CCCGGCTTGG ACCAGACCGC GACCCGTGTC CTTCCGGCCA AGCCCCACGC 2100

CTGGGCCCTG CTGAGGGGAC GCAACAAGAG CTACTCGCTG GGCCACTACT CCGGGGAGCG 2160

GGCGGCCCAG AGCCTGGGCG TGTGCTGTCC TCGGAGGGCT GCTCCCTGCT GGACATGGAC 2220

ACGGAGGGCC AGAAGCGGGA CTGCACGGTG CCGCTCTGCC GCATCCAGAG TTCTCCGCAC 2280

GTGCCGTCTG TCTTCGAGCT GGAGAAGGAG TTCCTCTCCT GA 2322

Domain Profile

S: 98    evlvswalqiArGmaYLhseapkkiihrdLksknvLl.......seekktlkicdFGtar  150

         + lv+wa+qiArGm+YLh+ea+++iihrdLks+n+Ll       +   ktlki+dFG ar

Q: 2     HILVNWAVQIARGMQYLHEEAVVSIIHRDLKSSNILLleriendDIGRKTLKITDFGLAR  61

         679**************************************9988899************

S: 151   elskstkmsaagtlawmaPEvlkeekvseksDvwSygvvLWelltrevPykdlselaiay  210

         e++k+tkmsaagt+ wmaPEv+k++ +s+ sD+w ygv+LWellt+evPy++++ la+ay

Q: 62    EWHKTTKMSAAGTYSWMAPEVIKSSLFSKGSDIWGYGVLLWELLTGEVPYRGIDGLAVAY  121

         ************************************************************

S: 211   kvalkglrlpipsscpeklkkLmkecwnedpekRpsfseivksl  254

         +va+++l+lpips+cpe+++kLm+ecw++dp+ Rpsfs i+++l

Q: 122   GVAVNKLTLPIPSTCPEPFAKLMEECWDQDPHVRPSFSCILEQL  165

         ****************************************9986

Domain Sequence
(FASTA)

HILVNWAVQI ARGMQYLHEE AVVSIIHRDL KSSNILLLER IENDDIGRKT LKITDFGLAR 60

EWHKTTKMSA AGTYSWMAPE VIKSSLFSKG SDIWGYGVLL WELLTGEVPY RGIDGLAVAY 120

GVAVNKLTLP IPSTCPEPFA KLMEECWDQD PHVRPSFSCI LEQL 164

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004709	; F:MAP kinase kinase kinase activity
GO:0000186	; P:activation of MAPKK activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR015785	; MAPKKK9/10/11-like.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013