EKS-TEN-00364

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00364

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	401.6	2.1E-120	193	479	287

Status

Unreviewed

Ensembl Protein

ENSTNIP00000020303

UniProt Accession

H3DIF9;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR2A

Gene Synonyms/Alias

ACVR2A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000017166	ENSTNIP00000020303	ENSTNIT00000020534

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

513

Protein Sequence
(FASTA)

MGAATKLAFA VFLISCCSGA ILGRSETQEC AYYNSSWEKD RTNRSGIEPC PSGEKDKRRH 60

CFATWKNISG AVEVVKQGCW LDDVNCYDSN ECVERKESPD VFFCCCEGNM CNEKFLYVPE 120

TKVTKPTSNP FSNKPQLLST LLYSLVPIIG LVAVVLFSFW MWRHHKLAYP AALVPTHDPG 180

PSPPSPVLGH KPLQLLEVKA RGRFGCVWKA QLLNEYVAVK IFPIQDKLSW QNEYEIYSLN 240

GMKHENILHF IGVEKRNNNL DLELWLITTY HDKGSLTDYL KANVVSWNEL CLIAQTAARG 300

LAYLHEDIPG HKDGHKPSIA HRDIKSKNVL LKNNLTACIA DFGLALQFEA GKSAGDTHGQ 360

VGTRRYMAPE VLEGAINFQR DAFLRIDMYA FGLVLWELVS RCTAADGPVD EYMLPFEEEV 420

GQHPSLEDMQ EVVVHKKLRP CLRDCWQKHT GLAMLCETIE DCWDHEAEAL SAGCVEERIG 480

QMQRQAPVIG PEEIVTVVTM VTNVDLPPKE SSL 513

Nucleotide Sequence
(FASTA)

ATGGGAGCTG CTACCAAACT GGCCTTCGCC GTTTTCCTCA TATCCTGCTG TTCAGGTGCT 60

ATTCTGGGCC GCTCGGAGAC GCAGGAGTGC GCCTACTACA ACTCCAGCTG GGAGAAGGAT 120

CGCACCAACC GCAGTGGGAT TGAACCCTGC CCCTCCGGAG AGAAAGACAA GCGGCGGCAC 180

TGCTTCGCCA CCTGGAAGAA CATCTCGGGC GCCGTGGAGG TCGTCAAGCA AGGCTGCTGG 240

CTGGACGACG TCAACTGCTA CGACAGTAAC GAGTGCGTCG AGAGGAAGGA GAGTCCCGAC 300

GTCTTCTTCT GCTGCTGCGA AGGCAACATG TGCAATGAGA AGTTCCTGTA TGTCCCCGAG 360

ACAAAAGTTA CTAAACCCAC CTCCAACCCG TTCTCCAATA AGCCCCAGCT TCTCAGCACG 420

CTGCTGTACT CGCTGGTTCC CATCATCGGC CTGGTCGCCG TGGTCCTCTT CTCCTTTTGG 480

ATGTGGAGGC ATCACAAGCT GGCCTACCCG GCGGCCCTCG TCCCCACACA CGATCCCGGA 540

CCCTCGCCCC CGTCCCCCGT GTTGGGGCAC AAACCGCTGC AGCTGCTGGA GGTGAAAGCC 600

AGGGGGCGCT TCGGCTGCGT GTGGAAGGCC CAGCTGCTGA ACGAGTACGT GGCTGTGAAG 660

ATCTTCCCCA TCCAGGACAA GCTGTCCTGG CAAAACGAGT ATGAGATCTA CAGTCTAAAC 720

GGCATGAAAC ACGAAAACAT CCTCCACTTC ATCGGCGTGG AGAAGAGGAA CAACAACCTG 780

GACCTGGAGC TGTGGCTCAT CACCACCTAC CACGACAAGG GGTCGCTGAC CGACTACCTG 840

AAGGCCAACG TGGTGTCGTG GAACGAGCTG TGCCTCATCG CTCAGACAGC AGCCCGTGGA 900

CTCGCGTACC TCCACGAAGA CATCCCCGGA CACAAGGATG GACACAAACC CTCTATCGCT 960

CACAGGGACA TCAAAAGTAA GAATGTGCTG CTGAAGAACA ACCTGACCGC CTGCATAGCC 1020

GACTTTGGCT TGGCGCTCCA GTTTGAGGCG GGAAAGTCTG CAGGAGACAC TCATGGACAG 1080

GTTGGGACAC GGCGCTACAT GGCACCCGAG GTTCTGGAGG GCGCCATCAA CTTCCAGCGC 1140

GACGCCTTCC TGCGCATCGA CATGTACGCC TTCGGGCTGG TGCTGTGGGA GCTGGTGTCC 1200

CGATGCACCG CCGCCGACGG TCCGGTCGAC GAGTACATGC TGCCGTTTGA GGAGGAGGTG 1260

GGCCAGCACC CGTCTCTGGA GGACATGCAG GAGGTCGTCG TTCACAAGAA ACTGAGGCCC 1320

TGCCTGCGAG ACTGCTGGCA GAAGCACACG GGTCTGGCCA TGCTCTGTGA GACCATCGAG 1380

GACTGCTGGG ACCACGAGGC CGAGGCTCTG TCGGCCGGCT GCGTGGAGGA GCGCATCGGC 1440

CAAATGCAGC GCCAGGCGCC CGTCATCGGC CCCGAGGAGA TCGTCACCGT CGTCACCATG 1500

GTGACCAACG TGGACCTCCC GCCCAAGGAG TCCAGCTTAT GA 1542

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         l+lle+ ++Gr+g+Vwka+l +e+vAvKif+ +d+ sw++E eiy+++ ++henil+fi+

Q: 193   LQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKLSWQNEYEIYSLNGMKHENILHFIG  252

         6899********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

          +k+++++  el+l+t+yh+kgsL+dyLk+++++++el+ +a+++a+Gla+LHe+i+g+k

Q: 253   VEKRNNNLDLELWLITTYHDKGSLTDYLKANVVSWNELCLIAQTAARGLAYLHEDIPGHK  312

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         + +Kp+iaHRD+kskN+l+k++lt+ciaD+GLal++e+ k++ d  ++ qvGt+RYmaPE

Q: 313   DGHKPSIAHRDIKSKNVLLKNNLTACIADFGLALQFEAGKSAGD--THGQVGTRRYMAPE  370

         *****************************************888..79************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vle+a+n+++ +af r+D+Y++gLvlWE++sRc+++d+ v+ey+lpfee+vg++Psle+m

Q: 371   VLEGAINFQR-DAFLRIDMYAFGLVLWELVSRCTAADGPVDEYMLPFEEEVGQHPSLEDM  429

         *********9.9************************************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         +evvv+kklrP +++ w+k+  l++l++++e+cWd+++ea l+a +v++r+

Q: 430   QEVVVHKKLRPCLRDCWQKHTGLAMLCETIEDCWDHEAEA-LSAGCVEERI  479

         **************************************98.99****9985

Domain Sequence
(FASTA)

LQLLEVKARG RFGCVWKAQL LNEYVAVKIF PIQDKLSWQN EYEIYSLNGM KHENILHFIG 60

VEKRNNNLDL ELWLITTYHD KGSLTDYLKA NVVSWNELCL IAQTAARGLA YLHEDIPGHK 120

DGHKPSIAHR DIKSKNVLLK NNLTACIADF GLALQFEAGK SAGDTHGQVG TRRYMAPEVL 180

EGAINFQRDA FLRIDMYAFG LVLWELVSRC TAADGPVDEY MLPFEEEVGQ HPSLEDMQEV 240

VVHKKLRPCL RDCWQKHTGL AMLCETIEDC WDHEAEALSA GCVEERI 287

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0043235	; C:receptor complex
GO:0017002	; F:activin-activated receptor activity
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0023014	; P:signal transduction by phosphorylation
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR015768	; Activin_II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR017194	; Transform_growth_fac-b_typ-2.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013