EKS-TEN-00462

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00462

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	446.5	2.7E-134	271	519	249

Status

Unreviewed

Ensembl Protein

ENSTNIP00000020356

UniProt Accession

H3DIL2;

Protein Name

Protein Synonyms/Alias

Gene Name

FYN (1 of 3)

Gene Synonyms/Alias

FYN (1 of 3);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000017219	ENSTNIP00000020356	ENSTNIT00000020587

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

536

Protein Sequence
(FASTA)

MGCVQCKDKE AAKLTDDRET SLSHHSGYRY GSDPTPQHYP SFGVTTIPNY NNFHGAATQG 60

VTVFGGVHTS SQSGTLRSRG GTGVTLFVAL YDYEARTEDD LSFRKGERFQ ILNSTEGDWW 120

EARSLTTGGT GYIPSNYVAP VDSIQAEDWY FGKLGRKDAE RQLLSNGNAR GTFLIRESET 180

TKGAYSLSIQ DWDDIKGDHV KHYKIRKLDN GGYYITTRAQ FETLQQLVQH YSARAAGLCC 240

RLIVPCHKGM PRLTDLSVKT KDVWEIPRES LQLIKRLGNG QFGEVWMGTW NGTTKVAVKT 300

LKPGTMSPES FLEEAQIMKK LRHDKLVQLY AVVSEEPIYI VTEYMSKGSL LDFLKDGEGR 360

GLKLPNLVDM AAQVAAGMAY IERMNYIHRD LSANILVGDS LVCKIADFGL ARLIEDNEYT 420

ARQGAKFPIK WTAPEAALYG KFTIKSDVWS FGILLTELVT KGRVPYPGMN NREVLEQVER 480

GYRMPCPQDC PTSLHELMVQ CWKKDPEERP TFEYLQAFLE DYFTATEPQY QPGDNL 536

Nucleotide Sequence
(FASTA)

ATGGGCTGTG TCCAATGTAA GGATAAAGAA GCAGCGAAAC TTACCGACGA CCGGGAGACC 60

AGCCTCTCGC ACCACTCGGG CTACCGCTAT GGGTCGGACC CCACGCCGCA GCACTACCCC 120

AGCTTTGGGG TCACCACCAT TCCTAACTAC AACAACTTCC ACGGCGCCGC CACCCAGGGG 180

GTGACGGTGT TTGGAGGGGT CCACACGTCC TCGCAGTCCG GAACGCTGAG GTCTCGTGGA 240

GGAACAGGGG TGACCCTGTT TGTGGCTCTC TATGACTACG AGGCGAGGAC TGAGGATGAC 300

CTCAGCTTCA GAAAGGGGGA GCGGTTCCAG ATCCTCAACA GCACCGAGGG AGACTGGTGG 360

GAGGCTCGTT CTCTCACCAC AGGTGGAACT GGTTACATTC CCAGTAATTA TGTTGCTCCG 420

GTGGACTCGA TTCAAGCTGA GGATTGGTAT TTTGGTAAAC TAGGGCGAAA GGACGCAGAG 480

AGGCAGCTGC TGTCCAACGG CAACGCCAGG GGCACTTTCC TCATCCGCGA AAGTGAAACA 540

ACCAAAGGGG CCTACTCTCT CTCCATTCAG GACTGGGATG ATATCAAAGG AGATCACGTC 600

AAGCACTATA AAATTCGCAA ATTGGACAAT GGAGGCTACT ACATCACCAC CAGAGCTCAG 660

TTTGAGACCC TTCAGCAGCT GGTGCAGCAC TACTCCGCCA GGGCTGCCGG GCTGTGCTGC 720

CGGTTGATCG TGCCGTGCCA CAAAGGCATG CCCCGCCTCA CCGACCTGTC CGTCAAAACC 780

AAAGACGTGT GGGAGATCCC GCGGGAGTCG CTGCAGCTCA TCAAACGTCT GGGCAACGGC 840

CAGTTTGGAG AAGTCTGGAT GGGCACGTGG AACGGCACCA CAAAGGTGGC GGTCAAGACG 900

CTGAAACCTG GCACCATGTC GCCCGAGTCC TTCCTGGAGG AGGCTCAGAT CATGAAGAAG 960

CTCCGACACG ACAAGCTGGT GCAGCTGTAC GCCGTGGTGT CCGAGGAGCC CATCTACATC 1020

GTCACGGAGT ACATGAGCAA AGGCAGTTTG CTTGACTTCC TCAAAGATGG AGAAGGACGA 1080

GGCCTCAAAC TGCCAAACCT AGTGGACATG GCTGCTCAGG TGGCGGCAGG CATGGCGTAC 1140

ATCGAGAGGA TGAACTACAT TCACAGAGAT CTGTCCGCCA ACATCCTGGT CGGCGACAGT 1200

CTGGTGTGCA AGATCGCTGA CTTCGGCCTG GCCAGGCTCA TCGAAGACAA CGAATACACA 1260

GCGAGACAAG GTGCCAAATT TCCAATAAAG TGGACCGCCC CCGAGGCTGC CCTGTACGGG 1320

AAATTCACCA TCAAGTCGGA CGTATGGTCG TTTGGGATTC TGCTGACAGA GCTGGTGACC 1380

AAGGGCAGAG TGCCGTATCC AGGCATGAAT AACCGGGAGG TGCTGGAGCA GGTGGAGCGG 1440

GGCTACCGGA TGCCGTGCCC TCAGGACTGC CCCACGTCGC TGCACGAGCT GATGGTGCAA 1500

TGCTGGAAGA AGGACCCTGA GGAAAGGCCC ACCTTCGAGT ACCTGCAGGC CTTTTTGGAG 1560

GACTACTTCA CTGCCACTGA GCCTCAGTAC CAGCCGGGGG ATAATCTCTG A 1611

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         l+l+k+lG+GqfGevw+g+w+g++kvavktlk+gt+spe+fleeaqi+kklrh+klv+ly

Q: 271   LQLIKRLGNGQFGEVWMGTWNGTTKVAVKTLKPGTMSPESFLEEAQIMKKLRHDKLVQLY  330

         689*********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avvse ePiyivte+m+kGslldflk+ eg+ lklp+lvd+aaqva+Gmay+e++n+ihr

Q: 331   AVVSE-EPIYIVTEYMSKGSLLDFLKDGEGRGLKLPNLVDMAAQVAAGMAYIERMNYIHR  389

         ****9.******************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl a n+lvg+slv+k+adfGlarlied+eyta++gak+PikWtaPea+ +gkftiksdv

Q: 390   DLSA-NILVGDSLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGKFTIKSDV  448

         **75.9******************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGillte+vtkG+vPypGm+n+evleqvergyr+p+p++cp++l+el+++cwkkdpee

Q: 449   WSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPTSLHELMVQCWKKDPEE  508

         ************************************************************

S: 241   rPtfetlqevl  251

         rPtfe+lq++l

Q: 509   RPTFEYLQAFL  519

         *******9876

Domain Sequence
(FASTA)

LQLIKRLGNG QFGEVWMGTW NGTTKVAVKT LKPGTMSPES FLEEAQIMKK LRHDKLVQLY 60

AVVSEEPIYI VTEYMSKGSL LDFLKDGEGR GLKLPNLVDM AAQVAAGMAY IERMNYIHRD 120

LSANILVGDS LVCKIADFGL ARLIEDNEYT ARQGAKFPIK WTAPEAALYG KFTIKSDVWS 180

FGILLTELVT KGRVPYPGMN NREVLEQVER GYRMPCPQDC PTSLHELMVQ CWKKDPEERP 240

TFEYLQAFL 249

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013