EKS-TEN-00200

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00200

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/RSKb	477.3	1.3E-143	418	675	258

Status

Unreviewed

Ensembl Protein

ENSTNIP00000020404

UniProt Accession

H3DIR0;

Protein Name

Ribosomal protein S6 kinase

Protein Synonyms/Alias

Gene Name

RPS6KA1

Gene Synonyms/Alias

RPS6KA1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000017266	ENSTNIP00000020404	ENSTNIT00000020636

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

735

Protein Sequence
(FASTA)

MEREKKKFTL SSLLRIYLRK KGREKKPVLF SSLQEDGDIK EINITHVVKE GSEKADASQF 60

ELLKVLGQGS FGKVFLVRKV TPPDANQLYA MKVLKKATLK VRDRVRTKME RNILADVNHP 120

FVVKLHYAFQ TEGKLYLILD FLRGGDLFTR LSKEVMFTEE DVKFYLAELA LGLDHLHSLG 180

IIYRDLKPEN ILLDEEGHIK LTDFGLCKEA IDHEKKAYSF CGTVEYMAPE VVNRQGHTHS 240

ADWWSFGVLM FEMLTGALPF QGKDRKETMN LILKARLGMP QFLSAEAQSL LRALFKRNPA 300

NRLDQGSGAD GAEEIKRHGF FSTIDWNKLF RREMKPPFRP AVARPDDTFY FDSEFTSRTP 360

KDSPGVPPSA GAHQLFRGFS FIASTLLEEE GSEEQVKPQP HPVVQQLHGK NLLFSDGYVL 420

KEDIGMGSFS VCKRCIHKAT NTEYAVKMID KTSTDPSEEI EILLRYGQHP NIITLKDVYD 480

NGKQVFLVTE LMRGGELLDR ILKQKFFSER EASAVLHTIT RTVEYLHSQG VVHRDLKPSN 540

ILYVDDSGNP ESIRICDFGF AKQLRANNGL LMTPCYTANF VAPEVLKRQG YDEGCDIWSL 600

GVLLYTMLAG FTPFANGPED TPDEILNRIG NGHFSLGGGN WDTVSDAAKD LVSKMLHVDP 660

HQRLTARQVL RHPWIVHRDK LPNSQLPHHD PKLVKGAMAA TYSALKNSQP TPELKPIESS 720

FLAQRRVRKL PSTSL 735

Nucleotide Sequence
(FASTA)

ATGGAGAGAG AGAAGAAAAA GTTTACCCTG AGCAGCTTGC TGAGAATCTA CCTGCGCAAA 60

AAGGGAAGAG AAAAAAAGCC CGTCTTGTTT TCATCTCTTC AGGAAGATGG AGACATCAAG 120

GAGATCAACA TCACCCACGT GGTCAAGGAG GGCTCGGAGA AGGCCGACGC CTCTCAGTTC 180

GAACTGCTCA AGGTGTTGGG GCAGGGCTCT TTCGGCAAAG TGTTTCTGGT TCGAAAGGTG 240

ACACCCCCGG ATGCTAACCA ACTCTACGCC ATGAAGGTCC TGAAGAAAGC GACGCTCAAA 300

GTGAGGGACC GTGTCAGGAC CAAGATGGAG AGGAACATCC TGGCCGACGT CAACCATCCC 360

TTTGTCGTCA AGCTGCACTA CGCGTTCCAG ACGGAAGGGA AGCTTTACTT GATCCTGGAC 420

TTCCTCAGAG GAGGAGATCT CTTTACGAGA CTTTCCAAAG AGGTGATGTT TACGGAGGAG 480

GATGTAAAGT TTTATCTGGC AGAGCTGGCG TTGGGACTGG ACCACCTCCA CAGCCTGGGC 540

ATCATATACA GAGACCTCAA ACCGGAGAAC ATTCTCCTGG ACGAAGAGGG CCACATCAAA 600

CTCACGGATT TTGGTTTGTG TAAAGAAGCC ATCGACCATG AGAAAAAAGC CTACTCCTTC 660

TGCGGGACGG TGGAGTACAT GGCCCCAGAG GTCGTCAACA GGCAGGGGCA CACCCACAGC 720

GCCGACTGGT GGTCGTTCGG GGTACTGATG TTTGAGATGC TGACTGGAGC ACTGCCGTTT 780

CAAGGGAAGG ATCGTAAAGA GACGATGAAC CTAATTCTGA AGGCGCGTCT GGGAATGCCT 840

CAGTTCTTGA GCGCAGAGGC CCAGTCACTG CTCAGGGCTT TGTTCAAGAG GAACCCCGCC 900

AACAGGCTCG ATCAAGGATC TGGAGCTGAT GGTGCAGAGG AGATCAAACG ACACGGCTTT 960

TTCTCCACCA TAGACTGGAA TAAACTTTTT AGGAGAGAAA TGAAGCCTCC GTTCAGACCA 1020

GCCGTGGCAC GTCCGGATGA TACCTTCTAC TTTGATTCGG AGTTCACGTC TCGGACCCCA 1080

AAAGACTCAC CAGGGGTTCC ACCCAGCGCT GGAGCCCACC AGCTCTTCAG AGGCTTCAGC 1140

TTTATCGCGT CGACTCTGCT GGAGGAGGAA GGTTCGGAGG AGCAGGTCAA GCCTCAGCCA 1200

CACCCAGTGG TGCAGCAACT ACACGGAAAG AACCTGCTGT TCAGCGACGG CTACGTGCTG 1260

AAGGAAGACA TCGGCATGGG CTCCTTCTCC GTCTGCAAAC GCTGCATCCA CAAAGCCACC 1320

AACACGGAGT ACGCCGTCAA GATGATTGAC AAGACCAGCA CGGATCCTTC TGAAGAGATA 1380

GAGATTCTGC TTCGATACGG ACAGCACCCG AATATCATAA CGCTGAAGGA CGTGTACGAC 1440

AACGGTAAGC AGGTGTTCCT GGTGACGGAG CTGATGCGCG GAGGGGAGCT GCTGGATCGG 1500

ATCCTCAAAC AGAAGTTCTT CTCGGAGAGG GAGGCCAGCG CCGTTCTTCA CACCATCACC 1560

AGGACCGTGG AGTACCTGCA CTCGCAGGGG GTGGTGCACA GAGACCTGAA GCCCAGCAAC 1620

ATCCTCTACG TTGACGATTC TGGAAATCCA GAGTCCATCA GGATCTGCGA CTTCGGGTTC 1680

GCTAAGCAGC TGCGCGCAAA CAACGGCCTG CTGATGACGC CGTGCTACAC GGCTAACTTC 1740

GTCGCTCCGG AGGTGCTGAA GCGCCAGGGC TACGATGAGG GCTGCGACAT CTGGAGCCTG 1800

GGGGTTCTGC TCTACACCAT GCTGGCAGGC TTCACACCGT TTGCCAACGG GCCCGAGGAC 1860

ACCCCGGATG AGATCCTGAA CAGGATAGGC AATGGCCACT TCAGCCTGGG CGGAGGCAAC 1920

TGGGACACGG TGTCAGATGC TGCCAAGGAC CTTGTGTCAA AGATGCTCCA CGTGGACCCC 1980

CACCAAAGAC TGACGGCCAG GCAGGTCCTC AGGCATCCCT GGATCGTCCA CAGAGACAAA 2040

CTTCCCAACA GCCAGCTGCC GCACCACGAC CCCAAACTGG TTAAGGGTGC GATGGCAGCC 2100

ACCTACTCTG CCCTGAAGAA CTCCCAGCCC ACTCCAGAGC TGAAGCCCAT CGAGAGCTCC 2160

TTCCTGGCCC AGAGACGCGT GAGGAAGCTT CCCTCCACGT CCCTGTAG 2208

Domain Profile

S: 1     yevkedlGvGsysvckrcvhkatnqefavkiidkskrdtseeieillryeqhpnivtlkd  60

         y++ked+G Gs+svckrc+hkatn+e+avk+idk+ +d+seeieillry+qhpni+tlkd

Q: 418   YVLKEDIGMGSFSVCKRCIHKATNTEYAVKMIDKTSTDPSEEIEILLRYGQHPNIITLKD  477

         679*********************************************************

S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120

         vyd+gk v+lv+el++GGelldri+k+kffsereasa+l+t++++veylh+qGvvhrdlk

Q: 478   VYDNGKQVFLVTELMRGGELLDRILKQKFFSEREASAVLHTITRTVEYLHSQGVVHRDLK  537

         ************************************************************

S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180

         p+nilyvd+s+n+esi+i+dfGfak++ra+ngll+tpcyt+nfvapevlkrqGyde+cd+

Q: 538   PSNILYVDDSGNPESIRICDFGFAKQLRANNGLLMTPCYTANFVAPEVLKRQGYDEGCDI  597

         ************************************************************

S: 181   wslGvllytmlaGyvpfangpedtaeeilakikeGkfslsGeawdsvseeakdlvskllt  240

         wslGvllytmlaG++pfangpedt++eil +i++G+fsl G++wd+vs++akdlvsk+l+

Q: 598   WSLGVLLYTMLAGFTPFANGPEDTPDEILNRIGNGHFSLGGGNWDTVSDAAKDLVSKMLH  657

         ************************************************************

S: 241   vdpakrlkleqllkhswl  258

         vdp++rl+++q+l+h+w+

Q: 658   VDPHQRLTARQVLRHPWI  675

         *****************8

Domain Sequence
(FASTA)

YVLKEDIGMG SFSVCKRCIH KATNTEYAVK MIDKTSTDPS EEIEILLRYG QHPNIITLKD 60

VYDNGKQVFL VTELMRGGEL LDRILKQKFF SEREASAVLH TITRTVEYLH SQGVVHRDLK 120

PSNILYVDDS GNPESIRICD FGFAKQLRAN NGLLMTPCYT ANFVAPEVLK RQGYDEGCDI 180

WSLGVLLYTM LAGFTPFANG PEDTPDEILN RIGNGHFSLG GGNWDTVSDA AKDLVSKMLH 240

VDPHQRLTAR QVLRHPWI 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016239	; Ribosomal_S6_kinase_II.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 2.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 2.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 2.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00108	; PROTEIN_KINASE_ST; 2.

Prints

Created Date

20-Feb-2013