EPS-TEN-00026

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-TEN-00026

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	280.1	2.4E-83	23	290	268

Status

Unreviewed

Ensembl Protein

ENSTNIP00000020486

UniProt Accession

H3DIZ2;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1A

Gene Synonyms/Alias

PPM1A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000017348	ENSTNIP00000020486	ENSTNIT00000020718

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

384

Protein Sequence
(FASTA)

MGAFLDKPKM EKYNSCGEGN SLRYGLSSMQ GWRVEMEDAH TAVIGLPHAL DHWSFFAVYD 60

GHAGSQVAKY CCEHLLEHIT SNSDFQRALQ EDPSVDNVKN GIRTGFLQID EHMRTISEKK 120

HGVDRSGSTA VGVMISPSHI YFINCGDSRG LLSRGGAVHF FTQDHKPNNP LEKERIQKAG 180

GSVMIQRVNG SLAVSRALGD FDYKCVHGKG PTEQLVSPEP EVYAIERSEG EDEFIILACD 240

GIWDVMANEQ LCDFVRSRLE VTDDLERVSN EIVDTCLYKG SRDNMSVVVI CFPGAPKVSP 300

EAVKKEADLD KYLEARVEEI LKKQGEEGVP DLVHVMRTLA SESIPNLPPG GELASKRTVI 360

EAMYNKLNPC RSDDTDSAST DDMW 384

Nucleotide Sequence
(FASTA)

ATGGGTGCAT TTCTGGACAA ACCAAAGATG GAAAAATACA ATTCCTGTGG TGAAGGTAAC 60

AGCCTGAGGT ATGGGCTGAG CAGCATGCAA GGCTGGCGGG TGGAGATGGA AGACGCGCAC 120

ACAGCCGTGA TCGGCCTGCC TCACGCCCTC GACCACTGGT CCTTCTTCGC TGTTTATGAC 180

GGCCACGCGG GCTCTCAGGT GGCCAAGTAT TGCTGTGAGC ACTTGCTGGA GCACATCACC 240

AGCAATTCAG ACTTCCAGAG AGCACTGCAG GAGGACCCGT CGGTGGACAA CGTGAAGAAC 300

GGCATCCGCA CGGGATTCCT GCAGATCGAC GAGCACATGC GAACCATCTC GGAGAAGAAG 360

CACGGCGTGG ACCGCAGCGG TTCCACAGCG GTGGGCGTGA TGATTTCCCC CAGCCATATC 420

TACTTTATCA ACTGCGGCGA CTCCCGCGGA CTCCTCAGTC GGGGCGGAGC CGTGCACTTC 480

TTCACACAAG ACCACAAACC CAACAATCCC CTGGAGAAGG AAAGAATCCA GAAAGCGGGC 540

GGCTCTGTCA TGATTCAGCG AGTTAACGGC TCCCTAGCTG TGTCCCGGGC TTTGGGGGAC 600

TTTGACTACA AATGCGTGCA CGGGAAGGGC CCGACAGAGC AGCTCGTGTC CCCCGAGCCC 660

GAAGTCTATG CGATAGAGAG ATCCGAGGGA GAAGACGAGT TCATCATCCT GGCGTGCGAC 720

GGCATCTGGG ACGTCATGGC CAACGAGCAG CTCTGCGACT TTGTCCGGTC CAGGCTGGAG 780

GTGACGGACG ACCTGGAGAG AGTCAGCAAC GAAATAGTGG ACACCTGTTT GTACAAGGGG 840

AGCCGAGACA ACATGAGCGT GGTGGTCATC TGCTTTCCTG GCGCCCCCAA GGTTTCTCCA 900

GAGGCGGTGA AGAAGGAGGC GGATTTGGAT AAATATCTGG AGGCCAGAGT AGAAGAGATT 960

CTGAAAAAGC AGGGCGAGGA AGGCGTTCCT GACCTGGTCC ACGTCATGCG AACGTTAGCG 1020

TCCGAGTCCA TCCCCAACCT TCCTCCTGGA GGAGAGCTGG CAAGCAAGCG AACTGTTATT 1080

GAAGCGATGT ACAACAAGCT GAACCCCTGC CGAAGTGACG ACACAGACTC TGCATCCACA 1140

GACGACATGT GGTAA 1155

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         ++g++s++g+r emeda+t+   ++  p + d+++ff+vyDGh+gs+vak+c e+l e++

Q: 23    RYGLSSMQGWRVEMEDAHTA---VIGLPHALDHWSFFAVYDGHAGSQVAKYCCEHLLEHI  79

         69****************97...6677777888***************************

S: 62    aeele.....sseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikdsk  116

         + + +     +++++ ++vk+ ++++Fl++de+++ ++ek++  d+sGstav ++i++s+

Q: 80    TSNSDfqralQEDPSVDNVKNGIRTGFLQIDEHMRTISEKKHGVDRSGSTAVGVMISPSH  139

         ***9999*999999**********************************************

S: 117   lyvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvLavsR  176

         +y++n+GdSr +L+r+g ++  ++dHkp+++ E+eRi++aggsv+ +   Rv+G+LavsR

Q: 140   IYFINCGDSRGLLSRGGAVHFFTQDHKPNNPLEKERIQKAGGSVMIQ---RVNGSLAVSR  196

         ***********************************************...**********

S: 177   alGdlylk.........pyvtpePevtshrltsede.fliLasDGlwdvvsneeavslvr  226

         alGd+++k         ++v+pePev+ +++++ ++ f+iLa+DG+wdv+ ne+++++vr

Q: 197   ALGDFDYKcvhgkgpteQLVSPEPEVYAIERSEGEDeFIILACDGIWDVMANEQLCDFVR  256

         *******************************765555***********************

S: 227   dvlekkeaeqeaakkLvklalargskdnvsaivv  260

         ++le +++++ +++++v+++l +gs+dn+s++v+

Q: 257   SRLEVTDDLERVSNEIVDTCLYKGSRDNMSVVVI  290

         *****************************99997

Domain Sequence
(FASTA)

RYGLSSMQGW RVEMEDAHTA VIGLPHALDH WSFFAVYDGH AGSQVAKYCC EHLLEHITSN 60

SDFQRALQED PSVDNVKNGI RTGFLQIDEH MRTISEKKHG VDRSGSTAVG VMISPSHIYF 120

INCGDSRGLL SRGGAVHFFT QDHKPNNPLE KERIQKAGGS VMIQRVNGSL AVSRALGDFD 180

YKCVHGKGPT EQLVSPEPEV YAIERSEGED EFIILACDGI WDVMANEQLC DFVRSRLEVT 240

DDLERVSNEI VDTCLYKGSR DNMSVVVI 268

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0000287	; F:magnesium ion binding
GO:0030145	; F:manganese ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR001932	; PP2C-like.
IPR012911	; PP2C_C.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481	; PP2C; 1.
PF07830	; PP2C_C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013