EKS-TEN-00442
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TEN-00442
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/PEK342.62.0E-1025971014418
StatusUnreviewed
Ensembl ProteinENSTNIP00000020593
UniProt AccessionH3DJ97;
Protein Name
Protein Synonyms/Alias
Gene NameEIF2AK4
Gene Synonyms/Alias EIF2AK4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTNIG00000017450ENSTNIP00000020593ENSTNIT00000020825
OrganismTetraodon nigroviridis
Functional Description
Protein Length1662
Protein Sequence
(FASTA)
VPCRRMSSQL TPADATDEHT IQQDNELEAL ASIFGDDFQD LRNKDPWKVK RPPEVYLCLR 60
PNGLNNGQGC YATVDLQVKC PPSYPDVPPE LELKNVKGLS NEKVQNLQNE LTKLAAARCG 120
EVMIYELADH IQGFLSEHNK PPPRSFHEEM LKNQQRQQEK RAQEEQQRMD QQRKQEEEME 180
KEIMAEIQRR EEEKREEKRR KEVAKLERLE SMDQSASASS ALLGKSPPTP VKAPPEATDG 240
RKVVGNRRRT TSNSRHRRDT FNEDNHRSPE VLHFSSSTFG ELLVHIGKSL GVSQRLVRSV 300
YNGFETNSGE FAVIYQWTLH WNKKIGKFLT TQEKAKIDNC KKQIHAAENE FNSLLKLDHP 360
NLAHYMALST SEKEECLVVN LLVEHVSGTN LNQSLSVHGA VPLDKLCHYT TQLLAALDYL 420
HSNSVVHKQL GASSVLVDSE GNVRLTDYSL SKRFADICKE DVFEQAHVRF SEGTAMPTKL 480
GKKGDVWNLG LMLLGLSQGK EVKEYPVKVP VSLPHDFQDF LNKCLCLNDA DRWTPQQLLD 540
HSFLKPPSPK NLPQDQDASP EDLAVDFAST VIPRSQILDA PFISGVQRQF SRYFNEFEEL 600
QLLGKGAFGA VIKVQNKLDG CYYAVKRIQV NPASKHFRRI KGEVTLLSRL NHENIVRYYN 660
AWIERHETPT TGVLSSTESS EPQSTPDKSP QGKKPPQRLN ELGLPDNVED AAPPPTLSSS 720
VEWSTSIERS SSAKCSGNQS SDEEDDDEDE DVFGASFLPS DSDSRSDIIF GNGDESADEL 780
SQVELSKRQT KDTAETMDSE CSPLIAHYLY IQMEYCEKST LRDTIDHGLY QDQNRLWRLF 840
REILDGLAYI HQQGMIHRDL KPVNIFLDSQ DHVKIGDFGL ATDHPANVAA GKFEVEEHST 900
GLMSKPDPTD NMTGMVGTAL YVSPEVQGNT KATYNQKVDL FSLGIILFEM SYRPMTTGAE 960
RISVLSQLRG VPIVFPQDFC TNEKSTQWRV IEWLLNHDPA LRPTTQEVLK SQLLPLPQME 1020
ESELHEVLQH TLANINGKAY RTMVGQLFAQ NTSPVMDYTY DIDLHKGSFN VNSAKLQQHV 1080
HETIIRIFKK HGAVRLQTPL LFPRNRKLYE GSELACFMDH SGMLVTLPYD LRMAFARYVA 1140
RNNITQLKRY SIDRVFRPRK LDRAHPRELL ECAFDIITPV TNSLLPDAEA IYAVSEIIQE 1200
FPSLQERNYH IYLNHTSLLK AILLHSGIPE DKLSQASNIL CDAMSEKLTK REVEAKFCNF 1260
SLSTNSLQML YKYIEQKGDL QELAPLLTSL TKHKTAVSQL AKQGLKDLEE VTGLLDKLAV 1320
KLQVVINLGL VYKVQHHSGV IFQFVAFVRK RKKTVPDIIA AGGRYDHLIA EFRGPASTVP 1380
VPSAVGISLS LEKVCFALAT MEEPPSVSYC DVLVVPVGQS SMTRAINVVQ RLWSTGISAD 1440
ITYDVSQSQE TLLEHCRLAG INCMALVSDK EGSHVKVKSF EKDRQSEKRI PELDLADHII 1500
QKCRNKFIEE KGISREISES MALQNPKGSL TSSVGSSEQH GGSSNVNVNV ISPEKVSAST 1560
RRRYETQIQT RLQNLGSNLQ NKSNDIEVLA VDLQKETLIN FLSLEFDNEY QFNISVKTLL 1620
SRLPKQRYLK SICDELHHFK IMKKVGVVVL YSYRDDYYKI LV 1662
Nucleotide Sequence
(FASTA)
GTGCCATGTA GAAGAATGAG CAGTCAGCTC ACTCCAGCCG ACGCGACGGA CGAGCACACA 60
ATCCAGCAGG ACAACGAGCT AGAGGCCCTC GCGTCTATTT TTGGAGATGA CTTCCAGGAC 120
CTACGAAACA AGGATCCGTG GAAGGTTAAA AGGCCCCCAG AGGTGTACCT CTGCCTGCGG 180
CCCAACGGGC TGAATAACGG CCAGGGTTGC TACGCGACGG TGGATTTGCA GGTCAAATGT 240
CCACCTTCGT ACCCAGACGT GCCTCCGGAG CTGGAGCTAA AAAACGTTAA AGGTCTTTCC 300
AATGAAAAAG TTCAGAACCT TCAGAATGAG CTTACCAAGC TGGCAGCTGC ACGATGTGGT 360
GAGGTGATGA TTTATGAACT AGCGGACCAC ATCCAGGGCT TCCTCAGCGA GCATAACAAA 420
CCCCCGCCAC GCTCTTTCCA CGAGGAGATG CTTAAGAACC AGCAGAGACA GCAGGAGAAA 480
CGAGCACAGG AGGAGCAGCA GAGGATGGAT CAGCAGCGCA AGCAGGAGGA GGAGATGGAA 540
AAAGAAATAA TGGCTGAAAT TCAAAGACGC GAAGAGGAGA AACGAGAGGA AAAACGAAGG 600
AAAGAGGTTG CCAAACTGGA GAGACTCGAG AGTATGGATC AGTCAGCCAG TGCAAGCTCT 660
GCCCTGCTGG GAAAGAGCCC CCCCACCCCT GTAAAAGCTC CTCCTGAAGC GACTGATGGA 720
AGGAAGGTAG TTGGTAACCG CCGTCGGACT ACCTCAAACT CACGCCACAG ACGTGATACC 780
TTCAACGAAG ACAACCATCG TTCGCCAGAA GTACTTCACT TCAGCAGCAG TACTTTTGGA 840
GAGCTCCTCG TCCACATAGG GAAGAGTTTG GGTGTGAGCC AGCGTCTCGT CCGCAGTGTT 900
TACAATGGGT TTGAGACAAA CTCTGGGGAG TTTGCTGTGA TATACCAGTG GACTCTCCAC 960
TGGAACAAGA AAATAGGCAA GTTCCTCACC ACTCAGGAGA AAGCCAAAAT TGATAACTGC 1020
AAGAAGCAGA TCCACGCAGC AGAGAACGAA TTTAACTCCC TCCTGAAGCT GGATCATCCA 1080
AACTTGGCTC ACTACATGGC ACTGAGCACC AGTGAGAAGG AAGAGTGCCT GGTGGTGAAC 1140
CTGCTGGTGG AGCATGTGTC CGGCACCAAT CTGAACCAAA GCTTGAGCGT CCATGGGGCA 1200
GTCCCTCTGG ACAAACTGTG CCATTACACA ACCCAGCTGC TGGCGGCTCT AGACTACCTA 1260
CACTCCAACT CTGTGGTCCA CAAACAGCTG GGTGCCTCCA GTGTGCTGGT GGACTCTGAA 1320
GGCAACGTTC GTCTGACTGA TTATAGCCTC TCCAAGAGAT TTGCTGACAT CTGCAAGGAG 1380
GACGTTTTTG AGCAAGCCCA CGTGCGATTC TCAGAGGGTA CAGCCATGCC CACAAAACTG 1440
GGCAAGAAGG GGGATGTGTG GAACCTGGGG CTGATGCTGC TGGGTCTAAG TCAGGGGAAG 1500
GAAGTGAAGG AGTACCCAGT GAAGGTGCCT GTCAGCCTGC CGCATGATTT CCAGGACTTT 1560
CTCAACAAGT GCTTGTGCTT GAACGATGCA GATCGTTGGA CACCTCAGCA GCTCCTGGAT 1620
CACTCTTTTC TCAAACCACC ATCACCTAAA AACTTACCAC AGGATCAGGA TGCTAGCCCA 1680
GAAGATCTGG CTGTGGACTT TGCATCAACA GTCATCCCAC GGAGTCAAAT CCTCGATGCC 1740
CCCTTCATCT CAGGAGTGCA GAGGCAGTTT TCTCGGTACT TCAATGAGTT TGAAGAGCTG 1800
CAGCTTCTTG GAAAGGGTGC CTTTGGTGCT GTTATCAAGG TTCAGAACAA ACTAGACGGT 1860
TGCTATTACG CCGTGAAGCG CATCCAGGTC AACCCGGCCA GCAAGCATTT CCGGCGAATT 1920
AAAGGTGAGG TGACGCTCCT GTCACGCCTC AACCACGAGA ACATCGTTCG CTATTACAAC 1980
GCCTGGATCG AACGTCATGA GACGCCCACC ACTGGGGTGC TGAGCAGCAC GGAGAGCTCA 2040
GAACCACAGA GCACCCCGGA CAAGTCCCCT CAGGGCAAAA AGCCTCCCCA GCGCCTGAAC 2100
GAGCTGGGCC TCCCGGACAA CGTGGAGGAC GCCGCGCCGC CTCCCACCCT GTCCAGCTCT 2160
GTGGAGTGGT CCACCTCCAT TGAGAGGTCC TCCAGTGCCA AGTGCAGTGG AAACCAGTCA 2220
AGCGATGAAG AGGATGATGA CGAGGATGAG GACGTGTTTG GCGCTTCCTT TTTGCCGTCA 2280
GATAGTGACT CCAGGAGTGA CATCATCTTT GGCAACGGCG ATGAAAGTGC AGATGAGTTG 2340
TCGCAGGTTG AGTTGAGCAA AAGGCAAACA AAGGACACAG CCGAGACGAT GGACTCGGAG 2400
TGTTCACCCC TCATTGCACA TTACCTTTAT ATACAAATGG AATACTGTGA AAAAAGTACT 2460
TTAAGGGACA CAATAGATCA CGGCCTCTAC CAGGACCAGA ACCGCTTGTG GAGACTTTTC 2520
AGGGAAATCC TGGATGGACT GGCCTACATC CATCAGCAGG GTATGATTCA CAGGGACCTG 2580
AAACCTGTCA ACATCTTCCT GGACTCACAG GACCATGTGA AGATTGGAGA TTTTGGCCTA 2640
GCTACAGACC ATCCTGCTAA CGTGGCTGCA GGAAAATTTG AGGTGGAAGA GCACAGCACA 2700
GGGTTGATGT CCAAACCAGA CCCAACAGAT AACATGACAG GCATGGTTGG CACTGCTCTT 2760
TACGTCAGTC CTGAGGTTCA AGGAAACACC AAAGCCACCT ACAACCAAAA AGTGGACCTC 2820
TTTAGCCTGG GCATCATCCT CTTTGAGATG TCCTATCGGC CCATGACCAC TGGGGCAGAG 2880
CGTATATCTG TCCTCAGCCA GCTACGTGGG GTGCCCATTG TCTTTCCTCA GGACTTCTGT 2940
ACCAATGAGA AGAGTACGCA GTGGAGAGTG ATCGAGTGGC TGCTGAACCA TGACCCAGCC 3000
CTGCGGCCCA CCACCCAGGA GGTGCTGAAG AGCCAATTAC TGCCTTTGCC ACAGATGGAG 3060
GAGTCTGAGC TTCACGAGGT GCTTCAGCAC ACCTTGGCCA ATATCAATGG CAAGGCCTAT 3120
CGCACCATGG TGGGCCAGCT GTTTGCCCAG AACACCTCTC CTGTCATGGA TTACACATAT 3180
GACATCGACC TGCACAAGGG CAGCTTCAAC GTTAACAGTG CAAAATTGCA GCAGCATGTG 3240
CACGAAACAA TCATAAGGAT CTTCAAGAAG CACGGTGCTG TGCGTCTCCA GACCCCACTG 3300
CTCTTCCCTA GAAACAGGAA GCTGTACGAA GGTAGCGAGC TGGCTTGCTT TATGGACCAC 3360
AGCGGAATGC TGGTTACACT GCCCTATGAC CTCCGTATGG CGTTTGCAAG ATATGTCGCT 3420
CGCAACAACA TCACCCAACT CAAGAGGTAT AGCATTGATC GCGTTTTCCG CCCCCGGAAG 3480
CTGGATCGAG CCCACCCCAG GGAGCTCCTG GAATGTGCCT TTGACATCAT CACGCCCGTT 3540
ACAAACAGCT TGCTTCCTGA CGCTGAGGCC ATTTACGCCG TCTCCGAAAT CATCCAGGAA 3600
TTCCCCAGCC TTCAGGAAAG GAACTATCAC ATTTACCTGA ACCACACCAG CCTGTTGAAG 3660
GCCATCCTGC TGCACAGCGG GATCCCCGAG GACAAACTGA GCCAGGCCTC CAACATACTG 3720
TGTGACGCCA TGAGTGAAAA GCTGACCAAA CGTGAGGTGG AGGCAAAGTT CTGCAATTTT 3780
TCTCTGTCAA CCAACAGTTT GCAGATGTTG TACAAGTACA TTGAACAGAA GGGGGACCTG 3840
CAGGAGCTGG CACCACTGCT GACGTCACTC ACCAAACACA AGACTGCTGT CAGTCAACTA 3900
GCCAAGCAGG GGCTCAAGGA CCTGGAGGAG GTCACGGGGT TGCTGGATAA GCTGGCGGTG 3960
AAACTGCAGG TGGTGATTAA TTTAGGGCTG GTCTACAAGG TGCAGCATCA TTCAGGCGTC 4020
ATCTTCCAGT TTGTGGCTTT CGTTAGAAAA CGCAAGAAGA CAGTGCCAGA CATCATAGCT 4080
GCTGGGGGAC GCTACGATCA CTTGATTGCA GAGTTTCGAG GTCCAGCCTC GACTGTACCG 4140
GTCCCCTCTG CCGTAGGAAT CAGTTTATCC CTTGAAAAAG TCTGTTTTGC CCTGGCTACC 4200
ATGGAGGAGC CACCTTCAGT GAGTTATTGC GATGTTCTGG TGGTCCCAGT CGGACAGTCT 4260
TCGATGACCA GAGCCATTAA TGTTGTCCAA AGACTGTGGA GCACTGGCAT CTCTGCAGAC 4320
ATCACCTACG ACGTCTCGCA GTCTCAGGAG ACCTTGCTGG AGCACTGCAG GCTGGCTGGG 4380
ATCAACTGCA TGGCCCTGGT CTCTGACAAG GAGGGGAGCC ATGTGAAGGT CAAATCCTTT 4440
GAGAAGGACA GACAGTCCGA AAAGCGGATT CCTGAGTTAG ATTTGGCAGA CCACATCATC 4500
CAGAAGTGTC GGAACAAATT TATTGAGGAA AAAGGCATCA GCAGAGAGAT CTCTGAAAGC 4560
ATGGCTCTTC AGAACCCTAA AGGATCGCTC ACCTCCTCAG TAGGCTCTTC CGAGCAACAT 4620
GGCGGCAGCA GCAACGTGAA TGTGAACGTC ATCAGTCCAG AGAAGGTTTC CGCCAGCACG 4680
CGGCGGCGCT ACGAGACTCA GATCCAAACC AGGCTGCAGA ACCTTGGGAG CAATTTGCAG 4740
AACAAAAGCA ACGACATCGA GGTTCTGGCT GTGGACCTGC AGAAGGAAAC GCTGATCAAC 4800
TTTCTGTCTC TGGAGTTTGA CAACGAGTAC CAGTTCAACA TCAGCGTGAA GACCCTCCTG 4860
TCTCGCCTGC CCAAGCAGCG CTACCTGAAG TCCATCTGCG ACGAGTTGCA CCATTTCAAA 4920
ATCATGAAAA AGGTCGGCGT GGTGGTTCTG TACAGCTACA GAGACGACTA CTACAAGATC 4980
CTGGTGTGA 4989
Domain Profile
S: 1     feeikvlGkGgfgvVlkaknkldkkeyaikriklnkakkelekverevkaLaklehpniv  60
         fee+++lGkG+fg+V+k++nkld+++ya+kri++n a+k++++++ ev++L++l+h+niv
Q: 597   FEELQLLGKGAFGAVIKVQNKLDGCYYAVKRIQVNPASKHFRRIKGEVTLLSRLNHENIV  656
         89**********************************************************
S: 61    rYfaawleekeesl..............................................  74
         rY++aw+e++e++                                               
Q: 657   RYYNAWIERHETPTtgvlsstessepqstpdkspqgkkppqrlnelglpdnvedaapppt  716
         ***********9998888888888888888888888888888888877777777777765
S: 75    ........tdsseveaeaeleesesseesdtk............................  98
                 t                      +                            
Q: 717   lsssvewsT----------------------Siersssakcsgnqssdeedddededvfg  754
         544444431......................13333333333333555566666777778
S: 99    .....................................................llyiqme  105
                                                              +lyiqme
Q: 755   asflpsdsdsrsdiifgngdesadelsqvelskrqtkdtaetmdsecspliahYLYIQME  814
         8888888888888888888888888888888888888888889999**************
S: 106   lceketLkdwiderkllesrselvmrlfkqllegleylHskgliHrdLkpsniFldsddq  165
         +cek+tL+d+id+  l++++++l+ rlf+++l+gl+y+H++g+iHrdLkp+niFlds+d+
Q: 815   YCEKSTLRDTIDHG-LYQDQNRLW-RLFREILDGLAYIHQQGMIHRDLKPVNIFLDSQDH  872
         **************.9********.***********************************
S: 166   vKigDFgLatalaealkedvkqdaqske.........akhtgqvgtklymsPeql..eks  214
         vKigDFgLat+   +  +  ++ +++++          + tg+vgt+ly+sPe++  +k+
Q: 873   VKIGDFGLATDHPANVAAGKFEVEEHSTglmskpdptDNMTGMVGTALYVSPEVQgnTKA  932
         ***********988888777777777776777776666*****************999**
S: 215   qYnkkvDifsLGlilfeLly.pfstemervetltelrd..gkipedfdd.kvpkekkllq  270
         +Yn+kvD+fsLG+ilfe++y p+ t+ er+++l +lr   + +p+df   +   + ++++
Q: 933   TYNQKVDLFSLGIILFEMSYrPMTTGAERISVLSQLRGvpIVFPQDFCTnEKSTQWRVIE  992
         **************************************9999*****554899999****
S: 271   kllsrdpkeRpsasellksell  292
         +ll++dp+ Rp+++e+lks+ll
Q: 993   WLLNHDPALRPTTQEVLKSQLL  1014
         ******************9986
Domain Sequence
(FASTA)
FEELQLLGKG AFGAVIKVQN KLDGCYYAVK RIQVNPASKH FRRIKGEVTL LSRLNHENIV 60
RYYNAWIERH ETPTTGVLSS TESSEPQSTP DKSPQGKKPP QRLNELGLPD NVEDAAPPPT 120
LSSSVEWSTS IERSSSAKCS GNQSSDEEDD DEDEDVFGAS FLPSDSDSRS DIIFGNGDES 180
ADELSQVELS KRQTKDTAET MDSECSPLIA HYLYIQMEYC EKSTLRDTID HGLYQDQNRL 240
WRLFREILDG LAYIHQQGMI HRDLKPVNIF LDSQDHVKIG DFGLATDHPA NVAAGKFEVE 300
EHSTGLMSKP DPTDNMTGMV GTALYVSPEV QGNTKATYNQ KVDLFSLGII LFEMSYRPMT 360
TGAERISVLS QLRGVPIVFP QDFCTNEKST QWRVIEWLLN HDPALRPTTQ EVLKSQLL 418
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>
EKS-ANC-00331
EKS-BOT-00339
EKS-CAE-00274
EKS-CAJ-00348
EKS-CAF-00347
EKS-CAP-00373
EKS-CII-00190
EKS-DAR-00703
EKS-DRM-00167
EKS-EQC-00331
EKS-FEC-00330
EKS-GAG-00288
EKS-GAA-00422
EKS-GOG-00336
EKS-HOS-00346
EKS-ICT-00323
EKS-LAC-00354
EKS-LOA-00353
EKS-MEG-00280
EKS-MOD-00335
EKS-MUM-00374
EKS-MUP-00335
EKS-MYL-00338
EKS-NOL-00310
EKS-ORN-00443
EKS-ORA-00296
EKS-ORC-00318
EKS-ORL-00410
EKS-OTG-00344
EKS-PAT-00322
EKS-PES-00299
EKS-PEM-00180
EKS-POA-00333
EKS-RAN-00354
EKS-SAH-00318
EKS-SUS-00304
EKS-TAG-00415
EKS-TAR-00446
EKS-TUT-00087
EKS-XET-00433
EKS-XIM-00429
EKS-SAC-00083
EKS-SCP-00084
Gene Ontology
GO:0005524; F:ATP binding
GO:0004694; F:eukaryotic translation initiation factor 2alpha kinase activity
GO:0000049; F:tRNA binding
GO:0006446; P:regulation of translational initiation
KEGG
InterPros
IPR004154; Anticodon-bd.
IPR026920; EIF2AK4.
IPR024435; GCN2_anticodon-bd_dom.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR006575; RWD-domain.
IPR008271; Ser/Thr_kinase_AS.
IPR016255; Ser/Thr_kinase_GCN2.
IPR016135; UBQ-conjugating_enzyme/RWD.
Pfam
PF12745; HGTP_anticodon2; 1.
PF00069; Pkinase; 3.
PF05773; RWD; 1.
SMARTs
SM00591; RWD; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00108; PROTEIN_KINASE_ST; 1.
PS50908; RWD; 1.
Prints
Created Date20-Feb-2013